diff --git a/ports/raspberrypi/boards/waveshare_rp2040_one/board.c b/ports/raspberrypi/boards/waveshare_rp2040_one/board.c
new file mode 100644
index 0000000000000..e6a868ab21226
--- /dev/null
+++ b/ports/raspberrypi/boards/waveshare_rp2040_one/board.c
@@ -0,0 +1,9 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2021 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#include "supervisor/board.h"
+
+// Use the MP_WEAK supervisor/shared/board.c versions of routines not defined here.
diff --git a/ports/raspberrypi/boards/waveshare_rp2040_one/mpconfigboard.h b/ports/raspberrypi/boards/waveshare_rp2040_one/mpconfigboard.h
new file mode 100644
index 0000000000000..c4dbbfd6e2c13
--- /dev/null
+++ b/ports/raspberrypi/boards/waveshare_rp2040_one/mpconfigboard.h
@@ -0,0 +1,22 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2021 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#pragma once
+
+#define MICROPY_HW_BOARD_NAME "Waveshare RP2040-One"
+#define MICROPY_HW_MCU_NAME "rp2040"
+
+#define DEFAULT_UART_BUS_TX (&pin_GPIO0)
+#define DEFAULT_UART_BUS_RX (&pin_GPIO1)
+
+#define DEFAULT_I2C_BUS_SDA (&pin_GPIO4)
+#define DEFAULT_I2C_BUS_SCL (&pin_GPIO5)
+
+#define DEFAULT_SPI_BUS_CK  (&pin_GPIO6)
+#define DEFAULT_SPI_BUS_MOSI (&pin_GPIO7)
+#define DEFAULT_SPI_BUS_MISO (&pin_GPIO8)
+
+#define MICROPY_HW_NEOPIXEL (&pin_GPIO16)
diff --git a/ports/raspberrypi/boards/waveshare_rp2040_one/mpconfigboard.mk b/ports/raspberrypi/boards/waveshare_rp2040_one/mpconfigboard.mk
new file mode 100644
index 0000000000000..c0ad9344e36a4
--- /dev/null
+++ b/ports/raspberrypi/boards/waveshare_rp2040_one/mpconfigboard.mk
@@ -0,0 +1,11 @@
+USB_VID = 0x2E8A
+USB_PID = 0x103A
+USB_PRODUCT = "RP2040-One"
+USB_MANUFACTURER = "Waveshare Electronics"
+
+CHIP_VARIANT = RP2040
+CHIP_FAMILY = rp2
+
+EXTERNAL_FLASH_DEVICES = "W25Q32JVxQ"
+
+CIRCUITPY__EVE = 1
diff --git a/ports/raspberrypi/boards/waveshare_rp2040_one/pico-sdk-configboard.h b/ports/raspberrypi/boards/waveshare_rp2040_one/pico-sdk-configboard.h
new file mode 100644
index 0000000000000..110195b779498
--- /dev/null
+++ b/ports/raspberrypi/boards/waveshare_rp2040_one/pico-sdk-configboard.h
@@ -0,0 +1,9 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2021 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#pragma once
+
+// Put board-specific pico-sdk definitions here. This file must exist.
diff --git a/ports/raspberrypi/boards/waveshare_rp2040_one/pins.c b/ports/raspberrypi/boards/waveshare_rp2040_one/pins.c
new file mode 100644
index 0000000000000..5b172616aba2e
--- /dev/null
+++ b/ports/raspberrypi/boards/waveshare_rp2040_one/pins.c
@@ -0,0 +1,62 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2021 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#include "shared-bindings/board/__init__.h"
