diff --git a/_template/pyproject.toml b/_template/pyproject.toml
index b180d32ad8..53387d14cd 100644
--- a/_template/pyproject.toml
+++ b/_template/pyproject.toml
@@ -29,7 +29,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
+  #"opentelemetry-api ~= 1.12",
 ]
 
 [project.entry-points.opentelemetry_instrumentor]
diff --git a/exporter/opentelemetry-exporter-prometheus-remote-write/pyproject.toml b/exporter/opentelemetry-exporter-prometheus-remote-write/pyproject.toml
index 4218e13472..d451c78af3 100644
--- a/exporter/opentelemetry-exporter-prometheus-remote-write/pyproject.toml
+++ b/exporter/opentelemetry-exporter-prometheus-remote-write/pyproject.toml
@@ -28,8 +28,8 @@ classifiers = [
 dependencies = [
   "protobuf ~= 4.21",
   "requests ~= 2.28",
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-sdk ~= 1.12",
+  #"opentelemetry-api ~= 1.12",
+  #"opentelemetry-sdk ~= 1.12",
   "python-snappy ~= 0.6",
 ]
 
diff --git a/exporter/opentelemetry-exporter-richconsole/pyproject.toml b/exporter/opentelemetry-exporter-richconsole/pyproject.toml
index 03a38a8647..4eb822daff 100644
--- a/exporter/opentelemetry-exporter-richconsole/pyproject.toml
+++ b/exporter/opentelemetry-exporter-richconsole/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-sdk ~= 1.12",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.5",
+  # "opentelemetry-sdk ~= 1.5",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "rich>=10.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
index c6dff9b9bd..95ac86f54e 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.5",
-  "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.5",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
index f6f4263ec6..151b7ed9d7 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
index 86df1fc38e..ccdfc3fd9b 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
     "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-    "opentelemetry-api ~= 1.12",
-    "opentelemetry-instrumentation == 0.50b0.dev",
-    "opentelemetry-semantic-conventions == 0.50b0.dev",
-    "opentelemetry-util-http == 0.50b0.dev",
+    # "opentelemetry-api ~= 1.12",
+    # "opentelemetry-instrumentation == 0.50b0.dev",
+    # "opentelemetry-semantic-conventions == 0.50b0.dev",
+    # "opentelemetry-util-http == 0.50b0.dev",
     "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-aiokafka/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiokafka/pyproject.toml
index 4398f686c8..8180ad5048 100644
--- a/instrumentation/opentelemetry-instrumentation-aiokafka/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiokafka/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.27",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.27",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
index 5236344665..19e0849d1e 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
index eef272575a..487a405367 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asgi/pyproject.toml
@@ -26,10 +26,10 @@ classifiers = [
 ]
 dependencies = [
   "asgiref ~= 3.0",
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
index b7e1287c72..332d49de95 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.14",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.14",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml
index b5ba5d6ad2..e66d5e6d3a 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml b/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml
index bc5c7c4426..aff929e598 100644
--- a/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-aws-lambda/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-propagator-aws-xray ~= 1.0",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-propagator-aws-xray ~= 1.0",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml b/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml
index 68628c427a..038029ea5d 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-boto/pyproject.toml
@@ -24,9 +24,9 @@ classifiers = [
   "Programming Language :: Python :: 3.11",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml b/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml
index 172642033d..4e3fd11668 100644
--- a/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-boto3sqs/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml b/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml
index 3e4618844f..f80bcd7e48 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-botocore/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-propagator-aws-xray ~= 1.0",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-propagator-aws-xray ~= 1.0",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml b/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml
index 98b1121db4..73c94568f7 100644
--- a/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-cassandra/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml b/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml
index 4c88789714..f8d5af2c7d 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-celery/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml b/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml
index 5c9436513f..5e1090bb9b 100644
--- a/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-confluent-kafka/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml
index da1b043672..39eac3bacc 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-django/pyproject.toml b/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
index 6b0204ef81..0f037068c3 100644
--- a/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-django/pyproject.toml
@@ -25,11 +25,11 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
index 32dcb1ad7e..ac04f7dbfb 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml b/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
index dd30ee6ba2..2aade3d22d 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-falcon/pyproject.toml
@@ -25,11 +25,11 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
   "packaging >= 20.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
index 9f64ab1ca4..e2f3a1b344 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/pyproject.toml
@@ -25,11 +25,11 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-asgi == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-asgi == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
index d5a27c78e7..7458537cbb 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
@@ -25,11 +25,11 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
   "packaging >= 21.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml b/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml
index 18cb2d3f0e..263cecdda8 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-grpc/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
index e4479223a4..a958b73dc0 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-httpx/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml b/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml
index 57f689a961..e6be9a659d 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml b/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
index d5dc500101..42ec4b6917 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.5",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.5",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml b/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml
index 2bb377f5ef..b02fc9448e 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-logging/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml b/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml
index 41273b0e22..4049b9db77 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-mysql/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml b/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
index 4edcbb08b1..ce5fd52f96 100644
--- a/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
index 4c32c12e82..ab88066d5d 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pika/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-api ~= 1.5",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.5",
   "packaging >= 20.0",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml b/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml
index 22af126330..8d544774c1 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/tests/test_psycopg_integration.py b/instrumentation/opentelemetry-instrumentation-psycopg/tests/test_psycopg_integration.py
index 4ddaad9174..4081070aeb 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/tests/test_psycopg_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/tests/test_psycopg_integration.py
@@ -378,6 +378,74 @@ def test_sqlcommenter_enabled(self, event_mocked):
         kwargs = event_mocked.call_args[1]
         self.assertEqual(kwargs["enable_commenter"], True)
 
