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Add GRIDSS somatic filter #187

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Add GRIDSS somatic filter #187

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Faizal-Eeman
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Description

Add GRIDSS somatic variant filter.

Closes #186

Testing Results

  • DNA A-mini
    • sample: HG002.N-0, S2.T-0
    • input yaml: /hot/software/pipeline/pipeline-call-sSV/Nextflow/development/pre-6.1.0/mmootor-filter-gridss/TWGSAMIN000001-T003-S03-F.yaml
    • config: /hot/software/pipeline/pipeline-call-sSV/Nextflow/development/pre-6.1.0/mmootor-filter-gridss/TWGSAMIN000001-T003-S03-F.config
    • output: /hot/software/pipeline/pipeline-call-sSV/Nextflow/development/pre-6.1.0/mmootor-filter-gridss

Checklist

  • I have read the code review guidelines and the code review best practice on GitHub check-list.

  • I have reviewed the Nextflow pipeline standards.

  • The name of the branch is meaningful and well formatted following the standards, using [AD_username (or 5 letters of AD if AD is too long)]-[brief_description_of_branch].

  • I have set up or verified the branch protection rule following the github standards before opening this pull request.

  • I have added my name to the contributors listings in the manifest block in the nextflow.config as part of this pull request, am listed
    already, or do not wish to be listed. (This acknowledgement is optional.)

  • I have added the changes included in this pull request to the CHANGELOG.md under the next release version or unreleased, and updated the date.

  • I have updated the version number in the metadata.yaml and manifest block of the nextflow.config file following semver, or the version number has already been updated. (Leave it unchecked if you are unsure about new version number and discuss it with the infrastructure team in this PR.)

  • I have tested the pipeline on at least one A-mini sample with algorithm = ['delly', 'manta']. The paths to the test config files and output directories are attached above.

@Faizal-Eeman Faizal-Eeman requested a review from a team as a code owner December 3, 2024 04:27
@@ -37,6 +37,17 @@ process {
}
}

withName: filter_sSV_GRIDSS {
cpus = 1
memory = 20.GB

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Have you tested to see how much memory this step uses with a variety of samples. Could there be an upper bound?
Also, did you consider this:
The Hartwig Medical Foundation has reimplemented gridss_somatic_filter in Java as [GRIPSS](https://github.com/hartwigmedical/hmftools/tree/master/gripss). GRIPSS is much faster, has additional features, and is the recommended tool for somatic filtering of GRIDSS output.

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github-actions bot commented Dec 9, 2024

Bleep bloop, I am a robot.

This is embarrassing... the main branch has test changes that haven't been merged into this branch, and I can't handle that. Please fix that and then I can fix the tests for you!

cd /path/to/your/repository/
git checkout mmootor-filter-gridss
git fetch origin
git merge origin/main
git push origin

@nwiltsie
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nwiltsie commented Dec 9, 2024

I specifically merged main to fix that... I'll debug.

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Wiz Scan Summary

Scanner Findings
Vulnerability Finding Vulnerabilities
Data Finding Sensitive Data 1 Info
Secret Finding Secrets
IaC Misconfiguration IaC Misconfigurations
Total 1 Info

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Add GRIDSS somatic filter
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