diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
index 8f0a383412..b7e4cff400 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
@@ -47,13 +47,14 @@ def get_dist_dependency_conflicts(
     extra = "extra"
     instruments = "instruments"
     instruments_marker = {extra: instruments}
-    for dep in dist.requires:
-        if extra not in dep or instruments not in dep:
-            continue
-
-        req = Requirement(dep)
-        if req.marker.evaluate(instruments_marker):
-            instrumentation_deps.append(req)
+    if dist.requires:
+        for dep in dist.requires:
+            if extra not in dep or instruments not in dep:
+                continue
+
+            req = Requirement(dep)
+            if req.marker.evaluate(instruments_marker):
+                instrumentation_deps.append(req)
 
     return get_dependency_conflicts(instrumentation_deps)