+    def test_sqlcommenter_enabled_instrument_connection_defaults(self):
+        with mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.__version__",
+            "foobar",
+        ), mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.pq.__build_version__",
+            "foobaz",
+        ), mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.threadsafety",
+            "123",
+        ), mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.apilevel",
+            "123",
+        ), mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.paramstyle",
+            "test",
+        ):
+            cnx = psycopg.connect(database="test")
+            cnx = PsycopgInstrumentor().instrument_connection(
+                cnx,
+                enable_commenter=True,
+            )
+            query = "Select 1"
+            cursor = cnx.cursor()
+            cursor.execute(query)
+            spans_list = self.memory_exporter.get_finished_spans()
+            span = spans_list[0]
+            span_id = format(span.get_span_context().span_id, "016x")
+            trace_id = format(span.get_span_context().trace_id, "032x")
+            self.assertEqual(
+                MockCursor.execute.call_args[0][0],
+                f"Select 1 /*db_driver='psycopg%%3Afoobar',dbapi_level='123',dbapi_threadsafety='123',driver_paramstyle='test',libpq_version='foobaz',traceparent='00-{trace_id}-{span_id}-01'*/",
+            )
+
+    def test_sqlcommenter_enabled_instrument_connection_with_options(self):
+        with mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.__version__",
+            "foobar",
+        ), mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.pq.__build_version__",
+            "foobaz",
+        ), mock.patch(
+            "opentelemetry.instrumentation.psycopg.psycopg.threadsafety",
+            "123",
+        ):
+            cnx = psycopg.connect(database="test")
+            cnx = PsycopgInstrumentor().instrument_connection(
+                cnx,
+                enable_commenter=True,
+                commenter_options={
+                    "dbapi_level": False,
+                    "dbapi_threadsafety": True,
+                    "driver_paramstyle": False,
+                    "foo": "ignored",
+                },
+            )
+            query = "Select 1"
+            cursor = cnx.cursor()
+            cursor.execute(query)
+            spans_list = self.memory_exporter.get_finished_spans()
+            span = spans_list[0]
+            span_id = format(span.get_span_context().span_id, "016x")
+            trace_id = format(span.get_span_context().trace_id, "032x")
+            self.assertEqual(
+                MockCursor.execute.call_args[0][0],
+                f"Select 1 /*db_driver='psycopg%%3Afoobar',dbapi_threadsafety='123',libpq_version='foobaz',traceparent='00-{trace_id}-{span_id}-01'*/",
+            )
+
     @mock.patch("opentelemetry.instrumentation.dbapi.wrap_connect")
     def test_sqlcommenter_disabled(self, event_mocked):
         cnx = psycopg.connect(database="test")
@@ -388,6 +456,33 @@ def test_sqlcommenter_disabled(self, event_mocked):
         kwargs = event_mocked.call_args[1]
         self.assertEqual(kwargs["enable_commenter"], False)
 
