diff --git a/config/F16.config b/config/F16.config
index 5d5b91d..87c78d7 100644
--- a/config/F16.config
+++ b/config/F16.config
@@ -37,6 +37,17 @@ process {
             }
         }
 
+    withName: filter_sSV_GRIDSS {
+        cpus = 1
+        memory = 3.GB
+        retry_strategy {
+            memory {
+                strategy = 'exponential'
+                operand = 2
+                }
+            }
+        }
+
     withName: call_sSV_Delly {
         cpus = 1
         memory = 16.GB
diff --git a/config/F32.config b/config/F32.config
index e44941d..7192170 100644
--- a/config/F32.config
+++ b/config/F32.config
@@ -37,6 +37,17 @@ process {
             }
         }
 
+    withName: filter_sSV_GRIDSS {
+        cpus = 1
+        memory = 6.GB
+        retry_strategy {
+            memory {
+                strategy = 'exponential'
+                operand = 2
+                }
+            }
+        }
+
     withName: call_sSV_Delly {
         cpus = 1
         memory = 30.GB
diff --git a/config/F72.config b/config/F72.config
index 0c01903..52613a0 100644
--- a/config/F72.config
+++ b/config/F72.config
@@ -37,6 +37,17 @@ process {
             }
         }
 
+    withName: filter_sSV_GRIDSS {
+        cpus = 1
+        memory = 12.GB
+        retry_strategy {
+            memory {
+                strategy = 'exponential'
+                operand = 2
+                }
+            }
+        }
+
     withName: call_sSV_Delly {
         cpus = 1
         memory = 30.GB
diff --git a/config/M64.config b/config/M64.config
index 01c71d6..6dee9a9 100644
--- a/config/M64.config
+++ b/config/M64.config
@@ -37,6 +37,17 @@ process {
             }
         }
 
+    withName: filter_sSV_GRIDSS {
+        cpus = 1
+        memory = 20.GB
+        retry_strategy {
+            memory {
+                strategy = 'exponential'
+                operand = 2
+                }
+            }
+        }
+
     withName: call_sSV_Delly {
         cpus = 1
         memory = 120.GB
diff --git a/config/schema.yaml b/config/schema.yaml
index e84434e..997d2c4 100644
--- a/config/schema.yaml
+++ b/config/schema.yaml
@@ -18,6 +18,11 @@ gridss_blacklist:
   mode: 'r'
   required: true
   help: 'Absolute path to GRIDSS2 blacklist BED file'
+gridss_pon_dir:
+  type: 'Path'
+  mode: 'r'
+  required: true
+  help: 'Absolute path to directory containing Panel Of Normals BED and BEDPE files'
 exclusion_file:
   type: 'Path'
   mode: 'r'
diff --git a/config/template.config b/config/template.config
index 9bf6224..8a8bdfc 100755
--- a/config/template.config
+++ b/config/template.config
@@ -16,6 +16,7 @@ params {
     // GRCh38 blacklist - /hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/ENCFF356LFX.bed
     gridss_blacklist = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/ENCFF356LFX.bed"
     gridss_reference_fasta = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
+    gridss_pon_dir = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/"
     // When GRIDSS errors OutOfMemory, update `other_jvm_heap`. Default is `4.GB`
     //other_jvm_heap = 4.GB
 
