From 3a7c1486116b00fcadbc3a07782a74754cd8f1e7 Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 11:33:10 +1000 Subject: [PATCH 1/9] fix: R_PRPPS_c, R_PRPPS_n removed 1 proton to balance --- curation/Reaction-SBtab.tsv | 1182 +++++++++++++++++------------------ 1 file changed, 591 insertions(+), 591 deletions(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 6741ead..42e6d3a 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -3,43 +3,43 @@ R__3SALAASPm cysteinesulfinate-aspartate mitochondrial shuttle M_3sala_m + M_asp__L_c <=> M_3sala_c + M_asp__L_m mc TRUE (WBGene00019326) PW106 R__4MOPt2im 4-methyl-2-oxopentanoate mitochondrial transport via proton symport M_4mop_c + M_h_c <=> M_4mop_m + M_h_m cm FALSE ND PW106 R__5FTHFt2 5-formyltetrahydrofolate transport via anion Exchange reactions M_h2o_c + M_5fthf_e <=> M_h2o_e + M_5fthf_c ce TRUE (WBGene00018964) or (WBGene00018966) PW107 -R_1_2_1_18_RXN_m Malonate-semialdehyde dehydrogenase (acetylating) M_msa_m + M_coa_m + M_nadp_m <=> M_co2_m + M_nadph_m + M_accoa_m m FALSE (WBGene00000114) PW038;PW010 R00706 RHEA:20804;RHEA:22992;RHEA:22988 added KEGG ID lenov -R_1_2_1_27_RXN_m Methylmalonate-semialdehyde dehydrogenase (acylating) M_h2o_m + M_coa_m + M_mmtsa_m + M_nad_m <=> M_hco3_m + M_h_m + M_nadh_m + M_ppcoa_m m FALSE (WBGene00000114) PW083 RHEA:20804;RHEA:22992;RHEA:22988 -R_1_2_4_4_RXN_c 2-keto-isovalerate dehydrogenase (lipoamide) M_3mob_c + M_bcaalip_c <=> M_co2_c + M_bcaadh2mp_c c FALSE (WBGene00012713) or (WBGene00006518) PW083 RHEA:13457;RHEA:13457 -R_1_2_4_4_RXN_m 2-keto-isovalerate dehydrogenase (lipoamide) M_3mob_m + M_bcaalip_m <=> M_co2_m + M_bcaadh2mp_m m FALSE (WBGene00012713) or (WBGene00006518) PW083 RHEA:13457;RHEA:13457 +R_1_2_1_18_RXN_m Malonate-semialdehyde dehydrogenase (acetylating) M_msa_m + M_coa_m + M_nadp_m <=> M_co2_m + M_nadph_m + M_accoa_m m FALSE (WBGene00000114) "PW038;PW010" R00706 "RHEA:20804;RHEA:22992;RHEA:22988" added KEGG ID lenov +R_1_2_1_27_RXN_m Methylmalonate-semialdehyde dehydrogenase (acylating) M_h2o_m + M_coa_m + M_mmtsa_m + M_nad_m <=> M_hco3_m + M_h_m + M_nadh_m + M_ppcoa_m m FALSE (WBGene00000114) PW083 "RHEA:20804;RHEA:22992;RHEA:22988" +R_1_2_4_4_RXN_c 2-keto-isovalerate dehydrogenase (lipoamide) M_3mob_c + M_bcaalip_c <=> M_co2_c + M_bcaadh2mp_c c FALSE (WBGene00012713) or (WBGene00006518) PW083 "RHEA:13457;RHEA:13457" +R_1_2_4_4_RXN_m 2-keto-isovalerate dehydrogenase (lipoamide) M_3mob_m + M_bcaalip_m <=> M_co2_m + M_bcaadh2mp_m m FALSE (WBGene00012713) or (WBGene00006518) PW083 "RHEA:13457;RHEA:13457" R_1_5_1_9_RXN_c Saccharopine dehydrogenase (NAD+, L-glutamate forming) M_h2o_c + M_saccrp__L_c + M_nad_c <=> M_L2aadp6sa_c + 6.0 M_h_c + M_glu__L_c + M_nadh_c c TRUE (WBGene00019819) PW079 Set reversibility to true jpnh -R_1_5_1_9_RXN_m Saccharopine dehydrogenase (NAD+, L-glutamate forming) M_h2o_m + M_saccrp__L_m + M_nad_m <=> M_L2aadp6sa_m + 6.0 M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00019819) PW079 set reversibility to true; replaced M_saccrp__L_m with M_saccrp_L_m jpnh; lenov +R_1_5_1_9_RXN_m Saccharopine dehydrogenase (NAD+, L-glutamate forming) M_h2o_m + M_saccrp__L_m + M_nad_m <=> M_L2aadp6sa_m + 6.0 M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00019819) PW079 "set reversibility to true; replaced M_saccrp__L_m with M_saccrp_L_m" "jpnh; lenov" R_1_5_5_1_RXN_m Electron-transferring-flavoprotein dehydrogenase M_q9_m + M_etfrd_m <=> M_q9h2_m + M_etfox_m m FALSE (WBGene00002855) PW098 RHEA:24052 R_1PFRUCTPHOSN_RXN_c 1-phosphofructokinase M_f1p_c + M_atp_c <=> M_fdp_c + 2.0 M_h_c + M_adp_c c FALSE PW031 R_2_1_1_64_RXN_m 3-Demethylubiqui-9 3-O-methyltransferase M_3dmub_m + M_amet_m <=> 2.0 M_h_m + M_q9h2_m + M_ahcys_m m FALSE PW003 R_2_1_1_77_RXN_c Protein-L-isoaspartate(D-aspartate) O-methyltransferase M_amet_c + M_prot_isoasp_c <=> M_ahcys_c + M_prot_iaspme_c c TRUE (WBGene00020090) PW102 Pathway should be protein methylation lenov R_2_1_1_77_RXN_m Protein-L-isoaspartate(D-aspartate) O-methyltransferase M_amet_m + M_prot_isoasp_m <=> M_ahcys_m + M_prot_iaspme_m m TRUE (WBGene00020090) PW102 Pathway should be protein methylation lenov R_2_1_1_77_RXN_n Protein-L-isoaspartate(D-aspartate) O-methyltransferase M_amet_n + M_prot_isoasp_n <=> M_ahcys_n + M_prot_iaspme_n n TRUE (WBGene00020090) PW102 Pathway should be protein methylation lenov -R_2_3_1_135_RXN_c phosphatidylcholine—retinol O-acyltransferase M_retinolCRBP_c + M_1ac2acg3pc_c <=> M_cretbpr_c + M_retest_c + M_2acg3pc_c c FALSE PW069 +R_2_3_1_135_RXN_c "phosphatidylcholine—retinol O-acyltransferase" M_retinolCRBP_c + M_1ac2acg3pc_c <=> M_cretbpr_c + M_retest_c + M_2acg3pc_c c FALSE PW069 R_2_3_1_168_RXN_c Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase M_coa_c + M_bcaadh2mp_c <=> M_ibcoa_c + M_bcaadh_c c FALSE (WBGene00014054) PW083 RHEA:18865 R_2_3_1_168_RXN_m Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase M_coa_m + M_bcaadh2mp_m <=> M_ibcoa_m + M_bcaadh_m m FALSE (WBGene00014054) PW083 RHEA:18865 -R_2_4_1_117_RXN_c dolichyl-phosphate β-glucosyltransferase M_udpg_c + M_dolp_c <=> M_udp_c + M_dolglcp_c c FALSE (WBGene00019276) PW011 [DELETION] Dupe of R_RC01005 jpnh +R_2_4_1_117_RXN_c "dolichyl-phosphate β-glucosyltransferase" M_udpg_c + M_dolp_c <=> M_udp_c + M_dolglcp_c c FALSE (WBGene00019276) PW011 [DELETION] Dupe of R_RC01005 jpnh R_2_4_1_119_RXN_c Dolichyl-diphosphooligosaccharide--protein glycosyltransferase M_doldpglcnacglcnacman_man_manman_manman_manmanmanglcglcglc_c + M_prot_asp_c <=> M_h_c + M_dolp_c + M_g3m8masn_c c TRUE (WBGene00020437) or (WBGene00020683 and WBGene00011638 and WBGene00000896 and WBGene00022793) PW011 RHEA:22980 -R_2_4_1_131_RXN_c Glycolipid 2-α-mannosyltransferase M_gdpmann_c + M_doldpglcnacglcnacman_man_manman_c <=> M_doldpglcnacglcnacman_man_manmanman_c + M_gdp_c c FALSE (WBGene00015162) PW011 RHEA:29523 -R_2_4_1_132_RXN_c Glycolipid 3-α-mannosyltransferase M_gdpmann_c + M_manlipo_c <=> M_doldpglcnacglcnacmanman_c + M_mmlipo_c c FALSE (WBGene00017282) PW011 -R_2_4_1_132_RXN_m Glycolipid 3-α-mannosyltransferase M_gdpmann_m + M_manlipo_m <=> M_doldpglcnacglcnacmanman_m + M_mmlipo_m m FALSE (WBGene00017282) PW011 -R_2_4_1_133_RXN_c xylosylprotein 4-β-galactosyltransferase M_udpgal_c + M_xser_c <=> M_h_c + M_udp_c + M_lxser_c c FALSE (WBGene00005021) PW114 RHEA:15297 -R_2_4_1_134_RXN_c galactosylxylosylprotein 3-β-galactosyltransferase M_udpgal_c + M_lxser_c <=> M_udp_c + M_l2xser_c c FALSE (WBGene00005020) PW114 RHEA:11780 -R_2_4_1_135_RXN_c galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase M_udpglcur_c + M_l2xser_c <=> M_udp_c + M_cs_hs_linkage_c c FALSE (WBGene00019546) or (WBGene00005026) or (WBGene00008293) or (WBGene00008479) or (WBGene00011781) or (WBGene00011650) or (WBGene00008160) PW114 RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168 -R_2_4_1_135_RXN_m galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase M_udpglcur_m + M_l2xser_m <=> M_udp_m + M_cs_hs_linkage_m m FALSE (WBGene00019546) PW114 RHEA:24168;RHEA:24168;RHEA:24168 -R_2_4_1_135_RXN_n galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase M_udpglcur_n + M_l2xser_n <=> M_udp_n + M_cs_hs_linkage_n n FALSE (WBGene00011781) PW114 RHEA:24168 +R_2_4_1_131_RXN_c "Glycolipid 2-α-mannosyltransferase" M_gdpmann_c + M_doldpglcnacglcnacman_man_manman_c <=> M_doldpglcnacglcnacman_man_manmanman_c + M_gdp_c c FALSE (WBGene00015162) PW011 RHEA:29523 +R_2_4_1_132_RXN_c "Glycolipid 3-α-mannosyltransferase" M_gdpmann_c + M_manlipo_c <=> M_doldpglcnacglcnacmanman_c + M_mmlipo_c c FALSE (WBGene00017282) PW011 +R_2_4_1_132_RXN_m "Glycolipid 3-α-mannosyltransferase" M_gdpmann_m + M_manlipo_m <=> M_doldpglcnacglcnacmanman_m + M_mmlipo_m m FALSE (WBGene00017282) PW011 +R_2_4_1_133_RXN_c "xylosylprotein 4-β-galactosyltransferase" M_udpgal_c + M_xser_c <=> M_h_c + M_udp_c + M_lxser_c c FALSE (WBGene00005021) PW114 RHEA:15297 +R_2_4_1_134_RXN_c "galactosylxylosylprotein 3-β-galactosyltransferase" M_udpgal_c + M_lxser_c <=> M_udp_c + M_l2xser_c c FALSE (WBGene00005020) PW114 RHEA:11780 +R_2_4_1_135_RXN_c "galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase" M_udpglcur_c + M_l2xser_c <=> M_udp_c + M_cs_hs_linkage_c c FALSE (WBGene00019546) or (WBGene00005026) or (WBGene00008293) or (WBGene00008479) or (WBGene00011781) or (WBGene00011650) or (WBGene00008160) PW114 "RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168;RHEA:24168" +R_2_4_1_135_RXN_m "galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase" M_udpglcur_m + M_l2xser_m <=> M_udp_m + M_cs_hs_linkage_m m FALSE (WBGene00019546) PW114 "RHEA:24168;RHEA:24168;RHEA:24168" +R_2_4_1_135_RXN_n "galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase" M_udpglcur_n + M_l2xser_n <=> M_udp_n + M_cs_hs_linkage_n n FALSE (WBGene00011781) PW114 RHEA:24168 R_2_4_1_141_RXN_c N-acetylglucosaminyldiphosphodolicholN-acetylglucosaminyltransferase M_uacgam_c + M_naglc2p_c <=> M_h_c + M_udp_c + M_chito2pdol_c c FALSE (WBGene00019725) or (WBGene00011193) PW011 -R_2_4_1_142_RXN_c chitobiosyldiphosphodolichol β-mannosyltransferase M_gdpmann_c + M_chito2pdol_c <=> M_h_c + M_gdp_c + M_admnsyl_c c FALSE (WBGene00020820) PW011 -R_2_4_1_142_RXN_m chitobiosyldiphosphodolichol β-mannosyltransferase M_gdpmann_m + M_chito2pdol_m <=> M_h_m + M_gdp_m + M_admnsyl_m m FALSE (WBGene00020820) PW011 -R_2_4_1_174_RXN_c glucuronylgalactosylproteoglycan4-β-N-acetylgalactosaminyltransferase M_udpacgal_c + M_cs_hs_linkage_c <=> M_h_c + M_udp_c + M_cs_pre_c c FALSE PW013 -R_2_4_1_175_RXN_c glucuronosyl-N-acetylgalactosaminyl-proteoglycan4-β-N-acetylgalactosaminyltransferase M_udpacgal_c + M_cs_pre1_c <=> M_h_c + M_udp_c + M_cs_pre2_c c FALSE (WBGene00005023 and WBGene00003253) PW013 RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996 +R_2_4_1_142_RXN_c "chitobiosyldiphosphodolichol β-mannosyltransferase" M_gdpmann_c + M_chito2pdol_c <=> M_h_c + M_gdp_c + M_admnsyl_c c FALSE (WBGene00020820) PW011 +R_2_4_1_142_RXN_m "chitobiosyldiphosphodolichol β-mannosyltransferase" M_gdpmann_m + M_chito2pdol_m <=> M_h_m + M_gdp_m + M_admnsyl_m m FALSE (WBGene00020820) PW011 +R_2_4_1_174_RXN_c "glucuronylgalactosylproteoglycan4-β-N-acetylgalactosaminyltransferase" M_udpacgal_c + M_cs_hs_linkage_c <=> M_h_c + M_udp_c + M_cs_pre_c c FALSE PW013 +R_2_4_1_175_RXN_c "glucuronosyl-N-acetylgalactosaminyl-proteoglycan4-β-N-acetylgalactosaminyltransferase" M_udpacgal_c + M_cs_pre1_c <=> M_h_c + M_udp_c + M_cs_pre2_c c FALSE (WBGene00005023 and WBGene00003253) PW013 "RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996" R_2_4_1_198_RXN_c phosphatidylinositol N-acetylglucosaminyltransferase M_uacgam_c + M_1ac2acg3pi_c <=> M_h_c + M_udp_c + M_6nadgpi_c c FALSE (WBGene00008431) or (WBGene00008504) or (WBGene00011860) PW028 R_2_4_1_198_RXN_m phosphatidylinositol N-acetylglucosaminyltransferase M_uacgam_m + M_1ac2acg3pi_m <=> M_h_m + M_udp_m + M_6nadgpi_m m FALSE (WBGene00008431) or (WBGene00008504) PW028 R_2_4_1_198_RXN_n phosphatidylinositol N-acetylglucosaminyltransferase M_uacgam_n + M_1ac2acg3pi_n <=> M_h_n + M_udp_n + M_6nadgpi_n n FALSE (WBGene00011860) PW028 -R_2_4_1_41_RXN_c polypeptide N-acetylgalactosaminyltransferase M_udpacgal_c + M_polypeptide_c <=> M_tn_antigen_c + M_h_c + M_udp_c c FALSE (WBGene00001636) or (WBGene00001635) or (WBGene00001628) or (WBGene00001632) or (WBGene00001630) or (WBGene00001629) PW113 RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424 +R_2_4_1_41_RXN_c polypeptide N-acetylgalactosaminyltransferase M_udpacgal_c + M_polypeptide_c <=> M_tn_antigen_c + M_h_c + M_udp_c c FALSE (WBGene00001636) or (WBGene00001635) or (WBGene00001628) or (WBGene00001632) or (WBGene00001630) or (WBGene00001629) PW113 "RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424;RHEA:23956;RHEA:52424" R_2_4_1_41_RXN_m polypeptide N-acetylgalactosaminyltransferase M_udpacgal_m + M_polypeptide_m <=> M_tn_antigen_m + M_h_m + M_udp_m m FALSE (WBGene00001632) PW113 -R_2_4_1_83_RXN_c dolichyl-phosphate β-D-mannosyltransferase M_gdpmann_c + M_dolp_c <=> M_gdp_c + M_dolmanp_c c TRUE (WBGene00009219) or (WBGene00022044) PW011 RHEA:21184 set to reversible janna -R_2_4_1_83_RXN_n dolichyl-phosphate β-D-mannosyltransferase M_gdpmann_n + M_dolp_n <=> M_gdp_n + M_dolmanp_n n TRUE (WBGene00022044) PW011 RHEA:21184 +R_2_4_1_83_RXN_c "dolichyl-phosphate β-D-mannosyltransferase" M_gdpmann_c + M_dolp_c <=> M_gdp_c + M_dolmanp_c c TRUE (WBGene00009219) or (WBGene00022044) PW011 RHEA:21184 set to reversible janna +R_2_4_1_83_RXN_n "dolichyl-phosphate β-D-mannosyltransferase" M_gdpmann_n + M_dolp_n <=> M_gdp_n + M_dolmanp_n n TRUE (WBGene00022044) PW011 RHEA:21184 R_2_4_2_26_RXN_c protein xylosyltransferase M_udpxyl_c + M_cprlser_c <=> M_udp_c + M_xser_c c FALSE (WBGene00005024) PW114 RHEA:50192 R_2_5_1_21_RXN_c Farnesyl-diphosphate farnesyltransferase 2.0 M_frdp_c <=> M_psqldp_c + M_ppi_c c FALSE PW002 added rxn name jpnh R_2_5_1_39_RXN_m 4-hydroxybenzoate nonaprenyltransferase M_4hbz_m + M_nonadp_m <=> M_ppi_m + M_npr4hben_m m FALSE (WBGene00000762) PW003 RHEA:44504 @@ -49,36 +49,36 @@ R_2_7_1_152_RXN_c Inositol-hexakisphosphate kinase M_atp_c + M_minohp_c <=> M_a R_2_7_1_152_RXN_n Inositol-hexakisphosphate kinase M_atp_n + M_minohp_n <=> M_adp_n + M_ppmi12346p_n n FALSE (WBGene00018508) PW029 R_2_7_4_24_RXN_c diphosphoinositol-pentakisphosphate kinase M_atp_c + M_ppmi12346p_c + M_h_c <=> M_adp_c + M_6bppoldm_c c FALSE (WBGene00018508) PW029 R_2_7_4_24_RXN_n diphosphoinositol-pentakisphosphate kinase M_atp_n + M_ppmi12346p_n + M_h_n <=> M_adp_n + M_6bppoldm_n n FALSE (WBGene00018508) PW029 -R_2_7_8_15_RXN_c UDP-N-acetylglucosamine—dolichyl-phosphateN-acetylglucosaminephosphotransferase M_uacgam_c + M_dolp_c <=> M_ump_c + M_naglc2p_c c TRUE WBGene00011607 or WBGene00013362 PW011 set to reversible janna +R_2_7_8_15_RXN_c "UDP-N-acetylglucosamine—dolichyl-phosphateN-acetylglucosaminephosphotransferase" M_uacgam_c + M_dolp_c <=> M_ump_c + M_naglc2p_c c TRUE WBGene00011607 or WBGene00013362 PW011 set to reversible janna R_2_MEBUCOA_FAD_RXN_c 2-methylacyl-CoA dehydrogenase M_h_c + M_fad_c + M_2mbcoa_c <=> M_fadh2_c + M_2mb2coa_c c FALSE (WBGene00019599) or (WBGene00019406) PW083 -R_2_MEBUCOA_FAD_RXN_m 2-methylacyl-CoA dehydrogenase M_h_m + M_fad_m + M_2mbcoa_m <=> M_fadh2_m + M_2mb2coa_m m FALSE (WBGene00020812) or (WBGene00020366) or (WBGene00019406) or (WBGene00019599) or (WBGene00019433) PW083 RHEA:14477 transferred ckaleta's comment to here: Irreversible version of the reaction catalyzed acdh-3 jpnh;ckaleta +R_2_MEBUCOA_FAD_RXN_m 2-methylacyl-CoA dehydrogenase M_h_m + M_fad_m + M_2mbcoa_m <=> M_fadh2_m + M_2mb2coa_m m FALSE (WBGene00020812) or (WBGene00020366) or (WBGene00019406) or (WBGene00019599) or (WBGene00019433) PW083 RHEA:14477 transferred ckaleta's comment to here: Irreversible version of the reaction catalyzed acdh-3 "jpnh;ckaleta" R_2AMADPTm L-2-aminoadipate shuttle (cytosol/mitochondria) M_akg_m + M_L2aadp_c <=> M_akg_c + M_L2aadp_m mc TRUE (WBGene00011226) PW079 -R_2OXOADOX_c R_2OXOADOX_c M_2oxoadp_c + M_coa_c + M_nad_c <=> M_co2_c + M_nadh_c + M_glutcoa_c c TRUE (WBGene00020950 and WBGene00010794 and WBGene00020679) PW072;PW079 RHEA:15045;RHEA:12188 -R_2OXOADOX_m R_2OXOADOX_m M_2oxoadp_m + M_coa_m + M_nad_m <=> M_co2_m + M_nadh_m + M_glutcoa_m m TRUE (WBGene00020679 and WBGene00014098) and WBGene00020950 and WBGene00010794 PW072;PW079 RHEA:15045;RHEA:12188;RHEA:12188 +R_2OXOADOX_c R_2OXOADOX_c M_2oxoadp_c + M_coa_c + M_nad_c <=> M_co2_c + M_nadh_c + M_glutcoa_c c TRUE (WBGene00020950 and WBGene00010794 and WBGene00020679) "PW072;PW079" "RHEA:15045;RHEA:12188" +R_2OXOADOX_m R_2OXOADOX_m M_2oxoadp_m + M_coa_m + M_nad_m <=> M_co2_m + M_nadh_m + M_glutcoa_m m TRUE (WBGene00020679 and WBGene00014098) and WBGene00020950 and WBGene00010794 "PW072;PW079" "RHEA:15045;RHEA:12188;RHEA:12188" R_2OXOADPTm 2-oxoadipate shuttle (cytosol/mitochondria) M_akg_m + M_2oxoadp_c <=> M_akg_c + M_2oxoadp_m mc TRUE (WBGene00011226) or (ND) PW072 -R_3_1_1_47_RXN_c 2-acetyl-1-alkylglycerophosphocholine esterase M_h2o_c + M_ak2gchol_c <=> M_h_c + M_ac_c + M_1alkg3pc_c c TRUE ((WBGene00003906 or WBGene00003907) or WBGene00007756) or WBGene00003047 PW056 RHEA:17777;RHEA:17777 -R_3_1_1_47_RXN_n 2-acetyl-1-alkylglycerophosphocholine esterase M_h2o_n + M_ak2gchol_n <=> M_h_n + M_ac_n + M_1alkg3pc_n n TRUE (WBGene00003907) or (WBGene00003906) PW056 RHEA:17777;RHEA:17777 +R_3_1_1_47_RXN_c 2-acetyl-1-alkylglycerophosphocholine esterase M_h2o_c + M_ak2gchol_c <=> M_h_c + M_ac_c + M_1alkg3pc_c c TRUE ((WBGene00003906 or WBGene00003907) or WBGene00007756) or WBGene00003047 PW056 "RHEA:17777;RHEA:17777" +R_3_1_1_47_RXN_n 2-acetyl-1-alkylglycerophosphocholine esterase M_h2o_n + M_ak2gchol_n <=> M_h_n + M_ac_n + M_1alkg3pc_n n TRUE (WBGene00003907) or (WBGene00003906) PW056 "RHEA:17777;RHEA:17777" R_3_1_1_69_RXN_c N-acetylglucosaminylphosphatidylinositol deacetylase M_h2o_c + M_6nadgpi_c <=> M_h_c + M_gpail_c + M_ac_c c FALSE (WBGene00013131) PW028 R_3_1_2_22_RXN_n palmitoyl[protein] hydrolase M_h2o_n + M_coa16_0_n <=> M_coa_n + M_fa16_0_n n FALSE (WBGene00004092) or (WBGene00020258) or (WBGene00019404) or (WBGene00020989) PW060 SPW001 RHEA:19233 R_3_1_2_23_RXN_m 4-hydroxybenzoyl-CoA thioesterase M_h2o_m + M_4hbzcoa_m <=> M_h_m + M_4hbz_m + M_coa_m m FALSE Unknown PW003 R_3_1_3_62_RXN_c Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase M_h2o_c + M_mi1345p_c <=> M_pi_c + M_h_c + M_mi145p_c c FALSE PW029 R_3_1_3_77_RXN_c acireductone synthase M_dkmpp_c + M_h2o_c <=> M_dhmtp_c + M_pi_c + M_h_c c FALSE (WBGene00010286) PW082 R_3_1_4_14_RXN_c [Acyl-carrier protein] phosphodiesterase M_h2o_c + M_ACP_c <=> M_pan4p_c + M_apoACP_c c FALSE PW037 -R_3_1_4_17_RXN_c 3′,5′-cyclic-nucleotide phosphodiesterase M_h2o_c + M_c35rnmp_c <=> M_h_c + M_nmp_c c FALSE (WBGene00022389) or (WBGene00020114) or (WBGene00011433) or (WBGene00003966) or (WBGene00016328) PW034 RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653 -R_3_1_4_17_RXN_m 3′,5′-cyclic-nucleotide phosphodiesterase M_h2o_m + M_c35rnmp_m <=> M_h_m + M_nmp_m m FALSE (WBGene00003966) PW034 -R_3_1_4_17_RXN_n 3′,5′-cyclic-nucleotide phosphodiesterase M_h2o_n + M_c35rnmp_n <=> M_h_n + M_nmp_n n FALSE (WBGene00003966) or (WBGene00016328) PW034 RHEA:14653 +R_3_1_4_17_RXN_c "3′,5′-cyclic-nucleotide phosphodiesterase" M_h2o_c + M_c35rnmp_c <=> M_h_c + M_nmp_c c FALSE (WBGene00022389) or (WBGene00020114) or (WBGene00011433) or (WBGene00003966) or (WBGene00016328) PW034 "RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653" +R_3_1_4_17_RXN_m "3′,5′-cyclic-nucleotide phosphodiesterase" M_h2o_m + M_c35rnmp_m <=> M_h_m + M_nmp_m m FALSE (WBGene00003966) PW034 +R_3_1_4_17_RXN_n "3′,5′-cyclic-nucleotide phosphodiesterase" M_h2o_n + M_c35rnmp_n <=> M_h_n + M_nmp_n n FALSE (WBGene00003966) or (WBGene00016328) PW034 RHEA:14653 R_3_2_1_106_RXN_c mannosyl-oligosaccharide glucosidase M_h2o_c + M_g3m8masn_c <=> M_glc2Man9GlcNac2Asn_c + M_glc_bD_c c FALSE (WBGene00008775) PW011 RHEA:55988 R_3_2_1_106_RXN_m mannosyl-oligosaccharide glucosidase M_h2o_m + M_g3m8masn_m <=> M_glc2Man9GlcNac2Asn_m + M_glc_bD_m m FALSE (WBGene00008775) PW011 RHEA:55988 R_3_2_1_106_RXN_n mannosyl-oligosaccharide glucosidase M_h2o_n + M_g3m8masn_n <=> M_glc2Man9GlcNac2Asn_n + M_glc_bD_n n FALSE (WBGene00008775) PW011 RHEA:55988 -R_3_2_1_114_RXN_c mannosyl-oligosaccharide 1,3-1,6-α-mannosidase 2.0 M_h2o_c + M_man5_c <=> M_MM_c + 2.0 M_man_c c FALSE (WBGene00010284) PW011 +R_3_2_1_114_RXN_c "mannosyl-oligosaccharide 1,3-1,6-α-mannosidase" 2.0 M_h2o_c + M_man5_c <=> M_MM_c + 2.0 M_man_c c FALSE (WBGene00010284) PW011 R_3_2_1_14_RXN_c chitinase M_chdex_c <=> M_h2o_c + M_chtn_c c FALSE (WBGene00000503) PW021 -R_3_2_1_25_RXN_c β-mannosidase M_mn_c + M_h2o_c <=> M_acgam_c + M_man_c c TRUE (WBGene00007904) PW012 -R_3_2_1_25_RXN_m β-mannosidase M_mn_m + M_h2o_m <=> M_acgam_m + M_man_m m TRUE (WBGene00007904) PW012 +R_3_2_1_25_RXN_c "β-mannosidase" M_mn_c + M_h2o_c <=> M_acgam_c + M_man_c c TRUE (WBGene00007904) PW012 +R_3_2_1_25_RXN_m "β-mannosidase" M_mn_m + M_h2o_m <=> M_acgam_m + M_man_m m TRUE (WBGene00007904) PW012 R_3_4_13_5_RXN_c Xaa-methyl-His dipeptidase M_h2o_c + M_LalaLglu_c <=> M_glu__L_c + M_ala__L_c c FALSE PW107 replaced M_ala__L_c with M_ala_L_c lenov -R_3_5_1_26_RXN_c N4-(β-N-acetylglucosaminyl)-L-asparaginase M_h2o_c + M_acBgamamAsn_c <=> M_acBgamam_c + M_h_c + M_asp__L_c c TRUE (WBGene00019867) PW012 replaced M_asp__L_c with M_asp_L_c lenov -R_3_5_1_26_RXN_m N4-(β-N-acetylglucosaminyl)-L-asparaginase M_h2o_m + M_acBgamamAsn_m <=> M_acBgamam_m + M_h_m + M_asp__L_m m TRUE (WBGene00019867) PW012 replaced M_asp__L_m with M_asp_L_m lenov -R_3_HYDROXYISOBUTYRYL_COA_HYDROLASE_RXN_m 3-hydroxyisobutyryl-CoA hydrolase M_h2o_m + M_3hibutcoa_m <=> M_h_m + M_coa_m + M_3hmp_m m TRUE (WBGene00017301) PW083 RHEA:20888;RHEA:20888 -R_3_HYDROXYISOBUTYRYL_COA_HYDROLASE_RXN_n 3-hydroxyisobutyryl-CoA hydrolase M_h2o_n + M_3hibutcoa_n <=> M_h_n + M_coa_n + M_3hmp_n n TRUE (WBGene00017301) PW083 RHEA:20888;RHEA:20888 +R_3_5_1_26_RXN_c "N4-(β-N-acetylglucosaminyl)-L-asparaginase" M_h2o_c + M_acBgamamAsn_c <=> M_acBgamam_c + M_h_c + M_asp__L_c c TRUE (WBGene00019867) PW012 replaced M_asp__L_c with M_asp_L_c lenov +R_3_5_1_26_RXN_m "N4-(β-N-acetylglucosaminyl)-L-asparaginase" M_h2o_m + M_acBgamamAsn_m <=> M_acBgamam_m + M_h_m + M_asp__L_m m TRUE (WBGene00019867) PW012 replaced M_asp__L_m with M_asp_L_m lenov +R_3_HYDROXYISOBUTYRYL_COA_HYDROLASE_RXN_m 3-hydroxyisobutyryl-CoA hydrolase M_h2o_m + M_3hibutcoa_m <=> M_h_m + M_coa_m + M_3hmp_m m TRUE (WBGene00017301) PW083 "RHEA:20888;RHEA:20888" +R_3_HYDROXYISOBUTYRYL_COA_HYDROLASE_RXN_n 3-hydroxyisobutyryl-CoA hydrolase M_h2o_n + M_3hibutcoa_n <=> M_h_n + M_coa_n + M_3hmp_n n TRUE (WBGene00017301) PW083 "RHEA:20888;RHEA:20888" R_34DHPHAMT_c R_34DHPHAMT_c M_34dhpha_c + M_amet_c <=> M_h_c + M_homoval_c + M_ahcys_c c FALSE PW077 R_34DHPLACOX_c R_34DHPLACOX_c M_h2o_c + M_34dhpac_c + M_nad_c <=> 2.0 M_h_c + M_34dhpha_c + M_nadh_c c TRUE (WBGene00000118) or (WBGene00000108) or (WBGene00000107) PW077 R_34HPLFM_c Hydroxyphenylpyruvate reductase M_h_c + M_nadh_c + M_34hpp_c <=> M_34hpl_c + M_nad_c c TRUE PW003 set to reversible janna @@ -89,12 +89,12 @@ R_35CGMPtn 35cGMP nuclear transport M_35cgmp_c <=> M_35cgmp_n cn TRUE PW108 R_3HAO_c 3-hydroxyanthranilate 3,4-dioxygenase M_3hanthrn_c + M_o2_c <=> M_cmusa_c + M_h_c c FALSE (WBGene00010595) PW072 RHEA:17953 R_3HBCD_c 3-hydroxybutyryl-CoA dehydratase M_h2o_c + M_b2coa_c <=> M_3hbcoa_R_c c FALSE (WBGene00001150) PW080 replaced M_3hbcoa_R_c with M_3hbcoa__R_c lenov R_3HBCD_m 3-hydroxybutyryl-CoA dehydratase M_h2o_m + M_b2coa_m <=> M_3hbcoa_R_m m FALSE (WBGene00001150) PW080 replaced M_3hbcoa_R_m with M_3hbcoa__R_m lenov -R_3HLYTCL_c R_3HLYTCL_c M_h_c + M_34dhphe_c <=> M_co2_c + M_dopa_c c TRUE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW077 RHEA:14345;RHEA:12272;RHEA:18533 -R_3HPCOAHYD_m 3-Hydroxypropionyl-CoA Hydrolase M_h2o_m + M_3hpcoa_m <=> M_3hpp_m + M_h_m + M_coa_m m FALSE (WBGene00017301) PW086;PW010 R03158 RHEA:20888;RHEA:20888 Added Name of rxn jpnh -R_3HPCOAHYD_n 3-Hydroxypropionyl-CoA Hydrolase M_h2o_n + M_3hpcoa_n <=> M_3hpp_n + M_h_n + M_coa_n n FALSE (WBGene00017301) PW086;PW010 R03158 RHEA:20888;RHEA:20888 Added Name of rxn jpnh -R_3HPPD_c 3-hydroxypropionate dehydrogenase M_nad_c + M_3hpp_c <=> M_h_c + M_nadh_c + M_msa_c c FALSE WBGene00012608 PW086;PW010 -R_3SALATAi_c 3-sulfino-L-alanine:2-oxoglutarate aminotransferase M_akg_c + M_3sala_c <=> M_3snpyr_c + M_glu__L_c c TRUE (WBGene00020146) or (WBGene00020145) or (WBGene00015778) or (WBGene00015771) PW082 RHEA:21824;RHEA:21824 set to reversible janna -R_3SALATAi_m 3-sulfino-L-alanine:2-oxoglutarate aminotransferase M_akg_m + M_3sala_m <=> M_3snpyr_m + M_glu__L_m m TRUE (WBGene00016652) or (WBGene00015778) PW082 RHEA:21824;RHEA:21824 set to reversible janna +R_3HLYTCL_c R_3HLYTCL_c M_h_c + M_34dhphe_c <=> M_co2_c + M_dopa_c c TRUE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW077 "RHEA:14345;RHEA:12272;RHEA:18533" +R_3HPCOAHYD_m 3-Hydroxypropionyl-CoA Hydrolase M_h2o_m + M_3hpcoa_m <=> M_3hpp_m + M_h_m + M_coa_m m FALSE (WBGene00017301) "PW086;PW010" R03158 "RHEA:20888;RHEA:20888" Added Name of rxn jpnh +R_3HPCOAHYD_n 3-Hydroxypropionyl-CoA Hydrolase M_h2o_n + M_3hpcoa_n <=> M_3hpp_n + M_h_n + M_coa_n n FALSE (WBGene00017301) "PW086;PW010" R03158 "RHEA:20888;RHEA:20888" Added Name of rxn jpnh +R_3HPPD_c 3-hydroxypropionate dehydrogenase M_nad_c + M_3hpp_c <=> M_h_c + M_nadh_c + M_msa_c c FALSE WBGene00012608 "PW086;PW010" +R_3SALATAi_c 3-sulfino-L-alanine:2-oxoglutarate aminotransferase M_akg_c + M_3sala_c <=> M_3snpyr_c + M_glu__L_c c TRUE (WBGene00020146) or (WBGene00020145) or (WBGene00015778) or (WBGene00015771) PW082 "RHEA:21824;RHEA:21824" set to reversible janna +R_3SALATAi_m 3-sulfino-L-alanine:2-oxoglutarate aminotransferase M_akg_m + M_3sala_m <=> M_3snpyr_m + M_glu__L_m m TRUE (WBGene00016652) or (WBGene00015778) PW082 "RHEA:21824;RHEA:21824" set to reversible janna R_3SPYRSP_c 3-Sulfinylpyruvate hydrolysis M_h2o_c + M_3snpyr_c <=> M_so3_c + M_h_c + M_pyr_c c FALSE PW082 