+    def test_sqlcommenter_disabled_default_instrument_connection(self):
+        cnx = psycopg.connect(database="test")
+        cnx = PsycopgInstrumentor().instrument_connection(
+            cnx,
+        )
+        query = "Select 1"
+        cursor = cnx.cursor()
+        cursor.execute(query)
+        self.assertEqual(
+            MockCursor.execute.call_args[0][0],
+            "Select 1",
+        )
+
+    def test_sqlcommenter_disabled_explicit_instrument_connection(self):
+        cnx = psycopg.connect(database="test")
+        cnx = PsycopgInstrumentor().instrument_connection(
+            cnx,
+            enable_commenter=False,
+        )
+        query = "Select 1"
+        cursor = cnx.cursor()
+        cursor.execute(query)
+        self.assertEqual(
+            MockCursor.execute.call_args[0][0],
+            "Select 1",
+        )
+
 
 class TestPostgresqlIntegrationAsync(
     PostgresqlIntegrationTestMixin, TestBase, IsolatedAsyncioTestCase
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml b/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
index daf8c8efd4..766e190e6a 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
index 0e1fa1a47f..5e8494a7d0 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml
index c9204d71b9..1db47c5bef 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml
index fe68be60ab..4321c9a064 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
index 585a52c879..98887fe72b 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/pyproject.toml
@@ -25,11 +25,11 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-wsgi == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml b/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml
index c46d97aa9a..d9ea693174 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-redis/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.12.1",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml b/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml
index b7ff83f4db..93101ad104 100644
--- a/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-remoulade/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml b/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
index 7dab991cbc..ede9277939 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-requests/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml b/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml
index d089fc27e9..d63f7eae34 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-dbapi == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml b/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
index 13c4cc0fc2..ab1abca921 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-starlette/pyproject.toml
@@ -25,11 +25,11 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-instrumentation-asgi == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-instrumentation-asgi == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml b/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml
index 3808b4ec0f..e5cca8745a 100644
--- a/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-system-metrics/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-api ~= 1.11",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.11",
   "psutil >= 5.9.0, < 7",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml b/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml
index 7f18ae7b40..09e75bef9c 100644
--- a/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-threading/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml b/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
index eaeb69324f..38855d582b 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-tornado/pyproject.toml
@@ -24,10 +24,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml b/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml
index f53e19018c..3e71c96925 100644
--- a/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-tortoiseorm/pyproject.toml
@@ -25,9 +25,9 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml b/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
index d7a98924aa..fc2c19ff8c 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-urllib/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml b/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
index b1cf28d8ff..8b41819485 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml b/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
index dddb4a4eb1..341bba8af8 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/pyproject.toml
@@ -25,10 +25,10 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
-  "opentelemetry-util-http == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-util-http == 0.50b0.dev",
 ]
 