diff --git a/main.nf b/main.nf
index a47f59e..e7e3bf5 100644
--- a/main.nf
+++ b/main.nf
@@ -55,7 +55,7 @@ include { call_sSV_Delly; filter_sSV_Delly } from './module/delly' addParams(
 include { call_sSV_Manta } from './module/manta' addParams(
     workflow_output_dir: "${params.output_dir_base}/Manta-${params.manta_version}"
     )
-include { preprocess_BAM_GRIDSS; run_assembly_GRIDSS; call_sSV_GRIDSS } from './module/gridss' addParams(
+include { preprocess_BAM_GRIDSS; run_assembly_GRIDSS; call_sSV_GRIDSS; filter_sSV_GRIDSS } from './module/gridss' addParams(
     workflow_output_dir: "${params.output_dir_base}/GRIDSS-${params.gridss_version}"
     )
 include { generate_sha512 as generate_sha512_BCFtools } from './module/sha512' addParams(
@@ -233,5 +233,11 @@ workflow {
             gridss_reference_files,
             params.gridss_blacklist
             )
+
+        filter_sSV_GRIDSS(
+            params.sample,
+            call_sSV_GRIDSS.out.gridss_vcf,
+            params.gridss_pon_dir
+            )
         }
     }
diff --git a/module/gridss.nf b/module/gridss.nf
index ea6a5d6..631c5a1 100644
--- a/module/gridss.nf
+++ b/module/gridss.nf
@@ -188,3 +188,45 @@ process call_sSV_GRIDSS {
             ${tumor_bam}
         """
     }
+
+process filter_sSV_GRIDSS {
+    container params.docker_image_gridss
+
+    publishDir "${params.workflow_output_dir}/output/",
+        pattern: "*.vcf.bgz*",
+        mode: "copy"
+
+    publishDir "${params.log_output_dir}/process-log",
+        pattern: ".command.*",
+        mode: "copy",
+        saveAs: { "${task.process.replace(':', '/')}/log${file(it).getName()}" }
+
+    input:
+        val(tumor_id)
+        path(gridss_vcf)
+        path(gridss_pon_dir)
+
+    output:
+        path "*vcf.bgz*", emit: gridss_filter_vcf_files
+        path ".command.*"
+
+    script:
+        output_filename = generate_standard_filename(
+            "GRIDSS2-${params.gridss_version}",
+            params.dataset_id,
+            tumor_id,
+            [:]
+            )
+
+        """
+        set -euo pipefail
+        /usr/local/share/gridss-2.13.2-1/gridss_somatic_filter \
+            --pondir ${gridss_pon_dir} \
+            --scriptdir /usr/local/share/gridss-2.13.2-1/ \
+            --input ${gridss_vcf} \
+            --output ${output_filename}_high-confidence-somatic.vcf \
+            --fulloutput ${output_filename}_high-low-confidence-somatic.vcf \
+            --normalordinal 1 \
+            --tumourordinal 2
+        """
+    }
diff --git a/test/config/ssv-all-tools.config b/test/config/ssv-all-tools.config
index 38f49df..8591a2d 100644
--- a/test/config/ssv-all-tools.config
+++ b/test/config/ssv-all-tools.config
@@ -14,6 +14,7 @@ params {
     reference_fasta = "/hot/resource/reference-genome/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
     gridss_reference_fasta = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
     gridss_blacklist = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/ENCFF356LFX.bed"
+    gridss_pon_dir = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/"
 
     exclusion_file = "/hot/resource/tool-specific-input/Delly/hg38/human.hg38.excl.tsv"
 
diff --git a/test/config/ssv-delly.config b/test/config/ssv-delly.config
index ce3d297..9188f64 100644
--- a/test/config/ssv-delly.config
+++ b/test/config/ssv-delly.config
@@ -14,6 +14,7 @@ params {
     reference_fasta = "/hot/resource/reference-genome/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
     gridss_reference_fasta = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
     gridss_blacklist = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/ENCFF356LFX.bed"
+    gridss_pon_dir = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/"
 
     exclusion_file = "/hot/resource/tool-specific-input/Delly/hg38/human.hg38.excl.tsv"
 
diff --git a/test/config/ssv-manta.config b/test/config/ssv-manta.config
index dacabcc..5046d4d 100644
--- a/test/config/ssv-manta.config
+++ b/test/config/ssv-manta.config
@@ -14,6 +14,7 @@ params {
     reference_fasta = "/hot/resource/reference-genome/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
     gridss_reference_fasta = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta"
     gridss_blacklist = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/ENCFF356LFX.bed"
+    gridss_pon_dir = "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/"
 
     exclusion_file = "/hot/resource/tool-specific-input/Delly/hg38/human.hg38.excl.tsv"
 
diff --git a/test/configtest-F16.json b/test/configtest-F16.json
index bb7012d..7eeb2c0 100644
--- a/test/configtest-F16.json
+++ b/test/configtest-F16.json
@@ -72,6 +72,7 @@
       "exclusion_file": "/hot/resource/tool-specific-input/Delly/hg38/human.hg38.excl.tsv",
       "filter_condition": "FILTER=\\='PASS'",
       "gridss_blacklist": "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/ENCFF356LFX.bed",
+      "gridss_pon_dir": "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/",
       "gridss_reference_fasta": "/hot/resource/tool-specific-input/GRIDSS-2.13.2/GRCh38-BI-20160721/Homo_sapiens_assembly38.fasta",
       "gridss_version": "2.13.2",
       "input": {
@@ -138,6 +139,16 @@
             }
           }
         },
+        "filter_sSV_GRIDSS": {
+          "cpus": "1",
+          "memory": "3 GB",
+          "retry_strategy": {
+            "memory": {
+              "operand": "2",
+              "strategy": "exponential"
+            }
+          }
+        },
         "preprocess_BAM_GRIDSS": {
           "cpus": "4",
           "memory": "10 GB",
@@ -304,6 +315,15 @@
           "closure": "retry_updater(3 GB, exponential, 2, $task.attempt, memory)"
         }
       },
+      "withName:filter_sSV_GRIDSS": {
+        "cpus": "1",
+        "memory": {
+          "1": "3 GB",
+          "2": "6 GB",
+          "3": "12 GB",
+          "closure": "retry_updater(3 GB, exponential, 2, $task.attempt, memory)"
+        }
+      },
       "withName:preprocess_BAM_GRIDSS": {
         "cpus": "4",
         "memory": {