R04861 Added rxn name jpnh R_3SPYRSP_m 3-Sulfinylpyruvate hydrolysis M_h2o_m + M_3snpyr_m <=> M_so3_m + M_h_m + M_pyr_m m FALSE PW082 R04861 Added rxn name jpnh R_4_2_1_109_RXN_c Methylthioribulose 1-phosphate dehydratase M_5mdru1p_c <=> M_dkmpp_c + M_h2o_c c FALSE (WBGene00013870) PW082 @@ -104,10 +104,10 @@ R_4ABZ_e PABA transport M_4abz_e <=> e TRUE PW111 R_4ABZt PABA transport M_4abz_c <=> M_4abz_e ce TRUE PW107 R_4CMCOAS_c 4-coumarate--CoA ligase M_T4hcinnm_c + M_atp_c + M_coa_c <=> M_4cmcoa_c + M_ppi_c + M_h_c + M_amp_c c FALSE (WBGene00022849) or (WBGene00008669) PW003 R_4CMCOAS_m 4-coumarate--CoA ligase M_T4hcinnm_m + M_atp_m + M_coa_m <=> M_4cmcoa_m + M_ppi_m + M_h_m + M_amp_m m FALSE (WBGene00007228) or (WBGene00007082) or (WBGene00022849) PW003 -R_5HLTDL_c Aromatic-L-amino-acid decarboxylase M_h_c + M_5htrp_c <=> M_co2_c + M_srtn_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW072 RHEA:14345;RHEA:12272;RHEA:18533 +R_5HLTDL_c Aromatic-L-amino-acid decarboxylase M_h_c + M_5htrp_c <=> M_co2_c + M_srtn_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW072 "RHEA:14345;RHEA:12272;RHEA:18533" R_5HTRPVESSEC 5-hydroxy-L-tryptophan secretion via secretory vesicle (ATP driven) M_h2o_c + M_5htrp_c + M_atp_c <=> M_pi_c + M_h_c + M_adp_c + M_5htrp_e c FALSE (WBGene00000295) or (ND) PW107 RHEA:20309 -R_6_PHOSPHOFRUCTO_2_KINASE_RXN_c 6-phosphofructo-2-kinase M_f6p_c + M_atp_c <=> M_f26bp_c + M_h_c + M_adp_c c TRUE (WBGene00022456) or (WBGene00019295) PW025 RHEA:17289;RHEA:15653 -R_6_PHOSPHOFRUCTO_2_KINASE_RXN_n 6-phosphofructo-2-kinase M_f6p_n + M_atp_n <=> M_f26bp_n + M_h_n + M_adp_n n TRUE (WBGene00019295) PW025 RHEA:17289;RHEA:15653 +R_6_PHOSPHOFRUCTO_2_KINASE_RXN_c 6-phosphofructo-2-kinase M_f6p_c + M_atp_c <=> M_f26bp_c + M_h_c + M_adp_c c TRUE (WBGene00022456) or (WBGene00019295) PW025 "RHEA:17289;RHEA:15653" +R_6_PHOSPHOFRUCTO_2_KINASE_RXN_n 6-phosphofructo-2-kinase M_f6p_n + M_atp_n <=> M_f26bp_n + M_h_n + M_adp_n n TRUE (WBGene00019295) PW025 "RHEA:17289;RHEA:15653" R_AABTN_c 4-acetamidobutanoate amidohydrolase M_h2o_c + M_4aabutn_c <=> M_ac_c + M_4abut_c c TRUE Unknown PW081 Added Rxn Name R_AACOAT_c Acetoacetate--CoA ligase M_acac_c + M_atp_c + M_coa_c <=> M_ppi_c + M_amp_c + M_aacoa_c c FALSE (WBGene00006351) PW136 SPW001 RHEA:16117 R_AACPS9_c Octanoyl Acyl-carrier protein cleavage M_ppi_c + M_amp_c + M_acp8_0_c <=> M_atp_c + M_fa8_0_c + M_ACP_c c FALSE PW060 SPW001 Updated name jpnh @@ -115,35 +115,35 @@ R_AADSACYCL_c R_AADSACYCL_c M_h2o_c + M_thp2c_c <=> M_L2aadp6sa_c c TRUE (WBGen R_AADSACYCL_m R_AADSACYCL_m M_h2o_m + M_thp2c_m <=> M_L2aadp6sa_m m TRUE (WBGene00000115) PW079 RHEA:16185 R_AATA_c 2-aminoadipate aminotransferase M_akg_c + M_L2aadp_c <=> M_2oxoadp_c + M_glu__L_c c TRUE PW079 R_AATA_m 2-aminoadipate aminotransferase M_akg_m + M_L2aadp_m <=> M_2oxoadp_m + M_glu__L_m m TRUE TBD PW079 -R_ABTA_m 4-aminobutyrate aminotransferase M_akg_m + M_4abut_m <=> M_sucsal_m + M_glu__L_m m TRUE (WBGene00001794) PW073 RHEA:23352;RHEA:13993 +R_ABTA_m 4-aminobutyrate aminotransferase M_akg_m + M_4abut_m <=> M_sucsal_m + M_glu__L_m m TRUE (WBGene00001794) PW073 "RHEA:23352;RHEA:13993" R_ABUTt4_2_r 4-aminobutyrate reversible transport in via sodium symport (1:2) 2.0 M_na1_e + M_4abut_e <=> 2.0 M_na1_c + M_4abut_c ec TRUE (WBGene00004910) PW107 -R_ACACCT_c acetoacetyl-CoA:acetate CoA-transferase M_acac_c + M_accoa_c <=> M_ac_c + M_aacoa_c c TRUE (WBGene00007330) PW010 R01359 added KEGG ID, changed name to KEGG one; changed pathway from acetoacetate degradation (to acetyl CoA) to propanoate metabolism lenov -R_ACACCT_m acetoacetyl-CoA:acetate CoA-transferase M_acac_m + M_accoa_m <=> M_ac_m + M_aacoa_m m TRUE (WBGene00007330) PW010 R01359 added KEGG ID, changed name to KEGG one; changed pathway from acetoacetate degradation (to acetyl CoA) to propanoate metabolism lenov -R_ACACT1_c Acetyl-CoA C-acetyltransferase 2.0 M_accoa_c <=> M_coa_c + M_aacoa_c c TRUE (WBGene00002183) or (WBGene00020166) or (WBGene00020164) PW080;PW062;PW083;PW010;PW001 R00238 changed pathway from acetoacetate degradation (to acetyl CoA) to PW010 lenov -R_ACACT1_m Acetyl-CoA C-acetyltransferase 2.0 M_accoa_m <=> M_coa_m + M_aacoa_m m TRUE WBGene00020164 or WBGene00020166 or WBGene00002183 PW080;PW062;PW083;PW010;PW001 R00238 changed pathway from acetoacetate degradation (to acetyl CoA) to PW010 lenov +R_ACACCT_c acetoacetyl-CoA:acetate CoA-transferase M_acac_c + M_accoa_c <=> M_ac_c + M_aacoa_c c TRUE (WBGene00007330) PW010 R01359 "added KEGG ID, changed name to KEGG one; changed pathway from acetoacetate degradation (to acetyl CoA) to propanoate metabolism" lenov +R_ACACCT_m acetoacetyl-CoA:acetate CoA-transferase M_acac_m + M_accoa_m <=> M_ac_m + M_aacoa_m m TRUE (WBGene00007330) PW010 R01359 "added KEGG ID, changed name to KEGG one; changed pathway from acetoacetate degradation (to acetyl CoA) to propanoate metabolism" lenov +R_ACACT1_c Acetyl-CoA C-acetyltransferase 2.0 M_accoa_c <=> M_coa_c + M_aacoa_c c TRUE (WBGene00002183) or (WBGene00020166) or (WBGene00020164) "PW080;PW062;PW083;PW010;PW001" R00238 changed pathway from acetoacetate degradation (to acetyl CoA) to PW010 lenov +R_ACACT1_m Acetyl-CoA C-acetyltransferase 2.0 M_accoa_m <=> M_coa_m + M_aacoa_m m TRUE WBGene00020164 or WBGene00020166 or WBGene00002183 "PW080;PW062;PW083;PW010;PW001" R00238 changed pathway from acetoacetate degradation (to acetyl CoA) to PW010 lenov R_ACACT10_c acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase M_coa_c + M_2maacoa_c <=> M_accoa_c + M_ppcoa_c c TRUE (WBGene00009952) PW083 R_ACACT10_m acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase M_coa_m + M_2maacoa_m <=> M_accoa_m + M_ppcoa_m m TRUE (WBGene00009952) or (WBGene00015125) PW083 -R_ACALD_c Acetaldehyde dehydrogenase (acetylating) M_coa_c + M_nad_c + M_acald_c <=> M_h_c + M_nadh_c + M_accoa_c c TRUE PW043;PW042 +R_ACALD_c Acetaldehyde dehydrogenase (acetylating) M_coa_c + M_nad_c + M_acald_c <=> M_h_c + M_nadh_c + M_accoa_c c TRUE "PW043;PW042" R_ACCOAC_c Acetyl-CoA carboxylase M_hco3_c + M_atp_c + M_accoa_c <=> M_pi_c + M_h_c + M_adp_c + M_malcoa_c c TRUE WBGene00012131 or WBGene00004076 PW060 SPW001 set to reversible janna R_accoatm accoatm M_accoa_m <=> M_accoa_c mc TRUE PW111 R_ACCOAtn acetyl-CoA transport, nuclear M_accoa_c <=> M_accoa_n cn TRUE PW108 R_ACETYLORNDEACET_RXN_c acetylornithine deacetylase M_acorn_c + M_h2o_c <=> M_orn_c + M_ac_c c TRUE (WBGene00007508) or (WBGene00007509) or (WBGene00007507) or (WBGene00015509) or (WBGene00016657) PW081 set to reversible janna R_ACETYLORNDEACET_RXN_n acetylornithine deacetylase M_acorn_n + M_h2o_n <=> M_orn_n + M_ac_n n TRUE (WBGene00007508) or (WBGene00007509) or (WBGene00007507) PW081 set to reversible janna -R_ACGAM6PS_c Glucosamine-phosphate N-acetyltransferase M_accoa_c + M_gam6p_c <=> M_acgam6p_c + M_h_c + M_coa_c c TRUE (WBGene00001647) or (WBGene00001646) PW032 RHEA:10292;RHEA:10292 +R_ACGAM6PS_c Glucosamine-phosphate N-acetyltransferase M_accoa_c + M_gam6p_c <=> M_acgam6p_c + M_h_c + M_coa_c c TRUE (WBGene00001647) or (WBGene00001646) PW032 "RHEA:10292;RHEA:10292" R_ACGAM6PS_m Glucosamine-phosphate N-acetyltransferase M_accoa_m + M_gam6p_m <=> M_acgam6p_m + M_h_m + M_coa_m m TRUE (WBGene00001647) PW032 RHEA:10292 R_ACGAM6PS_n Glucosamine-phosphate N-acetyltransferase M_accoa_n + M_gam6p_n <=> M_acgam6p_n + M_h_n + M_coa_n n TRUE (WBGene00001646) PW032 RHEA:10292 R_ACGAMPM_c Phosphoacetylglucosamine mutase M_acgam1p_c <=> M_acgam6p_c c TRUE (WBGene00009006) PW032 R_ACGAMPM_n Phosphoacetylglucosamine mutase M_acgam1p_n <=> M_acgam6p_n n TRUE (WBGene00009006) PW032 R_ACHE_c Acetylcholinesterase M_ach_c + M_h2o_c <=> M_chol_c + M_h_c + M_ac_c c TRUE (WBGene00000035) or (WBGene00000037) or (WBGene00000036) or (WBGene00000038) PW056 RHEA:17561 R_ACHtn Acetylcholin transport, nuclear trhough pores M_ach_n <=> M_ach_c nc TRUE PW108 -R_ACID__COA_LIGASE_GDP_FORMING_RXN_c carboxylic acid—CoA ligase (GDP-forming) M_gtp_c + M_coa_c + M_fatacid_c <=> M_pi_c + M_gdp_c + M_fataccoa_c c FALSE PW054 -R_ACITL_c ATP-citrate (pro-S-)-lyase M_cit_c + M_atp_c + M_coa_c <=> M_oaa_c + M_pi_c + M_adp_c + M_accoa_c c FALSE (WBGene00007350) or (WBGene00016995) or (WBGene00016995) or (WBGene00007150) PW023 SPW004 RHEA:21160;RHEA:17661;RHEA:22120;RHEA:21160 -R_ACONITATEHYDR_RXN_c R_ACONITATEHYDR_RXN_c M_h2o_c + M_acon_C_c <=> M_icit_c c TRUE (WBGene00000041) or (WBGene00000040) PW023;PW074;PW030 RHEA:10336;RHEA:10336 -R_ACONITATEHYDR_RXN_m R_ACONITATEHYDR_RXN_m M_h2o_m + M_acon_C_m <=> M_icit_m m TRUE (WBGene00000041) PW023;PW074;PW030 RHEA:10336 -R_ACONT_c Aconitate hydratase M_cit_c <=> M_h2o_c + M_acon_C_c c TRUE (WBGene00000041) or (WBGene00000040) PW023;PW074;PW030 RHEA:10336;RHEA:10336 -R_ACONT_m Aconitate hydratase M_cit_m <=> M_h2o_m + M_acon_C_m m TRUE (WBGene00000041) PW023;PW074;PW030 RHEA:10336 +R_ACID__COA_LIGASE_GDP_FORMING_RXN_c "carboxylic acid—CoA ligase (GDP-forming)" M_gtp_c + M_coa_c + M_fatacid_c <=> M_pi_c + M_gdp_c + M_fataccoa_c c FALSE PW054 +R_ACITL_c ATP-citrate (pro-S-)-lyase M_cit_c + M_atp_c + M_coa_c <=> M_oaa_c + M_pi_c + M_adp_c + M_accoa_c c FALSE (WBGene00007350) or (WBGene00016995) or (WBGene00016995) or (WBGene00007150) PW023 SPW004 "RHEA:21160;RHEA:17661;RHEA:22120;RHEA:21160" +R_ACONITATEHYDR_RXN_c R_ACONITATEHYDR_RXN_c M_h2o_c + M_acon_C_c <=> M_icit_c c TRUE (WBGene00000041) or (WBGene00000040) "PW023;PW074;PW030" "RHEA:10336;RHEA:10336" +R_ACONITATEHYDR_RXN_m R_ACONITATEHYDR_RXN_m M_h2o_m + M_acon_C_m <=> M_icit_m m TRUE (WBGene00000041) "PW023;PW074;PW030" RHEA:10336 +R_ACONT_c Aconitate hydratase M_cit_c <=> M_h2o_c + M_acon_C_c c TRUE (WBGene00000041) or (WBGene00000040) "PW023;PW074;PW030" "RHEA:10336;RHEA:10336" +R_ACONT_m Aconitate hydratase M_cit_m <=> M_h2o_m + M_acon_C_m m TRUE (WBGene00000041) "PW023;PW074;PW030" RHEA:10336 R_ACRNtm O-acetylcarnintine transport into mitochondria via diffusion M_acrn_c <=> M_acrn_m cm FALSE (WBGene00000996 ) or (ND) PW106 -R_ACS_c acetate--CoA ligase M_atp_c + M_coa_c + M_ac_c <=> M_ppi_c + M_amp_c + M_accoa_c c FALSE (WBGene00007969) PW018;PW022;PW023;PW030 RHEA:23176;RHEA:23176 +R_ACS_c acetate--CoA ligase M_atp_c + M_coa_c + M_ac_c <=> M_ppi_c + M_amp_c + M_accoa_c c FALSE (WBGene00007969) "PW018;PW022;PW023;PW030" "RHEA:23176;RHEA:23176" R_ACYLCOASYN_RXN_c 2,3,4-saturated fatty acyl-CoA synthetase M_atp_c + M_coa_c + M_fatacid_c <=> M_ppi_c + M_amp_c + M_fataccoa_c c FALSE (WBGene00009218) PW038 R_ACYLCOASYN_RXN_m 2,3,4-saturated fatty acyl-CoA synthetase M_atp_m + M_coa_m + M_fatacid_m <=> M_ppi_m + M_amp_m + M_fataccoa_m m FALSE (WBGene00009218) PW038 R_ACYLCOASYNTMITO0001 Acyl-CoA-synthethase (C4:0) M_atp_m + M_coa_m + M_but_m <=> M_ppi_m + M_amp_m + M_btcoa_m m FALSE WBGene00009221 or WBGene00019920 or WBGene00011173 or WBGene00011174 PW130 SPW001 [CHECKME] Replacement for reaction R_RXN909_123_m wimi @@ -161,23 +161,23 @@ R_ADNK1_m Adenosine kinase M_atp_m + M_adn_m <=> M_h_m + M_amp_m + M_adp_m m FA R_ADNtm adenosine facilated transport in mitochondria M_adn_c <=> M_adn_m cm TRUE (WBGene00001320) or (WBGene00010701) or (ND) PW106 R_ADPSUGPPHOSPHAT_RXN_c ADP-sugar diphosphatase M_h2o_c + M_adpsug_c <=> M_amp_c + M_adaldp_c c FALSE PW034 R_ADPT_c Adenine phosphoribosyltransferase M_prpp_c + M_ade_c <=> M_ppi_c + M_amp_c c FALSE WBGene00020557 or WBGene00013690 PW042 RHEA:17973 -R_ADSK_c Adenylylsulfate kinase M_aps_c + M_atp_c <=> M_paps_c + 2.0 M_h_c + M_adp_c c TRUE (WBGene00004091) PW096;PW042 set to reversible; replaced annotation sulfate activation for sulfonation with PW096, PW042 janna; lenov -R_ADSL1_c Adenylosuccinate lyase M_dcamp_c <=> M_amp_c + M_fum_c c TRUE (WBGene00011064) PW042 RHEA:16853;RHEA:23920 -R_ADSL2_c Adenylosuccinate lyase M_25aics_c <=> M_aicar_c + M_fum_c c TRUE (WBGene00011064) PW042 RHEA:16853;RHEA:23920 -R_ADSS_c adenylosuccinate synthetase M_asp__L_c + M_imp_c + M_gtp_c <=> M_pi_c + 2.0 M_h_c + M_dcamp_c + M_gdp_c c TRUE (WBGene00016509) or (WBGene00016509) or (WBGene00016509) PW042 20654742 RHEA:15753 added PMID and merged R_RC01135 into here; changed M_asp__L_c into M_asp_c jpnh; lenov -R_AGDC_c N-acetylglucosamine-6-phosphate deacetylase M_h2o_c + M_acgam6p_c <=> M_ac_c + M_gam6p_c c FALSE (WBGene00010308) PW009 R02059 added KEGG ID; removed redundant N-acetylglucosamine degradation I lenov +R_ADSK_c Adenylylsulfate kinase M_aps_c + M_atp_c <=> M_paps_c + 2.0 M_h_c + M_adp_c c TRUE (WBGene00004091) "PW096;PW042" "set to reversible; replaced annotation sulfate activation for sulfonation with PW096, PW042" "janna; lenov" +R_ADSL1_c Adenylosuccinate lyase M_dcamp_c <=> M_amp_c + M_fum_c c TRUE (WBGene00011064) PW042 "RHEA:16853;RHEA:23920" +R_ADSL2_c Adenylosuccinate lyase M_25aics_c <=> M_aicar_c + M_fum_c c TRUE (WBGene00011064) PW042 "RHEA:16853;RHEA:23920" +R_ADSS_c adenylosuccinate synthetase M_asp__L_c + M_imp_c + M_gtp_c <=> M_pi_c + 2.0 M_h_c + M_dcamp_c + M_gdp_c c TRUE (WBGene00016509) or (WBGene00016509) or (WBGene00016509) PW042 20654742 RHEA:15753 "added PMID and merged R_RC01135 into here; changed M_asp__L_c into M_asp_c" "jpnh; lenov" +R_AGDC_c N-acetylglucosamine-6-phosphate deacetylase M_h2o_c + M_acgam6p_c <=> M_ac_c + M_gam6p_c c FALSE (WBGene00010308) PW009 R02059 "added KEGG ID; removed redundant N-acetylglucosamine degradation I" lenov R_AHC_c Adenosylhomocysteinase M_h2o_c + M_ahcys_c <=> M_hcys__L_c + M_adn_c c TRUE (WBGene00019322) PW082 RHEA:21708 R_AHCYStn S-adenosyl-L-homocysteine nuclear transport M_ahcys_c <=> M_ahcys_n cn TRUE PW108 R_AICART_c Phosphoribosylaminoimidazolecarboxamide formyltransferase M_10fthf_c + M_aicar_c <=> M_thf_c + M_fprica_c c TRUE (WBGene00016957) PW042 -R_AIRC_c Phosphoribosylaminoimidazole carboxylase M_5aizc_c + 2.0 M_h_c <=> M_air_c + M_co2_c c TRUE (WBGene00015116) PW042 RHEA:22628;RHEA:10792 -R_AKGDH_m 2-oxoglutarate dehydrogenase complex M_akg_m + M_coa_m + M_nad_m <=> M_co2_m + M_nadh_m + M_succoa_m m FALSE (WBGene00014098 and WBGene00010794 and WBGene00020950 and WBGene00020679) PW023 SPW004 RHEA:15045;RHEA:12188;RHEA:12188 +R_AIRC_c Phosphoribosylaminoimidazole carboxylase M_5aizc_c + 2.0 M_h_c <=> M_air_c + M_co2_c c TRUE (WBGene00015116) PW042 "RHEA:22628;RHEA:10792" +R_AKGDH_m 2-oxoglutarate dehydrogenase complex M_akg_m + M_coa_m + M_nad_m <=> M_co2_m + M_nadh_m + M_succoa_m m FALSE (WBGene00014098 and WBGene00010794 and WBGene00020950 and WBGene00020679) PW023 SPW004 "RHEA:15045;RHEA:12188;RHEA:12188" R_AKGMALtm alpha-ketoglutarate/malate transporter M_akg_m + M_mal__L_c <=> M_akg_c + M_mal__L_m mc TRUE WBGene00015186 or (ND) PW106 R_AKGt4_3 AKG transport via sodium symport M_akg_e + 3.0 M_na1_e <=> M_akg_c + 3.0 M_na1_c ec TRUE (WBGene00007138) PW107 R_Alanine_transport Alanine transport M_ala__L_c <=> M_ala__L_e ce TRUE PW107 replaced M_ala__L_c and M_ala__L_e with M_ala_L_c and M_ala_L_e lenov R_ALATA_L_c Alanine aminotransferase M_akg_c + M_ala__L_c <=> M_glu__L_c + M_pyr_c c TRUE (WBGene00016333) PW073 changed M_ala__L_c into M_ala_L_c lenov -R_ALCD2if_c R_ALCD2if_c M_h_c + M_nadh_c + M_acald_c <=> M_etoh_c + M_nad_c c TRUE (WBGene00010790) or (WBGene00019240) or (WBGene00021647) or (WBGene00010791) or (WBGene00017060) or (WBGene00021747) PW018;PW022;PW023;PW030 RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740 -R_ALDD2_c R_ALDD2_c M_h2o_c + M_nad_c + M_acald_c <=> 2.0 M_h_c + M_nadh_c + M_ac_c c TRUE (WBGene00000107) or (WBGene00000108) or (WBGene00000118) or (WBGene00000110) PW018;PW022;PW023;PW030 -R_ALDD2_m R_ALDD2_m M_h2o_m + M_nad_m + M_acald_m <=> 2.0 M_h_m + M_nadh_m + M_ac_m m TRUE (WBGene00000107 or WBGene00000108 or WBGene00000110) or WBGene00000115 PW018;PW022;PW023;PW030 RHEA:16185 +R_ALCD2if_c R_ALCD2if_c M_h_c + M_nadh_c + M_acald_c <=> M_etoh_c + M_nad_c c TRUE (WBGene00010790) or (WBGene00019240) or (WBGene00021647) or (WBGene00010791) or (WBGene00017060) or (WBGene00021747) "PW018;PW022;PW023;PW030" "RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740" +R_ALDD2_c R_ALDD2_c M_h2o_c + M_nad_c + M_acald_c <=> 2.0 M_h_c + M_nadh_c + M_ac_c c TRUE (WBGene00000107) or (WBGene00000108) or (WBGene00000118) or (WBGene00000110) "PW018;PW022;PW023;PW030" +R_ALDD2_m R_ALDD2_m M_h2o_m + M_nad_m + M_acald_m <=> 2.0 M_h_m + M_nadh_m + M_ac_m m TRUE (WBGene00000107 or WBGene00000108 or WBGene00000110) or WBGene00000115 "PW018;PW022;PW023;PW030" RHEA:16185 R_ALDOSE_1_EPIMERASE_RXN_c Aldose 1-epimerase M_glc_aD_c <=> M_glc_bD_c c TRUE WBGene00015270 or WBGene00044734 PW020 R_AM6SAD_c Aminomuconate-semialdehyde dehydrogenase M_h2o_c + M_am6sa_c + M_nad_c <=> M_amuco_c + 2.0 M_h_c + M_nadh_c c FALSE (WBGene00000116) or (TBD) PW072 R_AMETt2m S-Adenosyl-L-methionine reversible transport, mitochondrial M_ahcys_m + M_amet_c <=> M_ahcys_c + M_amet_m mc TRUE (WBGene00008364) PW106 @@ -187,11 +187,11 @@ R_Ammonia_transport Ammonia transport M_nh3_c <=> M_nh3_e ce TRUE PW107 R_AMMONIAtm AMMONIA mitochndria transport (diffusion) M_nh3_c <=> M_nh3_m cm TRUE PW106 R_AMMONIAtn AMMONIA nuclear transport (diffusion) M_nh3_c <=> M_nh3_n cn TRUE PW108 R_AMP_NUCLEOSID_RXN_c AMP nucleosidase M_h2o_c + M_amp_c <=> M_r5p_c + M_ade_c c TRUE PW042 -R_AMPDA_c AMP deaminase M_h2o_c + M_amp_c <=> M_nh3_c + M_imp_c c FALSE (WBGene00016415) PW042 RHEA:14777;RHEA:14777;RHEA:14777;RHEA:14777 -R_AMPTASECG_c L-cysteinylglycine dipeptidase M_h2o_c + M_cgly_c <=> M_gly_c + M_cys__L_c c TRUE (WBGene00002249 or WBGene00002250) or WBGene00011587 PW071;PW070 Made name more explicit lenov +R_AMPDA_c AMP deaminase M_h2o_c + M_amp_c <=> M_nh3_c + M_imp_c c FALSE (WBGene00016415) PW042 "RHEA:14777;RHEA:14777;RHEA:14777;RHEA:14777" +R_AMPTASECG_c L-cysteinylglycine dipeptidase M_h2o_c + M_cgly_c <=> M_gly_c + M_cys__L_c c TRUE (WBGene00002249 or WBGene00002250) or WBGene00011587 "PW071;PW070" Made name more explicit lenov R_anACRNtm an O-acylcarnitine transport into mitochondria via diffusion M_acycrn_c <=> M_acycrn_m cm FALSE (WBGene00000996 ) PW106 -R_APAT2_m beta-alanine:2-oxoglutarate aminotransferase M_akg_m + M_ala_B_m <=> M_msa_m + M_glu__L_m m TRUE (WBGene00001794) PW086 R00908 RHEA:23352;RHEA:13993 Added Rxn Name jpnh -R_APRTO2_c N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing) M_h2o_c + M_aprut_c + M_o2_c <=> M_h2o2_c + M_nh3_c + M_n4abutn_c + M_h_c c FALSE (WBGene00017361) PW081 R04025 Added rxn name from kegg jpnh; lenov +R_APAT2_m beta-alanine:2-oxoglutarate aminotransferase M_akg_m + M_ala_B_m <=> M_msa_m + M_glu__L_m m TRUE (WBGene00001794) PW086 R00908 "RHEA:23352;RHEA:13993" Added Rxn Name jpnh +R_APRTO2_c N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing) M_h2o_c + M_aprut_c + M_o2_c <=> M_h2o2_c + M_nh3_c + M_n4abutn_c + M_h_c c FALSE (WBGene00017361) PW081 R04025 Added rxn name from kegg "jpnh; lenov" R_ARACHDFATPtc R_ARACHDFATPtc M_atp_c + M_coa_c + M_fa20_4_5z8z11z14z_e <=> M_coa20_4_5z8z11z14z_c + M_ppi_c + M_amp_c c FALSE (WBGene00020837 or WBGene00012804 or WBGene00010421 or WBGene00012629 or WBGene00016628 or WBGene00010307 or WBGene00017012 or WBGene00009218) PW105 R_ARACHFATPtc Arachidate CoA-synthase + import rxn M_atp_c + M_coa_c + M_fa20_0_e <=> M_coa20_0_c + M_ppi_c + M_amp_c c FALSE (WBGene00020837 or WBGene00012804 or WBGene00010421 or WBGene00012629 or WBGene00016628 or WBGene00010307 or WBGene00017012 or WBGene00009218) PW111 [CHECK ME] Added rxn name, but compartmentalisation seems unsual jpnh R_ARCRNtm O-Arachidoylcarnitine transport into mitochondria via diffusion M_carn20_0__L_c <=> M_carn20_0__L_m cm FALSE (WBGene00000996 ) PW106 @@ -479,54 +479,54 @@ R_ASCRODDBIOSYNTH0068 M_h2o_c + M_bkas_34coa_c <=> M_h_c + M_bkas_34_c + M_coa_ R_ASCRODDBIOSYNTH0069 M_h2o_c + M_bkas_38coa_c <=> M_h_c + M_bkas_38_c + M_coa_c c FALSE PW135 SPW002 [CHECKME] changed pathway and superpathway wimi R_ASCRODDBIOSYNTH0070 M_h2o_c + M_bkas_9coa_c <=> M_h_c + M_bkas_9_c + M_coa_c c FALSE PW135 SPW002 [CHECKME] changed pathway and superpathway wimi R_ASNN_c Asparaginase M_h2o_c + M_asn__L_c <=> M_nh3_c + M_h_c + M_asp__L_c c TRUE (WBGene00007756) PW073 changed M_asp__L_c and M_asn__L_c into M_asp_L_c and M_asn_L_c lenov -R_ASNS1_c asparagine synthetase (glutamine-hydrolysing) M_h2o_c + M_gln__L_c + M_asp__L_c + M_atp_c <=> M_ppi_c + 2.0 M_h_c + M_asn__L_c + M_glu__L_c + M_amp_c c FALSE (WBGene00019730) or (WBGene00003816) PW073 [DELETION] replaced with R_RC00578_new due to incorrect stoichiometry; changed M_asp__L_c and M_asn__L_c into M_asp_L_c and M_asn_L_c jpnh; lenov +R_ASNS1_c asparagine synthetase (glutamine-hydrolysing) M_h2o_c + M_gln__L_c + M_asp__L_c + M_atp_c <=> M_ppi_c + 2.0 M_h_c + M_asn__L_c + M_glu__L_c + M_amp_c c FALSE (WBGene00019730) or (WBGene00003816) PW073 "[DELETION] replaced with R_RC00578_new due to incorrect stoichiometry; changed M_asp__L_c and M_asn__L_c into M_asp_L_c and M_asn_L_c" "jpnh; lenov" R_Asparagine_transport Asparagine transport M_asn__L_c <=> M_asn__L_e ce TRUE PW107 replaced M_asn__L_c and M_asn__L_e with M_asn_L_c and M_asn_L_e lenov R_ASPARTATE_RACEMASE_RXN_c aspartate racemase M_asp__L_c <=> M_asp__D_c c FALSE PW073 changed M_asp__L_c and M_asp__D_c into M_asp_L_c and M_asp_D_c lenov R_Aspartate_transport Aspartate transport M_asp__L_c <=> M_asp__L_e ce TRUE PW107 -R_ASPCT_c Aspartate carbamoyltransferase M_cbp_c + M_asp__L_c <=> M_pi_c + M_h_c + M_cbasp_c c TRUE (WBGene00004259) PW043 RHEA:18633;RHEA:20013;RHEA:24296 changed M_asp__L_c into M_asp_c lenov +R_ASPCT_c Aspartate carbamoyltransferase M_cbp_c + M_asp__L_c <=> M_pi_c + M_h_c + M_cbasp_c c TRUE (WBGene00004259) PW043 "RHEA:18633;RHEA:20013;RHEA:24296" changed M_asp__L_c into M_asp_c lenov R_ASPDt6 D-aspartate transport via Na, H symport and K antiport M_h_e + 3.0 M_na1_e + M_asp__D_e + M_k_c <=> M_h_c + M_asp__D_c + M_k_e + 3.0 M_na1_c ec FALSE (WBGene00001620) or (WBGene00001625) PW107 replaced M_asp__D_e and M_asp__D_c with M_asp_D_e and M_asp_D_c lenov R_ASPGLUm aspartate-glutamate mitochondrial shuttle M_h_c + M_glu__L_c + M_asp__L_m <=> M_h_m + M_glu__L_m + M_asp__L_c cm TRUE WBGene00019326 PW106 Changed M_asp__L_c and M_asp__L_m into M_asp_L_c and M_asp_L_m lenov R_ASPt6 L-aspartate transport via Na, H symport and K antiport M_h_e + M_asp__L_e + 3.0 M_na1_e + M_k_c <=> M_h_c + M_asp__L_c + M_k_e + 3.0 M_na1_c ec FALSE (WBGene00001620) or (WBGene00001625) PW107 changed M_asp__L_e and M_asp__L_c into M_asp_L_e and M_asp_L_e lenov -R_ASPTA_c Aspartate aminotransferase M_oaa_c + M_glu__L_c <=> M_akg_c + M_asp__L_c c FALSE (WBGene00020146) or (WBGene00020145) or (WBGene00015771) or (WBGene00015778) PW073;PW074 RHEA:21824;RHEA:21824 [DELETION] merged into R_RC00355; changed M_asp__L_c into M_asp_c jpnh;lenov -R_ASPTA_m Aspartate aminotransferase M_oaa_m + M_glu__L_m <=> M_akg_m + M_asp__L_m m FALSE (WBGene00016652) or (WBGene00015778) PW073;PW074 RHEA:21824;RHEA:21824 changed M_asp__L_m into M_asp_L_m lenov -R_ATPH1_c Apyrase 2.0 M_h2o_c + M_atp_c <=> 2.0 M_pi_c + 3.0 M_h_c + M_amp_c c FALSE (WBGene00003254) PW042;PW043 RHEA:36799 +R_ASPTA_c Aspartate aminotransferase M_oaa_c + M_glu__L_c <=> M_akg_c + M_asp__L_c c FALSE (WBGene00020146) or (WBGene00020145) or (WBGene00015771) or (WBGene00015778) "PW073;PW074" "RHEA:21824;RHEA:21824" "[DELETION] merged into R_RC00355; changed M_asp__L_c into M_asp_c" "jpnh;lenov" +R_ASPTA_m Aspartate aminotransferase M_oaa_m + M_glu__L_m <=> M_akg_m + M_asp__L_m m FALSE (WBGene00016652) or (WBGene00015778) "PW073;PW074" "RHEA:21824;RHEA:21824" changed M_asp__L_m into M_asp_L_m lenov +R_ATPH1_c Apyrase 2.0 M_h2o_c + M_atp_c <=> 2.0 M_pi_c + 3.0 M_h_c + M_amp_c c FALSE (WBGene00003254) "PW042;PW043" RHEA:36799 R_ATPtm ADP/ATP transporter, mitochondrial M_atp_m + M_adp_c <=> M_atp_c + M_adp_m mc FALSE (WBGene00010485) or (WBGene00020140) or (WBGene00007057) or (WBGene00006439) or (ND) PW106 R_ATPtn ATP diffusion in nucleus M_atp_c <=> M_atp_n cn TRUE PW108 -R_BBHOX_c γ-butyrobetaine dioxygenase M_akg_c + M_4tmeabutn_c + M_o2_c <=> M_co2_c + M_crn_c + M_succ_c c FALSE (WBGene00001522) or (WBGene00001523) PW080 RHEA:24028 +R_BBHOX_c "γ-butyrobetaine dioxygenase" M_akg_c + M_4tmeabutn_c + M_o2_c <=> M_co2_c + M_crn_c + M_succ_c c FALSE (WBGene00001522) or (WBGene00001523) PW080 RHEA:24028 R_BCRNtm O-Butanoylcarnitine transport into mitochondria via diffusion M_btcrn_c <=> M_btcrn_m cm FALSE (WBGene00000996 ) PW106 -R_BETA_CAROTENE_1515_DIOXYGENASE_RXN_c β-carotene 15,15′-monooxygenase M_caro_c + M_o2_c <=> 2.0 M_retinal_c c FALSE (WBGene00018755) or (WBGene00012914) PW069 -R_BETA_CAROTENE_1515_DIOXYGENASE_RXN_n β-carotene 15,15′-monooxygenase M_caro_n + M_o2_n <=> 2.0 M_retinal_n n FALSE (WBGene00018755) or (WBGene00012914) PW069 -R_BETAGALACTOSID_RXN_c β-galactosidase M_h2o_c + M_lcts_c <=> M_glc_bD_c + M_gal_c c TRUE (WBGene00019225) or (WBGene00011832) PW017 replaced pathway galactose degradation with galactose metabolism +R_BETA_CAROTENE_1515_DIOXYGENASE_RXN_c "β-carotene 15,15′-monooxygenase" M_caro_c + M_o2_c <=> 2.0 M_retinal_c c FALSE (WBGene00018755) or (WBGene00012914) PW069 +R_BETA_CAROTENE_1515_DIOXYGENASE_RXN_n "β-carotene 15,15′-monooxygenase" M_caro_n + M_o2_n <=> 2.0 M_retinal_n n FALSE (WBGene00018755) or (WBGene00012914) PW069 +R_BETAGALACTOSID_RXN_c "β-galactosidase" M_h2o_c + M_lcts_c <=> M_glc_bD_c + M_gal_c c TRUE (WBGene00019225) or (WBGene00011832) PW017 replaced pathway galactose degradation with galactose metabolism R_BETAOXMITO0001 Acyl-CoA-dehydrogenase (C18, mitochondrial) M_h_m + M_fad_m + M_coa18_0_m <=> M_fadh2_m + M_coa18_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_140_m wimi -R_BETAOXMITO0002 Enoyl-CoA-hydratase (C18, mitochondrial) M_coa18_1_2e_m + M_h2o_m <=> M_coa18_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_143_m wimi +R_BETAOXMITO0002 Enoyl-CoA-hydratase (C18, mitochondrial) M_coa18_1_2e_m + M_h2o_m <=> M_coa18_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_143_m wimi R_BETAOXMITO0003 (S)-3-hydroxyacyl-CoA-dehydrogenase (C18, mitochondrial) M_nad_m + M_coa18_0_3oh__S_m <=> M_h_m + M_nadh_m + M_coa18_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_144_m wimi R_BETAOXMITO0004 3-ketothiolase (C18, mitochondrial) M_coa18_0_3o_m + M_coa_m <=> M_accoa_m + M_coa16_0_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_146_m wimi R_BETAOXMITO0005 Acyl-CoA-dehydrogenase (C16, mitochondrial) M_h_m + M_fad_m + M_coa16_0_m <=> M_fadh2_m + M_coa16_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_62_m wimi -R_BETAOXMITO0006 Enoyl-CoA-hydratase (C16, mitochondrial) M_coa16_1_2e_m + M_h2o_m <=> M_coa16_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_64_m wimi +R_BETAOXMITO0006 Enoyl-CoA-hydratase (C16, mitochondrial) M_coa16_1_2e_m + M_h2o_m <=> M_coa16_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_64_m wimi R_BETAOXMITO0007 (S)-3-hydroxyacyl-CoA-dehydrogenase (C16, mitochondrial) M_nad_m + M_coa16_0_3oh__S_m <=> M_h_m + M_nadh_m + M_coa16_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_65_m wimi R_BETAOXMITO0008 3-ketothiolase (C16, mitochondrial) M_coa16_0_3o_m + M_coa_m <=> M_accoa_m + M_coa14_0_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_68_m wimi R_BETAOXMITO0009 Acyl-CoA-dehydrogenase (C14, mitochondrial) M_h_m + M_fad_m + M_coa14_0_m <=> M_fadh2_m + M_coa14_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_69_m wimi -R_BETAOXMITO0010 Enoyl-CoA-hydratase (C14, mitochondrial) M_coa14_1_2e_m + M_h2o_m <=> M_coa14_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_71_m wimi +R_BETAOXMITO0010 Enoyl-CoA-hydratase (C14, mitochondrial) M_coa14_1_2e_m + M_h2o_m <=> M_coa14_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_71_m wimi R_BETAOXMITO0011 (S)-3-hydroxyacyl-CoA-dehydrogenase (C14, mitochondrial) M_nad_m + M_coa14_0_3oh__S_m <=> M_h_m + M_nadh_m + M_coa14_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_74_m wimi R_BETAOXMITO0012 3-ketothiolase (C14, mitochondrial) M_coa14_0_3o_m + M_coa_m <=> M_accoa_m + M_coa12_0_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_76_m wimi R_BETAOXMITO0013 Acyl-CoA-dehydrogenase (C12, mitochondrial) M_h_m + M_fad_m + M_coa12_0_m <=> M_fadh2_m + M_coa12_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_81_m wimi -R_BETAOXMITO0014 Enoyl-CoA-hydratase (C12, mitochondrial) M_h2o_m + M_coa12_1_2e_m <=> M_coa12_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_83_m wimi +R_BETAOXMITO0014 Enoyl-CoA-hydratase (C12, mitochondrial) M_h2o_m + M_coa12_1_2e_m <=> M_coa12_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_83_m wimi R_BETAOXMITO0015 (S)-3-hydroxyacyl-CoA-dehydrogenase (C12, mitochondrial) M_nad_m + M_coa12_0_3oh__S_m <=> M_h_m + M_nadh_m + M_coa12_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_72_m wimi R_BETAOXMITO0016 3-ketothiolase (C12, mitochondrial) M_coa_m + M_coa12_0_3o_m <=> M_accoa_m + M_coa10_0_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_84_m wimi R_BETAOXMITO0017 Acyl-CoA-dehydrogenase (C10, mitochondrial) M_h_m + M_fad_m + M_coa10_0_m <=> M_fadh2_m + M_coa10_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_85_m wimi -R_BETAOXMITO0018 Enoyl-CoA-hydratase (C10, mitochondrial) M_h2o_m + M_coa10_1_2e_m <=> M_coa10_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_87_m wimi +R_BETAOXMITO0018 Enoyl-CoA-hydratase (C10, mitochondrial) M_h2o_m + M_coa10_1_2e_m <=> M_coa10_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_87_m wimi R_BETAOXMITO0019 (S)-3-hydroxyacyl-CoA-dehydrogenase (C10, mitochondrial) M_nad_m + M_coa10_0_3oh__S_m <=> M_h_m + M_nadh_m + M_coa10_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_88_m wimi R_BETAOXMITO0020 3-ketothiolase (C10, mitochondrial) M_coa_m + M_coa10_0_3o_m <=> M_accoa_m + M_coa8_0_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_90_m wimi R_BETAOXMITO0021 Acyl-CoA-dehydrogenase (C8, mitochondrial) M_h_m + M_fad_m + M_coa8_0_m <=> M_fadh2_m + M_coa8_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_91_m wimi -R_BETAOXMITO0022 Enoyl-CoA-hydratase (C8, mitochondrial) M_h2o_m + M_coa8_1_2e_m <=> M_coa8_0_3oh__S_c m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_93_m wimi +R_BETAOXMITO0022 Enoyl-CoA-hydratase (C8, mitochondrial) M_h2o_m + M_coa8_1_2e_m <=> M_coa8_0_3oh__S_c m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_93_m wimi R_BETAOXMITO0023 (S)-3-hydroxyacyl-CoA-dehydrogenase (C8, mitochondrial) M_nad_m + M_coa8_0_3oh__S_c <=> M_h_m + M_nadh_m + M_coa8_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_94_m wimi R_BETAOXMITO0024 3-ketothiolase (C8, mitochondrial) M_coa_m + M_coa8_0_3o_m <=> M_accoa_m + M_coa6_0_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_96_m wimi R_BETAOXMITO0025 Acyl-CoA-dehydrogenase (C6, mitochondrial) M_h_m + M_fad_m + M_coa6_0_m <=> M_fadh2_m + M_coa6_1_2e_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_97_m wimi -R_BETAOXMITO0026 Enoyl-CoA-hydratase (C6, mitochondrial) M_h2o_m + M_coa6_1_2e_m <=> M_coa6_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Replacement for reaction R_RXN909_99_m wimi +R_BETAOXMITO0026 Enoyl-CoA-hydratase (C6, mitochondrial) M_h2o_m + M_coa6_1_2e_m <=> M_coa6_0_3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Replacement for reaction R_RXN909_99_m wimi R_BETAOXMITO0027 (S)-3-hydroxyacyl-CoA-dehydrogenase (C6, mitochondrial) M_nad_m + M_coa6_0_3oh__S_m <=> M_h_m + M_nadh_m + M_coa6_0_3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_100_m wimi R_BETAOXMITO0028 3-ketothiolase (C6, mitochondrial) M_coa_m + M_coa6_0_3o_m <=> M_accoa_m + M_btcoa_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] Replacement for reaction R_RXN909_103_m wimi R_BETAOXMITO0029 Acyl-CoA-dehydrogenase (C4, mitochondrial) M_h_m + M_fad_m + M_btcoa_m <=> M_fadh2_m + M_b2coa_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW134 SPW001 RHEA:14477 [CHECKME] Replacement for reaction R_RXN909_105_m wimi -R_BETAOXMITO0030 Enoyl-CoA-hydratase (C4, mitochondrial) M_h2o_m + M_b2coa_m <=> M_3hbcoa_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 RHEA:16105;RHEA:20724 [CHECKME] New detailed reactions for mitochondrial beta-oxidation wimi +R_BETAOXMITO0030 Enoyl-CoA-hydratase (C4, mitochondrial) M_h2o_m + M_b2coa_m <=> M_3hbcoa_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW134 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] New detailed reactions for mitochondrial beta-oxidation wimi R_BETAOXMITO0031 (S)-3-hydroxyacyl-CoA-dehydrogenase (C4, mitochondrial) M_nad_m + M_3hbcoa_m <=> M_h_m + M_nadh_m + M_aacoa_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW134 SPW001 [CHECKME] New detailed reactions for mitochondrial beta-oxidation wimi R_BETAOXMITO0032 3-ketothiolase (C4, mitochondrial) M_coa_m + M_aacoa_m <=> 2.0 M_accoa_m m FALSE WBGene00009952 or WBGene00015125 PW134 SPW001 [CHECKME] New detailed reactions for mitochondrial beta-oxidation wimi R_BETAOXPEROX0001 Acyl-CoA oxidase (C30, peroxisomal) M_o2_c + M_coa30_0_c <=> M_h2o2_c + M_coa30_1_2e_c c FALSE WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00008167 or WBGene00010336 or WBGene00019060 PW121 SPW001 RHEA:38959 [CHECKME] Detailed reactions for peroxisomal beta-oxidation wimi @@ -636,21 +636,21 @@ R_BIO0013 Fatty acid composition (TAG) M_Rtotal3coa_c <=> M_Rtotal5coa_c c TRUE R_BIO0014 Fatty acid composition (Ether-lipid acyl) M_fataccoa_c <=> M_Rtotal6coa_c c TRUE PW109 R_BIO0015 Assembly of minor components of biomass M_ISclustprot_m + M_focytC_m + M_hemeprotein_c + 4.0 M_peptide_c + M_protSfarC_c + M_protSfarCmet_c + M_protSfar_c + M_protSgerC_c + M_protSgerCmet_c + M_protSger_c <=> M_apoISclustprot_m + M_apocytc_m + M_apohemeprotein_c + M_biomass_minor_c + 6.0 M_protCys_c c FALSE PW109 R_BIO0099 Assembly of biomass from RNA and DNA 0.017 M_DNA_n + 0.003 M_DNA_m + 0.833 M_RNA_n + 0.147 M_RNA_m <=> M_dnarnatotal_c nm FALSE PW109 added to include DNA and RNA biomass in overall biomass. NEED TO ADD STOICHIOMETRY janna -R_BIO0100 Assembly of body biomass (with storage) 0.029368 M_tre_c + 0.117468 M_1ac2ac3acglyc_c + 0.058654 M_Glycans_c + 0.130046 M_PhosphoL_c + 0.188823 M_dnarnatotal_c + 1e-05 M_biomass_minor_c + 0.207025 M_collg_c + 0.230149 M_glygn2_c + 1.152647 M_prot_mito_m + 4.028712 M_prot_other_c <=> M_Biomass_c c FALSE PW109 added back from iCEL model, was previously removed; replaced M_glycogen_c with M_glygn2_c lenov +R_BIO0100 Assembly of body biomass (with storage) 0.029368 M_tre_c + 0.117468 M_1ac2ac3acglyc_c + 0.058654 M_Glycans_c + 0.130046 M_PhosphoL_c + 0.188823 M_dnarnatotal_c + 1e-05 M_biomass_minor_c + 0.207025 M_collg_c + 0.230149 M_glygn2_c + 1.152647 M_prot_mito_m + 4.028712 M_prot_other_c <=> M_Biomass_c c FALSE PW109 "added back from iCEL model, was previously removed; replaced M_glycogen_c with M_glygn2_c" lenov R_BIO0101 Assembly of body biomass (without storage) 0.069111 M_Glycans_c + 0.15323 M_PhosphoL_c + 0.22249 M_dnarnatotal_c + 1e-05 M_biomass_minor_c + 0.24394 M_collg_c + 1.3582 M_prot_mito_m + 4.747 M_prot_other_c <=> M_Biomass_c c FALSE PW109 Should add M_DNA_m and M_RNA_m lenov -R_BIO0102 Assembly of embryonic biomass 0.029215 M_tre_c + 0.11685 M_1ac2ac3acglyc_c + 0.188823 M_dnarnatotal_c + 0.058347 M_Glycans_c + 0.12937 M_PhosphoL_c + 1e-05 M_biomass_minor_c + 0.22894 M_glygn2_c + 1.1466 M_prot_mito_m + 4.5801 M_prot_other_c <=> M_Biomass_c c FALSE PW109 Should add M_DNA_m and M_RNA_m; replaced M_glycogen_c with M_glygn2_c lenov +R_BIO0102 Assembly of embryonic biomass 0.029215 M_tre_c + 0.11685 M_1ac2ac3acglyc_c + 0.188823 M_dnarnatotal_c + 0.058347 M_Glycans_c + 0.12937 M_PhosphoL_c + 1e-05 M_biomass_minor_c + 0.22894 M_glygn2_c + 1.1466 M_prot_mito_m + 4.5801 M_prot_other_c <=> M_Biomass_c c FALSE PW109 "Should add M_DNA_m and M_RNA_m; replaced M_glycogen_c with M_glygn2_c" lenov R_BIO0103 Assembly of progeny biomass 0.069111 M_Glycans_c + 0.15323 M_PhosphoL_c + 0.22249 M_dnarnatotal_c + 1e-05 M_biomass_minor_c + 0.24394 M_collg_c + 1.3582 M_prot_mito_m + 4.747 M_prot_other_c <=> M_Biomass_c c FALSE PW109 Should add M_DNA_m and M_RNA_m lenov R_Biomass2 Biomass2 10.0 M_h2o_c + 4.0 M_h_c + 2.0 M_nadh_c + M_outerlps_BAC_c <=> 2.0 M_etha_c + 9.0 M_glc_aD_c + 2.0 M_nad_c + M_pyr_c c FALSE PW109 [DELETION] Exact duplicate of R_DGR0017 jpnh R_biotin_Exchange_reactions_e biotin transport M_btn_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_biotin_transport biotin transport M_btn_c <=> M_btn_e ce TRUE PW107 -R_BPNT_c 3′(2′),5′-bisphosphate nucleotidase M_pap_c + M_h2o_c <=> M_pi_c + M_amp_c c FALSE WBGene00044063 or WBGene00012390 PW042 -R_BPNT2_c R_BPNT2_c M_h2o_c + M_paps_c <=> M_aps_c + M_pi_c c FALSE WBGene00044063 or WBGene00012390 PW096;PW042 replaced annotation sulfate activation for sulfonation with PW096, PW042 lenov -R_BPNT2_m R_BPNT2_m M_h2o_m + M_paps_m <=> M_aps_m + M_pi_m m FALSE (WBGene00044063) or (WBGene00012390) PW096;PW042 replaced annotation sulfate activation for sulfonation with PW096, PW042 +R_BPNT_c "3′(2′),5′-bisphosphate nucleotidase" M_pap_c + M_h2o_c <=> M_pi_c + M_amp_c c FALSE WBGene00044063 or WBGene00012390 PW042 +R_BPNT2_c R_BPNT2_c M_h2o_c + M_paps_c <=> M_aps_c + M_pi_c c FALSE WBGene00044063 or WBGene00012390 "PW096;PW042" replaced annotation sulfate activation for sulfonation with PW096, PW042 lenov +R_BPNT2_m R_BPNT2_m M_h2o_m + M_paps_m <=> M_aps_m + M_pi_m m FALSE (WBGene00044063) or (WBGene00012390) "PW096;PW042" replaced annotation sulfate activation for sulfonation with PW096, PW042 R_BUP2_c R_BUP2_c M_h2o_c + M_3uib_c + M_h_c <=> M_co2_c + M_nh3_c + M_3aib__D_c c TRUE (WBGene00017440) PW043 Replaced M_3aib__D_c with M_3aib_D_c lenov -R_BUTYRATE__COA_LIGASE_RXN_c butyrate—CoA ligase M_atp_c + M_coa_c + M_fatacid_c <=> M_ppi_c + M_amp_c + M_fataccoa_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW054 [DELETION] Duplicate reaction of R_ACYLCOASYN_RXN_c and general reaction of the proper cytosolic BTCoA ligase reaction R_RXN909_123_c jpnh +R_BUTYRATE__COA_LIGASE_RXN_c "butyrate—CoA ligase" M_atp_c + M_coa_c + M_fatacid_c <=> M_ppi_c + M_amp_c + M_fataccoa_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW054 [DELETION] Duplicate reaction of R_ACYLCOASYN_RXN_c and general reaction of the proper cytosolic BTCoA ligase reaction R_RXN909_123_c jpnh R_C_AMCOXO_c 2-aminomuconate reductase M_h2o_c + M_amuco_c + M_h_c + M_nadh_c <=> M_nh3_c + M_2oxoadp_c + M_nad_c c FALSE PW072 R_Ca2_e Ca2 te <=> M_ca2_e e TRUE PW111 -R_CAATPS Ca ATPase M_h2o_c + 3.0 M_h_c + M_atp_c + M_ca2_c <=> M_pi_c + M_h_e + M_adp_c + M_ca2_e c FALSE (WBGene00003153) or (WBGene00019875) PW107 RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105 +R_CAATPS Ca ATPase M_h2o_c + 3.0 M_h_c + M_atp_c + M_ca2_c <=> M_pi_c + M_h_e + M_adp_c + M_ca2_e c FALSE (WBGene00003153) or (WBGene00019875) PW107 "RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105;RHEA:18105" R_CARBODEHYDRAT_RXN_c carbonic anhydrase M_h2co3_c <=> M_co2_c + M_h2o_c c TRUE (WBGene00000282) or (WBGene00000281) or (WBGene00077690) or (WBGene00000284) PW098 RHEA:10748 R_CARBODEHYDRAT_RXN_m carbonic anhydrase M_h2co3_m <=> M_co2_m + M_h2o_m m TRUE (WBGene00000245) PW098 RHEA:10748 R_CARBODEHYDRAT_RXN_n carbonic anhydrase M_h2co3_n <=> M_co2_n + M_h2o_n n TRUE (WBGene00000281) or (WBGene00077690) or (WBGene00000284) PW098 RHEA:10748 @@ -693,12 +693,12 @@ R_CARNSHUT0036 Acyl-CoA:L-carnitine O-acyltransferase I (C18:0, mitochondrial) M R_CARNSHUT0037 Acyl-CoA:L-carnitine O-acyltransferase I (C18:1(9Z), mitochondrial) M_carn18_1_9z__L_m + M_coa_m <=> M_coa18_1_9z_m + M_crn_m m TRUE WBGene00011122 PW067 SPW001 [CHECKME] Replacement for old PW067 reactions wimi R_CARNSHUT0038 Acyl-CoA:L-carnitine O-acyltransferase I (C18:1(11Z), mitochondrial) M_carn18_1_11z__L_m + M_coa_m <=> M_coa18_1_11z_m + M_crn_m m TRUE WBGene00011122 PW067 SPW001 [CHECKME] Replacement for old PW067 reactions wimi R_CARNSHUT0039 Acyl-CoA:L-carnitine O-acyltransferase I (C18:2(9Z,12Z), mitochondrial) M_lnlccrn_m + M_coa_m <=> M_coa18_2_9z12z_m + M_crn_m m TRUE WBGene00011122 PW067 SPW001 [CHECKME] Replacement for old PW067 reactions wimi -R_CAT_c Catalase 2.0 M_h2o2_c <=> 2.0 M_h2o_c + M_o2_c c FALSE (WBGene00013220) or (WBGene00000831) or (WBGene00000830) PW030 RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309 -R_CAT_m Catalase 2.0 M_h2o2_m <=> 2.0 M_h2o_m + M_o2_m m FALSE (WBGene00013220) or (WBGene00000831) or (WBGene00000830) PW030 RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309 +R_CAT_c Catalase 2.0 M_h2o2_c <=> 2.0 M_h2o_c + M_o2_c c FALSE (WBGene00013220) or (WBGene00000831) or (WBGene00000830) PW030 "RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309" +R_CAT_m Catalase 2.0 M_h2o2_m <=> 2.0 M_h2o_m + M_o2_m m FALSE (WBGene00013220) or (WBGene00000831) or (WBGene00000830) PW030 "RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309" R_CAt7r calcium / sodium antiporter (1:3), reversible 3.0 M_na1_e + M_ca2_c <=> M_ca2_e + 3.0 M_na1_c ec TRUE (WBGene00003567) or (WBGene00003566) PW107 -R_CBIAT_c ATP:cobinamide Cobeta-adenosyltransferase M_atp_c + M_cbi_c <=> M_pppi_c + M_h_c + M_adocbi_c c FALSE (WBGene00016144) PW005 R07268 [CHECKME] substrate and product only appear in this reaction; pathway moved from cobinamide metabolism to porphyrin and chlorophyll metabolism lenov +R_CBIAT_c ATP:cobinamide Cobeta-adenosyltransferase M_atp_c + M_cbi_c <=> M_pppi_c + M_h_c + M_adocbi_c c FALSE (WBGene00016144) PW005 R07268 "[CHECKME] substrate and product only appear in this reaction; pathway moved from cobinamide metabolism to porphyrin and chlorophyll metabolism" lenov R_CBLAT_c Cob(I)alamin adenosyltransferase M_atp_c + M_cbl1_c <=> M_pppi_c + M_h_c + M_adocbl_c c FALSE (WBGene00016144) PW006 -R_CBPS_c carbamoyl-phosphate synthetase (glutamine-hydrolysing) M_h2o_c + M_hco3_c + M_gln__L_c + 2.0 M_atp_c <=> M_cbp_c + M_pi_c + 4.0 M_h_c + M_glu__L_c + 2.0 M_adp_c c FALSE (WBGene00004259) PW043 RHEA:18633;RHEA:20013;RHEA:24296 +R_CBPS_c carbamoyl-phosphate synthetase (glutamine-hydrolysing) M_h2o_c + M_hco3_c + M_gln__L_c + 2.0 M_atp_c <=> M_cbp_c + M_pi_c + 4.0 M_h_c + M_glu__L_c + 2.0 M_adp_c c FALSE (WBGene00004259) PW043 "RHEA:18633;RHEA:20013;RHEA:24296" R_CDPDAGtm cdp-diacylglycerol transport to mitochndria M_cdpdag_c <=> M_cdpdag_m cm FALSE PW056 [DELETION] Dupe of R_TCM0195 jpnh R_CeCRNtm O-cerotoylcarnitine transport into mitochondria via diffusion M_carn26_0__L_c <=> M_carn26_0__L_m cm FALSE (WBGene00000996 ) PW106 R_CGLYt3_2_ Cys-Gly transport in via proton symport 2.0 M_h_e + M_cgly_e <=> 2.0 M_h_c + M_cgly_c ec FALSE (WBGene00003878) or (ND) PW107 @@ -711,7 +711,7 @@ R_Choline_Exchange_reactions_e Choline transport M_chol_e <=> e TRUE PW111 R_CHOLINE_OXIDASE_RXN_m Choline oxidase M_chol_m + M_o2_m <=> M_betald_m + M_h2o2_m m FALSE (WBGene00007917) PW056 R_CHOLINE_OXIDASEII_RXN_m Betaine aldehyde oxidase M_betald_m + M_h2o_m + 2.0 M_h_m + M_fad_m + M_o2_m <=> M_h2o2_m + M_fadh2_m + M_glyb_m m FALSE (WBGene00000115) PW056 RHEA:16185 R_Choline_transport Choline transport M_chol_c <=> M_chol_e ce TRUE (WBGene00000501) or (ND) PW107 -R_CHOLK_c choline kinase M_chol_c + M_atp_c <=> M_cholp_c + M_h_c + M_adp_c c FALSE (WBGene00000509 or WBGene00000510 or WBGene00000511 or WBGene00000512 or WBGene00000513) or WBGene00000514 PW056 RHEA:12837;RHEA:12837;RHEA:12837;RHEA:12837;RHEA:13069 +R_CHOLK_c choline kinase M_chol_c + M_atp_c <=> M_cholp_c + M_h_c + M_adp_c c FALSE (WBGene00000509 or WBGene00000510 or WBGene00000511 or WBGene00000512 or WBGene00000513) or WBGene00000514 PW056 "RHEA:12837;RHEA:12837;RHEA:12837;RHEA:12837;RHEA:13069" R_CHOLt4 choline, sodium cotransport M_chol_e + M_na1_e <=> M_chol_c + M_na1_c ec TRUE (WBGene00000501) PW107 R_CHOLtn Choline transport, nuclear through pores M_chol_c <=> M_chol_n cn TRUE PW108 R_CITL_c Citrate lyase M_cit_c <=> M_oaa_c + M_ac_c c TRUE (WBGene00007234) PW074 @@ -729,9 +729,9 @@ R_CLBIOSYNTH0004 Phosphatidylglycerophosphatase M_h2o_m + M_1ac2acg3pg3p_m <=> M R_CLBIOSYNTH0005 CDP-diacylglycerol:phosphatidylglycerol 3-phosphatidyltransferase (mitochondrial) M_cdpdag_m + M_1ac2acg3pg_m <=> M_h_c + M_cmp_m + M_clpn_m m FALSE WBGene00017763 PW142 SPW003 [CHECKME] replaces R_RXN_8141_m wimi R_CLBIOSYNTH0006 Phospholipase A2 (CL) M_h2o_m + M_clpn_m <=> M_h_c + M_fatacid_m + M_mlclpn_m m FALSE PW142 SPW003 [CHECKME] added for cardiolipin remodeling wimi R_CLBIOSYNTH0007 monolysocardiolipin acyltransferase M_mlclpn_m + M_fataccoa_m <=> M_coa_m + M_clpn_m m FALSE WBGene00006491 PW142 SPW003 [CHECKME] added for cardiolipin remodeling wimi -R_CMPKI_RXN_c Cytidylate kinase M_atp_c + M_cmp_c <=> M_adp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW043;PW042 set to reversible janna -R_CMPKI_RXN_m Cytidylate kinase M_atp_m + M_cmp_m <=> M_adp_m + M_cdp_m m TRUE (WBGene00007812) or (WBGene00009575) PW043;PW042 set to reversible janna -R_CMPKI_RXN_n Cytidylate kinase M_atp_n + M_cmp_n <=> M_h_n + M_adp_n + M_cdp_n n TRUE (WBGene00007812) PW043;PW042 set to reversible janna +R_CMPKI_RXN_c Cytidylate kinase M_atp_c + M_cmp_c <=> M_adp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) "PW043;PW042" set to reversible janna +R_CMPKI_RXN_m Cytidylate kinase M_atp_m + M_cmp_m <=> M_adp_m + M_cdp_m m TRUE (WBGene00007812) or (WBGene00009575) "PW043;PW042" set to reversible janna +R_CMPKI_RXN_n Cytidylate kinase M_atp_n + M_cmp_n <=> M_h_n + M_adp_n + M_cdp_n n TRUE (WBGene00007812) "PW043;PW042" set to reversible janna R_CMPtm cmp transport to mitochndria M_cmp_c <=> M_cmp_m cm TRUE ND PW106 set to reversible janna R_CO2_Exchange_reactions_e CO2 transport M_co2_e <=> e FALSE PW111 Set directionality to FALSE` jpnh R_CO2_transport CO2 transport M_co2_c <=> M_co2_e ce TRUE ND PW107 @@ -742,35 +742,35 @@ R_COAtn coenzyme A transport, nuclear M_coa_c <=> M_coa_n cn TRUE PW108 R_CRMT_n nuclear cytidine residue C5 methylation M_cytr_n + M_amet_n <=> M_m5cytr_n + M_ahcys_n n FALSE (WBGene00013151) 25635753 There is no associated demethylation. The RNA is degraded with the methylation? lenov R_CRNATBtc Sodium-Carnitine-Chloride symporter 2.0 M_na1_e + M_cl_e + M_crn_e <=> M_cl_c + M_crn_c + 2.0 M_na1_c ec FALSE WBGene00004910 PW111 Added rxn name jpnh R_CRNtim L-carnitine transport out of mitochondria via diffusion M_crn_c <=> M_crn_m cm TRUE (WBGene00000996 ) or (ND) PW106 set to reversible -R_CS_c Citrate (si)-synthase M_oaa_c + M_h2o_c + M_accoa_c <=> M_cit_c + M_h_c + M_coa_c c FALSE (WBGene00000833) PW023;PW030 RHEA:16845 -R_CS_m Citrate (si)-synthase M_oaa_m + M_h2o_m + M_accoa_m <=> M_cit_m + M_h_m + M_coa_m m FALSE (WBGene00000833) PW023;PW030 RHEA:16845 +R_CS_c Citrate (si)-synthase M_oaa_c + M_h2o_c + M_accoa_c <=> M_cit_c + M_h_c + M_coa_c c FALSE (WBGene00000833) "PW023;PW030" RHEA:16845 +R_CS_m Citrate (si)-synthase M_oaa_m + M_h2o_m + M_accoa_m <=> M_cit_m + M_h_m + M_coa_m m FALSE (WBGene00000833) "PW023;PW030" RHEA:16845 R_CSND_c Cytosine deaminase M_h2o_c + M_csn_c <=> M_nh3_c + M_ura_c c TRUE PW043 R_CTPS2_c CTP synthetase M_h2o_c + M_gln__L_c + M_atp_c + M_utp_c <=> M_pi_c + 3.0 M_h_c + M_glu__L_c + M_adp_c + M_ctp_c c FALSE (WBGene00012316) PW043 RHEA:26426 R_CTPtn CTP diffusion in nucleus M_ctp_c <=> M_ctp_n cn TRUE PW108 R_cu2_e copper exchange rxn <=> M_cu2_e e TRUE PW111 Improved rxn name jpnh -R_CYANST_c Thiosulfate sulfurtransferase M_tsul_c + M_cyan_c <=> M_so3_c + 2.0 M_h_c + M_tcynt_c c TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW096 RHEA:16881;RHEA:16881 set to reversible janna -R_CYANST_m Thiosulfate sulfurtransferase M_tsul_m + M_cyan_m <=> M_so3_m + 2.0 M_h_m + M_tcynt_m m TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW096 RHEA:16881;RHEA:16881 set to reversible janna +R_CYANST_c Thiosulfate sulfurtransferase M_tsul_c + M_cyan_c <=> M_so3_c + 2.0 M_h_c + M_tcynt_c c TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW096 "RHEA:16881;RHEA:16881" set to reversible janna +R_CYANST_m Thiosulfate sulfurtransferase M_tsul_m + M_cyan_m <=> M_so3_m + 2.0 M_h_m + M_tcynt_m m TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW096 "RHEA:16881;RHEA:16881" set to reversible janna R_CYANtm Cyanide transport via diffusion (mitochondrial) M_cyan_c <=> M_cyan_m cm TRUE ND PW106 -R_CYOOm2_m Cytochrome-c oxidase 8.0 M_h_m + M_o2_m + 4.0 M_cytc_red_m <=> 2.0 M_h2o_m + 4.0 M_h_i + 4.0 M_cytc_m m FALSE (WBGene00022170 and WBGene00012553 and WBGene00012354 and WBGene00017926 and WBGene00000371 and WBGene00009161 and WBGene00010962 and WBGene00010965 and WBGene00010964 and WBGene00006519) PW007 RHEA:11436;RHEA:11436;RHEA:11436 replaced aerobic respiration with oxidative phosphorylation lenov -R_CYSDS_c L-cysteine hydrogen-sulfide-lyase (deaminating; pyruvate-forming) M_h2o_c + M_cys__L_c <=> M_nh3_c + M_h_c + M_h2s_c + M_pyr_c c TRUE (WBGene00022856) or (WBGene00009048) or (WBGene00007533) PW082 R00782 RHEA:14005 Added rxn name jpnh +R_CYOOm2_m Cytochrome-c oxidase 8.0 M_h_m + M_o2_m + 4.0 M_cytc_red_m <=> 2.0 M_h2o_m + 4.0 M_h_i + 4.0 M_cytc_m m FALSE (WBGene00022170 and WBGene00012553 and WBGene00012354 and WBGene00017926 and WBGene00000371 and WBGene00009161 and WBGene00010962 and WBGene00010965 and WBGene00010964 and WBGene00006519) PW007 "RHEA:11436;RHEA:11436;RHEA:11436" replaced aerobic respiration with oxidative phosphorylation lenov +R_CYSDS_c "L-cysteine hydrogen-sulfide-lyase (deaminating; pyruvate-forming)" M_h2o_c + M_cys__L_c <=> M_nh3_c + M_h_c + M_h2s_c + M_pyr_c c TRUE (WBGene00022856) or (WBGene00009048) or (WBGene00007533) PW082 R00782 RHEA:14005 Added rxn name jpnh R_CYSO_c Cysteine dioxygenase M_cys__L_c + M_o2_c <=> M_h_c + M_3sala_c c FALSE (WBGene00018986) PW082 RHEA:20441 -R_CYSS_c Cysteine synthase M_acser_c + M_h2s_c <=> M_h_c + M_cys__L_c + M_ac_c c TRUE (WBGene00007653) or (WBGene00019096) or (WBGene00010759) or (WBGene00019962) PW082 RHEA:14829;RHEA:14829;RHEA:17821;RHEA:14829;RHEA:14829 +R_CYSS_c Cysteine synthase M_acser_c + M_h2s_c <=> M_h_c + M_cys__L_c + M_ac_c c TRUE (WBGene00007653) or (WBGene00019096) or (WBGene00010759) or (WBGene00019962) PW082 "RHEA:14829;RHEA:14829;RHEA:17821;RHEA:14829;RHEA:14829" R_CYSSNAT4te Cysteine-Sodium transport M_cys__L_e + M_na1_e <=> M_cys__L_c + M_na1_c ec TRUE WBGene00004905 PW111 Added rxn name jpnh R_Cysteine_transport Cysteine transport M_cys__L_c <=> M_cys__L_e ce TRUE ND PW107 -R_CYSTGL_c Cystathionine γ-lyase M_cyst__L_c + M_h2o_c <=> M_nh3_c + M_h_c + M_cys__L_c + M_2obut_c c FALSE (WBGene00022856) or (WBGene00009048) or (WBGene00007533) PW082 RHEA:14005 +R_CYSTGL_c "Cystathionine γ-lyase" M_cyst__L_c + M_h2o_c <=> M_nh3_c + M_h_c + M_cys__L_c + M_2obut_c c FALSE (WBGene00022856) or (WBGene00009048) or (WBGene00007533) PW082 RHEA:14005 R_Cystm Cystein reversible mitochondrial transport M_cys__L_c <=> M_cys__L_m cm TRUE ND PW106 -R_CYSTS_c Cystathionine β-synthase M_hcys__L_c + M_ser__L_c <=> M_cyst__L_c + M_h2o_c c TRUE (WBGene00013866) or (WBGene00018783) PW082 -R_CYTD_c Cytidine deaminase M_h2o_c + M_cytd_c <=> M_nh3_c + M_uri_c c TRUE (WBGene00000391) or (WBGene00000392) PW043 RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069 -R_CYTD_n Cytidine deaminase M_h2o_n + M_cytd_n <=> M_nh3_n + M_uri_n n TRUE (WBGene00000391) or (WBGene00000392) PW043 RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069 -R_CYTDK1_c R_CYTDK1_c M_atp_c + M_cytd_c <=> 2.0 M_h_c + M_adp_c + M_cmp_c c FALSE WBGene00007089 or WBGene00008948 PW042;PW043 +R_CYSTS_c "Cystathionine β-synthase" M_hcys__L_c + M_ser__L_c <=> M_cyst__L_c + M_h2o_c c TRUE (WBGene00013866) or (WBGene00018783) PW082 +R_CYTD_c Cytidine deaminase M_h2o_c + M_cytd_c <=> M_nh3_c + M_uri_c c TRUE (WBGene00000391) or (WBGene00000392) PW043 "RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069" +R_CYTD_n Cytidine deaminase M_h2o_n + M_cytd_n <=> M_nh3_n + M_uri_n n TRUE (WBGene00000391) or (WBGene00000392) PW043 "RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069" +R_CYTDK1_c R_CYTDK1_c M_atp_c + M_cytd_c <=> 2.0 M_h_c + M_adp_c + M_cmp_c c FALSE WBGene00007089 or WBGene00008948 "PW042;PW043" R_CYTDK2_c cytidine kinase M_gtp_c + M_cytd_c <=> M_h_c + M_gdp_c + M_cmp_c c TRUE PW043 Added reaction name jpnh R_CYTDt2r Cytidine transport M_h_e + M_cytd_e <=> M_h_c + M_cytd_c ec TRUE (WBGene00018716 or WBGene00014092) or (ND) PW111 Added rxn name jpnh R_CYTDtm cytidine facilated transport in mitochondria M_cytd_c <=> M_cytd_m cm TRUE (WBGene00001320) or (WBGene00010701) or (ND) PW106 R_CYTDtn cytidine transport in nucleus M_cytd_c <=> M_cytd_n cn TRUE PW108 -R_cytidine_Exchange_reactions_e cytidine transport M_cytd_e <=> e TRUE PW111 [CHECK ME] compare to above reaction; Removed space from reaction ID jpnh +R_cytidine_Exchange_reactions_e cytidine transport M_cytd_e <=> e TRUE PW111 "[CHECK ME] compare to above reaction; Removed space from reaction ID" jpnh R_cytidine_transport cytidine transport M_cytd_c <=> M_cytd_e ce TRUE ND PW107 R_CYTOCHROME_B5_REDUCTASE_RXN_c Cytochrome-b5 reductase M_nadh_c + 2.0 M_ficytb5_c <=> M_nad_c + 2.0 M_focytb5_c c FALSE PW031 [DELETION] Merged into RC00100 jpnh -R_D_PPENTOMUT_RXN_c D-deoxyribose 1,5-phosphomutase M_2dr1p_c <=> M_2dr5p_c c TRUE (WBGene00012803) PW043;PW042 +R_D_PPENTOMUT_RXN_c D-deoxyribose 1,5-phosphomutase M_2dr1p_c <=> M_2dr5p_c c TRUE (WBGene00012803) "PW043;PW042" R_DABIOSYNTH0001 DAF-36 rieske monooxygenase M_chsterol_c + M_h_c + M_nadph_c + M_o2_c <=> M_7dhchsterol_c + 2 M_h2o_c + M_nadp_c c FALSE WBGene00007536 PW144 SPW003 R_DABIOSYNTH0002 7-dehydrocholesterol lathosterole conversion M_7dhchsterol_c + M_h_c + M_nadph_c + M_o2_c <=> M_lthstrl_c + 2 M_h2o_c + M_nadp_c c FALSE PW144 SPW003 R_DABIOSYNTH0003 lathosterole reduction M_lthstrl_c + M_nad_c <=> M_lthstrone_c + M_h_c + M_nadh_c c FALSE WBGene00000979 PW144 SPW003 [CHECKME] replaces R_dafaRXN01 wimi @@ -781,7 +781,7 @@ R_DADA_c R_DADA_c M_h2o_c + M_dad_2_c <=> M_nh3_c + M_din_c c TRUE (WBGene00015 R_DADA_n R_DADA_n M_h2o_n + M_dad_2_n <=> M_nh3_n + M_din_n n TRUE (WBGene00015551) or (WBGene00000080) or (WBGene00000079) PW042 RHEA:10120 R_DARDMT_n nuclear desoxyadenosine residue N6 demethylation M_mdadnr_n + M_akg_n + M_o2_n <=> M_dadnr_n + M_co2_n + M_succ_n n FALSE (WBGene00017304) RHEA:49524 25936839 The field is very skeptical lenov R_DARMT_n nuclear desoxyadenosine residue N6 methylation M_dadnr_n + M_amet_n <=> M_mdadnr_n + M_ahcys_n n FALSE (WBGene00015939) RHEA:15197 25936839 The field is very skeptical lenov -R_DASPO1p_c D-aspartate oxidase M_h2o_c + M_asp__D_c + M_o2_c <=> M_oaa_c + M_h2o2_c + M_nh3_c + M_h_c c FALSE (WBGene00008127) or (WBGene00017565) PW073 RHEA:12512;RHEA:12512 changed M_asp__D_c into M_asp_D_c lenov +R_DASPO1p_c D-aspartate oxidase M_h2o_c + M_asp__D_c + M_o2_c <=> M_oaa_c + M_h2o2_c + M_nh3_c + M_h_c c FALSE (WBGene00008127) or (WBGene00017565) PW073 "RHEA:12512;RHEA:12512" changed M_asp__D_c into M_asp_D_c lenov R_DATPtn dATP diffusion in nucleus M_datp_c <=> M_datp_n cn TRUE PW108 R_DCRNtm O-decanoylcarnitine transport into mitochondria via diffusion M_carn10_0__L_c <=> M_carn10_0__L_m cm FALSE (WBGene00000996 ) PW106 R_DCTPD_c dCTP deaminase M_h2o_c + M_dctp_c <=> M_nh3_c + M_dutp_c c TRUE (WBGene00010609) PW043 @@ -797,7 +797,7 @@ R_DEOXYINOPHOSPHOR_RXN_c R_DEOXYINOPHOSPHOR_RXN_c M_pi_c + M_din_c <=> M_hxan_c R_DEOXYINOPHOSPHOR_RXN_n R_DEOXYINOPHOSPHOR_RXN_n M_pi_n + M_din_n <=> M_hxan_n + M_2dr1p_n n TRUE (WBGene00019298) PW042 R_deoxynucbiomass_m biomass production from mitochondrial DNA 0.381 M_dadnr_m + 0.119 M_dguar_m + 0.381 M_dthyr_m + 0.119 M_dcytr_m <=> M_DNA_m m FALSE PW109 replace production of biomass from deoxynucleotides by deoxynucleotide residues lenov R_deoxynucbiomass_n biomass production from nuclear DNA 0.325 M_dadnr_n + 0.175 M_dguar_n + 0.325 M_dthyr_n + 0.175 M_dcytr_n <=> M_DNA_n n FALSE PW109 replace production of biomass from deoxynucleotides by deoxynucleotide residues lenov -R_DEOXYRIBOSE_P_ALD_RXN_c Deoxyribose-phosphate aldolase M_2dr5p_c <=> M_g3p_c + M_acald_c c TRUE (WBGene00017283) PW043;PW042 +R_DEOXYRIBOSE_P_ALD_RXN_c Deoxyribose-phosphate aldolase M_2dr5p_c <=> M_g3p_c + M_acald_c c TRUE (WBGene00017283) "PW043;PW042" R_DGR0001 Bacterial peptide degradation M_protein_BAC_c <=> 0.064161 M_lys__L_c + 0.079118 M_val__L_c + 0.05432 M_ile__L_c + 0.084235 M_leu__L_c + 0.034639 M_phe__L_c + 0.11454 M_gly_c + 0.047432 M_thr__L_c + 0.017123 M_cys__L_c + 0.049203 M_gln__L_c + 0.049203 M_glu__L_c + 0.040346 M_ser__L_c + 0.028735 M_met__L_c + 0.017713 M_his__L_c + 0.010628 M_trp__L_c + 0.04133 M_pro__L_c + 0.025782 M_tyr__L_c + 0.096044 M_ala__L_c + 0.055304 M_arg__L_c + 0.04507 M_asn__L_c + 0.04507 M_asp__L_c c FALSE ND PW110 R_DGR0002 Bacterial RNA degradation M_rna_BAC_c <=> 0.31768 M_gmp_c + 0.26761 M_amp_c + 0.21753 M_ump_c + 0.19718 M_cmp_c c FALSE ND PW110 R_DGR0003 Bacterial DNA degradation M_dna_BAC_c <=> 0.24651 M_damp_c + 0.25349 M_dgmp_c + 0.25349 M_dcmp_c + 0.24651 M_dtmp_c c FALSE ND PW110 @@ -825,23 +825,23 @@ R_DGR0024 Bacterial phosphatidate degradation 3.0 M_h2o_c + M_1ac2acglyc3p_BAC_ R_DGR0025 Bacterial phosphatidylserine uptake M_1ac2acg3ps_BAC_e <=> M_1ac2acg3ps_BAC_c ec FALSE PW110 R_DGR0026 Bacterial phosphatidylserine degradation 3.0 M_h2o_c + M_1ac2acg3ps_BAC_c <=> M_glyc_c + 3.0 M_h_c + 2.0 M_Rtotal_BAC_c + M_pser_L_c c FALSE WBGene00007419 or WBGene00044468 PW110 R_DGR0027 glycogen assimilation M_glycogen_BAC_e <=> M_glycogen_BAC_c ec FALSE PW110 -R_DGR0028 bacterial glycogen degradation 100 M_pi_c + M_glycogen_BAC_c <=> 100 M_g1p_c + 100 M_ldex_c c FALSE WBGene00020696 PW110;PW053 Replaced M_dxtrn1_c by M_ldex_c on the right. Should we keep this reaction though? Janna adds: This reaction is providing all the glucose and dextrin to the model. Have updated the stoichiometry as 0.5 units of glucose per unit of glycogen is ridiculous. Plus ldex was limiting for our worm biomass construction. lenov; janna +R_DGR0028 bacterial glycogen degradation 100 M_pi_c + M_glycogen_BAC_c <=> 100 M_g1p_c + 100 M_ldex_c c FALSE WBGene00020696 "PW110;PW053" Replaced M_dxtrn1_c by M_ldex_c on the right. Should we keep this reaction though? Janna adds: This reaction is providing all the glucose and dextrin to the model. Have updated the stoichiometry as 0.5 units of glucose per unit of glycogen is ridiculous. Plus ldex was limiting for our worm biomass construction. "lenov; janna" R_DGR0029 dephosphorylation of thiamine pyrophosphate 2.0 M_h2o_e + M_thmpp_e <=> 2.0 M_pi_e + M_h_e + M_thm_e e FALSE PW110 R_DGTPtn dGTP diffusion in nucleus M_dgtp_c <=> M_dgtp_n cn TRUE PW108 R_DGULND_c dehydro-L-gulonate decarboxylase M_3dhguln_c + M_h_c <=> M_co2_c + M_xylu_L_c c FALSE Unknown PW033 R_DHAK_c Glycerone kinase M_dha_c + M_atp_c <=> M_dhap_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00020962) PW052 R_DHAK_n Glycerone kinase M_dha_n + M_atp_n <=> M_dhap_n + 2.0 M_h_n + M_adp_n n FALSE (WBGene00020962) PW052 R_DHCR71_c R_DHCR71_c M_nadp_c + M_dsmsterol_c <=> M_h_c + M_nadph_c + M_ddsmsterol_c c FALSE PW047 -R_DHCR72_c 7-dehydrocholesterol reductase M_nadp_c + M_chsterol_c <=> M_h_c + M_7dhchsterol_c + M_nadph_c c FALSE (WBGene00007536) PW047 RHEA:45024;RHEA:51644 abraham +R_DHCR72_c 7-dehydrocholesterol reductase M_nadp_c + M_chsterol_c <=> M_h_c + M_7dhchsterol_c + M_nadph_c c FALSE (WBGene00007536) PW047 "RHEA:45024;RHEA:51644" abraham R_DHFR_c Dihydrofolate reductase M_thf_c + M_nadp_c <=> M_h_c + M_dhf_c + M_nadph_c c TRUE (WBGene00007974) PW091 RHEA:15009 -R_DHORTS_c Dihydroorotase M_dhor_S_c + M_h2o_c <=> M_h_c + M_cbasp_c c TRUE (WBGene00004259) PW043 RHEA:18633;RHEA:20013;RHEA:24296 -R_DHPM1_c Dihydropyrimidinase M_h2o_c + M_56dura_c <=> M_cala_c + M_h_c c TRUE (WBGene00000964) or (WBGene00000964) or (WBGene00000963) or (WBGene00000963) PW043 RHEA:16121;RHEA:16121 -R_DHPM2_c R_DHPM2_c M_h2o_c + M_56dthm_c <=> M_3uib_c + M_h_c c TRUE WBGene00000963 or WBGene00000964 PW043 RHEA:16121;RHEA:16121 -R_DIACYLGLYKIN_RXN_c Diacylglycerol kinase M_atp_c + M_1ac2acglyc_c <=> M_adp_c + M_1ac2acglyc3p_c c TRUE (WBGene00000959) or (WBGene00000958) or (WBGene00000960) or (WBGene00019428) PW056 RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272 -R_DIACYLGLYKIN_RXN_n Diacylglycerol kinase M_atp_n + M_1ac2acglyc_n <=> M_adp_n + M_1ac2acglyc3p_n n TRUE (WBGene00000958) or (WBGene00000960) or (WBGene00019428) PW056 RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272 +R_DHORTS_c Dihydroorotase M_dhor_S_c + M_h2o_c <=> M_h_c + M_cbasp_c c TRUE (WBGene00004259) PW043 "RHEA:18633;RHEA:20013;RHEA:24296" +R_DHPM1_c Dihydropyrimidinase M_h2o_c + M_56dura_c <=> M_cala_c + M_h_c c TRUE (WBGene00000964) or (WBGene00000964) or (WBGene00000963) or (WBGene00000963) PW043 "RHEA:16121;RHEA:16121" +R_DHPM2_c R_DHPM2_c M_h2o_c + M_56dthm_c <=> M_3uib_c + M_h_c c TRUE WBGene00000963 or WBGene00000964 PW043 "RHEA:16121;RHEA:16121" +R_DIACYLGLYKIN_RXN_c Diacylglycerol kinase M_atp_c + M_1ac2acglyc_c <=> M_adp_c + M_1ac2acglyc3p_c c TRUE (WBGene00000959) or (WBGene00000958) or (WBGene00000960) or (WBGene00019428) PW056 "RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272" +R_DIACYLGLYKIN_RXN_n Diacylglycerol kinase M_atp_n + M_1ac2acglyc_n <=> M_adp_n + M_1ac2acglyc3p_n n TRUE (WBGene00000958) or (WBGene00000960) or (WBGene00019428) PW056 "RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272" R_DIDPtn dIDP nuclear transport M_didp_c <=> M_didp_n cn TRUE PW108 R_DITPtn dITP nuclear transport M_ditp_c <=> M_ditp_n cn TRUE PW108 -R_DMATT_c Dimethylallyltransferase M_ipdp_c + M_dmpp_c <=> M_grdp_c + M_ppi_c c TRUE (WBGene00011058) PW001;PW003 +R_DMATT_c Dimethylallyltransferase M_ipdp_c + M_dmpp_c <=> M_grdp_c + M_ppi_c c TRUE (WBGene00011058) "PW001;PW003" R_DMHISTDMT protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase M_akg_n + M_Ndmelys_n + M_o2_n <=> M_co2_n + M_Nmelys_n + M_fald_n + M_succ_n n FALSE WBGene00020821 PW101 RHEA:42032 Histone demethylation takes place in the nucleus lenov R_DMN0001 pyridoxal phosphate demand M_pydx5p_c <=> c FALSE PW039 R_DMN0002 vitamin B12 demand (adocbl form) M_adocbl_m <=> m FALSE PW006 @@ -916,8 +916,8 @@ R_DMN1005 Forssman hapten demand M_forssman_c <=> c FALSE PW098 R_DMN1006 D-Glucosaminylphosphatidylinositol demand M_gpail_c <=> c FALSE PW052 replaced pathway Glycosylphosphatidylinositol(GPI)-anchor biosynthesis by glycerolipid metabolism lenov R_DMN1007 Inositol 1,3,4-trisphosphate demand M_mi134p_c <=> c FALSE PW029 R_DNADtn dNAD transport, nuclear trhough pore M_dnad_c <=> M_dnad_n cn TRUE PW108 -R_dnasynth_m DNA polymerisation in mitochondria 0.368 M_h2o_m + 0.368 M_atp_m + 0.381 M_datp_m + 0.119 M_dgtp_m + 0.381 M_dttp_m + 0.119 M_dctp_m <=> 0.368 M_pi_m + M_ppi_m + 0.368 M_h_m + 0.368 M_adp_m + 0.381 M_dadnr_m + 0.119 M_dguar_m + 0.381 M_dthyr_m + 0.119 M_dcytr_m m FALSE WBGene00012936 and WBGene00009368 and WBGene00017237 and WBGene00008645 and WBGene00019380 and WBGene00013258 and (WBGene00020964 or WBGene00021905) and WBGene00021344 and WBGene00013150 and WBGene00018721 and WBGene00017696 and WBGene00020823 and WBGene00001002 and WBGene00008722 and (WBGene00004180 or WBGene00020761) and WBGene00004181 and WBGene00011016 PW044 RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508 replace the generic production of DNA to represent each deoxynucleotide residue. base composition from http://www.mitoage.info/view/17513/species/ For the gene association, I assumed the same as for the nuclear genome lenov -R_dnasynth_n DNA polymerisation in nucleus 0.368 M_h2o_n + 0.368 M_atp_n + 0.325 M_datp_n + 0.175 M_dgtp_n + 0.325 M_dttp_n + 0.175 M_dctp_n <=> 0.368 M_pi_n + M_ppi_n + 0.368 M_h_n + 0.368 M_adp_n + 0.325 M_dadnr_n + 0.175 M_dguar_n + 0.325 M_dthyr_n + 0.175 M_dcytr_n n FALSE WBGene00012936 and WBGene00009368 and WBGene00017237 and WBGene00008645 and WBGene00019380 and WBGene00013258 and (WBGene00020964 or WBGene00021905) and WBGene00021344 and WBGene00013150 and WBGene00018721 and WBGene00017696 and WBGene00020823 and WBGene00001002 and WBGene00008722 and (WBGene00004180 or WBGene00020761) and WBGene00004181 and WBGene00011016 PW044 RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508 replace the generic production of DNA to represent each deoxynucleotide residue lenov +R_dnasynth_m DNA polymerisation in mitochondria 0.368 M_h2o_m + 0.368 M_atp_m + 0.381 M_datp_m + 0.119 M_dgtp_m + 0.381 M_dttp_m + 0.119 M_dctp_m <=> 0.368 M_pi_m + M_ppi_m + 0.368 M_h_m + 0.368 M_adp_m + 0.381 M_dadnr_m + 0.119 M_dguar_m + 0.381 M_dthyr_m + 0.119 M_dcytr_m m FALSE WBGene00012936 and WBGene00009368 and WBGene00017237 and WBGene00008645 and WBGene00019380 and WBGene00013258 and (WBGene00020964 or WBGene00021905) and WBGene00021344 and WBGene00013150 and WBGene00018721 and WBGene00017696 and WBGene00020823 and WBGene00001002 and WBGene00008722 and (WBGene00004180 or WBGene00020761) and WBGene00004181 and WBGene00011016 PW044 "RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508" replace the generic production of DNA to represent each deoxynucleotide residue. base composition from http://www.mitoage.info/view/17513/species/ For the gene association, I assumed the same as for the nuclear genome lenov +R_dnasynth_n DNA polymerisation in nucleus 0.368 M_h2o_n + 0.368 M_atp_n + 0.325 M_datp_n + 0.175 M_dgtp_n + 0.325 M_dttp_n + 0.175 M_dctp_n <=> 0.368 M_pi_n + M_ppi_n + 0.368 M_h_n + 0.368 M_adp_n + 0.325 M_dadnr_n + 0.175 M_dguar_n + 0.325 M_dthyr_n + 0.175 M_dcytr_n n FALSE WBGene00012936 and WBGene00009368 and WBGene00017237 and WBGene00008645 and WBGene00019380 and WBGene00013258 and (WBGene00020964 or WBGene00021905) and WBGene00021344 and WBGene00013150 and WBGene00018721 and WBGene00017696 and WBGene00020823 and WBGene00001002 and WBGene00008722 and (WBGene00004180 or WBGene00020761) and WBGene00004181 and WBGene00011016 PW044 "RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508;RHEA:22508" replace the generic production of DNA to represent each deoxynucleotide residue lenov R_DNDPt10m dADP transport via dCDP antiport M_dadp_c + M_dcdp_m <=> M_dadp_m + M_dcdp_c cm FALSE (WBGene00016588) or (ND) PW106 R_DNDPt11m dADP transport via dGDP antiport M_dgdp_m + M_dadp_c <=> M_dgdp_c + M_dadp_m mc FALSE (WBGene00016588) or (ND) PW106 set to reversible janna R_DNDPt12m dADP transport via ADP antiport M_dadp_c + M_adp_m <=> M_dadp_m + M_adp_c cm FALSE (WBGene00016588) or (ND) PW106 @@ -971,26 +971,26 @@ R_DOPAVESSEC Dopamine secretion via secretory vesicle (ATP driven) M_h2o_c + M_ R_DPCOAK_c Dephospho-CoA kinase M_atp_c + M_dpcoa_c <=> 2.0 M_h_c + M_adp_c + M_coa_c c FALSE (WBGene00022031) or (WBGene00011500) PW037 R_DPMVD_c Diphosphomevalonate decarboxylase M_5dpmev_c + M_atp_c <=> M_ipdp_c + M_co2_c + M_pi_c + M_adp_c c TRUE (WBGene00012984) PW001 R01121 added KEGGID, ChEBI ms R_DTDPtn dTDP nuclear transport M_dtdp_c <=> M_dtdp_n cn TRUE PW108 -R_DTMPK_c Thymidylate kinase M_atp_c + M_dtmp_c <=> M_adp_c + M_dtdp_c c TRUE (WBGene00011272) PW042;PW043 RHEA:13517 set to reversible janna -R_DTMPK_n Thymidylate kinase M_atp_n + M_dtmp_n <=> M_adp_n + M_dtdp_n n TRUE (WBGene00011272) PW042;PW043 RHEA:13517 set to reversible janna +R_DTMPK_c Thymidylate kinase M_atp_c + M_dtmp_c <=> M_adp_c + M_dtdp_c c TRUE (WBGene00011272) "PW042;PW043" RHEA:13517 set to reversible janna +R_DTMPK_n Thymidylate kinase M_atp_n + M_dtmp_n <=> M_adp_n + M_dtdp_n n TRUE (WBGene00011272) "PW042;PW043" RHEA:13517 set to reversible janna R_DTTPtn dTTP diffusion in nucleus M_dttp_c <=> M_dttp_n cn TRUE PW108 R_DUDPtn dUDP nuclear transport M_dudp_c <=> M_dudp_n cn TRUE PW108 R_DUMPtn dUMP nuclear transport M_dump_c <=> M_dump_n cn TRUE PW108 R_DURAD_c Dihydropyrimidine dehydrogenase (NADP+) M_h_c + M_ura_c + M_nadph_c <=> M_56dura_c + M_nadp_c c TRUE (WBGene00016103) PW043 RHEA:18093 set to reversible janna R_DURAD2_c R_DURAD2_c M_h_c + M_thym_c + M_nadph_c <=> M_56dthm_c + M_nadp_c c TRUE (WBGene00016103) PW043 RHEA:18093 set to reversible janna -R_DURIK1_c Deoxyuridine kinase M_atp_c + M_duri_c <=> 2.0 M_h_c + M_adp_c + M_dump_c c FALSE (WBGene00006568) PW043 RHEA:19129;RHEA:19129 Added reaction name jpnh +R_DURIK1_c Deoxyuridine kinase M_atp_c + M_duri_c <=> 2.0 M_h_c + M_adp_c + M_dump_c c FALSE (WBGene00006568) PW043 "RHEA:19129;RHEA:19129" Added reaction name jpnh R_DURItn deoxyuridine transport in nucleus M_duri_c <=> M_duri_n cn TRUE PW108 -R_DUTPDP_c dUTP pyrophosphatase M_h2o_c + M_dutp_c <=> M_ppi_c + M_h_c + M_dump_c c FALSE WBGene00001823 or WBGene00010609 PW043 RHEA:23996;RHEA:44644 [DELETION] Dupe of R_RXN909_4_c jpnh +R_DUTPDP_c dUTP pyrophosphatase M_h2o_c + M_dutp_c <=> M_ppi_c + M_h_c + M_dump_c c FALSE WBGene00001823 or WBGene00010609 PW043 "RHEA:23996;RHEA:44644" [DELETION] Dupe of R_RXN909_4_c jpnh R_DUTPDP_m dUTP pyrophosphatase M_h2o_m + M_dutp_m <=> M_ppi_m + M_h_m + M_dump_m m FALSE (WBGene00010609) PW043 R_DUTPDP_n dUTP pyrophosphatase M_h2o_n + M_dutp_n <=> M_ppi_n + M_h_n + M_dump_n n FALSE (WBGene00010609) PW043 R_ECOAH8_c 3-hydroxystearoyl-dehydratase <=> M_h2o_c + M_coa18_1_2e_c c FALSE PW060 SPW001 [DELETION] Incorrect stoichiometry R_ECOAH8_new_c 3-hydroxyoctadecanoyl-dehydratase M_coa18_0_3oh__S_c <=> M_h2o_c + M_coa18_1_2e_c c FALSE PW060 SPW001 R07760 [CHECK ME] Renamed reaction to better reflect the chemical name of the enzyme. Added the reactant to the reaction. This reaction should replace R_ECOAH8_c - please remove the new from !Reaction post merge jpnh 4.2.1.134 -R_ECOAH9i_c Tiglyl-CoA hydratase M_h2o_c + M_2mb2coa_c <=> M_3hmbcoa_c c TRUE (WBGene00020347) or (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 RHEA:16105;RHEA:20724 set to reversible janna -R_ECOAH9i_m Tiglyl-CoA hydratase M_h2o_m + M_2mb2coa_m <=> M_3hmbcoa_m m TRUE (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) or (WBGene00020347) PW083 RHEA:16105;RHEA:20724 set to reversible janna +R_ECOAH9i_c Tiglyl-CoA hydratase M_h2o_c + M_2mb2coa_c <=> M_3hmbcoa_c c TRUE (WBGene00020347) or (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 "RHEA:16105;RHEA:20724" set to reversible janna +R_ECOAH9i_m Tiglyl-CoA hydratase M_h2o_m + M_2mb2coa_m <=> M_3hmbcoa_m m TRUE (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) or (WBGene00020347) PW083 "RHEA:16105;RHEA:20724" set to reversible janna R_ENO_c Phosphopyruvate hydratase M_2pg_c <=> M_h2o_c + M_pep_c c TRUE (WBGene00011884) or (WBGene00011884) PW018 SPW004 RHEA:10164 R_ENO_m Phosphopyruvate hydratase M_2pg_m <=> M_h2o_m + M_pep_m m TRUE (WBGene00011884) PW018 SPW004 RHEA:10164 R_ETFCLOS_RXN_c R_ETFCLOS_RXN_c M_nadh_c + M_etfox_c <=> M_nad_c + M_etfrd_c c FALSE (WBGene00017734 and WBGene00009187) PW098 -R_ETHAK_c ethanolamine kinase M_etha_c + M_atp_c <=> M_ethamp_c + M_h_c + M_adp_c c FALSE WBGene00000515 or (WBGene00000509 or WBGene00000510 or WBGene00000511 or WBGene00000512 or WBGene00000513) PW056 RHEA:12837;RHEA:12837;RHEA:12837;RHEA:12837;RHEA:13069 +R_ETHAK_c ethanolamine kinase M_etha_c + M_atp_c <=> M_ethamp_c + M_h_c + M_adp_c c FALSE WBGene00000515 or (WBGene00000509 or WBGene00000510 or WBGene00000511 or WBGene00000512 or WBGene00000513) PW056 "RHEA:12837;RHEA:12837;RHEA:12837;RHEA:12837;RHEA:13069" R_ETHERLIPIDBIOSYNTH0001 Fatty acyl-CoA reductase M_fataccoa_c + 2 M_nadph_c + 2 M_h_c <=> M_alkylR1oh_c + 2 M_nadp_c + M_coa_c c FALSE WBGene00022200 PW141 SPW003 [CHECKME] replaces nonsense reaction R_RC01998 wimi R_ETHERLIPIDBIOSYNTH0002 Glycerone-phosphate O-acyltransferase M_dhap_c + M_fataccoa_c <=> M_coa_c + M_1acdhap_c c FALSE WBGene00012911 PW141 SPW003 [CHECKME] replaces R_2_3_1_42_RXN_c wimi R_ETHERLIPIDBIOSYNTH0003 Alkyldihydroxyacetonephosphate synthase M_1acdhap_c + M_alkylR1oh_c <=> M_h_c + M_fatacid_c + M_1alkglycerone3p_c c FALSE WBGene00000081 PW141 SPW003 [CHECKME] replaces non-sense reaction R_RC04311 wimi @@ -1244,8 +1244,8 @@ R_FABIOSYNTHBRANCHEDMITO0016 3-hydroxylacyl-ACP dehydratase (C13iso, mitochondri R_FABIOSYNTHBRANCHEDMITO0017 Enoyl-ACP reductase (C13iso, mitochondrial) M_acp12_1_2e11me_m + M_h_m + M_nadph_m <=> M_nadp_m + M_acp12_0_11me_m m FALSE WBGene00009342 PW123 SPW001 [CHECKME] Reactions for biosynthesis of branched chain fatty acids wimi R_FABIOSYNTHBRANCHEDMITO0018 acyl-ACP-hydrolase (C13iso, mitochondrial) M_acp12_0_11me_m + M_h2o_m <=> M_fa12_0_11me_m + M_ACP_m m FALSE WBGene00009342 PW123 SPW001 [CHECKME] Reactions for biosynthesis of branched chain fatty acids wimi R_FABIOSYNTHBRANCHEDMITO0018 acyl-ACP-hydrolase (C13iso, mitochondrial) M_acp12_0_11me_m + M_h2o_m <=> M_fa12_0_11me_m + M_ACP_m + M_h_m m FALSE WBGene00009342 PW123 SPW001 [CHECKME] Reactions for biosynthesis of branched chain fatty acids wimi -R_FABIOSYNTHCYTO0001 Malonyl-CoA-ACP transacylase M_malcoa_c + M_ACP_c <=> M_malACP_c + M_coa_c c FALSE WBGene00009342 PW122;PW124 SPW001 [CHECKME] Reactions for biosynthesis of fatty acids wimi -R_FABIOSYNTHCYTO0001 Malonyl-CoA-ACP transacylase M_malcoa_c + M_ACP_c <=> M_malACP_c + M_coa_c c FALSE WBGene00009342 PW122;PW124 SPW001 [CHECKME] Reactions for biosynthesis of fatty acids wimi +R_FABIOSYNTHCYTO0001 Malonyl-CoA-ACP transacylase M_malcoa_c + M_ACP_c <=> M_malACP_c + M_coa_c c FALSE WBGene00009342 "PW122;PW124" SPW001 [CHECKME] Reactions for biosynthesis of fatty acids wimi +R_FABIOSYNTHCYTO0001 Malonyl-CoA-ACP transacylase M_malcoa_c + M_ACP_c <=> M_malACP_c + M_coa_c c FALSE WBGene00009342 "PW122;PW124" SPW001 [CHECKME] Reactions for biosynthesis of fatty acids wimi R_FABIOSYNTHMITO0001 Malonyl-CoA-ACP transacylase M_malcoa_m + M_ACP_m <=> M_malACP_m + M_coa_m m FALSE WBGene00009342 PW123 SPW001 [CHECKME] Reactions for biosynthesis of branched chain fatty acids wimi R_FABIOSYNTHSTRAIGHTCYTO0001 Acetyl-CoA-ACP transacylase M_accoa_c + M_ACP_c <=> M_acACP_c + M_coa_c c FALSE WBGene00009342 PW124 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTCYTO0002 3-ketoacyl-ACP synthase (C4, cytosolic) M_acACP_c + M_malACP_c + M_h_c <=> M_actACP_c + M_co2_c + M_ACP_c c FALSE WBGene00009342 PW124 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi @@ -1287,7 +1287,7 @@ R_FABIOSYNTHSTRAIGHTMTIO0001 Acetyl-CoA-ACP transacylase M_accoa_m + M_ACP_m <=> R_FABIOSYNTHSTRAIGHTMTIO0002 3-ketoacyl-ACP synthase (C4, mitochondrial) M_acACP_m + M_malACP_m + M_h_m <=> M_actACP_m + M_co2_m + M_ACP_m m FALSE WBGene00009345 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0003 3-ketoacyl-ACP reductase (C4, mitochondrial) M_actACP_m + M_h_m + M_nadph_m <=> M_3hbutACP_m + M_nadp_m m FALSE WBGene00009347 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0004 3-hydroxylacyl-ACP dehydratase (C4, mitochondrial) M_3hbutACP_m <=> M_but2eACP_m + M_h2o_m m FALSE WBGene00009349 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi -R_FABIOSYNTHSTRAIGHTMTIO0005 Enoyl-ACP reductase (C4, mitochondrial) M_but2eACP_m + M_h_m + M_nadph_m <=> M_nadp_m + M_butACP_m m FALSE WBGene00006693 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids; updated gene wimi; jpnh +R_FABIOSYNTHSTRAIGHTMTIO0005 Enoyl-ACP reductase (C4, mitochondrial) M_but2eACP_m + M_h_m + M_nadph_m <=> M_nadp_m + M_butACP_m m FALSE WBGene00006693 PW131 SPW001 "[CHECKME] Reactions for biosynthesis of straight fatty acids; updated gene" "wimi; jpnh" R_FABIOSYNTHSTRAIGHTMTIO0006 3-ketoacyl-ACP synthase (C6, mitochondrial) M_butACP_m + M_malACP_m + M_h_m <=> M_acp6_0_3o_m + M_co2_m + M_ACP_m m FALSE WBGene00009353 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0007 3-ketoacyl-ACP reductase (C6, mitochondrial) M_acp6_0_3o_m + M_h_m + M_nadph_m <=> M_acp6_0_3oh__R_m + M_nadp_m m FALSE WBGene00009355 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0008 3-hydroxylacyl-ACP