 [project.optional-dependencies]
diff --git a/opentelemetry-contrib-instrumentations/pyproject.toml b/opentelemetry-contrib-instrumentations/pyproject.toml
index a0edde1390..4e34c557e0 100644
--- a/opentelemetry-contrib-instrumentations/pyproject.toml
+++ b/opentelemetry-contrib-instrumentations/pyproject.toml
@@ -29,55 +29,55 @@ classifiers = [
     "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-    "opentelemetry-instrumentation-aio-pika==0.50b0.dev",
-    "opentelemetry-instrumentation-aiohttp-client==0.50b0.dev",
-    "opentelemetry-instrumentation-aiohttp-server==0.50b0.dev",
-    "opentelemetry-instrumentation-aiokafka==0.50b0.dev",
-    "opentelemetry-instrumentation-aiopg==0.50b0.dev",
-    "opentelemetry-instrumentation-asgi==0.50b0.dev",
-    "opentelemetry-instrumentation-asyncio==0.50b0.dev",
-    "opentelemetry-instrumentation-asyncpg==0.50b0.dev",
-    "opentelemetry-instrumentation-aws-lambda==0.50b0.dev",
-    "opentelemetry-instrumentation-boto==0.50b0.dev",
-    "opentelemetry-instrumentation-boto3sqs==0.50b0.dev",
-    "opentelemetry-instrumentation-botocore==0.50b0.dev",
-    "opentelemetry-instrumentation-cassandra==0.50b0.dev",
-    "opentelemetry-instrumentation-celery==0.50b0.dev",
-    "opentelemetry-instrumentation-click==0.50b0.dev",
-    "opentelemetry-instrumentation-confluent-kafka==0.50b0.dev",
-    "opentelemetry-instrumentation-dbapi==0.50b0.dev",
-    "opentelemetry-instrumentation-django==0.50b0.dev",
-    "opentelemetry-instrumentation-elasticsearch==0.50b0.dev",
-    "opentelemetry-instrumentation-falcon==0.50b0.dev",
-    "opentelemetry-instrumentation-fastapi==0.50b0.dev",
-    "opentelemetry-instrumentation-flask==0.50b0.dev",
-    "opentelemetry-instrumentation-grpc==0.50b0.dev",
-    "opentelemetry-instrumentation-httpx==0.50b0.dev",
-    "opentelemetry-instrumentation-jinja2==0.50b0.dev",
-    "opentelemetry-instrumentation-kafka-python==0.50b0.dev",
-    "opentelemetry-instrumentation-logging==0.50b0.dev",
-    "opentelemetry-instrumentation-mysql==0.50b0.dev",
-    "opentelemetry-instrumentation-mysqlclient==0.50b0.dev",
-    "opentelemetry-instrumentation-pika==0.50b0.dev",
-    "opentelemetry-instrumentation-psycopg==0.50b0.dev",
-    "opentelemetry-instrumentation-psycopg2==0.50b0.dev",
-    "opentelemetry-instrumentation-pymemcache==0.50b0.dev",
-    "opentelemetry-instrumentation-pymongo==0.50b0.dev",
-    "opentelemetry-instrumentation-pymysql==0.50b0.dev",
-    "opentelemetry-instrumentation-pyramid==0.50b0.dev",
-    "opentelemetry-instrumentation-redis==0.50b0.dev",
-    "opentelemetry-instrumentation-remoulade==0.50b0.dev",
-    "opentelemetry-instrumentation-requests==0.50b0.dev",
-    "opentelemetry-instrumentation-sqlalchemy==0.50b0.dev",
-    "opentelemetry-instrumentation-sqlite3==0.50b0.dev",
-    "opentelemetry-instrumentation-starlette==0.50b0.dev",
-    "opentelemetry-instrumentation-system-metrics==0.50b0.dev",
-    "opentelemetry-instrumentation-threading==0.50b0.dev",
-    "opentelemetry-instrumentation-tornado==0.50b0.dev",
-    "opentelemetry-instrumentation-tortoiseorm==0.50b0.dev",