+
+static const mp_rom_map_elem_t board_module_globals_table[] = {
+    CIRCUITPYTHON_BOARD_DICT_STANDARD_ITEMS
+
+    { MP_ROM_QSTR(MP_QSTR_GP0), MP_ROM_PTR(&pin_GPIO0) },
+    { MP_ROM_QSTR(MP_QSTR_TX), MP_ROM_PTR(&pin_GPIO0) },
+
+    { MP_ROM_QSTR(MP_QSTR_GP1), MP_ROM_PTR(&pin_GPIO1) },
+    { MP_ROM_QSTR(MP_QSTR_RX), MP_ROM_PTR(&pin_GPIO1) },
+
+    { MP_ROM_QSTR(MP_QSTR_GP2), MP_ROM_PTR(&pin_GPIO2) },
+    { MP_ROM_QSTR(MP_QSTR_GP3), MP_ROM_PTR(&pin_GPIO3) },
+    { MP_ROM_QSTR(MP_QSTR_GP4), MP_ROM_PTR(&pin_GPIO4) },
+    { MP_ROM_QSTR(MP_QSTR_GP5), MP_ROM_PTR(&pin_GPIO5) },
+    { MP_ROM_QSTR(MP_QSTR_GP6), MP_ROM_PTR(&pin_GPIO6) },
+    { MP_ROM_QSTR(MP_QSTR_GP7), MP_ROM_PTR(&pin_GPIO7) },
+    { MP_ROM_QSTR(MP_QSTR_GP8), MP_ROM_PTR(&pin_GPIO8) },
+    { MP_ROM_QSTR(MP_QSTR_GP9), MP_ROM_PTR(&pin_GPIO9) },
+    { MP_ROM_QSTR(MP_QSTR_GP10), MP_ROM_PTR(&pin_GPIO10) },
+    { MP_ROM_QSTR(MP_QSTR_GP11), MP_ROM_PTR(&pin_GPIO11) },
+    { MP_ROM_QSTR(MP_QSTR_GP12), MP_ROM_PTR(&pin_GPIO12) },
+    { MP_ROM_QSTR(MP_QSTR_GP13), MP_ROM_PTR(&pin_GPIO13) },
+    { MP_ROM_QSTR(MP_QSTR_GP14), MP_ROM_PTR(&pin_GPIO14) },
+    { MP_ROM_QSTR(MP_QSTR_GP15), MP_ROM_PTR(&pin_GPIO15) },
+    { MP_ROM_QSTR(MP_QSTR_GP16), MP_ROM_PTR(&pin_GPIO16) },
+    { MP_ROM_QSTR(MP_QSTR_NEOPIXEL), MP_ROM_PTR(&pin_GPIO16) },
+    { MP_ROM_QSTR(MP_QSTR_GP17), MP_ROM_PTR(&pin_GPIO17) },
+    { MP_ROM_QSTR(MP_QSTR_GP18), MP_ROM_PTR(&pin_GPIO18) },
+    { MP_ROM_QSTR(MP_QSTR_GP19), MP_ROM_PTR(&pin_GPIO19) },
+    { MP_ROM_QSTR(MP_QSTR_GP20), MP_ROM_PTR(&pin_GPIO20) },
+    { MP_ROM_QSTR(MP_QSTR_GP21), MP_ROM_PTR(&pin_GPIO21) },
+    { MP_ROM_QSTR(MP_QSTR_GP22), MP_ROM_PTR(&pin_GPIO22) },
+    { MP_ROM_QSTR(MP_QSTR_GP23), MP_ROM_PTR(&pin_GPIO23) },
+    { MP_ROM_QSTR(MP_QSTR_GP24), MP_ROM_PTR(&pin_GPIO24) },
+    { MP_ROM_QSTR(MP_QSTR_GP25), MP_ROM_PTR(&pin_GPIO25) },
+
+    { MP_ROM_QSTR(MP_QSTR_GP26_A0), MP_ROM_PTR(&pin_GPIO26) },
+    { MP_ROM_QSTR(MP_QSTR_GP26), MP_ROM_PTR(&pin_GPIO26) },
+    { MP_ROM_QSTR(MP_QSTR_A0), MP_ROM_PTR(&pin_GPIO26) },
+
+    { MP_ROM_QSTR(MP_QSTR_GP27_A1), MP_ROM_PTR(&pin_GPIO27) },
+    { MP_ROM_QSTR(MP_QSTR_GP27), MP_ROM_PTR(&pin_GPIO27) },
+    { MP_ROM_QSTR(MP_QSTR_A1), MP_ROM_PTR(&pin_GPIO27) },
+
+    { MP_ROM_QSTR(MP_QSTR_GP28_A2), MP_ROM_PTR(&pin_GPIO28) },
+    { MP_ROM_QSTR(MP_QSTR_GP28), MP_ROM_PTR(&pin_GPIO28) },
+    { MP_ROM_QSTR(MP_QSTR_A2), MP_ROM_PTR(&pin_GPIO28) },
+
+    { MP_ROM_QSTR(MP_QSTR_GP29_A3), MP_ROM_PTR(&pin_GPIO29) },
+    { MP_ROM_QSTR(MP_QSTR_GP29), MP_ROM_PTR(&pin_GPIO29) },
+    { MP_ROM_QSTR(MP_QSTR_A3), MP_ROM_PTR(&pin_GPIO29) },
+
+    { MP_ROM_QSTR(MP_QSTR_UART), MP_ROM_PTR(&board_uart_obj) },
+};
+MP_DEFINE_CONST_DICT(board_module_globals, board_module_globals_table);