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Manta has a parallelization option with `-j` to make use of multiple cores; it'd be good to explore increasing the number of CPUs for optimization. See call-sSNV Strelka-2 workflow for an example.
Not sure how effective this change would be for SV calling but it took 5-7 days for Manta to call SVs in large WGS samples (400-600GB normal/tumor BAMs) using v6.1.0.
Originally posted by @yashpatel6 in #74 (comment)
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