-    "opentelemetry-instrumentation-urllib==0.50b0.dev",
-    "opentelemetry-instrumentation-urllib3==0.50b0.dev",
-    "opentelemetry-instrumentation-wsgi==0.50b0.dev",
+    # "opentelemetry-instrumentation-aio-pika==0.50b0.dev",
+    # "opentelemetry-instrumentation-aiohttp-client==0.50b0.dev",
+    # "opentelemetry-instrumentation-aiohttp-server==0.50b0.dev",
+    # "opentelemetry-instrumentation-aiokafka==0.50b0.dev",
+    # "opentelemetry-instrumentation-aiopg==0.50b0.dev",
+    # "opentelemetry-instrumentation-asgi==0.50b0.dev",
+    # "opentelemetry-instrumentation-asyncio==0.50b0.dev",
+    # "opentelemetry-instrumentation-asyncpg==0.50b0.dev",
+    # "opentelemetry-instrumentation-aws-lambda==0.50b0.dev",
+    # "opentelemetry-instrumentation-boto==0.50b0.dev",
+    # "opentelemetry-instrumentation-boto3sqs==0.50b0.dev",
+    # "opentelemetry-instrumentation-botocore==0.50b0.dev",
+    # "opentelemetry-instrumentation-cassandra==0.50b0.dev",
+    # "opentelemetry-instrumentation-celery==0.50b0.dev",
+    # "opentelemetry-instrumentation-click==0.50b0.dev",
+    # "opentelemetry-instrumentation-confluent-kafka==0.50b0.dev",
+    # "opentelemetry-instrumentation-dbapi==0.50b0.dev",
+    # "opentelemetry-instrumentation-django==0.50b0.dev",
+    # "opentelemetry-instrumentation-elasticsearch==0.50b0.dev",
+    # "opentelemetry-instrumentation-falcon==0.50b0.dev",
+    # "opentelemetry-instrumentation-fastapi==0.50b0.dev",
+    # "opentelemetry-instrumentation-flask==0.50b0.dev",
+    # "opentelemetry-instrumentation-grpc==0.50b0.dev",
+    # "opentelemetry-instrumentation-httpx==0.50b0.dev",
+    # "opentelemetry-instrumentation-jinja2==0.50b0.dev",
+    # "opentelemetry-instrumentation-kafka-python==0.50b0.dev",
+    # "opentelemetry-instrumentation-logging==0.50b0.dev",
+    # "opentelemetry-instrumentation-mysql==0.50b0.dev",
+    # "opentelemetry-instrumentation-mysqlclient==0.50b0.dev",
+    # "opentelemetry-instrumentation-pika==0.50b0.dev",
+    # "opentelemetry-instrumentation-psycopg==0.50b0.dev",
+    # "opentelemetry-instrumentation-psycopg2==0.50b0.dev",
+    # "opentelemetry-instrumentation-pymemcache==0.50b0.dev",
+    # "opentelemetry-instrumentation-pymongo==0.50b0.dev",
+    # "opentelemetry-instrumentation-pymysql==0.50b0.dev",
+    # "opentelemetry-instrumentation-pyramid==0.50b0.dev",
+    # "opentelemetry-instrumentation-redis==0.50b0.dev",
+    # "opentelemetry-instrumentation-remoulade==0.50b0.dev",
+    # "opentelemetry-instrumentation-requests==0.50b0.dev",
+    # "opentelemetry-instrumentation-sqlalchemy==0.50b0.dev",
+    # "opentelemetry-instrumentation-sqlite3==0.50b0.dev",
+    # "opentelemetry-instrumentation-starlette==0.50b0.dev",
+    # "opentelemetry-instrumentation-system-metrics==0.50b0.dev",
+    # "opentelemetry-instrumentation-threading==0.50b0.dev",
+    # "opentelemetry-instrumentation-tornado==0.50b0.dev",
+    # "opentelemetry-instrumentation-tortoiseorm==0.50b0.dev",
+    # "opentelemetry-instrumentation-urllib==0.50b0.dev",
+    # "opentelemetry-instrumentation-urllib3==0.50b0.dev",
+    # "opentelemetry-instrumentation-wsgi==0.50b0.dev",
 ]
 
 [project.urls]
diff --git a/opentelemetry-distro/pyproject.toml b/opentelemetry-distro/pyproject.toml
index dd995f2f99..81c374b327 100644
--- a/opentelemetry-distro/pyproject.toml
+++ b/opentelemetry-distro/pyproject.toml
@@ -26,9 +26,9 @@ classifiers = [
   "Typing :: Typed",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-instrumentation == 0.50b0.dev",
-  "opentelemetry-sdk ~= 1.13",
+  # "opentelemetry-api ~= 1.12",
+  # "opentelemetry-instrumentation == 0.50b0.dev",
+  # "opentelemetry-sdk ~= 1.13",
 ]
 
 [project.optional-dependencies]
diff --git a/opentelemetry-instrumentation/pyproject.toml b/opentelemetry-instrumentation/pyproject.toml
index f8aad72f4a..d34f4b8a63 100644
--- a/opentelemetry-instrumentation/pyproject.toml
+++ b/opentelemetry-instrumentation/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.4",
-  "opentelemetry-semantic-conventions == 0.50b0.dev",
+  # "opentelemetry-api ~= 1.4",
+  # "opentelemetry-semantic-conventions == 0.50b0.dev",
   "wrapt >= 1.0.0, < 2.0.0",
   "packaging >= 18.0",
 ]
diff --git a/processor/opentelemetry-processor-baggage/pyproject.toml b/processor/opentelemetry-processor-baggage/pyproject.toml
index 29fc2e8681..a68144ec54 100644
--- a/processor/opentelemetry-processor-baggage/pyproject.toml
+++ b/processor/opentelemetry-processor-baggage/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.5",
-  "opentelemetry-sdk ~= 1.5",
+  #"opentelemetry-api ~= 1.5",
+  #"opentelemetry-sdk ~= 1.5",
   "wrapt >= 1.0.0, < 2.0.0",
 ]
 
diff --git a/propagator/opentelemetry-propagator-aws-xray/pyproject.toml b/propagator/opentelemetry-propagator-aws-xray/pyproject.toml
index 14f16409b3..9729fe8d99 100644
--- a/propagator/opentelemetry-propagator-aws-xray/pyproject.toml
+++ b/propagator/opentelemetry-propagator-aws-xray/pyproject.toml
@@ -25,7 +25,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.16",
+  # "opentelemetry-api ~= 1.16",
 ]
 
 [project.entry-points.opentelemetry_propagator]
diff --git a/propagator/opentelemetry-propagator-ot-trace/pyproject.toml b/propagator/opentelemetry-propagator-ot-trace/pyproject.toml
index 93c7ad6784..34eb65e7f3 100644
--- a/propagator/opentelemetry-propagator-ot-trace/pyproject.toml
+++ b/propagator/opentelemetry-propagator-ot-trace/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-api ~= 1.12",
-  "opentelemetry-sdk ~= 1.12",
+  #"opentelemetry-api ~= 1.12",
+  #"opentelemetry-sdk ~= 1.12",
 ]
 
 [project.entry-points.opentelemetry_propagator]
diff --git a/resource/opentelemetry-resource-detector-azure/pyproject.toml b/resource/opentelemetry-resource-detector-azure/pyproject.toml
index 9427a1bee4..6fa4e85a50 100644
--- a/resource/opentelemetry-resource-detector-azure/pyproject.toml
+++ b/resource/opentelemetry-resource-detector-azure/pyproject.toml
@@ -25,8 +25,8 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-sdk ~= 1.21",
-  "opentelemetry-instrumentation ~= 0.44b0",
+  # "opentelemetry-sdk ~= 1.21",
+  # "opentelemetry-instrumentation ~= 0.44b0",
 ]
 
 [project.entry-points.opentelemetry_resource_detector]
diff --git a/resource/opentelemetry-resource-detector-container/pyproject.toml b/resource/opentelemetry-resource-detector-container/pyproject.toml
index 3993ecd06c..c38791e694 100644
--- a/resource/opentelemetry-resource-detector-container/pyproject.toml
+++ b/resource/opentelemetry-resource-detector-container/pyproject.toml
@@ -25,7 +25,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-sdk ~= 1.12",
+  #"opentelemetry-sdk ~= 1.12",
 ]
 
 [project.entry-points.opentelemetry_resource_detector]
diff --git a/sdk-extension/opentelemetry-sdk-extension-aws/pyproject.toml b/sdk-extension/opentelemetry-sdk-extension-aws/pyproject.toml
index 767bebdd10..df63f47092 100644
--- a/sdk-extension/opentelemetry-sdk-extension-aws/pyproject.toml
+++ b/sdk-extension/opentelemetry-sdk-extension-aws/pyproject.toml
@@ -25,7 +25,7 @@ classifiers = [
   "Programming Language :: Python :: 3.12",
 ]
 dependencies = [
-  "opentelemetry-sdk ~= 1.12",
+  #"opentelemetry-sdk ~= 1.12",
 ]
 
 [project.entry-points.opentelemetry_id_generator]
diff --git a/tox.ini b/tox.ini
index 5fa58e5139..74d059bf78 100644
--- a/tox.ini
+++ b/tox.ini
@@ -573,11 +573,11 @@ commands_pre =
   cassandra: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   cassandra: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
 
-  dbapi: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  dbapi: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  dbapi: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  dbapi: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  dbapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
+  ; dbapi: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; dbapi: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; dbapi: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; dbapi: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; dbapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
 
   django: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   django: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
@@ -598,19 +598,19 @@ commands_pre =
   fastapi: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   fastapi: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
 
-  mysql: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  mysql: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  mysql: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  mysql: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  mysql-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
-  mysql-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
-  lint-instrumentation-mysql: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
+  ; mysql: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; mysql: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; mysql: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; mysql: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; mysql-0: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
+  ; mysql-1: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
+  ; lint-instrumentation-mysql: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
 
-  mysqlclient: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  mysqlclient: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  mysqlclient: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  mysqlclient: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  mysqlclient: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
+  ; mysqlclient: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; mysqlclient: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; mysqlclient: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; mysqlclient: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; mysqlclient: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
 
   pymemcache: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   pymemcache: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
@@ -629,26 +629,26 @@ commands_pre =
   pymongo: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   pymongo: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
 
-  psycopg: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  psycopg: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  psycopg: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  psycopg: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  py3{8,9}-test-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
-  py3{10,11,12}-test-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
-  pypy3-test-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
-  lint-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
-
-  psycopg2: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  psycopg2: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  psycopg2: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  psycopg2: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  psycopg2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
-
-  pymysql: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  pymysql: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  pymysql: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  pymysql: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  pymysql: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
+  ; psycopg: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; psycopg: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; psycopg: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; psycopg: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; py3{8,9}-test-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
+  ; py3{10,11,12}-test-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
+  ; pypy3-test-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
+  ; lint-instrumentation-psycopg: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
+
+  ; psycopg2: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; psycopg2: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; psycopg2: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; psycopg2: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; psycopg2: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
+
+  ; pymysql: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; pymysql: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; pymysql: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; pymysql: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; pymysql: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
 
   pyramid: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   pyramid: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
@@ -656,11 +656,11 @@ commands_pre =
   pyramid: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
   pyramid: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
 
-  sqlite3: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
-  sqlite3: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
-  sqlite3: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
-  sqlite3: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
-  sqlite3: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
+  ; sqlite3: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
+  ; sqlite3: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions
+  ; sqlite3: pip install opentelemetry-sdk@{env:CORE_REPO}\#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk
+  ; sqlite3: pip install opentelemetry-test-utils@{env:CORE_REPO}\#egg=opentelemetry-test-utils&subdirectory=tests/opentelemetry-test-utils
+  ; sqlite3: pip install -r {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
 
   redis: pip install opentelemetry-api@{env:CORE_REPO}\#egg=opentelemetry-api&subdirectory=opentelemetry-api
   redis: pip install opentelemetry-semantic-conventions@{env:CORE_REPO}\#egg=opentelemetry-semantic-conventions&subdirectory=opentelemetry-semantic-conventions