dehydratase (C6, mitochondrial) M_acp6_0_3oh__R_m <=> M_acp6_1_2e_m + M_h2o_m m FALSE WBGene00009357 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi @@ -1318,8 +1318,8 @@ R_FABIOSYNTHSTRAIGHTMTIO0031 Acyl-ACP-hydrolase (C6, mitochondrial) M_acp6_0_m + R_FABIOSYNTHSTRAIGHTMTIO0031 Acyl-ACP-hydrolase (C6, mitochondrial) M_acp6_0_m + M_h2o_m <=> M_fa6_0_m + M_ACP_m + M_h_m m FALSE WBGene00009403 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0032 Acyl-ACP-hydrolase (C8, mitochondrial) M_acp8_0_m + M_h2o_m <=> M_fa8_0_m + M_ACP_m m FALSE WBGene00009405 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0032 Acyl-ACP-hydrolase (C8, mitochondrial) M_acp8_0_m + M_h2o_m <=> M_fa8_0_m + M_ACP_m + M_h_m m FALSE WBGene00009405 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi -R_FABIOSYNTHSTRAIGHTMTIO0033 Acyl-ACP-hydrolase (C10, mitochondrial) M_acp10_0_m + M_h2o_m <=> M_fa10_0_m + M_ACP_m m FALSE WBGene00009407 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids; CHECKME dead gene wimi; jpnh -R_FABIOSYNTHSTRAIGHTMTIO0033 Acyl-ACP-hydrolase (C10, mitochondrial) M_acp10_0_m + M_h2o_m <=> M_fa10_0_m + M_ACP_m + M_h_m m FALSE WBGene00009407 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids; CHECKME dead gene wimi; jpnh +R_FABIOSYNTHSTRAIGHTMTIO0033 Acyl-ACP-hydrolase (C10, mitochondrial) M_acp10_0_m + M_h2o_m <=> M_fa10_0_m + M_ACP_m m FALSE WBGene00009407 PW131 SPW001 "[CHECKME] Reactions for biosynthesis of straight fatty acids; CHECKME dead gene" "wimi; jpnh" +R_FABIOSYNTHSTRAIGHTMTIO0033 Acyl-ACP-hydrolase (C10, mitochondrial) M_acp10_0_m + M_h2o_m <=> M_fa10_0_m + M_ACP_m + M_h_m m FALSE WBGene00009407 PW131 SPW001 "[CHECKME] Reactions for biosynthesis of straight fatty acids; CHECKME dead gene" "wimi; jpnh" R_FABIOSYNTHSTRAIGHTMTIO0034 Acyl-ACP-hydrolase (C12, mitochondrial) M_acp12_0_m + M_h2o_m <=> M_fa12_0_m + M_ACP_m m FALSE WBGene00009409 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0034 Acyl-ACP-hydrolase (C12, mitochondrial) M_acp12_0_m + M_h2o_m <=> M_fa12_0_m + M_ACP_m + M_h_m m FALSE WBGene00009409 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi R_FABIOSYNTHSTRAIGHTMTIO0035 Acyl-ACP-hydrolase (C14, mitochondrial) M_acp14_0_m + M_h2o_m <=> M_fa14_0_m + M_ACP_m m FALSE WBGene00009411 PW131 SPW001 [CHECKME] Reactions for biosynthesis of straight fatty acids wimi @@ -1334,7 +1334,7 @@ R_FAELONGBRANCHED0001 fatty acid elongation (C13iso to C15iso, condensation) M_h R_FAELONGBRANCHED0002 fatty acid elongation (C13:0iso to C15:0iso, 1st reduction) M_coa14_0_3o13me_c + M_nadph_c + M_h_c <=> M_coa14_0_3oh13me__S_c + M_nadp_c c FALSE WBGene00002891 PW128 SPW001 RHEA:48680 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi R_FAELONGBRANCHED0003 fatty acid elongation (C13:0iso to C15:0iso, dehydration) M_coa14_0_3oh13me__S_c <=> M_coa14_1_2e13me_c + M_h2o_c c FALSE WBGene00020517 PW128 SPW001 RHEA:45812 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi R_FAELONGBRANCHED0004 fatty acid elongation (C13:0iso to C15:0iso, 2nd reduction) M_coa14_1_2e13me_c + M_nadph_c + M_h_c <=> M_coa14_0_13me_c + M_nadp_c c FALSE WBGene00000198 PW128 SPW001 RHEA:14473 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi -R_FAELONGBRANCHED0005 fatty acid elongation (C15iso to C17iso, condensation) M_h_c + M_malcoa_c + M_coa14_0_13me_c <=> M_co2_c + M_coa_c + M_coa16_0_3o15me_c c FALSE WBGene00001243 or WBGene00001244 PW128 SPW001 RHEA:32727;RHEA:32727 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi +R_FAELONGBRANCHED0005 fatty acid elongation (C15iso to C17iso, condensation) M_h_c + M_malcoa_c + M_coa14_0_13me_c <=> M_co2_c + M_coa_c + M_coa16_0_3o15me_c c FALSE WBGene00001243 or WBGene00001244 PW128 SPW001 "RHEA:32727;RHEA:32727" [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi R_FAELONGBRANCHED0006 fatty acid elongation (C15:0iso to C17:0iso, 1st reduction) M_coa16_0_3o15me_c + M_nadph_c + M_h_c <=> M_coa16_0_3oh15me__S_c + M_nadp_c c FALSE WBGene00002891 PW128 SPW001 RHEA:48680 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi R_FAELONGBRANCHED0007 fatty acid elongation (C15:0iso to C17:0iso, dehydration) M_coa16_0_3oh15me__S_c <=> M_coa16_1_2e15me_c + M_h2o_c c FALSE WBGene00020517 PW128 SPW001 RHEA:45812 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi R_FAELONGBRANCHED0008 fatty acid elongation (C15:0iso to C17:0iso, 2nd reduction) M_coa16_1_2e15me_c + M_nadph_c + M_h_c <=> M_coa16_0_15me_c + M_nadp_c c FALSE WBGene00000198 PW128 SPW001 RHEA:14473 [CHECKME] Reactions for fatty acid elongation of iso fatty acids wimi @@ -1387,7 +1387,7 @@ R_FAELONGSTRAIGHT0013 fatty acid desaturation (C18:2(9Z,12Z) to C18:3(9Z,12Z,15Z R_FAELONGSTRAIGHT0014 fatty acid desaturation (C18:2(9Z,12Z) to C18:3(6Z,9Z,12Z), delta-6 desaturase) 2 M_h_c + M_o2_c + 2.0 M_focytb5_c + M_coa18_2_9z12z_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_coa18_3_6z9z12_c c FALSE WBGene00001395 PW129 SPW001 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0015 fatty acid desaturation (C18:3(6Z,9Z,12Z) to C18:4(6Z,9Z,12Z,15Z, delta-15 desaturase) 2 M_h_c + M_o2_c + 2.0 M_focytb5_c + M_coa18_3_6z9z12_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_strdnccoa_c c FALSE WBGene00001395 PW129 SPW001 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0016 fatty acid desaturation (C18:3(9Z,12Z,15Z) to C18:4(6Z,9Z,12Z,15Z), delta-6 desaturase) 2 M_h_c + M_o2_c + 2.0 M_focytb5_c + M_coa18_3_9z12z15z_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_strdnccoa_c c FALSE WBGene00001395 PW129 SPW001 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi -R_FAELONGSTRAIGHT0017 fatty acid elongation (C18:3(6Z,9Z,12Z to C20:3(8Z,11Z,14Z), condensation) M_h_c + M_malcoa_c + M_coa18_3_6z9z12_c <=> M_co2_c + M_coa_c + M_coa20_3_8z11z14z_c c FALSE WBGene00001239 or WBGene00001240 PW129 SPW001 RHEA:32727;RHEA:32727;RHEA:32727 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi +R_FAELONGSTRAIGHT0017 fatty acid elongation (C18:3(6Z,9Z,12Z to C20:3(8Z,11Z,14Z), condensation) M_h_c + M_malcoa_c + M_coa18_3_6z9z12_c <=> M_co2_c + M_coa_c + M_coa20_3_8z11z14z_c c FALSE WBGene00001239 or WBGene00001240 PW129 SPW001 "RHEA:32727;RHEA:32727;RHEA:32727" [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0018 fatty acid elongation (C18:3(6Z,9Z,12Z to C20:3(8Z,11Z,14Z), 1st reduction) M_coa20_3_8z11z14z_c + M_nadph_c + M_h_c <=> M_coa20_3_8z11z14z3oh__R_c + M_nadp_c c FALSE WBGene00002891 PW129 SPW001 RHEA:48680 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0019 fatty acid elongation (C18:3(6Z,9Z,12Z to C20:3(8Z,11Z,14Z), dehydration) M_coa20_3_8z11z14z3oh__R_c <=> M_coa20_4_2e8z11z14z_c + M_h2o_c c TRUE WBGene00020517 PW129 SPW001 RHEA:45812 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0020 fatty acid elongation (C18:3(6Z,9Z,12Z to C20:3(8Z,11Z,14Z), 2nd reduction) M_coa20_4_2e8z11z14z_c + M_nadph_c + M_h_c <=> M_dlnlcgcoa_c + M_nadp_c c FALSE WBGene00000198 PW129 SPW001 RHEA:14473 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi @@ -1438,7 +1438,7 @@ R_FAELONGSTRAIGHT0064 Acyl-CoA-thioesterase (C24:0) M_coa24_0_c + M_h2o_c <=> M_ R_FAELONGSTRAIGHT0065 Acyl-CoA-thioesterase (C26:0) M_coa26_0_c + M_h2o_c <=> M_fa26_0_c + M_coa_c + M_h_c c FALSE PW129 SPW001 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0066 Acyl-CoA-thioesterase (C28:0) M_coa28_0_c + M_h2o_c <=> M_fa28_0_c + M_coa_c + M_h_c c FALSE PW129 SPW001 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi R_FAELONGSTRAIGHT0067 Acyl-CoA-thioesterase (C30:0) M_coa30_0_c + M_h2o_c <=> M_fa30_0_c + M_coa_c + M_h_c c FALSE PW129 SPW001 [CHECKME] Reactions for fatty acid elongation of straight fatty acids wimi -R_FBA_c Fructose-bisphosphate aldolase M_fdp_c <=> M_dhap_c + M_g3p_c c TRUE (WBGene00017166) or (WBGene00011474) PW018 SPW004 RHEA:14729;RHEA:14729;RHEA:14729 +R_FBA_c Fructose-bisphosphate aldolase M_fdp_c <=> M_dhap_c + M_g3p_c c TRUE (WBGene00017166) or (WBGene00011474) PW018 SPW004 "RHEA:14729;RHEA:14729;RHEA:14729" R_FBA_n Fructose-bisphosphate aldolase M_fdp_n <=> M_dhap_n + M_g3p_n n TRUE (WBGene00011474) PW018 SPW004 RHEA:14729 R_FBA2_c R_FBA2_c M_f1p_c <=> M_dhap_c + M_glyald_c c TRUE (WBGene00011474) PW020 RHEA:14729 R_FBA2_n R_FBA2_n M_f1p_n <=> M_dhap_n + M_glyald_n n TRUE (WBGene00011474) PW020 RHEA:14729 @@ -1446,7 +1446,7 @@ R_fe2_e fe2 te <=> M_fe2_e e TRUE PW111 R_FK_c fucokinase M_atp_c + M_fuc_L_c <=> M_fuc1p_L_c + M_h_c + M_adp_c c FALSE (WBGene00007745) PW025 Changed M_fuc1p__L_c into M_fuc1p_L_c lenov R_FKYNH_c Arylformamidase M_Lfmkynr_c + M_h2o_c <=> M_Lkynr_c + M_for_c + 3.0 M_h_c c FALSE (WBGene00017051) PW072 R_FLDR_c Flavodoxin--NADP(+) reductase M_h_c + M_nadph_c + M_etfox_c <=> M_nadp_c + M_etfrd_c c FALSE (WBGene00001485) PW040 -R_FMNAT_c FAD synthetase 2.0 M_h_c + M_atp_c + M_fmn_c <=> M_ppi_c + M_fad_c c FALSE (WBGene00011271) PW040 RHEA:17237;RHEA:17237 +R_FMNAT_c FAD synthetase 2.0 M_h_c + M_atp_c + M_fmn_c <=> M_ppi_c + M_fad_c c FALSE (WBGene00011271) PW040 "RHEA:17237;RHEA:17237" R_FOLABCCte Folate transport M_h2o_c + M_atp_c + M_fol_c <=> M_pi_c + M_h_c + M_adp_c + M_fol_e c FALSE ( WBGene00003411 or WBGene00000022 or WBGene00000020 or WBGene00000421 or WBGene00000023 or WBGene00018982 or WBGene00003407 or WBGene00003408 or WBGene00003407 or WBGene00003408 or WBGene00003996 or WBGene00003412) PW111 added rxn name jpnh R_folate_Exchange_reactions_e Folate transport M_fol_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_FOLOAT1tc Folate transport M_akg_c + M_na1_e + M_fol_e <=> M_akg_e + M_fol_c + M_na1_c ce TRUE WBGene00003411 PW111 Removed space from reaction ID jpnh @@ -1458,27 +1458,27 @@ R_FTHFL_c Formate--tetrahydrofolate ligase M_for_c + M_atp_c + M_thf_c <=> M_p R_FTHFL_m Formate--tetrahydrofolate ligase M_for_m + M_atp_m + M_thf_m <=> M_pi_m + M_adp_m + M_10fthf_m m TRUE (WBGene00019492) PW091 R_FUM_c Fumarate hydratase M_mal__L_c <=> M_h2o_c + M_fum_c c TRUE (WBGene00001503) PW023 SPW004 RHEA:12460 R_FUM_m Fumarate hydratase M_mal__L_m <=> M_h2o_m + M_fum_m m TRUE (WBGene00001503) PW023 SPW004 RHEA:12460 -R_FUMAC_c Fumarylacetoacetase M_4fumacac_c + M_h2o_c <=> M_acac_c + M_h_c + M_fum_c c TRUE (WBGene00019620) PW076;PW077 RHEA:10244 +R_FUMAC_c Fumarylacetoacetase M_4fumacac_c + M_h2o_c <=> M_acac_c + M_h_c + M_fum_c c TRUE (WBGene00019620) "PW076;PW077" RHEA:10244 R_FUMSO3tm Fumarate:sulfite antiport, mitochondrial M_so3_m + M_fum_c <=> M_so3_c + M_fum_m mc TRUE (WBGene00019656) or (ND) PW106 R_FUMSO4tm Fumarate:sulfate antiport, mitochondrial M_so4_m + M_fum_c <=> M_so4_c + M_fum_m mc TRUE (WBGene00019656) or (ND) PW106 R_FUMtm fumarate transport, mitochondrial M_pi_m + M_fum_c <=> M_pi_c + M_fum_m mc TRUE (WBGene00019656) or (ND) PW106 R_FUMTSULtm Fumarate:thiosulfate antiport, mitochondrial M_tsul_m + M_fum_c <=> M_tsul_c + M_fum_m mc TRUE (WBGene00019656) or (ND) PW106 R_G1PP_c Glucose-1-phosphatase M_h2o_c + M_g1p_c <=> M_glc_aD_c + M_pi_c c FALSE PW018 SPW004 -R_G3PD1_c Glycerol-3-phosphate dehydrogenase (NAD+) M_dhap_c + M_h_c + M_nadh_c <=> M_glyc3p_c + M_nad_c c TRUE (WBGene00010778) or (WBGene00009824) PW052;PW056 RHEA:11092;RHEA:11092;RHEA:11092;RHEA:11092;RHEA:11092 set to reversible janna -R_G5SD_c Glutamate-5-semialdehyde dehydrogenase M_pi_c + M_glu5sa_c + M_nadp_c <=> M_glu5p_c + M_h_c + M_nadph_c c TRUE (WBGene00011938) PW081 RHEA:14877;RHEA:19541 -R_G5SD_m Glutamate-5-semialdehyde dehydrogenase M_pi_m + M_glu5sa_m + M_nadp_m <=> M_glu5p_m + M_h_m + M_nadph_m m TRUE (WBGene00011938) PW081 RHEA:14877;RHEA:19541 +R_G3PD1_c Glycerol-3-phosphate dehydrogenase (NAD+) M_dhap_c + M_h_c + M_nadh_c <=> M_glyc3p_c + M_nad_c c TRUE (WBGene00010778) or (WBGene00009824) "PW052;PW056" "RHEA:11092;RHEA:11092;RHEA:11092;RHEA:11092;RHEA:11092" set to reversible janna +R_G5SD_c Glutamate-5-semialdehyde dehydrogenase M_pi_c + M_glu5sa_c + M_nadp_c <=> M_glu5p_c + M_h_c + M_nadph_c c TRUE (WBGene00011938) PW081 "RHEA:14877;RHEA:19541" +R_G5SD_m Glutamate-5-semialdehyde dehydrogenase M_pi_m + M_glu5sa_m + M_nadp_m <=> M_glu5p_m + M_h_m + M_nadph_m m TRUE (WBGene00011938) PW081 "RHEA:14877;RHEA:19541" R_G6PDA_c glucosamine-6-phosphate deaminase M_h2o_c + M_gam6p_c <=> M_nh3_c + M_f6p_c + M_h_c c FALSE (WBGene00011399) or (WBGene00011399) or (WBGene00011399) or (WBGene00011399) PW009 R00765 added KEGG ID lenov R_G6PDH2r_c Glucose-6-phosphate 1-dehydrogenase M_g6p_B_c + M_nadp_c <=> M_6pgl_c + M_h_c + M_nadph_c c TRUE (WBGene00007108) PW027 SPW004 RHEA:15841 R_G6PDH2r_n Glucose-6-phosphate 1-dehydrogenase M_g6p_B_n + M_nadp_n <=> M_6pgl_n + M_h_n + M_nadph_n n TRUE (WBGene00007108) PW027 SPW004 RHEA:15841 -R_GALE_c UDP-galactose 4-epimerase M_udpg_c <=> M_udpgal_c c TRUE (WBGene00008132) PW031;PW017 RHEA:22168;RHEA:20517 Updated RXN ID and name to be consistent with NCBI, wormbase, and BIGG. Mutants have been analyzed in C. elegans and show impact on PW017. Found in cytosol and nucleus in human https://www.proteinatlas.org/ENSG00000117308-GALE/cell also Reviewed in C. elegans in https://doi.org/10.1534/genetics.117.300106 nel -R_GALK_c Galactokinase M_adgal_c + M_atp_c <=> M_gal1p_c + M_h_c + M_adp_c c FALSE (WBGene00006461) PW031;PW017 28978773 Reviewed in C. elegans in https://doi.org/10.1534/genetics.117.300106 nel -R_GALM_c D-galactose 1-epimerase M_gal_c <=> M_adgal_c c TRUE (WBGene00015270) or (WBGene00044734) PW017 Human homolog expressed in cytosol (https://www.ncbi.nlm.nih.gov/protein/NP_620156.1). Crystal structure analyzed in C. elegans (1LUR) 10.1074/jbc.M402347200 However a BLAST of the structure sequence shows higher homology to the predicted solute carriers: WBGene00015271 or WBGene00021219 but these two don't show high homology to the human or top hits of the human -> C.eleg BLAST. I also updated the RXN ID to be consistent with BIGG;replaced pathway galactose degradation with galactose metabolism nel, lenov +R_GALE_c UDP-galactose 4-epimerase M_udpg_c <=> M_udpgal_c c TRUE (WBGene00008132) "PW031;PW017" "RHEA:22168;RHEA:20517" Updated RXN ID and name to be consistent with NCBI, wormbase, and BIGG. Mutants have been analyzed in C. elegans and show impact on PW017. Found in cytosol and nucleus in human https://www.proteinatlas.org/ENSG00000117308-GALE/cell also Reviewed in C. elegans in https://doi.org/10.1534/genetics.117.300106 nel +R_GALK_c Galactokinase M_adgal_c + M_atp_c <=> M_gal1p_c + M_h_c + M_adp_c c FALSE (WBGene00006461) "PW031;PW017" 28978773 Reviewed in C. elegans in https://doi.org/10.1534/genetics.117.300106 nel +R_GALM_c D-galactose 1-epimerase M_gal_c <=> M_adgal_c c TRUE (WBGene00015270) or (WBGene00044734) PW017 "Human homolog expressed in cytosol (https://www.ncbi.nlm.nih.gov/protein/NP_620156.1). Crystal structure analyzed in C. elegans (1LUR) 10.1074/jbc.M402347200 However a BLAST of the structure sequence shows higher homology to the predicted solute carriers: WBGene00015271 or WBGene00021219 but these two don't show high homology to the human or top hits of the human -> C.eleg BLAST. I also updated the RXN ID to be consistent with BIGG;replaced pathway galactose degradation with galactose metabolism" nel, lenov R_GALt1r galactose transport (uniport) M_gal_e <=> M_gal_c ec TRUE (WBGene00019979) or (WBGene00019207) or (ND) PW107 -R_GALU_c UTP--glucose-1-phosphate uridylyltransferase M_g1p_c + M_h_c + M_utp_c <=> M_ppi_c + M_udpg_c c TRUE WBGene00016996 or WBGene00010665 PW031;PW019;PW045;PW017 FLAGGED: Need to verify localization. Wormbase reports ER, human homolog seen in nucleus and mitochondrion (https://www.proteinatlas.org/ENSG00000169764-UGP2/cell); replaced L-ascorbate biosynthesis with PW045 nel; replaced L-ascorbate biosynthesis with PW045 -R_GAPD_c Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) M_g3p_c + M_pi_c + M_nad_c <=> M_h_c + M_nadh_c + M_13dpg_c c TRUE (WBGene00001684) or (WBGene00001684) or (WBGene00001685) or (WBGene00001685) or (WBGene00001683) or (WBGene00001683) or (WBGene00001686) or (WBGene00001686) PW018 SPW004 RHEA:10300;RHEA:10300;RHEA:10300;RHEA:10300 +R_GALU_c UTP--glucose-1-phosphate uridylyltransferase M_g1p_c + M_h_c + M_utp_c <=> M_ppi_c + M_udpg_c c TRUE WBGene00016996 or WBGene00010665 "PW031;PW019;PW045;PW017" "FLAGGED: Need to verify localization. Wormbase reports ER, human homolog seen in nucleus and mitochondrion (https://www.proteinatlas.org/ENSG00000169764-UGP2/cell); replaced L-ascorbate biosynthesis with PW045" "nel; replaced L-ascorbate biosynthesis with PW045" +R_GAPD_c Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) M_g3p_c + M_pi_c + M_nad_c <=> M_h_c + M_nadh_c + M_13dpg_c c TRUE (WBGene00001684) or (WBGene00001684) or (WBGene00001685) or (WBGene00001685) or (WBGene00001683) or (WBGene00001683) or (WBGene00001686) or (WBGene00001686) PW018 SPW004 "RHEA:10300;RHEA:10300;RHEA:10300;RHEA:10300" R_GARFT_c Phosphoribosylglycinamide formyltransferase M_gar_c + M_10fthf_c <=> M_h_c + M_fgam_c + M_thf_c c TRUE (WBGene00018174) PW042 Removed the redundant 5-aminoimidazole ribonucleotide biosynthesis pathway lenov -R_GCVP_RXN_c Glycine dehydrogenase (decarboxylating) M_gly_c + M_lip_gcvh_c <=> M_co2_c + M_amehl_c c FALSE (WBGene00020022 and WBGene00009918 and WBGene00008354) PW074 RHEA:24304;RHEA:24304 fixed gene associations. Cytosolic reaction real? hjs -R_GCVP_RXN_m Glycine dehydrogenase (decarboxylating) M_gly_m + M_lip_gcvh_m <=> M_co2_m + M_amehl_m m FALSE (WBGene00020022 and WBGene00009918 and WBGene00008354) PW074 RHEA:24304;RHEA:24304 fixed gene association hjs +R_GCVP_RXN_c Glycine dehydrogenase (decarboxylating) M_gly_c + M_lip_gcvh_c <=> M_co2_c + M_amehl_c c FALSE (WBGene00020022 and WBGene00009918 and WBGene00008354) PW074 "RHEA:24304;RHEA:24304" fixed gene associations. Cytosolic reaction real? hjs +R_GCVP_RXN_m Glycine dehydrogenase (decarboxylating) M_gly_m + M_lip_gcvh_m <=> M_co2_m + M_amehl_m m FALSE (WBGene00020022 and WBGene00009918 and WBGene00008354) PW074 "RHEA:24304;RHEA:24304" fixed gene association hjs R_GCVT_RXN_c Aminomethyltransferase M_thf_c + M_amehl_c <=> M_nh3_c + M_mlthf_c + M_dhlip_gcvh_c c FALSE (WBGene00017765 and WBGene00009918 and WBGene00008354) PW074 RHEA:16945 fixed gene associations. Cytosolic reaction real? hjs R_GCVT_RXN_m Aminomethyltransferase M_thf_m + M_amehl_m <=> M_nh3_m + M_mlthf_m + M_dhlip_gcvh_m m FALSE (WBGene00017765 and WBGene00009918 and WBGene00008354) PW074 RHEA:16945 fixed gene association hjs R_GDP_KIN_RXN_c Nucleoside-diphosphate kinase M_atp_c + M_gdp_c <=> M_h_c + M_gtp_c + M_adp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW042 RHEA:44640 set to reversible janna @@ -1487,41 +1487,41 @@ R_GDP_KIN_RXN_n Nucleoside-diphosphate kinase M_atp_n + M_gdp_n <=> M_h_n + M_g R_GDPMNH_c GDP-mannose mannosyl hydrolase M_h2o_c + M_gdpmann_c <=> M_h_c + M_gdp_c + M_man_c c TRUE PW025 R_GF6PTA_c Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) M_f6p_c + M_gln__L_c <=> M_glu__L_c + M_gam6p_c c TRUE (WBGene00008546) or (WBGene00009035) PW032 R_GF6PTA_m Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) M_f6p_m + M_gln__L_m <=> M_glu__L_m + M_gam6p_m m TRUE (WBGene00009035) PW032 -R_GFUCS_c GDP-L-fucose synthase M_gdpddman_c + M_h_c + M_nadph_c <=> M_gdpfuc_c + M_nadp_c c TRUE (WBGene00019813) PW031;PW025 RHEA:18885 16650000 genes identified and cloned in C. elegans. Human homolog localized to the cytosol and nucleus (https://www.proteinatlas.org/ENSG00000104522-TSTA3/cell) nel -R_GHMT2_c glycine hydroxymethyltransferase M_ser__L_c + M_thf_c <=> M_h2o_c + M_gly_c + M_mlthf_c c TRUE (WBGene00003214) PW074;PW091 RHEA:15481 -R_GHMT2_m glycine hydroxymethyltransferase M_ser__L_m + M_thf_m <=> M_h2o_m + M_gly_m + M_mlthf_m m TRUE (WBGene00003214) PW074;PW091 RHEA:15481 +R_GFUCS_c GDP-L-fucose synthase M_gdpddman_c + M_h_c + M_nadph_c <=> M_gdpfuc_c + M_nadp_c c TRUE (WBGene00019813) "PW031;PW025" RHEA:18885 16650000 genes identified and cloned in C. elegans. Human homolog localized to the cytosol and nucleus (https://www.proteinatlas.org/ENSG00000104522-TSTA3/cell) nel +R_GHMT2_c glycine hydroxymethyltransferase M_ser__L_c + M_thf_c <=> M_h2o_c + M_gly_c + M_mlthf_c c TRUE (WBGene00003214) "PW074;PW091" RHEA:15481 +R_GHMT2_m glycine hydroxymethyltransferase M_ser__L_m + M_thf_m <=> M_h2o_m + M_gly_m + M_mlthf_m m TRUE (WBGene00003214) "PW074;PW091" RHEA:15481 R_GHMT3_c 4-Trimethylammoniobutanal :: (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine conversion M_3htmelys_c <=> M_4tmeabut_c + M_gly_c c TRUE Unknown PW101 R_GK1_c Guanylate kinase M_atp_c + M_gmp_c <=> M_adp_c + M_gdp_c c TRUE (WBGene00020190) PW042 R_GK1_m Guanylate kinase M_atp_m + M_gmp_m <=> M_h_m + M_adp_m + M_gdp_m m TRUE (WBGene00020190) PW042 -R_GLBRAN amylo-(1,4->1,6)-transglycosylase M_glygn1_c <=> M_glygn2_c c FALSE (WBGene00011409) PW019;PW053 Changed name to more explicit synonym, added group lenov +R_GLBRAN amylo-(1,4->1,6)-transglycosylase M_glygn1_c <=> M_glygn2_c c FALSE (WBGene00011409) "PW019;PW053" Changed name to more explicit synonym, added group lenov R_GLCAASE4_c R_GLCAASE4_c M_h2o_c + M_cs_a_deg2_c <=> M_cs_a_deg3_c + M_glcur_c c FALSE (WBGene00013693) PW014 R_GLCt1r glucose transport (uniport) M_glc_bD_e <=> M_glc_bD_c ec TRUE (WBGene00019979) or (WBGene00019207) PW107 -R_GLGNS1 glycogen synthase M_ggn_c + 4.0 M_udpg_c <=> 4.0 M_h_c + 4.0 M_udp_c + M_glygn1_c c FALSE (WBGene00001793) PW019;PW053 RHEA:18549 Changed the stoichiometry of UDP-glucose from 3 to 4, update name, added group. lenov +R_GLGNS1 glycogen synthase M_ggn_c + 4.0 M_udpg_c <=> 4.0 M_h_c + 4.0 M_udp_c + M_glygn1_c c FALSE (WBGene00001793) "PW019;PW053" RHEA:18549 Changed the stoichiometry of UDP-glucose from 3 to 4, update name, added group. lenov R_GLNLASE_c R_GLNLASE_c M_gullac_c + M_h2o_c <=> M_guln_c + M_h_c c TRUE PW045 replaced L-ascorbate biosynthesis with ascorbate and aldarate metabolism -R_GLNS_c Glutamate--ammonia ligase M_nh3_c + M_glu__L_c + M_atp_c <=> M_pi_c + M_h_c + M_gln__L_c + M_adp_c c FALSE (WBGene00001604) or (WBGene00001602) or (WBGene00001606) or (WBGene00001607) or (WBGene00001603) or (WBGene00001603) or (WBGene00001603) PW073 RHEA:16169;RHEA:16169;RHEA:16169 -R_GLU5K_c Glutamate 5-kinase M_glu__L_c + M_atp_c <=> M_glu5p_c + M_adp_c c FALSE (WBGene00011938) PW081 RHEA:14877;RHEA:19541 -R_GLU5K_m Glutamate 5-kinase M_glu__L_m + M_atp_m <=> M_glu5p_m + M_adp_m m FALSE (WBGene00011938) PW081 RHEA:14877;RHEA:19541 +R_GLNS_c Glutamate--ammonia ligase M_nh3_c + M_glu__L_c + M_atp_c <=> M_pi_c + M_h_c + M_gln__L_c + M_adp_c c FALSE (WBGene00001604) or (WBGene00001602) or (WBGene00001606) or (WBGene00001607) or (WBGene00001603) or (WBGene00001603) or (WBGene00001603) PW073 "RHEA:16169;RHEA:16169;RHEA:16169" +R_GLU5K_c Glutamate 5-kinase M_glu__L_c + M_atp_c <=> M_glu5p_c + M_adp_c c FALSE (WBGene00011938) PW081 "RHEA:14877;RHEA:19541" +R_GLU5K_m Glutamate 5-kinase M_glu__L_m + M_atp_m <=> M_glu5p_m + M_adp_m m FALSE (WBGene00011938) PW081 "RHEA:14877;RHEA:19541" R_GLUCYS_c Glutamate--cysteine ligase M_cys__L_c + M_glu__L_c + M_atp_c <=> M_pi_c + 2.0 M_h_c + M_glucys_c + M_adp_c c FALSE WBGene00001527 or WBGene00017084 PW070 RHEA:13285 R_GLUD_c glutamate dehydrogenase M_h2o_c + M_glu__L_c + M_nad_c <=> M_akg_c + M_nh3_c + 2.0 M_h_c + M_nadh_c c TRUE (WBGene00014095) PW073 R00243 added KEGG ID R_GLUD_m glutamate dehydrogenase M_h2o_m + M_glu__L_m + M_nad_m <=> M_akg_m + M_nh3_m + 2.0 M_h_m + M_nadh_m m TRUE (WBGene00014095) PW073 R00243 added KEGG ID lenov R_GLUDC_m Glutamate decarboxylase M_h_m + M_glu__L_m <=> M_co2_m + M_4abut_m m TRUE (WBGene00006762) PW073 R_GLUDy_c glutamate dehydrogenase (NADP+) M_h2o_c + M_glu__L_c + M_nadp_c <=> M_akg_c + M_nh3_c + 2.0 M_h_c + M_nadph_c c TRUE (WBGene00014095) PW073 R_GLUDy_m glutamate dehydrogenase (NADP+) M_h2o_m + M_glu__L_m + M_nadp_m <=> M_akg_m + M_nh3_m + 2.0 M_h_m + M_nadph_m m TRUE (WBGene00014095) PW073 -R_GLUN_c Glutaminase M_h2o_c + M_gln__L_c <=> M_nh3_c + M_h_c + M_glu__L_c c TRUE (WBGene00007480) or (WBGene00008435) or (WBGene00009271) PW073 RHEA:15889;RHEA:15889 +R_GLUN_c Glutaminase M_h2o_c + M_gln__L_c <=> M_nh3_c + M_h_c + M_glu__L_c c TRUE (WBGene00007480) or (WBGene00008435) or (WBGene00009271) PW073 "RHEA:15889;RHEA:15889" R_GLUN_m Glutaminase M_h2o_m + M_gln__L_m <=> M_nh3_m + M_h_m + M_glu__L_m m TRUE (WBGene00008435) PW073 RHEA:15889 R_GLUPRT_c Amidophosphoribosyltransferase M_pram_c + M_ppi_c + M_glu__L_c <=> M_h2o_c + M_prpp_c + M_gln__L_c c TRUE (WBGene00011407) PW042 RHEA:14905 Removed the redundant 5-aminoimidazole ribonucleotide biosynthesis pathway lenov R_GLUS_c glutamate synthase (NADH) 2.0 M_glu__L_c + M_nad_c <=> M_akg_c + M_h_c + M_gln__L_c + M_nadh_c c TRUE (WBGene00012326) PW073 R_GLUSy_c glutamate synthase (NADPH) M_akg_c + M_h_c + M_gln__L_c + M_nadph_c <=> 2.0 M_glu__L_c + M_nadp_c c FALSE (WBGene00012326) PW073 R_GLUt2m L-glutamate reversible transport via proton symport, mitochondrial M_h_c + M_glu__L_c <=> M_h_m + M_glu__L_m cm TRUE (WBGene00018901) or (WBGene00019326) or (WBGene00008979) or (ND) PW106 R_GLUt6 Glutamate transport via Na, H symport and K antiport M_h_e + M_glu__L_e + 3.0 M_na1_e + M_k_c <=> M_h_c + M_glu__L_c + M_k_e + 3.0 M_na1_c ec FALSE (WBGene00001620) or (WBGene00001625) PW107 -R_GLUTACONYL_COA_DECARBOXYLASE_RXN_c glutaconyl-CoA decarboxylase M_h_c + M_glutaconyl_coa_c <=> M_co2_c + M_b2coa_c c FALSE PW079;PW080 +R_GLUTACONYL_COA_DECARBOXYLASE_RXN_c glutaconyl-CoA decarboxylase M_h_c + M_glutaconyl_coa_c <=> M_co2_c + M_b2coa_c c FALSE "PW079;PW080" R_Glutamate_transport Glutamate transport M_glu__L_c <=> M_glu__L_e ce TRUE ND PW107 R_Glutamine_transport Glutamine transport M_gln__L_c <=> M_gln__L_e ce TRUE ND PW107 -R_GLUTAREDOXIN_RXN_c Glutaredoxin reaction M_grxox_c + 2.0 M_E_c <=> M_grxrd_c c FALSE PW070 added rxn name; replaced M_E__c with M_E_c jpnh; lenov -R_GLUTARYL_COA_DEHYDROG_RXN_c glutaryl-CoA dehydrogenase M_h_c + M_fad_c + M_glutcoa_c <=> M_fadh2_c + M_glutaconyl_coa_c c FALSE PW079;PW080 -R_GLUTARYL_COA_DEHYDROGENASE_RXN_c glutaryl-CoA dehydrogenase 2.0 M_h_c + M_fad_c + M_glutcoa_c <=> M_co2_c + M_fadh2_c + M_b2coa_c c TRUE (WBGene00010052) PW080;PW072;PW062 -R_GLUTARYL_COA_DEHYDROGENASE_RXN_m glutaryl-CoA dehydrogenase 2.0 M_h_m + M_fad_m + M_glutcoa_m <=> M_co2_m + M_fadh2_m + M_b2coa_m m TRUE (WBGene00010052) PW080;PW072;PW062 -R_GLUTARYL_COA_DEHYDROGENASE_RXN_n glutaryl-CoA dehydrogenase 2.0 M_h_n + M_fad_n + M_glutcoa_n <=> M_co2_n + M_fadh2_n + M_b2coa_n n TRUE (WBGene00010052) PW080;PW072;PW062 +R_GLUTAREDOXIN_RXN_c Glutaredoxin reaction M_grxox_c + 2.0 M_E_c <=> M_grxrd_c c FALSE PW070 "added rxn name; replaced M_E__c with M_E_c" "jpnh; lenov" +R_GLUTARYL_COA_DEHYDROG_RXN_c glutaryl-CoA dehydrogenase M_h_c + M_fad_c + M_glutcoa_c <=> M_fadh2_c + M_glutaconyl_coa_c c FALSE "PW079;PW080" +R_GLUTARYL_COA_DEHYDROGENASE_RXN_c glutaryl-CoA dehydrogenase 2.0 M_h_c + M_fad_c + M_glutcoa_c <=> M_co2_c + M_fadh2_c + M_b2coa_c c TRUE (WBGene00010052) "PW080;PW072;PW062" +R_GLUTARYL_COA_DEHYDROGENASE_RXN_m glutaryl-CoA dehydrogenase 2.0 M_h_m + M_fad_m + M_glutcoa_m <=> M_co2_m + M_fadh2_m + M_b2coa_m m TRUE (WBGene00010052) "PW080;PW072;PW062" +R_GLUTARYL_COA_DEHYDROGENASE_RXN_n glutaryl-CoA dehydrogenase 2.0 M_h_n + M_fad_n + M_glutcoa_n <=> M_co2_n + M_fadh2_n + M_b2coa_n n TRUE (WBGene00010052) "PW080;PW072;PW062" R_GluToAscrLump lump reaction from glucose to ascarylose M_glc_aD_c <=> M_ascr_c c FALSE TBD PW050 SPW002 [CHECK ME]First instance of Ascr biosynthesis wimi R_GLUVESSEC L-glutamate secretion via secretory vesicle (ATP driven) M_h2o_c + M_glu__L_c + M_atp_c <=> M_pi_c + M_h_c + M_glu__L_e + M_adp_c c FALSE (WBGene00001135) PW107 R_GLYAT_m Glycine C-acetyltransferase M_gly_m + M_accoa_m <=> M_2aobut_m + M_h_m + M_coa_m m TRUE (WBGene00012007) PW074 @@ -1529,8 +1529,8 @@ R_GLYC3Ptm glycerol-3-phosphate shuttle M_glyc3p_c <=> M_glyc3p_m cm FALSE ND PW R_GLYCEROL_1_PHOSPHATASE_RXN_c Glycerol-1-phosphatase M_h2o_c + M_glyc3p_c <=> M_glyc_c + M_pi_c c TRUE PW052 R_Glycine_transport Glycine transport M_gly_c <=> M_gly_e ce TRUE ND PW107 R_Glycogenin_Exchange_reactions_c Glycogenin transport M_HC02136_c <=> c TRUE PW111 Replaces the demand from extracellular compartment lenov -R_GLYCOGENIN_GLUCOSYLTRANSFERASE_RXN_c glycogenin self-glycosylation M_udpg_c + M_HC02136_c <=> M_udp_c + M_glucosyl_glycogenin_c c FALSE (WBGene00006863) or (WBGene00012020) PW019;PW053 RHEA:23360;RHEA:56560 Added to the group PW053; Explicit glycogenin could be omitted on the left - to be coordinated with R_RCC0046 lenov -R_GLYCOPHOSPHORYL_RXN_c glycogen phosphorylase 3 M_pi_c + M_glygn2_c <=> 3 M_g1p_c + M_ldex_c c FALSE (WBGene00020696) PW019;PW053 Changed M_glygn3_c into M_glygn2_c, changed stoichiometry to produce 3 G1P, added group lenov +R_GLYCOGENIN_GLUCOSYLTRANSFERASE_RXN_c glycogenin self-glycosylation M_udpg_c + M_HC02136_c <=> M_udp_c + M_glucosyl_glycogenin_c c FALSE (WBGene00006863) or (WBGene00012020) "PW019;PW053" "RHEA:23360;RHEA:56560" "Added to the group PW053; Explicit glycogenin could be omitted on the left - to be coordinated with R_RCC0046" lenov +R_GLYCOPHOSPHORYL_RXN_c glycogen phosphorylase 3 M_pi_c + M_glygn2_c <=> 3 M_g1p_c + M_ldex_c c FALSE (WBGene00020696) "PW019;PW053" Changed M_glygn3_c into M_glygn2_c, changed stoichiometry to produce 3 G1P, added group lenov R_GLYCPDIESTER_RXN_c Glycerophosphodiester phosphodiesterase M_h2o_c + M_g3pc_c <=> M_chol_c + M_glyc3p_c + M_h_c c FALSE (WBGene00011644) or (WBGene00011929) or (WBGene00010092) or (WBGene00020446) or (WBGene00022532) PW056 R_GLYCtm glycerol transport M_glyc_c <=> M_glyc_m cm TRUE ND PW106 R_GLYK_c Glycerol kinase M_glyc_c + M_atp_c <=> M_glyc3p_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00020007) PW052 @@ -1540,7 +1540,7 @@ R_GLYOXII_RXN_c Hydroxyacylglutathione hydrolase M_lgt_S_c + M_h2o_c <=> M_h_c R_GLYOXII_RXN_n Hydroxyacylglutathione hydrolase M_lgt_S_n + M_h2o_n <=> M_h_n + M_lac__D_n + M_gthrd_n n FALSE (WBGene00012459) PW024 replaced M_lgt__S_n with M_lgt_S_n lenov R_GLYOXYLATE_OXIDASE_RXN_c glyoxylate oxidase M_h2o_c + M_o2_c + M_glx_c <=> M_h2o2_c + M_oxa_c + M_h_c c FALSE (WBGene00009334) PW030 R_GLYOXYLATE_OXIDASE_RXN_m glyoxylate oxidase M_h2o_m + M_o2_m + M_glx_m <=> M_h2o2_m + M_oxa_m + M_h_m m FALSE (WBGene00009334) PW030 -R_GMAND_c GDP-mannose 4,6-dehydratase M_gdpmann_c <=> M_h2o_c + M_gdpddman_c c FALSE (WBGene00000266) or (WBGene00010166) PW031;PW025 RHEA:23820;RHEA:23820 genes identified and cloned in C. elegans nel +R_GMAND_c GDP-mannose 4,6-dehydratase M_gdpmann_c <=> M_h2o_c + M_gdpddman_c c FALSE (WBGene00000266) or (WBGene00010166) "PW031;PW025" "RHEA:23820;RHEA:23820" genes identified and cloned in C. elegans nel R_GMP_REDUCT_RXN_c GMP reductase M_nh3_c + M_imp_c + M_nadp_c <=> M_h_c + M_gmp_c + M_nadph_c c TRUE (WBGene00017984) PW034 R_GMP_REDUCT_RXN_n GMP reductase M_nh3_n + M_imp_n + M_nadp_n <=> M_h_n + M_gmp_n + M_nadph_n n TRUE (WBGene00017984) PW034 R_GMPS2_c GMP synthetase (glutamine-hydrolysing) M_h2o_c + M_xmp_c + M_gln__L_c + M_atp_c <=> M_ppi_c + 3.0 M_h_c + M_glu__L_c + M_gmp_c + M_amp_c c FALSE (WBGene00010912) or (WBGene00010912) PW042 RHEA:11680 @@ -1549,28 +1549,28 @@ R_GND_c R_GND_c M_6pgc_c + M_nadp_c <=> M_co2_c + M_ru5p_D_c + M_nadph_c c TRUE R_GND_m R_GND_m M_6pgc_m + M_nadp_m <=> M_co2_m + M_ru5p_D_m + M_nadph_m m TRUE (WBGene00012015) PW027 SPW004 R_GND2_c R_GND2_c M_6pgc_c + M_nad_c <=> M_co2_c + M_ru5p_D_c + M_nadh_c c TRUE (WBGene00012015) or (WBGene00012015) or (WBGene00012015) PW027 SPW004 R_GND2_m R_GND2_m M_6pgc_m + M_nad_m <=> M_co2_m + M_ru5p_D_m + M_nadh_m m TRUE (WBGene00012015) PW027 SPW004 -R_GRTT_c geranyltranstransferase M_ipdp_c + M_grdp_c <=> M_ppi_c + M_frdp_c c TRUE (WBGene00011058) PW001 R08528 (JANNA: restored M_frdp_c as was blocked after this change; can look in more detail at pathway including M_ct_frdp_c later) added KEGGID, ChEBI; change to M_ct_frdp_c from M_frdp_c ms -R_GSHTRAN_RXN_c Glutathione transferase M_RX_c + M_gthrd_c <=> M_HX_c + M_S_Substituted_Glutathione_c c FALSE (WBGene00017054) or (WBGene00014251) or (WBGene00001758) or (WBGene00001758) or (WBGene00001784) or (WBGene00001752) or (WBGene00001753) or (WBGene00001750) or (WBGene00001786) or (WBGene00001751) or (WBGene00001754) or (WBGene00001755) or (WBGene00001756) or (WBGene00001749) or (WBGene00016204) or (WBGene00016204) or (WBGene00001792) or (WBGene00001771) or (WBGene00001773) PW070 RHEA:16437;RHEA:24424;RHEA:15969;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437 -R_GSHTRAN_RXN_m Glutathione transferase M_RX_m + M_gthrd_m <=> M_HX_m + M_S_Substituted_Glutathione_m m FALSE (WBGene00017054) or (WBGene00001752) or (WBGene00001753) or (WBGene00001754) or (WBGene00001755) or (WBGene00001771) PW070 RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437 +R_GRTT_c geranyltranstransferase M_ipdp_c + M_grdp_c <=> M_ppi_c + M_frdp_c c TRUE (WBGene00011058) PW001 R08528 "(JANNA: restored M_frdp_c as was blocked after this change; can look in more detail at pathway including M_ct_frdp_c later) added KEGGID, ChEBI; change to M_ct_frdp_c from M_frdp_c" ms +R_GSHTRAN_RXN_c Glutathione transferase M_RX_c + M_gthrd_c <=> M_HX_c + M_S_Substituted_Glutathione_c c FALSE (WBGene00017054) or (WBGene00014251) or (WBGene00001758) or (WBGene00001758) or (WBGene00001784) or (WBGene00001752) or (WBGene00001753) or (WBGene00001750) or (WBGene00001786) or (WBGene00001751) or (WBGene00001754) or (WBGene00001755) or (WBGene00001756) or (WBGene00001749) or (WBGene00016204) or (WBGene00016204) or (WBGene00001792) or (WBGene00001771) or (WBGene00001773) PW070 "RHEA:16437;RHEA:24424;RHEA:15969;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437" +R_GSHTRAN_RXN_m Glutathione transferase M_RX_m + M_gthrd_m <=> M_HX_m + M_S_Substituted_Glutathione_m m FALSE (WBGene00017054) or (WBGene00001752) or (WBGene00001753) or (WBGene00001754) or (WBGene00001755) or (WBGene00001771) PW070 "RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437;RHEA:16437" R_GSNK_m R_GSNK_m M_atp_m + M_gsn_m <=> 2.0 M_h_m + M_gmp_m + M_adp_m m FALSE PW042 R_GSNt2r Guanosine transport M_h_e + M_gsn_e <=> M_h_c + M_gsn_c ec TRUE (WBGene00018716 or WBGene00014092) or (ND) PW107 [CHECK ME] Identical except H usage? jpnh. R_GSNtm guanosine facilated transport in mitochondria M_gsn_c <=> M_gsn_m cm TRUE (WBGene00001320) or (WBGene00010701) or (ND) PW106 -R_GTHDH_c Glutathione dehydrogenase (ascorbate) M_dhdascb_c + 2.0 M_gthrd_c <=> M_gthox_c + M_h_c + M_ascb__L_c c FALSE PW070 [DELETION] Merged into R_RC01108; replaced M_ascb__L_c with M_ascb__L_c jpnh; lenov +R_GTHDH_c Glutathione dehydrogenase (ascorbate) M_dhdascb_c + 2.0 M_gthrd_c <=> M_gthox_c + M_h_c + M_ascb__L_c c FALSE PW070 "[DELETION] Merged into R_RC01108; replaced M_ascb__L_c with M_ascb__L_c" "jpnh; lenov" R_GTHO_c Glutathione reductase (NADPH) M_nadp_c + 2.0 M_gthrd_c <=> M_gthox_c + M_h_c + M_nadph_c c TRUE (WBGene00008117) PW070 RHEA:11740 -R_GTHO_m Glutathione reductase (NADPH) M_nadp_m + 2.0 M_gthrd_m <=> M_gthox_m + M_h_m + M_nadph_m m TRUE (WBGene00008117) or (WBGene00014028) PW070 RHEA:11740;RHEA:11740 -R_GTHP_c glutathione peroxidase M_h2o2_c + 2.0 M_gthrd_c <=> 2.0 M_h2o_c + M_gthox_c c TRUE (WBGene00019846) or (WBGene00007517) or (WBGene00007516) or (WBGene00022377) or (WBGene00011045) or (WBGene00018850) or (WBGene00009165) PW070 RHEA:16833;RHEA:16833;RHEA:16833 set to reversible janna +R_GTHO_m Glutathione reductase (NADPH) M_nadp_m + 2.0 M_gthrd_m <=> M_gthox_m + M_h_m + M_nadph_m m TRUE (WBGene00008117) or (WBGene00014028) PW070 "RHEA:11740;RHEA:11740" +R_GTHP_c glutathione peroxidase M_h2o2_c + 2.0 M_gthrd_c <=> 2.0 M_h2o_c + M_gthox_c c TRUE (WBGene00019846) or (WBGene00007517) or (WBGene00007516) or (WBGene00022377) or (WBGene00011045) or (WBGene00018850) or (WBGene00009165) PW070 "RHEA:16833;RHEA:16833;RHEA:16833" set to reversible janna R_GTHP_m glutathione peroxidase M_h2o2_m + 2.0 M_gthrd_m <=> 2.0 M_h2o_m + M_gthox_m m TRUE (WBGene00018850) PW070 set to reversible janna R_GTHS_c glutathione synthetase M_glucys_c + M_gly_c + M_atp_c <=> M_pi_c + 2.0 M_h_c + M_adp_c + M_gthrd_c c FALSE (WBGene00010941) PW070 RHEA:13557 R_GTPCI_c GTP cyclohydrolase I M_h2o_c + M_gtp_c <=> M_ahdt_c + M_for_c + M_h_c c TRUE (WBGene00000298) PW091 RHEA:17473 R_GTPCI_n GTP cyclohydrolase I M_h2o_n + M_gtp_n <=> M_ahdt_n + M_for_n + M_h_n n TRUE (WBGene00000298) PW091 RHEA:17473 R_GTPtn GTP diffusion in nucleus M_gtp_c <=> M_gtp_n cn TRUE PW108 -R_GUACYC_c Guanylate cyclase M_gtp_c <=> M_ppi_c + M_35cgmp_c c TRUE ((WBGene00001528 or WBGene00001538 or WBGene00001540 or WBGene00001541 or WBGene00001543 or WBGene00001529 or WBGene00001545 or WBGene00001546 or WBGene00001548 or WBGene00001530 or WBGene00001554 or WBGene00001532 or WBGene00001535) or (WBGene00001542 or WBGene00020131) or (WBGene00001551 or WBGene00001553 or WBGene00001555 or WBGene00001556 or WBGene00001557)) or (WBGene00000068 or WBGene00000071) or WBGene00000069 or (WBGene00000907 or WBGene00001544 or WBGene00001547 or WBGene00001549 or WBGene00007314 or WBGene00001552 or WBGene00001531 or WBGene00001536) PW042 RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:15389;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665 +R_GUACYC_c Guanylate cyclase M_gtp_c <=> M_ppi_c + M_35cgmp_c c TRUE ((WBGene00001528 or WBGene00001538 or WBGene00001540 or WBGene00001541 or WBGene00001543 or WBGene00001529 or WBGene00001545 or WBGene00001546 or WBGene00001548 or WBGene00001530 or WBGene00001554 or WBGene00001532 or WBGene00001535) or (WBGene00001542 or WBGene00020131) or (WBGene00001551 or WBGene00001553 or WBGene00001555 or WBGene00001556 or WBGene00001557)) or (WBGene00000068 or WBGene00000071) or WBGene00000069 or (WBGene00000907 or WBGene00001544 or WBGene00001547 or WBGene00001549 or WBGene00007314 or WBGene00001552 or WBGene00001531 or WBGene00001536) PW042 "RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:15389;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665;RHEA:13665" R_GUAD_c Guanine deaminase M_h2o_c + M_gua_c <=> M_nh3_c + M_xan_c c FALSE (WBGene00000775) PW042 R_Guanosine_Exchange_reactions_e Guanosine transport M_gsn_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Guanosine_transport Guanosine transport M_gsn_c <=> M_gsn_e ce TRUE ND PW107 [CHECK ME] Identical except H usage? jpnh. R_GUAPRT_c R_GUAPRT_c M_prpp_c + M_gua_c <=> M_ppi_c + M_gmp_c c TRUE WBGene00020557 or WBGene00013690 PW042 RHEA:17973 R_GULN3D_c L-gulonate 3-dehydrogenase M_guln_c + M_nad_c <=> M_3dhguln_c + M_h_c + M_nadh_c c TRUE (WBGene00022130) PW033 -R_GULND_c Glucuronate reductase M_guln_c + M_nadp_c <=> M_h_c + M_nadph_c + M_glcur_c c TRUE Unknown PW033;PW045 replaced L-ascorbate biosynthesis with PW045 lenov +R_GULND_c Glucuronate reductase M_guln_c + M_nadp_c <=> M_h_c + M_nadph_c + M_glcur_c c TRUE Unknown "PW033;PW045" replaced L-ascorbate biosynthesis with PW045 lenov R_H2O2tn hydrogen peroxide nuclear transport M_h2o2_c <=> M_h2o2_n cn TRUE PW108 R_H2OGLYAQPt R_H2OGLYAQPt M_h2o_e + M_glyc_e <=> M_h2o_c + M_glyc_c ec TRUE (WBGene00000170 or WBGene00000175 or WBGene00000171 or WBGene00000169 or WBGene00000176) PW107 R_H2Otm H2O transport, mitochondrial M_h2o_c <=> M_h2o_m cm TRUE (WBGene00000172) or (WBGene00000174) or (ND) PW106 @@ -1580,26 +1580,26 @@ R_H4ET3_c R_H4ET3_c M_m3gacpail_c + M_1ac2acg3pe_c <=> M_em3gacpail_c + M_1ac2a R_HACD9_m 3-hydroxy-2-methylbutyryl-CoA dehydrogenase M_nad_m + M_3hmbcoa_m <=> M_h_m + M_nadh_m + M_2maacoa_m m FALSE WBGene00000181 or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) PW083 [DELETION] Dupe of R_RXN909_15_m jpnh R_HCO3_NAt bicarbonate transport (Na/HCO3 cotransport) M_hco3_e + M_na1_e <=> M_hco3_c + M_na1_c ec TRUE (WBGene00009920) PW107 R_HCRNtm O-hexanoylcarnitine transport into mitochondria via diffusion M_carn6_0__L_c <=> M_carn6_0__L_m cm FALSE (WBGene00000996 ) PW106 -R_HDCAFAPMtc Hexadecanoate Transport M_fa16_0_e <=> M_fa16_0_c ec TRUE (WBGene00000170 or WBGene00000175 or WBGene00000171 or WBGene00000169 or WBGene00000176) or (ND) PW107 added name; set to reversible jpnh; janna +R_HDCAFAPMtc Hexadecanoate Transport M_fa16_0_e <=> M_fa16_0_c ec TRUE (WBGene00000170 or WBGene00000175 or WBGene00000171 or WBGene00000169 or WBGene00000176) or (ND) PW107 "added name; set to reversible" "jpnh; janna" R_Heme_Exchange_reactions_e pheme transport M_pheme_e <=> e TRUE PW111 Removed space from reaction ID jpnh -R_HEX1_c beta-D-Glucokinase M_glc_bD_c + M_atp_c <=> M_g6p_B_c + 2.0 M_h_c + M_adp_c c FALSE WBGene00008780 or WBGene00010416 or WBGene00022306 PW031;PW018;PW026 R01600 fixed the name lenov +R_HEX1_c beta-D-Glucokinase M_glc_bD_c + M_atp_c <=> M_g6p_B_c + 2.0 M_h_c + M_adp_c c FALSE WBGene00008780 or WBGene00010416 or WBGene00022306 "PW031;PW018;PW026" R01600 fixed the name lenov R_HEX4_c D-mannose transport M_atp_c + M_man_c <=> M_man6p_c + M_h_c + M_adp_c c FALSE (WBGene00010416) or (WBGene00022306) or (WBGene00008780) PW025 R_HEX4_m D-mannose transport M_atp_m + M_man_m <=> M_man6p_m + M_h_m + M_adp_m m FALSE (WBGene00010416) PW025 R_HEX4_n D-mannose transport M_atp_n + M_man_n <=> M_man6p_n + M_h_n + M_adp_n n FALSE (WBGene00010416) or (WBGene00022306) or (WBGene00008780) PW025 R_HEX7_c Fructokinase M_fru_B_c + M_atp_c <=> M_f6p_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00008780) PW031 R_HEX7_n Fructokinase M_fru_B_n + M_atp_n <=> M_f6p_n + 2.0 M_h_n + M_adp_n n FALSE (WBGene00008780) PW031 -R_HGNTOR_c Homogentisate 1,2-dioxygenase M_hgentis_c + M_o2_c <=> M_4mlacac_c + M_h_c c FALSE (WBGene00001843) PW076;PW077 RHEA:15449 -R_HGNTOR_n Homogentisate 1,2-dioxygenase M_hgentis_n + M_o2_n <=> M_4mlacac_n + M_h_n n FALSE (WBGene00001843) PW076;PW077 RHEA:15449 +R_HGNTOR_c Homogentisate 1,2-dioxygenase M_hgentis_c + M_o2_c <=> M_4mlacac_c + M_h_c c FALSE (WBGene00001843) "PW076;PW077" RHEA:15449 +R_HGNTOR_n Homogentisate 1,2-dioxygenase M_hgentis_n + M_o2_n <=> M_4mlacac_n + M_h_n n FALSE (WBGene00001843) "PW076;PW077" RHEA:15449 R_HISD_c Histidine ammonia-lyase M_his__L_c <=> M_urcan_c + M_nh3_c + M_h_c c FALSE (WBGene00009813) PW084 RHEA:21232 -R_HISTACET Acetyl-CoA:histone acetyltransferase M_accoa_n + M_Nlys_n <=> M_h_n + M_coa_n + M_Naclys_n n FALSE ((WBGene00008209 or WBGene00000366) or WBGene00045419 or WBGene00007029 or WBGene00020596 or WBGene00044069 or WBGene00014123 or WBGene00010537 or WBGene00021636) or WBGene00007914 PW101 RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948 Histone acetylation takes place in the nucleus lenov -R_HISTDIMET histone-L-lysine N6-methyltransferase (acting on monomethylated residues) M_Nmelys_n + M_amet_n <=> M_Ndmelys_n + M_h_n + M_ahcys_n n FALSE (WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206) PW101 RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024 Histone dimethylation takes place in the nucleus lenov +R_HISTACET Acetyl-CoA:histone acetyltransferase M_accoa_n + M_Nlys_n <=> M_h_n + M_coa_n + M_Naclys_n n FALSE ((WBGene00008209 or WBGene00000366) or WBGene00045419 or WBGene00007029 or WBGene00020596 or WBGene00044069 or WBGene00014123 or WBGene00010537 or WBGene00021636) or WBGene00007914 PW101 "RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948;RHEA:45948" Histone acetylation takes place in the nucleus lenov +R_HISTDIMET histone-L-lysine N6-methyltransferase (acting on monomethylated residues) M_Nmelys_n + M_amet_n <=> M_Ndmelys_n + M_h_n + M_ahcys_n n FALSE (WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206) PW101 "RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024" Histone dimethylation takes place in the nucleus lenov R_Histidine_Exchange_reactions_e Histidine transport M_his__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Histidine_transport Histidine transport M_his__L_c <=> M_his__L_e ce TRUE ND PW107 -R_HISTONE_LYSINE_N_METHYLTRANSFERASE_RXN_n Histone-lysine N-methyltransferase M_Nlys_n + M_amet_n <=> M_Nmelys_n + M_h_n + M_ahcys_n n FALSE (WBGene00011729) or (WBGene00003040) or (WBGene00016603) or (WBGene00019584) or (WBGene00004782) or (WBGene00019883) or (WBGene00018023) or (WBGene00003220) or (WBGene00021515) or (WBGene00021474) or (WBGene00010067) or (WBGene00012302) or (WBGene00010120) or (WBGene00022512) or (WBGene00016313) or (WBGene00004781) or (WBGene00019690) or (WBGene00020006) or (WBGene00021282) or (WBGene00008062) or (WBGene00022431) or (WBGene00008206) PW101 RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:1004;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024 Histone methylation is irreversible; merged all Gene associations from different compartments; replace pathway annotation with histone modification lenov +R_HISTONE_LYSINE_N_METHYLTRANSFERASE_RXN_n Histone-lysine N-methyltransferase M_Nlys_n + M_amet_n <=> M_Nmelys_n + M_h_n + M_ahcys_n n FALSE (WBGene00011729) or (WBGene00003040) or (WBGene00016603) or (WBGene00019584) or (WBGene00004782) or (WBGene00019883) or (WBGene00018023) or (WBGene00003220) or (WBGene00021515) or (WBGene00021474) or (WBGene00010067) or (WBGene00012302) or (WBGene00010120) or (WBGene00022512) or (WBGene00016313) or (WBGene00004781) or (WBGene00019690) or (WBGene00020006) or (WBGene00021282) or (WBGene00008062) or (WBGene00022431) or (WBGene00008206) PW101 "RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:1004;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024" "Histone methylation is irreversible; merged all Gene associations from different compartments; replace pathway annotation with histone modification" lenov R_HKYNH_c R_HKYNH_c M_h2o_c + M_hLkynr_c <=> M_3hanthrn_c + M_h_c + M_ala__L_c c TRUE (WBGene00015802) PW072 replaced M_ala__L_c with M_ala_L_c lenov R_HMGCOAR_c Hydroxymethylglutaryl-CoA reductase (NADPH) 2.0 M_h_c + 2.0 M_nadph_c + M_hmgcoa_c <=> M_mev_R_c + M_coa_c + 2.0 M_nadp_c c TRUE (WBGene00017268) PW001 R02082 RHEA:15989 added KEGGID ms -R_HMGCOAS_c Hydroxymethylglutaryl-CoA synthase M_h2o_c + M_accoa_c + M_aacoa_c <=> M_h_c + M_coa_c + M_hmgcoa_c c TRUE (WBGene00017769) PW083;PW001 R01978 RHEA:10188 added KEGGID ms -R_HMGCOAS_m Hydroxymethylglutaryl-CoA synthase M_h2o_m + M_accoa_m + M_aacoa_m <=> M_h_m + M_coa_m + M_hmgcoa_m m TRUE (WBGene00017769) PW083;PW001 R01978 RHEA:10188 added KEGGID ms +R_HMGCOAS_c Hydroxymethylglutaryl-CoA synthase M_h2o_c + M_accoa_c + M_aacoa_c <=> M_h_c + M_coa_c + M_hmgcoa_c c TRUE (WBGene00017769) "PW083;PW001" R01978 RHEA:10188 added KEGGID ms +R_HMGCOAS_m Hydroxymethylglutaryl-CoA synthase M_h2o_m + M_accoa_m + M_aacoa_m <=> M_h_m + M_coa_m + M_hmgcoa_m m TRUE (WBGene00017769) "PW083;PW001" R01978 RHEA:10188 added KEGGID ms R_HMGL_c Hydroxymethylglutaryl-CoA lyase M_hmgcoa_c <=> M_acac_c + M_accoa_c c TRUE (WBGene00022150) PW083 R_HMGL_m Hydroxymethylglutaryl-CoA lyase M_hmgcoa_m <=> M_acac_m + M_accoa_m m TRUE (WBGene00022150) PW083 R_HOLO_ACP_SYNTH_RXN_c Holo-[acyl-carrier protein] synthase M_coa_c + M_apoACP_c <=> M_pap_c + M_ACP_c c FALSE (WBGene00020215) or (WBGene00012142) PW037 @@ -1622,21 +1622,21 @@ R_ICASBIOSYNTH0011 icas10-CoA hydrolase M_icas_10coa_c + M_h2o_c <=> M_icas_10_c R_ICASBIOSYNTH0012 icas1-CoA hydrolase M_icas_1coa_c + M_h2o_c <=> M_icas_1_c + M_coa_c + M_h_c c FALSE R_ICASBIOSYNTH0013 icas9-CoA hydrolase M_icas_9coa_c + M_h2o_c <=> M_icas_9_c + M_coa_c + M_h_c c FALSE R_IDPtn IDP nuclear transport M_idp_c <=> M_idp_n cn TRUE PW108 -R_ILEB0AT2tc R_ILEB0AT2tc M_ile__L_e + M_na1_e <=> M_ile__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 RHEA:21824;RHEA:21824 +R_ILEB0AT2tc R_ILEB0AT2tc M_ile__L_e + M_na1_e <=> M_ile__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 "RHEA:21824;RHEA:21824" R_ILEt5m Isoleucine mitochondrial transport M_ile__L_c <=> M_ile__L_m cm TRUE ND PW106 -R_ILETA_c Isoleucine transaminase M_akg_c + M_ile__L_c <=> M_3mop_c + M_glu__L_c c TRUE (WBGene00001149) PW083 RHEA:18321;RHEA:24801;RHEA:24813 (set to reversible, janna) Corrected gene association ckaleta 2.6.1.42 +R_ILETA_c Isoleucine transaminase M_akg_c + M_ile__L_c <=> M_3mop_c + M_glu__L_c c TRUE (WBGene00001149) PW083 "RHEA:18321;RHEA:24801;RHEA:24813" (set to reversible, janna) Corrected gene association ckaleta 2.6.1.42 R_ILETA_m Isoleucine transaminase M_akg_m + M_ile__L_m <=> M_3mop_m + M_glu__L_m m TRUE (WBGene00012855) PW083 Corrected gene association ckaleta 2.6.1.42 R_IMPC_c IMP cyclohydrolase M_h2o_c + M_imp_c <=> M_fprica_c c TRUE (WBGene00016957) PW042 R_IMPD_c IMP dehydrogenase M_h2o_c + M_imp_c + M_nad_c <=> M_xmp_c + M_h_c + M_nadh_c c TRUE (WBGene00020682) PW042 R_INSK_c Inosine kinase M_atp_c + M_ins_c <=> 2.0 M_h_c + M_imp_c + M_adp_c c FALSE PW042 R_INSt2 R_INSt2 M_h_e + M_ins_e <=> M_h_c + M_ins_c ec TRUE (WBGene00018716 or WBGene00014092) or (ND) PW107 -R_IPDDI_c Isopentenyl-diphosphate δ-isomerase M_ipdp_c <=> M_dmpp_c c TRUE (WBGene00019460) PW001 R01123 added KEGGID, ChEBI ms -R_ISOCIT_CLEAV_RXN_m Isocitrate lyase M_icit_m <=> M_glx_m + M_succ_m m TRUE (WBGene00001564) PW074;PW030 RHEA:13245;RHEA:18181 -R_ISOCIT_CLEAV_RXN_n Isocitrate lyase M_icit_n <=> M_glx_n + M_succ_n n TRUE (WBGene00001564) PW074;PW030 RHEA:13245;RHEA:18181 -R_ISOCITDEH_RXN_c Isocitrate dehydrogenase (NADP+) M_nadp_c + M_icit_c <=> M_akg_c + M_co2_c + M_nadph_c c FALSE (WBGene00010317) PW023 SPW004 RHEA:19629;RHEA:19629 -R_ISOCITDEH_RXN_m Isocitrate dehydrogenase (NADP+) M_nadp_m + M_icit_m <=> M_akg_m + M_co2_m + M_nadph_m m FALSE WBGene00010317 or WBGene00007942 PW023 SPW004 RHEA:19629;RHEA:19629;RHEA:19629 +R_IPDDI_c "Isopentenyl-diphosphate δ-isomerase" M_ipdp_c <=> M_dmpp_c c TRUE (WBGene00019460) PW001 R01123 added KEGGID, ChEBI ms +R_ISOCIT_CLEAV_RXN_m Isocitrate lyase M_icit_m <=> M_glx_m + M_succ_m m TRUE (WBGene00001564) "PW074;PW030" "RHEA:13245;RHEA:18181" +R_ISOCIT_CLEAV_RXN_n Isocitrate lyase M_icit_n <=> M_glx_n + M_succ_n n TRUE (WBGene00001564) "PW074;PW030" "RHEA:13245;RHEA:18181" +R_ISOCITDEH_RXN_c Isocitrate dehydrogenase (NADP+) M_nadp_c + M_icit_c <=> M_akg_c + M_co2_c + M_nadph_c c FALSE (WBGene00010317) PW023 SPW004 "RHEA:19629;RHEA:19629" +R_ISOCITDEH_RXN_m Isocitrate dehydrogenase (NADP+) M_nadp_m + M_icit_m <=> M_akg_m + M_co2_m + M_nadph_m m FALSE WBGene00010317 or WBGene00007942 PW023 SPW004 "RHEA:19629;RHEA:19629;RHEA:19629" R_ISOCITRATE_DEHYDROGENASE_NAD__RXN_c Isocitrate dehydrogenase (NAD+) M_nad_c + M_icit_c <=> M_akg_c + M_co2_c + M_nadh_c c FALSE (WBGene00009664) PW023 SPW004 RHEA:23632 -R_ISOCITRATE_DEHYDROGENASE_NAD__RXN_m Isocitrate dehydrogenase (NAD+) M_nad_m + M_icit_m <=> M_akg_m + M_co2_m + M_nadh_m m FALSE (WBGene00016266) or (WBGene00009664) or (WBGene00009440) or (WBGene00007993) PW023 SPW004 RHEA:23632;RHEA:23632 +R_ISOCITRATE_DEHYDROGENASE_NAD__RXN_m Isocitrate dehydrogenase (NAD+) M_nad_m + M_icit_m <=> M_akg_m + M_co2_m + M_nadh_m m FALSE (WBGene00016266) or (WBGene00009664) or (WBGene00009440) or (WBGene00007993) PW023 SPW004 "RHEA:23632;RHEA:23632" R_ISOCITRATE_DEHYDROGENASE_NAD__RXN_n Isocitrate dehydrogenase (NAD+) M_nad_n + M_icit_n <=> M_akg_n + M_co2_n + M_nadh_n n FALSE (WBGene00009664) PW023 SPW004 RHEA:23632 R_Isoleucine_Exchange_reactions_e Isoleucine transport M_ile__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Isoleucine_transport Isoleucine transport M_ile__L_c <=> M_ile__L_e ce TRUE ND PW107 @@ -1649,33 +1649,33 @@ R_L_GULONOLACTONE_OXIDASE_RXN_c L-gulonolactone oxidase M_gullac_c + M_o2_c <=> R_Lact2r lactose transport (uniport) M_lac__L_e <=> M_lac__L_c ec TRUE (WBGene00008214) or (ND) PW107 R_LACTATEDH_c D-lactate dehydrogenase M_lac__D_c + M_nad_c <=> M_pyr_c + M_nadh_c + M_h_c c TRUE PW024 replaces R_DLACTDEHYDROGFAD_RXN_c lenov R_LCRNtm O-lauroylcarnitine transport into mitochondria via diffusion M_carn12_0__L_c <=> M_carn12_0__L_m cm FALSE (WBGene00000996 ) PW106 -R_LDH_L_c L-lactate dehydrogenase M_nad_c + M_lac__L_c <=> M_h_c + M_nadh_c + M_pyr_c c TRUE (WBGene00002262) or (WBGene00002262) or (WBGene00002262) PW022 SPW004 RHEA:23444;RHEA:23444 -R_LEUB0AT2tc R_LEUB0AT2tc M_leu__L_e + M_na1_e <=> M_leu__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 RHEA:21824;RHEA:21824 +R_LDH_L_c L-lactate dehydrogenase M_nad_c + M_lac__L_c <=> M_h_c + M_nadh_c + M_pyr_c c TRUE (WBGene00002262) or (WBGene00002262) or (WBGene00002262) PW022 SPW004 "RHEA:23444;RHEA:23444" +R_LEUB0AT2tc R_LEUB0AT2tc M_leu__L_e + M_na1_e <=> M_leu__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 "RHEA:21824;RHEA:21824" R_Leucine_Exchange_reactions_e Leucine transport M_leu__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Leucine_transport Leucine transport M_leu__L_c <=> M_leu__L_e ce TRUE ND PW107 R_LEUt5m leucine mitochondrial transport M_leu__L_c <=> M_leu__L_m cm TRUE ND PW106 -R_LEUTA_c Leucine transaminase M_akg_c + M_leu__L_c <=> M_4mop_c + M_glu__L_c c TRUE (WBGene00001149) PW083 RHEA:18321;RHEA:24801;RHEA:24813 Corrected gene association based on localization ckaleta 2.6.1.42 -R_LEUTA_m Leucine transaminase M_akg_m + M_leu__L_m <=> M_4mop_m + M_glu__L_m m TRUE (WBGene00001149) PW083 RHEA:18321;RHEA:24801;RHEA:24813 Corrected gene association based on localization ckaleta 2.6.1.42 +R_LEUTA_c Leucine transaminase M_akg_c + M_leu__L_c <=> M_4mop_c + M_glu__L_c c TRUE (WBGene00001149) PW083 "RHEA:18321;RHEA:24801;RHEA:24813" Corrected gene association based on localization ckaleta 2.6.1.42 +R_LEUTA_m Leucine transaminase M_akg_m + M_leu__L_m <=> M_4mop_m + M_glu__L_m m TRUE (WBGene00001149) PW083 "RHEA:18321;RHEA:24801;RHEA:24813" Corrected gene association based on localization ckaleta 2.6.1.42 R_LGNCFATPtc R_LGNCFATPtc M_atp_c + M_coa_c + M_fa24_0_e <=> M_coa24_0_c + M_ppi_c + M_amp_c c FALSE (WBGene00020837 or WBGene00012804 or WBGene00010421 or WBGene00012629 or WBGene00016628 or WBGene00010307 or WBGene00017012 or WBGene00009218) PW107 R_LGNCFATtc R_LGNCFATtc M_fa24_0_e <=> M_fa24_0_c ec FALSE (WBGene00000170 or WBGene00000175 or WBGene00000171 or WBGene00000169 or WBGene00000176) PW107 R_LINOLEICBETAOX0001 Acyl-CoA-dehydrogenase (C18:2(9Z,12Z), mitochondrial) M_h_m + M_fad_m + M_coa18_2_9z12z_m <=> M_fadh2_m + M_coa18_3_2e9z12z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW118 SPW001 RHEA:14477 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi -R_LINOLEICBETAOX0002 Enoyl-CoA-hydratase (C18:3(2E,9Z,12Z), mitochondrial) M_coa18_3_2e9z12z_m + M_h2o_m <=> M_coa18_2_9z12z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi +R_LINOLEICBETAOX0002 Enoyl-CoA-hydratase (C18:3(2E,9Z,12Z), mitochondrial) M_coa18_3_2e9z12z_m + M_h2o_m <=> M_coa18_2_9z12z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0003 (S)-3-hydroxyacyl-CoA-dehydrogenase (C18:2(9Z,12Z,3(S)OH), mitochondrial) M_nad_m + M_coa18_2_9z12z3oh__S_m <=> M_h_m + M_nadh_m + M_coa18_2_9z12z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0004 3-ketothiolase (C18:2(9Z,12Z,3O), mitochondrial) M_coa18_2_9z12z3o_m + M_coa_m <=> M_accoa_m + M_coa16_2_7z10z_m m FALSE WBGene00009952 or WBGene00015125 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0005 Acyl-CoA-dehydrogenase (C16:2(7Z,10Z), mitochondrial) M_h_m + M_fad_m + M_coa16_2_7z10z_m <=> M_fadh2_m + M_coa16_3_2e7z10z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW118 SPW001 RHEA:14477 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi -R_LINOLEICBETAOX0006 Enoyl-CoA-hydratase (C16:3(2E,7Z,10Z), mitochondrial) M_coa16_3_2e7z10z_m + M_h2o_m <=> M_coa16_2_7z10z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi +R_LINOLEICBETAOX0006 Enoyl-CoA-hydratase (C16:3(2E,7Z,10Z), mitochondrial) M_coa16_3_2e7z10z_m + M_h2o_m <=> M_coa16_2_7z10z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0007 (S)-3-hydroxyacyl-CoA-dehydrogenase (C16:2(7Z,10Z,3(S)OH), mitochondrial) M_nad_m + M_coa16_2_7z10z3oh__S_m <=> M_h_m + M_nadh_m + M_coa16_2_7z10z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0008 3-ketothiolase (C16:2(7Z,10Z,3O), mitochondrial) M_coa16_2_7z10z3o_m + M_coa_m <=> M_accoa_m + M_coa14_2_5z8z_m m FALSE WBGene00009952 or WBGene00015125 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0009 Acyl-CoA-dehydrogenase (C14:2(5Z,8Z), mitochondrial) M_h_m + M_fad_m + M_coa14_2_5z8z_m <=> M_fadh2_m + M_coa14_3_2e5z8z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW118 SPW001 RHEA:14477 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi -R_LINOLEICBETAOX0010 Enoyl-CoA-hydratase (C14:3(2E,5Z,8Z), mitochondrial) M_coa14_3_2e5z8z_m + M_h2o_m <=> M_coa14_2_5z8z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi +R_LINOLEICBETAOX0010 Enoyl-CoA-hydratase (C14:3(2E,5Z,8Z), mitochondrial) M_coa14_3_2e5z8z_m + M_h2o_m <=> M_coa14_2_5z8z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0011 (S)-3-hydroxyacyl-CoA-dehydrogenase (C14:2(5Z,8Z,3(S)OH), mitochondrial) M_nad_m + M_coa14_2_5z8z3oh__S_m <=> M_h_m + M_nadh_m + M_coa14_2_5z8z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0012 3-ketothiolase (C14:2(5Z,8Z,3O), mitochondrial) M_coa14_2_5z8z3o_m + M_coa_m <=> M_accoa_m + M_coa12_2_3z6z_m m FALSE WBGene00009952 or WBGene00015125 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0013 Enoyl-CoA delta isomerase (C12:2(3Z,6Z), mitochondrial) M_coa12_2_3z6z_m <=> M_coa12_2_2e6z_m m FALSE WBGene00001153 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi -R_LINOLEICBETAOX0014 Enoyl-CoA-hydratase (C12:2(2E,6Z), mitochondrial) M_coa12_2_2e6z_m + M_h2o_m <=> M_coa12_1_6z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi +R_LINOLEICBETAOX0014 Enoyl-CoA-hydratase (C12:2(2E,6Z), mitochondrial) M_coa12_2_2e6z_m + M_h2o_m <=> M_coa12_1_6z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW118 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0015 (S)-3-hydroxyacyl-CoA-dehydrogenase (C12:1(6Z,3(S)OH), mitochondrial) M_nad_m + M_coa12_1_6z3oh__S_m <=> M_h_m + M_nadh_m + M_coa12_1_6z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0016 3-ketothiolase (C12:1(6Z,3O), mitochondrial) M_coa12_1_6z3o_m + M_coa_m <=> M_accoa_m + M_coa10_1_4z_m m FALSE WBGene00009952 or WBGene00015125 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0017 Acyl-CoA-dehydrogenase (C10:1(4Z), mitochondrial) M_h_m + M_fad_m + M_coa10_1_4z_m <=> M_fadh2_m + M_coa10_2_2e4z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW118 SPW001 RHEA:14477 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi -R_LINOLEICBETAOX0018 2,4-dienoyl-CoA reductase (C10:2(2E,4Z), mitochondrial) M_coa10_2_2e4z_m + M_nadph_m + M_h_m <=> M_coa10_1_3e_m + M_nadp_m m FALSE WBGene00018380 or WBGene00012177 or WBGene00011467 or WBGene00009973 PW118 SPW001 RHEA:12136;RHEA:12136 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi +R_LINOLEICBETAOX0018 2,4-dienoyl-CoA reductase (C10:2(2E,4Z), mitochondrial) M_coa10_2_2e4z_m + M_nadph_m + M_h_m <=> M_coa10_1_3e_m + M_nadp_m m FALSE WBGene00018380 or WBGene00012177 or WBGene00011467 or WBGene00009973 PW118 SPW001 "RHEA:12136;RHEA:12136" [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LINOLEICBETAOX0019 Enoyl-CoA delta isomerase (C10:1(3Z), mitochondrial) M_coa10_1_3e_m <=> M_coa10_1_2e_m m FALSE WBGene00001153 PW118 SPW001 [CHECKME] Detailed Replacement for lumped reaction R_RMC0091 wimi R_LIPOIC_ACID_e Lipoic acid transport M_lipoate_e <=> e TRUE PW111 R_LIPOIC_ACID_transport Lipoic acid transport M_lipoate_c <=> M_lipoate_e ce TRUE PW107 @@ -1684,17 +1684,17 @@ R_Lysine_transport Lysine transport M_lys__L_c <=> M_lys__L_e ce TRUE ND PW107 R_LYStm Lysine mitochondrial transport via ornithine carrier M_h_m + M_lys__L_c <=> M_h_c + M_lys__L_m mc TRUE (WBGene00020422) or (ND) PW106 R_LYStn L-lysine transport, nuclear M_lys__L_c <=> M_lys__L_n cn TRUE PW108 R_M4CET3_c R_M4CET3_c M_m3emgacpail_c + M_1ac2acg3pe_c <=> M_mem2emgacpail_c + M_1ac2acglyc_c c FALSE (WBGene00016159) PW028 -R_MACACI_c Maleylacetoacetate isomerase M_4mlacac_c <=> M_4fumacac_c c TRUE WBGene00021817 or WBGene00001790 or WBGene00001791 PW076;PW077 RHEA:14817 -R_MALS_c malate synthase M_h2o_c + M_glx_c + M_accoa_c <=> M_h_c + M_coa_c + M_mal__L_c c TRUE (WBGene00001564) PW030 RHEA:13245;RHEA:18181 -R_MALS_m malate synthase M_h2o_m + M_glx_m + M_accoa_m <=> M_h_m + M_coa_m + M_mal__L_m m TRUE (WBGene00001564) PW030 RHEA:13245;RHEA:18181 +R_MACACI_c Maleylacetoacetate isomerase M_4mlacac_c <=> M_4fumacac_c c TRUE WBGene00021817 or WBGene00001790 or WBGene00001791 "PW076;PW077" RHEA:14817 +R_MALS_c malate synthase M_h2o_c + M_glx_c + M_accoa_c <=> M_h_c + M_coa_c + M_mal__L_c c TRUE (WBGene00001564) PW030 "RHEA:13245;RHEA:18181" +R_MALS_m malate synthase M_h2o_m + M_glx_m + M_accoa_m <=> M_h_m + M_coa_m + M_mal__L_m m TRUE (WBGene00001564) PW030 "RHEA:13245;RHEA:18181" R_MALSO3tm Malate:sulfite antiport, mitochondrial M_so3_m + M_mal__L_c <=> M_so3_c + M_mal__L_m mc TRUE (WBGene00019656) or (ND) PW106 R_MALSO4tm Malate:sulfate antiport, mitochondrial M_so4_m + M_mal__L_c <=> M_so4_c + M_mal__L_m mc TRUE (WBGene00019656) or (ND) PW106 R_MALSULtm malate:thiosulfate antiport, mitochondrial M_tsul_m + M_mal__L_c <=> M_tsul_c + M_mal__L_m mc TRUE (WBGene00019656) or (ND) PW106 R_MALtm malate transport, mitochondrial M_pi_m + M_mal__L_c <=> M_pi_c + M_mal__L_m mc TRUE (WBGene00019656) or (ND) PW106 -R_MAN1PT_c Mannose-1-phosphate guanylyltransferase M_man1p_c + M_h_c + M_gtp_c <=> M_gdpmann_c + M_ppi_c c TRUE (WBGene00021628) or (WBGene00016583) PW031;PW025 RHEA:15229 Human homolog shows localization in the nucleus (https://www.proteinatlas.org/ENSG00000173540-GMPPB/cell) nel -R_MAN1PT_n Mannose-1-phosphate guanylyltransferase M_man1p_n + M_h_n + M_gtp_n <=> M_gdpmann_n + M_ppi_n n TRUE (WBGene00021628) PW031;PW025 (set to reversible, janna)Human homolog shows localization in the nucleus (https://www.proteinatlas.org/ENSG00000173540-GMPPB/cell) nel -R_MAN6PI_c Mannose-6-phosphate isomerase M_man6p_c <=> M_f6p_c c TRUE (WBGene00015464) or (WBGene00014013) PW031;PW025 -R_MAN6PI_n Mannose-6-phosphate isomerase M_man6p_n <=> M_f6p_n n TRUE (WBGene00015464) or (WBGene00014013) PW031;PW025 +R_MAN1PT_c Mannose-1-phosphate guanylyltransferase M_man1p_c + M_h_c + M_gtp_c <=> M_gdpmann_c + M_ppi_c c TRUE (WBGene00021628) or (WBGene00016583) "PW031;PW025" RHEA:15229 Human homolog shows localization in the nucleus (https://www.proteinatlas.org/ENSG00000173540-GMPPB/cell) nel +R_MAN1PT_n Mannose-1-phosphate guanylyltransferase M_man1p_n + M_h_n + M_gtp_n <=> M_gdpmann_n + M_ppi_n n TRUE (WBGene00021628) "PW031;PW025" (set to reversible, janna)Human homolog shows localization in the nucleus (https://www.proteinatlas.org/ENSG00000173540-GMPPB/cell) nel +R_MAN6PI_c Mannose-6-phosphate isomerase M_man6p_c <=> M_f6p_c c TRUE (WBGene00015464) or (WBGene00014013) "PW031;PW025" +R_MAN6PI_n Mannose-6-phosphate isomerase M_man6p_n <=> M_f6p_n n TRUE (WBGene00015464) or (WBGene00014013) "PW031;PW025" R_MANt1r mannose transport (uniport) M_man_e <=> M_man_c ec TRUE (WBGene00019979) or (WBGene00019207) or (ND) PW107 R_MARBIOSYNTH0001 Trehalose acyl transferase M_tre_c + M_fataccoa_c <=> M_lmar_c + M_coa_c c FALSE PW143 SPW003 [CHECKME] added maradolipid biosynthesis and degradation wimi R_MARBIOSYNTH0002 Lysomarado acyl transferase M_lmar_c + M_fataccoa_c <=> M_mar_c + M_coa_c c FALSE PW143 SPW003 [CHECKME] added maradolipid biosynthesis and degradation wimi @@ -1702,20 +1702,20 @@ R_MARBIOSYNTH0003 Marado hydrolase M_mar_c + M_h2o_c <=> M_lmar_c + M_fatacid_c R_MARBIOSYNTH0004 Lysomarado hydrolase M_lmar_c + M_h2o_c <=> M_tre_c + M_fatacid_c + M_h_c c FALSE PW143 SPW003 [CHECKME] added maradolipid biosynthesis and degradation wimi R_MCD_m malonyl-CoA decarboxylase M_h_m + M_malcoa_m <=> M_co2_m + M_accoa_m m FALSE (WBGene00009439) PW038 R00233 added KEGG ID lenov R_MCRNtm O-Myristoylcarnitine transport into mitochondria via diffusion M_carn14_0__L_c <=> M_carn14_0__L_m cm FALSE (WBGene00000996 ) PW106 -R_MDH_c Malate dehydrogenase M_nad_c + M_mal__L_c <=> M_oaa_c + M_h_c + M_nadh_c c TRUE (WBGene00018491) or (WBGene00018491) PW023;PW073;PW030;PW018 RHEA:21432;RHEA:21432 -R_MDH_m Malate dehydrogenase M_nad_m + M_mal__L_m <=> M_oaa_m + M_h_m + M_nadh_m m TRUE WBGene00018491 or WBGene00003162 PW023;PW073;PW030;PW018 RHEA:21432;RHEA:21432;RHEA:21432 +R_MDH_c Malate dehydrogenase M_nad_c + M_mal__L_c <=> M_oaa_c + M_h_c + M_nadh_c c TRUE (WBGene00018491) or (WBGene00018491) "PW023;PW073;PW030;PW018" "RHEA:21432;RHEA:21432" +R_MDH_m Malate dehydrogenase M_nad_m + M_mal__L_m <=> M_oaa_m + M_h_m + M_nadh_m m TRUE WBGene00018491 or WBGene00003162 "PW023;PW073;PW030;PW018" "RHEA:21432;RHEA:21432;RHEA:21432" R_ME1_c Malate dehydrogenase (oxaloacetate decarboxylating) M_nad_c + M_mal__L_c <=> M_co2_c + M_nadh_c + M_pyr_c c TRUE PW018 SPW004 R_ME2_c Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) M_nadp_c + M_mal__L_c <=> M_co2_c + M_nadph_c + M_pyr_c c TRUE (WBGene00012983) PW018 SPW004 R_ME2_m Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) M_nadp_m + M_mal__L_m <=> M_co2_m + M_nadph_m + M_pyr_m m TRUE (WBGene00012983) PW018 SPW004 -R_METAT_c Methionine adenosyltransferase M_h2o_c + M_met__L_c + M_atp_c <=> M_pi_c + M_ppi_c + M_h_c + M_amet_c c FALSE (WBGene00006416) or (WBGene00015540) or (WBGene00015538) or (WBGene00008205) PW082 R00177 RHEA:21080;RHEA:21080;RHEA:21080;RHEA:21080 22939621 lenov 2.5.1.6 -R_METB0AT2tc R_METB0AT2tc M_met__L_e + M_na1_e <=> M_met__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652 or WBGene00004905) PW107 RHEA:21824;RHEA:21824 +R_METAT_c Methionine adenosyltransferase M_h2o_c + M_met__L_c + M_atp_c <=> M_pi_c + M_ppi_c + M_h_c + M_amet_c c FALSE (WBGene00006416) or (WBGene00015540) or (WBGene00015538) or (WBGene00008205) PW082 R00177 "RHEA:21080;RHEA:21080;RHEA:21080;RHEA:21080" 22939621 lenov 2.5.1.6 +R_METB0AT2tc R_METB0AT2tc M_met__L_e + M_na1_e <=> M_met__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652 or WBGene00004905) PW107 "RHEA:21824;RHEA:21824" R_Methionine_Exchange_reactions_e Methionine transport M_met__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Methionine_transport Methionine transport M_met__L_c <=> M_met__L_e ce TRUE ND PW107 -R_METHYLACYLYLCOA_HYDROXY_RXN_c Methylacrylyl-CoA hydratase M_h2o_c + M_2mp2coa_c <=> M_3hibutcoa_c c TRUE (WBGene00001156) or (WBGene00020347) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 RHEA:16105;RHEA:20724 -R_METHYLACYLYLCOA_HYDROXY_RXN_m Methylacrylyl-CoA hydratase M_h2o_m + M_2mp2coa_m <=> M_3hibutcoa_m m TRUE (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) or (WBGene00020347) or (WBGene00001151) PW083 RHEA:16105;RHEA:20724 +R_METHYLACYLYLCOA_HYDROXY_RXN_c Methylacrylyl-CoA hydratase M_h2o_c + M_2mp2coa_c <=> M_3hibutcoa_c c TRUE (WBGene00001156) or (WBGene00020347) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 "RHEA:16105;RHEA:20724" +R_METHYLACYLYLCOA_HYDROXY_RXN_m Methylacrylyl-CoA hydratase M_h2o_m + M_2mp2coa_m <=> M_3hibutcoa_m m TRUE (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) or (WBGene00020347) or (WBGene00001151) PW083 "RHEA:16105;RHEA:20724" R_METrRNAtm Met tRNA transport M_mettrna_c <=> M_mettrna_m cm TRUE PW111 -R_METS_c 5-methyltetrahydrofolate--homocysteine S-methyltransferase M_hcys__L_c + M_5mthf_c <=> M_met__L_c + M_thf_c c TRUE WBGene00010988 and WBGene00006510 PW091;PW082 RHEA:23908;RHEA:11172 -R_METS_n 5-methyltetrahydrofolate--homocysteine S-methyltransferase M_hcys__L_n + M_5mthf_n <=> M_met__L_n + M_thf_n n TRUE (WBGene00010988) PW091;PW082 RHEA:11172 +R_METS_c 5-methyltetrahydrofolate--homocysteine S-methyltransferase M_hcys__L_c + M_5mthf_c <=> M_met__L_c + M_thf_c c TRUE WBGene00010988 and WBGene00006510 "PW091;PW082" "RHEA:23908;RHEA:11172" +R_METS_n 5-methyltetrahydrofolate--homocysteine S-methyltransferase M_hcys__L_n + M_5mthf_n <=> M_met__L_n + M_thf_n n TRUE (WBGene00010988) "PW091;PW082" RHEA:11172 R_MEVK1_c Mevalonate kinase M_mev_R_c + M_atp_c <=> M_5pmev_c + 2.0 M_h_c + M_adp_c c TRUE (WBGene00021534) PW001 R02245 added KEGGID ms R_mg2_e mg2 te <=> M_mg2_e e TRUE PW111 R_MGCH_c Methylglutaconyl-CoA hydratase M_hmgcoa_c <=> M_h2o_c + M_3mgcoa_c c TRUE (WBGene00001154) PW083 @@ -1726,7 +1726,7 @@ R_MI13456PK_c 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate kinase M_atp_c + M_mi R_MI13456PK_n 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate kinase M_atp_n + M_mi13456p_n <=> 2.0 M_h_n + M_adp_n + M_minohp_n n FALSE (WBGene00012466) PW029 RHEA:20313 added rxn name jpnh R_MI1345PK_c 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate phosphotransferase 2.0 M_h_c + M_adp_c + M_mi13456p_c <=> M_atp_c + M_mi1345p_c c FALSE (WBGene00014081) PW029 added rxn name jpnh R_MI1345PK_n 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate phosphotransferase 2.0 M_h_n + M_adp_n + M_mi13456p_n <=> M_atp_n + M_mi1345p_n n FALSE (WBGene00014081) PW029 added rxn name jpnh -R_MI1345PP_c D-myo-Inositol 1,3,4,5-tetrakisphosphate 5-phosphohydrolase M_h2o_c + M_mi1345p_c <=> M_pi_c + M_mi134p_c c TRUE (WBGene00007620) or (WBGene00002146) or (WBGene00015278) PW029 RHEA:19797;RHEA:11392 added rxn name jpnh +R_MI1345PP_c D-myo-Inositol 1,3,4,5-tetrakisphosphate 5-phosphohydrolase M_h2o_c + M_mi1345p_c <=> M_pi_c + M_mi134p_c c TRUE (WBGene00007620) or (WBGene00002146) or (WBGene00015278) PW029 "RHEA:19797;RHEA:11392" added rxn name jpnh R_MI1346PK_c inositol-tetrakisphosphate 5-kinase M_atp_c + M_mi1346p_c <=> M_h_c + M_adp_c + M_mi13456p_c c FALSE PW029 R_MI134PK_c inositol-1,3,4-trisphosphate 5/6-kinase M_atp_c + M_mi134p_c <=> M_h_c + M_adp_c + M_mi1346p_c c FALSE PW029 R_MI1456PK_c D-myo-Inositol 1,3,4,5-tetrakisphosphate kinase M_atp_c + M_mi1456p_c <=> 2.0 M_h_c + M_adp_c + M_mi13456p_c c FALSE (WBGene00014081) PW029 added rxn name jpnh @@ -1735,15 +1735,15 @@ R_MI145P6K_c Inositol-polyphosphate multikinase M_atp_c + M_mi145p_c <=> 2.0 M_ R_MI145P6K_n Inositol-polyphosphate multikinase M_atp_n + M_mi145p_n <=> 2.0 M_h_n + M_adp_n + M_mi1456p_n n TRUE (WBGene00014081) PW029 set to reversible janna R_MI145PK_c 1D-myo-inositol-trisphosphate 3-kinase M_atp_c + M_mi145p_c <=> 2.0 M_h_c + M_adp_c + M_mi1345p_c c TRUE (WBGene00020631) or (WBGene00014081) or (WBGene00021260) or (WBGene00009262) or (WBGene00002979) PW029 RHEA:11020 set to reversible janna R_MI145PK_n 1D-myo-inositol-trisphosphate 3-kinase M_atp_n + M_mi145p_n <=> 2.0 M_h_n + M_adp_n + M_mi1345p_n n TRUE (WBGene00014081) or (WBGene00021260) or (WBGene00009262) PW029 set to reversible janna -R_MI145PP_c Inositol-1,4,5-trisphosphate 5-phosphatase M_h2o_c + M_mi145p_c <=> M_pi_c + M_mi14p_c c TRUE (WBGene00007620) or (WBGene00002146) or (WBGene00015278) PW029 RHEA:19797;RHEA:11392 +R_MI145PP_c Inositol-1,4,5-trisphosphate 5-phosphatase M_h2o_c + M_mi145p_c <=> M_pi_c + M_mi14p_c c TRUE (WBGene00007620) or (WBGene00002146) or (WBGene00015278) PW029 "RHEA:19797;RHEA:11392" R_MITOIMPORT0001 Fatty acid import by diffusion (C4:0) M_but_c <=> M_but_m cm TRUE PW132 SPW001 [CHECKME] Short chain fatty acids can enter mitochondria by diffusion wimi R_MITOIMPORT0002 Fatty acid import by diffusion (C6:0) M_fa6_0_c <=> M_fa6_0_m cm TRUE PW132 SPW001 [CHECKME] Short chain fatty acids can enter mitochondria by diffusion wimi R_MITOIMPORT0003 Fatty acid import by diffusion (C8:0) M_fa8_0_c <=> M_fa8_0_m cm TRUE PW132 SPW001 [CHECKME] Short chain fatty acids can enter mitochondria by diffusion wimi R_MITOIMPORT0004 Fatty acid import by diffusion (C10:0) M_fa10_0_c <=> M_fa10_0_m cm TRUE PW132 SPW001 [CHECKME] Short chain fatty acids can enter mitochondria by diffusion wimi R_MITOIMPORT0005 Fatty acid import by diffusion (C12:0) M_fa12_0_c <=> M_fa12_0_m cm TRUE PW132 SPW001 [CHECKME] Short chain fatty acids can enter mitochondria by diffusion wimi -R_MME_m Methylmalonyl-CoA epimerase M_mmcoa_R_m <=> M_mmcoa_S_m m TRUE (WBGene00008415) PW001;PW010 -R_MMM2_m Methylmalonyl-CoA mutase M_mmcoa_R_m <=> M_succoa_m m TRUE WBGene00014202 PW001;PW010 RHEA:22888 -R_MMSAD3_m Malonate-semialdehyde dehydrogenase (acetylating) M_msa_m + M_coa_m + M_nad_m <=> M_co2_m + M_nadh_m + M_accoa_m m FALSE (WBGene00000114) PW038;PW010 R00705 RHEA:20804;RHEA:22992;RHEA:22988 added name to rxn; added KEGG ID jpnh; lenov +R_MME_m Methylmalonyl-CoA epimerase M_mmcoa_R_m <=> M_mmcoa_S_m m TRUE (WBGene00008415) "PW001;PW010" +R_MMM2_m Methylmalonyl-CoA mutase M_mmcoa_R_m <=> M_succoa_m m TRUE WBGene00014202 "PW001;PW010" RHEA:22888 +R_MMSAD3_m Malonate-semialdehyde dehydrogenase (acetylating) M_msa_m + M_coa_m + M_nad_m <=> M_co2_m + M_nadh_m + M_accoa_m m FALSE (WBGene00000114) "PW038;PW010" R00705 "RHEA:20804;RHEA:22992;RHEA:22988" "added name to rxn; added KEGG ID" "jpnh; lenov" R_mn2_e mn2 te <=> M_mn2_e e TRUE PW111 R_MONOPHENOL_MONOOXYGENASE_RXN_c Monophenol monooxygenase M_tyr__L_c + M_o2_c <=> M_h2o_c + M_dopaqn_c c TRUE (WBGene00016419) PW077 R_MTAP_c 5'-methylthioadenosine phosphorylase M_5mta_c + M_pi_c <=> M_5mdr1p_c + M_ade_c c TRUE (WBGene00015064) PW082 @@ -1751,7 +1751,7 @@ R_MTHFC_c Methenyltetrahydrofolate cyclohydrolase M_h2o_c + M_methf_c <=> M_h_c R_MTHFC_m Methenyltetrahydrofolate cyclohydrolase M_h2o_m + M_methf_m <=> M_h_m + M_10fthf_m m TRUE WBGene00019492 or WBGene00000929 PW091 R_MTHFD2_c Methylenetetrahydrofolate dehydrogenase (NAD+) M_mlthf_c + M_nad_c <=> M_nadh_c + M_methf_c c TRUE (WBGene00000929) PW091 set to reversible janna R_MTHFD2_m Methylenetetrahydrofolate dehydrogenase (NAD+) M_mlthf_m + M_nad_m <=> M_nadh_m + M_methf_m m TRUE (WBGene00000929) PW091 set to reversible janna -R_MTHFR2_c Methylenetetrahydrofolate reductase (NADPH) M_h_c + M_mlthf_c + M_nadh_c <=> M_5mthf_c + M_nad_c c TRUE (WBGene00015512) PW091 RHEA:19817;RHEA:19821 set to reversible janna +R_MTHFR2_c Methylenetetrahydrofolate reductase (NADPH) M_h_c + M_mlthf_c + M_nadh_c <=> M_5mthf_c + M_nad_c c TRUE (WBGene00015512) PW091 "RHEA:19817;RHEA:19821" set to reversible janna R_MTRI_c 5-methylthioribose-1-phosphate isomerase M_5mdr1p_c <=> M_5mdru1p_c c TRUE (WBGene00007236) PW082 set to reversible janna R_MYO_INOSITOL_1_PHOSPHATE_SYNTHASE_RXN_c myo-inositol-1-phosphate synthase M_g6p_B_c <=> M_mi3p_D_c c FALSE (WBGene00012148) PW029 replaced M_mi3p__D_c with M_mi3p_D_c lenov R_MYO_INOSITOL_OXYGENASE_RXN_c Myo-inositol oxygenase M_inost_c + M_o2_c <=> M_h2o_c + M_h_c + M_glcur_c c FALSE (WBGene00016920) PW029 @@ -1760,26 +1760,26 @@ R_myoinositol_Exchange_reactions_e myoinositol transport M_inost_e <=> e TRUE P R_myoinositol_transport myoinositol transport M_inost_c <=> M_inost_e ce TRUE ND PW107 R_N_Acetylglucosamine_Exchange_reactions_e N Acetylglucosamine transport M_acgam_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_N_ACETYLGLUCOSAMINE_KINASE_RXN_c N-acetylglucosamine kinase M_acgam_c + M_atp_c <=> M_acgam6p_c + M_h_c + M_adp_c c FALSE (WBGene00021057) PW009 R01201 added KEGG ID lenov -R_N_ACETYLGLUCOSAMINE_KINASE_RXN_n N-acetylglucosamine kinase M_acgam_n + M_atp_n <=> M_acgam6p_n + M_h_n + M_adp_n n FALSE (WBGene00021057) PW009 R01201 added KEGG ID; removed redundant N-acetylglucosamine degradation I lenov +R_N_ACETYLGLUCOSAMINE_KINASE_RXN_n N-acetylglucosamine kinase M_acgam_n + M_atp_n <=> M_acgam6p_n + M_h_n + M_adp_n n FALSE (WBGene00021057) PW009 R01201 "added KEGG ID; removed redundant N-acetylglucosamine degradation I" lenov R_N_Acetylglucosamine_transport N Acetylglucosamine transport M_acgam_c <=> M_acgam_e ce TRUE TBD PW107 R_Na_H_Exchange_reactions sodium/proton Exchange reactionsr M_h_c + M_na1_e <=> M_h_e + M_na1_c ce TRUE (WBGene00003730 ) or (ND) PW107 Removed space from ID jpnh R_na1_e na1 te <=> M_na1_e e TRUE PW111 R_NABTNO_c N4-Acetylaminobutanal:NAD+ oxidoreductase M_h2o_c + M_n4abutn_c + M_nad_c <=> M_4aabutn_c + 2.0 M_h_c + M_nadh_c c TRUE (WBGene00000108) or (WBGene00000107) or (WBGene00000118) or (WBGene00000110) PW081 R05050 Added rxn name from kegg jpnh R_NABTNO_m N4-Acetylaminobutanal:NAD+ oxidoreductase M_h2o_m + M_n4abutn_m + M_nad_m <=> M_4aabutn_m + 2.0 M_h_m + M_nadh_m m TRUE (WBGene00000115) or (WBGene00000108) or (WBGene00000107) PW081 R05050 RHEA:16185 Added rxn name from kegg jpnh -R_NADDP_n NAD+ pyrophosphatase M_h2o_n + M_nad_n <=> M_nmn_n + 2.0 M_h_n + M_amp_n n FALSE (WBGene00003586) PW036 RHEA:11800;RHEA:48868 -R_NADH_DEHYDROG_A_RXN_8_m NADH dehydrogenase (ubiqui 8) 5.0 M_h_m + M_q8_m + M_nadh_m <=> 4.0 M_h_i + M_q8h2_m + M_nad_m m FALSE (WBGene00019401 and WBGene00021800 and WBGene00009051 and WBGene00013406 and WBGene00020636 and WBGene00015810 and WBGene00013237 and WBGene00006463 and WBGene00007684 and WBGene00021849 and WBGene00007192 and WBGene00017508 and WBGene00021839 and WBGene00022169 and WBGene00013308 and WBGene00003061 and WBGene00010326 and WBGene00021562 and WBGene00012166 and WBGene00010957 and WBGene00010967 and WBGene00010963 and WBGene00010958 and WBGene00010966 and WBGene00010961 and WBGene00010959 and WBGene00009992 and WBGene00001520 and WBGene00012376 and WBGene00016393 and WBGene00003831 and WBGene00008414 and WBGene00009712 and WBGene00022380 and WBGene00008225 and WBGene00007880) PW007 RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356 replaced aerobic respiration with oxidative phosphorylation lenov -R_NADH_DEHYDROG_A_RXN_9_m NADH dehydrogenase (ubiqui 9) 5.0 M_h_m + M_q9_m + M_nadh_m <=> 4.0 M_h_i + M_q9h2_m + M_nad_m m FALSE (WBGene00019401 and WBGene00021800 and WBGene00009051 and WBGene00013406 and WBGene00020636 and WBGene00015810 and WBGene00013237 and WBGene00006463 and WBGene00007684 and WBGene00021849 and WBGene00007192 and WBGene00017508 and WBGene00021839 and WBGene00022169 and WBGene00013308 and WBGene00003061 and WBGene00010326 and WBGene00021562 and WBGene00012166 and WBGene00010957 and WBGene00010967 and WBGene00010963 and WBGene00010958 and WBGene00010966 and WBGene00010961 and WBGene00010959 and WBGene00009992 and WBGene00001520 and WBGene00012376 and WBGene00016393 and WBGene00003831 and WBGene00008414 and WBGene00009712 and WBGene00022380 and WBGene00008225 and WBGene00007880) PW007 RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356 replaced aerobic respiration with oxidative phosphorylation lenov +R_NADDP_n NAD+ pyrophosphatase M_h2o_n + M_nad_n <=> M_nmn_n + 2.0 M_h_n + M_amp_n n FALSE (WBGene00003586) PW036 "RHEA:11800;RHEA:48868" +R_NADH_DEHYDROG_A_RXN_8_m NADH dehydrogenase (ubiqui 8) 5.0 M_h_m + M_q8_m + M_nadh_m <=> 4.0 M_h_i + M_q8h2_m + M_nad_m m FALSE (WBGene00019401 and WBGene00021800 and WBGene00009051 and WBGene00013406 and WBGene00020636 and WBGene00015810 and WBGene00013237 and WBGene00006463 and WBGene00007684 and WBGene00021849 and WBGene00007192 and WBGene00017508 and WBGene00021839 and WBGene00022169 and WBGene00013308 and WBGene00003061 and WBGene00010326 and WBGene00021562 and WBGene00012166 and WBGene00010957 and WBGene00010967 and WBGene00010963 and WBGene00010958 and WBGene00010966 and WBGene00010961 and WBGene00010959 and WBGene00009992 and WBGene00001520 and WBGene00012376 and WBGene00016393 and WBGene00003831 and WBGene00008414 and WBGene00009712 and WBGene00022380 and WBGene00008225 and WBGene00007880) PW007 "RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356" replaced aerobic respiration with oxidative phosphorylation lenov +R_NADH_DEHYDROG_A_RXN_9_m NADH dehydrogenase (ubiqui 9) 5.0 M_h_m + M_q9_m + M_nadh_m <=> 4.0 M_h_i + M_q9h2_m + M_nad_m m FALSE (WBGene00019401 and WBGene00021800 and WBGene00009051 and WBGene00013406 and WBGene00020636 and WBGene00015810 and WBGene00013237 and WBGene00006463 and WBGene00007684 and WBGene00021849 and WBGene00007192 and WBGene00017508 and WBGene00021839 and WBGene00022169 and WBGene00013308 and WBGene00003061 and WBGene00010326 and WBGene00021562 and WBGene00012166 and WBGene00010957 and WBGene00010967 and WBGene00010963 and WBGene00010958 and WBGene00010966 and WBGene00010961 and WBGene00010959 and WBGene00009992 and WBGene00001520 and WBGene00012376 and WBGene00016393 and WBGene00003831 and WBGene00008414 and WBGene00009712 and WBGene00022380 and WBGene00008225 and WBGene00007880) PW007 "RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356" replaced aerobic respiration with oxidative phosphorylation lenov R_nadhtm nadhtm M_nadh_m <=> M_nadh_c mc TRUE PW111 R_NADK_c NAD(+) kinase M_atp_c + M_nad_c <=> 2.0 M_h_c + M_adp_c + M_nadp_c c FALSE (WBGene00022307) PW036 R_nadphtm nadphtm M_nadph_m <=> M_nadph_c mc TRUE PW111 R_NADPHtn NADPH transport, nuclear through pores M_nadph_n <=> M_nadph_c nc TRUE PW108 -R_NADPPPS_c R_NADPPPS_c M_pi_c + M_nad_c <=> M_h2o_c + M_nadp_c c FALSE (WBGene00011879) or (WBGene00017427) or (WBGene00022770) or (WBGene00008936) or (WBGene00011262) or (WBGene00018696) or (WBGene00010411) or (WBGene00013646) or (WBGene00022246) or (WBGene00022245) or (WBGene00022379) or (WBGene00015161) or (WBGene00022181) or (WBGene00007331) or (WBGene00007328) or (WBGene00009146) or (WBGene00008801) or (WBGene00008804) or (WBGene00008802) or (WBGene00004023) or (WBGene00004020) or (WBGene00016152) or (WBGene00020471) PW036 RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017 +R_NADPPPS_c R_NADPPPS_c M_pi_c + M_nad_c <=> M_h2o_c + M_nadp_c c FALSE (WBGene00011879) or (WBGene00017427) or (WBGene00022770) or (WBGene00008936) or (WBGene00011262) or (WBGene00018696) or (WBGene00010411) or (WBGene00013646) or (WBGene00022246) or (WBGene00022245) or (WBGene00022379) or (WBGene00015161) or (WBGene00022181) or (WBGene00007331) or (WBGene00007328) or (WBGene00009146) or (WBGene00008801) or (WBGene00008804) or (WBGene00008802) or (WBGene00004023) or (WBGene00004020) or (WBGene00016152) or (WBGene00020471) PW036 "RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017" R_NADPPPS_m R_NADPPPS_m M_pi_m + M_nad_m <=> M_h2o_m + M_nadp_m m FALSE (WBGene00044044) or (WBGene00010411) or (WBGene00013654) PW036 R_nadptm nadptm M_nadp_m <=> M_nadp_c mc TRUE PW111 -R_NADS1_c NAD(+) synthetase M_nh3_c + M_dnad_c + M_atp_c <=> M_ppi_c + M_h_c + M_amp_c + M_nad_c c FALSE (WBGene00007698) PW036 RHEA:24384;RHEA:24384 -R_NADS1_m NAD(+) synthetase M_nh3_m + M_dnad_m + M_atp_m <=> M_ppi_m + M_h_m + M_amp_m + M_nad_m m FALSE (WBGene00007698) PW036 RHEA:24384;RHEA:24384 -R_NADS2_c NAD(+) synthetase (glutamine-hydrolysing) M_h2o_c + M_dnad_c + M_gln__L_c + M_atp_c <=> M_ppi_c + 2.0 M_h_c + M_glu__L_c + M_amp_c + M_nad_c c FALSE (WBGene00007698) PW036 RHEA:24384;RHEA:24384 -R_NADS2_m NAD(+) synthetase (glutamine-hydrolysing) M_h2o_m + M_dnad_m + M_gln__L_m + M_atp_m <=> M_ppi_m + 2.0 M_h_m + M_glu__L_m + M_amp_m + M_nad_m m FALSE (WBGene00007698) PW036 RHEA:24384;RHEA:24384 +R_NADS1_c NAD(+) synthetase M_nh3_c + M_dnad_c + M_atp_c <=> M_ppi_c + M_h_c + M_amp_c + M_nad_c c FALSE (WBGene00007698) PW036 "RHEA:24384;RHEA:24384" +R_NADS1_m NAD(+) synthetase M_nh3_m + M_dnad_m + M_atp_m <=> M_ppi_m + M_h_m + M_amp_m + M_nad_m m FALSE (WBGene00007698) PW036 "RHEA:24384;RHEA:24384" +R_NADS2_c NAD(+) synthetase (glutamine-hydrolysing) M_h2o_c + M_dnad_c + M_gln__L_c + M_atp_c <=> M_ppi_c + 2.0 M_h_c + M_glu__L_c + M_amp_c + M_nad_c c FALSE (WBGene00007698) PW036 "RHEA:24384;RHEA:24384" +R_NADS2_m NAD(+) synthetase (glutamine-hydrolysing) M_h2o_m + M_dnad_m + M_gln__L_m + M_atp_m <=> M_ppi_m + 2.0 M_h_m + M_glu__L_m + M_amp_m + M_nad_m m FALSE (WBGene00007698) PW036 "RHEA:24384;RHEA:24384" R_nadtm nadtm M_nad_m <=> M_nad_c mc TRUE PW111 R_NADtn NAD transport, nuclear through pores M_nad_n <=> M_nad_c nc TRUE PW108 R_NADTRHD_c NAD(P)(+) transhydrogenase (AB-specific) M_nadph_c + M_nad_c <=> M_nadh_c + M_nadp_c c FALSE (WBGene00003778) PW036 @@ -1787,28 +1787,28 @@ R_NADTRHD_m NAD(P)(+) transhydrogenase (AB-specific) M_nadph_m + M_nad_m <=> M_ R_NAPRT_c Nicotinate phosphoribosyltransferase M_nicrnt_c + M_ppi_c <=> M_prpp_c + M_h_c + M_nac_c c TRUE (WBGene00021882) PW036 RHEA:36163 R_NAPRT_m Nicotinate phosphoribosyltransferase M_nicrnt_m + M_ppi_m <=> M_prpp_m + M_h_m + M_nac_m m TRUE (WBGene00021882) PW036 RHEA:36163 R_NCKt Na+/Ca2+-K+ Exchange reactions M_ca2_e + M_k_e + 4.0 M_na1_c <=> 4.0 M_na1_e + M_ca2_c + M_k_c ec TRUE (WBGene00003569 ) or (WBGene00003570) PW107 -R_NDP3_c Guanosine-diphosphatase M_h2o_c + M_gdp_c <=> M_pi_c + M_h_c + M_gmp_c c FALSE (WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697 PW042 RHEA:36799;RHEA:36799;RHEA:36799 +R_NDP3_c Guanosine-diphosphatase M_h2o_c + M_gdp_c <=> M_pi_c + M_h_c + M_gmp_c c FALSE (WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697 PW042 "RHEA:36799;RHEA:36799;RHEA:36799" R_NDP3_m Guanosine-diphosphatase M_h2o_m + M_gdp_m <=> M_pi_m + M_h_m + M_gmp_m m FALSE (WBGene00017244) PW042 RHEA:36799 -R_NDP7_c R_NDP7_c M_h2o_c + M_udp_c <=> M_pi_c + M_h_c + M_ump_c c FALSE (WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697 PW043 RHEA:36799;RHEA:36799;RHEA:36799 +R_NDP7_c R_NDP7_c M_h2o_c + M_udp_c <=> M_pi_c + M_h_c + M_ump_c c FALSE (WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697 PW043 "RHEA:36799;RHEA:36799;RHEA:36799" R_NDP7_m R_NDP7_m M_h2o_m + M_udp_m <=> M_pi_m + M_h_m + M_ump_m m FALSE (WBGene00017244) PW043 RHEA:36799 -R_NDPK2_c ATP:UDP phosphotransferase M_atp_c + M_udp_c <=> M_h_c + M_adp_c + M_utp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set reversibility=TRUE jpnh; janna -R_NDPK2_m ATP:UDP phosphotransferase M_atp_m + M_udp_m <=> M_h_m + M_adp_m + M_utp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 added name to rxn; set to reversible jpnh; janna -R_NDPK2_n ATP:UDP phosphotransferase M_atp_n + M_udp_n <=> M_h_n + M_adp_n + M_utp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK3_c ATP:CDP phosphotransferase M_atp_c + M_cdp_c <=> M_h_c + M_adp_c + M_ctp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK3_m ATP:CDP phosphotransferase M_atp_m + M_cdp_m <=> M_h_m + M_adp_m + M_ctp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 added name to rxn; set to reversible jpnh; janna -R_NDPK3_n ATP:CDP phosphotransferase M_atp_n + M_cdp_n <=> M_h_n + M_adp_n + M_ctp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK4_c ATP:dTDP phosphotransferase M_atp_c + M_dtdp_c <=> M_h_c + M_adp_c + M_dttp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK4_m ATP:dTDP phosphotransferase M_atp_m + M_dtdp_m <=> M_h_m + M_adp_m + M_dttp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 added name to rxn; set to reversible jpnh; janna -R_NDPK4_n ATP:dTDP phosphotransferase M_atp_n + M_dtdp_n <=> M_h_n + M_adp_n + M_dttp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna +R_NDPK2_c ATP:UDP phosphotransferase M_atp_c + M_udp_c <=> M_h_c + M_adp_c + M_utp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set reversibility=TRUE" "jpnh; janna" +R_NDPK2_m ATP:UDP phosphotransferase M_atp_m + M_udp_m <=> M_h_m + M_adp_m + M_utp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK2_n ATP:UDP phosphotransferase M_atp_n + M_udp_n <=> M_h_n + M_adp_n + M_utp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK3_c ATP:CDP phosphotransferase M_atp_c + M_cdp_c <=> M_h_c + M_adp_c + M_ctp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK3_m ATP:CDP phosphotransferase M_atp_m + M_cdp_m <=> M_h_m + M_adp_m + M_ctp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK3_n ATP:CDP phosphotransferase M_atp_n + M_cdp_n <=> M_h_n + M_adp_n + M_ctp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK4_c ATP:dTDP phosphotransferase M_atp_c + M_dtdp_c <=> M_h_c + M_adp_c + M_dttp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK4_m ATP:dTDP phosphotransferase M_atp_m + M_dtdp_m <=> M_h_m + M_adp_m + M_dttp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK4_n ATP:dTDP phosphotransferase M_atp_n + M_dtdp_n <=> M_h_n + M_adp_n + M_dttp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" R_NDPK5_c ATP:dGDP phosphotransferase M_dgdp_c + M_atp_c <=> M_dgtp_c + M_adp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW042 RHEA:44640 set to reversible janna R_NDPK5_m R_NDPK5_m M_dgdp_m + M_atp_m <=> M_dgtp_m + M_adp_m m TRUE (WBGene00019899) or (WBGene00021692) PW042 set to reversible janna R_NDPK5_n R_NDPK5_n M_dgdp_n + M_atp_n <=> M_dgtp_n + M_adp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW042 RHEA:44640 set to reversible janna -R_NDPK6_c ATP:dUDP phosphotransferase M_atp_c + M_dudp_c <=> M_adp_c + M_dutp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK6_m ATP:dUDP phosphotransferase M_atp_m + M_dudp_m <=> M_adp_m + M_dutp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 added name to rxn; set to reversible; added the R_ janna; jpnh -R_NDPK6_n ATP:dUDP phosphotransferase M_atp_n + M_dudp_n <=> M_adp_n + M_dutp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK7_c ATP:dCDP phosphotransferase M_atp_c + M_dcdp_c <=> M_adp_c + M_dctp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna -R_NDPK7_m ATP:dCDP phosphotransferase M_atp_m + M_dcdp_m <=> M_adp_m + M_dctp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 added name to rxn; set to reversible jpnh; janna -R_NDPK7_n ATP:dCDP phosphotransferase M_atp_n + M_dcdp_n <=> M_adp_n + M_dctp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 added name to rxn; set to reversible jpnh; janna +R_NDPK6_c ATP:dUDP phosphotransferase M_atp_c + M_dudp_c <=> M_adp_c + M_dutp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK6_m ATP:dUDP phosphotransferase M_atp_m + M_dudp_m <=> M_adp_m + M_dutp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 "added name to rxn; set to reversible; added the R_" "janna; jpnh" +R_NDPK6_n ATP:dUDP phosphotransferase M_atp_n + M_dudp_n <=> M_adp_n + M_dutp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK7_c ATP:dCDP phosphotransferase M_atp_c + M_dcdp_c <=> M_adp_c + M_dctp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK7_m ATP:dCDP phosphotransferase M_atp_m + M_dcdp_m <=> M_adp_m + M_dctp_m m TRUE (WBGene00019899) or (WBGene00021692) PW043 "added name to rxn; set to reversible" "jpnh; janna" +R_NDPK7_n ATP:dCDP phosphotransferase M_atp_n + M_dcdp_n <=> M_adp_n + M_dctp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW043 RHEA:44640 "added name to rxn; set to reversible" "jpnh; janna" R_NDPK8_c ATP:dADP phosphotransferase M_atp_c + M_dadp_c <=> M_datp_c + M_adp_c c TRUE (WBGene00019899) or (WBGene00018851) or (WBGene00009119) or (WBGene00021692) PW042 RHEA:44640 set to reversible janna R_NDPK8_m R_NDPK8_m M_atp_m + M_dadp_m <=> M_datp_m + M_adp_m m TRUE (WBGene00019899) or (WBGene00021692) PW042 set to reversible janna R_NDPK8_n R_NDPK8_n M_atp_n + M_dadp_n <=> M_datp_n + M_adp_n n TRUE (WBGene00019899) or (WBGene00009119) or (WBGene00021692) PW042 RHEA:44640 set to reversible janna @@ -1824,9 +1824,9 @@ R_NKCC2t Na+-K+-Cl- cotransport (NH4+) M_nh3_e + M_na1_e + 2.0 M_cl_e <=> M_nh3 R_NKCCt Na+-K+-Cl- cotransport M_na1_e + 2.0 M_cl_e + M_k_e <=> 2.0 M_cl_c + M_na1_c + M_k_c ec TRUE (WBGene00012543) PW107 R_NMNtn NMN transport, nuclear trhough pore M_nmn_c <=> M_nmn_n cn TRUE PW108 R_NNAM_c Nicotinamidase M_h2o_c + M_ncam_c <=> M_nh3_c + M_h_c + M_nac_c c TRUE (WBGene00021395) PW036 -R_NNAT_c Nicotinate-nucleotide adenylyltransferase M_nicrnt_c + M_atp_c + M_h_c <=> M_dnad_c + M_ppi_c c TRUE WBGene00012295 or WBGene00009176 PW036 RHEA:21360;RHEA:22860;RHEA:22860;RHEA:21360 set to reversible janna -R_NNAT_m Nicotinate-nucleotide adenylyltransferase M_nicrnt_m + M_atp_m + M_h_m <=> M_dnad_m + M_ppi_m m FALSE (WBGene00009176) PW036 RHEA:21360;RHEA:22860 -R_NNAT_n Nicotinate-nucleotide adenylyltransferase M_atp_n + M_nicrnt_n + M_h_n <=> M_ppi_n + M_dnad_n n FALSE (WBGene00012295) or (WBGene00009176) PW036 RHEA:21360;RHEA:22860;RHEA:22860;RHEA:21360 +R_NNAT_c Nicotinate-nucleotide adenylyltransferase M_nicrnt_c + M_atp_c + M_h_c <=> M_dnad_c + M_ppi_c c TRUE WBGene00012295 or WBGene00009176 PW036 "RHEA:21360;RHEA:22860;RHEA:22860;RHEA:21360" set to reversible janna +R_NNAT_m Nicotinate-nucleotide adenylyltransferase M_nicrnt_m + M_atp_m + M_h_m <=> M_dnad_m + M_ppi_m m FALSE (WBGene00009176) PW036 "RHEA:21360;RHEA:22860" +R_NNAT_n Nicotinate-nucleotide adenylyltransferase M_atp_n + M_nicrnt_n + M_h_n <=> M_ppi_n + M_dnad_n n FALSE (WBGene00012295) or (WBGene00009176) PW036 "RHEA:21360;RHEA:22860;RHEA:22860;RHEA:21360" R_NTD10_c R_NTD10_c M_h2o_c + M_xmp_c <=> M_pi_c + M_xtsn_c c TRUE WBGene00017775 or WBGene00012423 or WBGene00022201 PW042 R_NTD11_c R_NTD11_c M_h2o_c + M_imp_c <=> M_pi_c + M_ins_c c TRUE WBGene00017775 or WBGene00012423 or WBGene00022201 PW042 R_NTD7_c AMP-5'-nucleotidase M_h2o_c + M_amp_c <=> M_pi_c + M_adn_c c TRUE WBGene00017775 or WBGene00012423 or WBGene00022201 PW042 @@ -1842,27 +1842,27 @@ R_OCDCAFAPMtc octadecanoate (n-C18:0) transport M_fa18_0_e <=> M_fa18_0_c ec TRU R_OCDCAFATPtc R_OCDCAFATPtc M_atp_c + M_coa_c + M_fa18_0_e <=> M_ppi_c + M_amp_c + M_coa18_0_c c FALSE (WBGene00020837 or WBGene00012804 or WBGene00010421 or WBGene00012629 or WBGene00016628 or WBGene00010307 or WBGene00017012 or WBGene00009218 or WBGene00013039 or WBGene00015389 or WBGene00013578) PW107 R_OH_Exchange_reactions_e OH transport M_oh_e <=> e TRUE (WBGene00007388) Removed space from reaction ID jpnh R_OLEICBETAOX0001 Acyl-CoA-dehydrogenase (C18:1(9Z), mitochondrial) M_h_m + M_fad_m + M_coa18_1_9z_c <=> M_fadh2_m + M_coa18_2_2e9z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW117 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi -R_OLEICBETAOX0002 Enoyl-CoA-hydratase (C18:2(2E,9Z), mitochondrial) M_coa18_2_2e9z_m + M_h2o_m <=> M_coa18_1_9z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW117 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi +R_OLEICBETAOX0002 Enoyl-CoA-hydratase (C18:2(2E,9Z), mitochondrial) M_coa18_2_2e9z_m + M_h2o_m <=> M_coa18_1_9z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW117 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0003 (S)-3-hydroxyacyl-CoA-dehydrogenase (C18:1(9Z,3(S)OH), mitochondrial) M_nad_m + M_coa18_1_9z3oh__S_m <=> M_h_m + M_nadh_m + M_coa18_1_9z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0004 3-ketothiolase (C18:1(9Z,3O), mitochondrial) M_coa18_1_9z3o_m + M_coa_m <=> M_accoa_m + M_coa16_1_7z_m m FALSE WBGene00009952 or WBGene00015125 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0005 Acyl-CoA-dehydrogenase (C16:1(7Z), mitochondrial) M_h_m + M_fad_m + M_coa16_1_7z_m <=> M_fadh2_m + M_coa16_2_2e7z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW117 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi -R_OLEICBETAOX0006 Enoyl-CoA-hydratase (C16:2(2E,7Z), mitochondrial) M_coa16_2_2e7z_m + M_h2o_m <=> M_coa16_1_7z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW117 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi +R_OLEICBETAOX0006 Enoyl-CoA-hydratase (C16:2(2E,7Z), mitochondrial) M_coa16_2_2e7z_m + M_h2o_m <=> M_coa16_1_7z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW117 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0007 (S)-3-hydroxyacyl-CoA-dehydrogenase (C16:1(7Z,3(S)OH), mitochondrial) M_nad_m + M_coa16_1_7z3oh__S_m <=> M_h_m + M_nadh_m + M_coa16_1_7z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0008 3-ketothiolase (C16:1(7Z,3O), mitochondrial) M_coa16_1_7z3o_m + M_coa_m <=> M_accoa_m + M_coa14_1_5z_m m FALSE WBGene00009952 or WBGene00015125 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0009 Acyl-CoA-dehydrogenase (C14:1(5Z), mitochondrial) M_h_m + M_fad_m + M_coa14_1_5z_m <=> M_fadh2_m + M_coa14_2_2e5z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW117 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi -R_OLEICBETAOX0010 Enoyl-CoA-hydratase (C14:2(2E,5Z), mitochondrial) M_coa14_2_2e5z_m + M_h2o_m <=> M_coa14_1_5z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW117 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi +R_OLEICBETAOX0010 Enoyl-CoA-hydratase (C14:2(2E,5Z), mitochondrial) M_coa14_2_2e5z_m + M_h2o_m <=> M_coa14_1_5z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW117 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0011 (S)-3-hydroxyacyl-CoA-dehydrogenase (C14:1(5Z,3(S)OH), mitochondrial) M_nad_m + M_coa14_1_5z3oh__S_m <=> M_h_m + M_nadh_m + M_coa14_1_5z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0012 3-ketothiolase (C14:1(5Z,3O), mitochondrial) M_coa14_1_5z3o_m + M_coa_m <=> M_accoa_m + M_coa12_1_3z_m m FALSE WBGene00009952 or WBGene00015125 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi R_OLEICBETAOX0013 Enoyl-CoA delta isomerase (C12:1(3Z), mitochondrial) M_coa12_1_3z_m <=>M_coa12_1_2e_m m FALSE WBGene00001153 PW117 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0089 wimi -R_OMEGA_HYDROXYDECANOATE_DEHYDROGENASE_RXN_c ω-hydroxydecanoate dehydrogenase M_fa10_0_10oh_c + M_nad_c <=> M_fa10_0_10o_c + M_h_c + M_nadh_c c FALSE PW060 SPW001 -R_OMPDC_c Orotidine-5'-phosphate decarboxylase M_orot5p_c + M_h_c <=> M_co2_c + M_ump_c c TRUE WBGene00020036 or WBGene00011559 PW043 RHEA:10380;RHEA:11596 +R_OMEGA_HYDROXYDECANOATE_DEHYDROGENASE_RXN_c "ω-hydroxydecanoate dehydrogenase" M_fa10_0_10oh_c + M_nad_c <=> M_fa10_0_10o_c + M_h_c + M_nadh_c c FALSE PW060 SPW001 +R_OMPDC_c Orotidine-5'-phosphate decarboxylase M_orot5p_c + M_h_c <=> M_co2_c + M_ump_c c TRUE WBGene00020036 or WBGene00011559 PW043 "RHEA:10380;RHEA:11596" R_OPAH_c 5-oxoprolinase (ATP-hydrolysing) M_5oxpro_c + 2.0 M_h2o_c + M_atp_c <=> M_pi_c + 2.0 M_h_c + M_glu__L_c + M_adp_c c FALSE (WBGene00021430) PW071 R_ORNDECARBOX_RXN_c Ornithine decarboxylase M_h_c + M_orn_c <=> M_co2_c + M_ptrc_c c FALSE WBGene00018764 or WBGene00003844 PW081 RHEA:22964 [DELETION] Merge into R_RXN909_41_c jpnh R_ORNITHINE_GLU_AMINOTRANSFORASE_RXN_m Ornithine--oxo-glutarate aminotransferase M_akg_m + M_orn_m <=> M_glu5sa_m + M_glu__L_m m TRUE (WBGene00015814) PW081 RHEA:13877 R_ORNt3m ornithine mitochondrial transport via proton antiport M_h_c + M_orn_m <=> M_h_m + M_orn_c cm TRUE (WBGene00020422) or (ND) PW106 R_ORNt4m ornithine mitochondrial transport Exchange reactions with citruline M_citr__L_c + M_h_c + M_orn_m <=> M_h_m + M_orn_c + M_citr__L_m cm TRUE (WBGene00020422) PW106 replaced M_citr__L_m and M_citr__L_c with M_citr_L_m and M_citr_L_c lenov R_ORNtiDF ornithine transport via diffusion (extracellular to cytosol) M_orn_e <=> M_orn_c ec TRUE (WBGene00017747 ) or (WBGene00015197) or (WBGene00016806) or (ND) PW107 set to reversible janna -R_ORPT_c Orotate phosphoribosyltransferase M_orot5p_c + M_ppi_c <=> M_orot_c + M_prpp_c c TRUE (WBGene00011559) or (WBGene00020036) PW043 RHEA:10380;RHEA:11596 +R_ORPT_c Orotate phosphoribosyltransferase M_orot5p_c + M_ppi_c <=> M_orot_c + M_prpp_c c TRUE (WBGene00011559) or (WBGene00020036) PW043 "RHEA:10380;RHEA:11596" R_Oscr_even M_fa20_0_c + M_o2_c + M_nadph_c + M_h_c <=> M_20oharach_c + M_h2o_c + M_nadp_c c FALSE TBD PW050 SPW002 [CHECK ME]First instance of Ascr biosynthesis wimi R_Oscr_evenCoA M_atp_c + M_coa_c + M_oscr_36_c <=> M_ppi_c + M_amp_c + M_oscr_36coa_c c FALSE TBD PW050 SPW002 [CHECK ME]First instance of Ascr biosynthesis wimi R_Oscr_odd M_fa21_0_c + M_o2_c + M_nadph_c + M_h_c <=> M_21ohfa21_c + M_h2o_c + M_nadp_c c FALSE TBD PW050 SPW002 [CHECK ME]First instance of Ascr biosynthesis wimi @@ -1977,15 +1977,15 @@ R_PADGBIOSYNTH0013 Monoacylglycerol-acyl transferase (2-acyl-MG) M_fataccoa_c + R_PADGBIOSYNTH0014 1-acyl-sn-glycerol kinase (cytosol) M_atp_c + M_1acglyc_c <=> M_h_c + M_adp_c + M_1acglyc3p_c c FALSE WBGene00018674 PW137 SPW003 [CHECKME] replaces R_ACYLGLYCEROL_KINASE_RXN_c wimi R_PAI5pLtn phosphatidylinositol 5 transport (diffusion) M_1ac2acg3pi5p_c <=> M_1ac2acg3pi5p_n cn TRUE PW108 R_PALMITOLEICBETAOX0001 Acyl-CoA-dehydrogenase (C16:1(9Z), mitochondrial) M_h_m + M_fad_m + M_coa16_1_9z_m <=> M_fadh2_m + M_coa16_2_2e9z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW116 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi -R_PALMITOLEICBETAOX0002 Enoyl-CoA-hydratase (C16:2(2E,9Z), mitochondrial) M_coa16_2_2e9z_m + M_h2o_m <=> M_coa16_1_9z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW116 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi +R_PALMITOLEICBETAOX0002 Enoyl-CoA-hydratase (C16:2(2E,9Z), mitochondrial) M_coa16_2_2e9z_m + M_h2o_m <=> M_coa16_1_9z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW116 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0003 (S)-3-hydroxyacyl-CoA-dehydrogenase (C16:1(9Z,3(S)OH), mitochondrial) M_nad_m + M_coa16_1_9z3oh__S_m <=> M_h_m + M_nadh_m + M_coa16_1_9z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0004 3-ketothiolase (C16:1(9Z,3O), mitochondrial) M_coa16_1_9z3o_m + M_coa_m <=> M_accoa_m + M_coa14_1_7z_m m FALSE WBGene00009952 or WBGene00015125 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0005 Acyl-CoA-dehydrogenase (C14:1(7Z), mitochondrial) M_h_m + M_fad_m + M_coa14_1_7z_m <=> M_fadh2_m + M_coa14_2_2e7z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW116 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi -R_PALMITOLEICBETAOX0006 Enoyl-CoA-hydratase (C14:2(2E,7Z), mitochondrial) M_coa14_2_2e7z_m + M_h2o_m <=> M_coa14_1_7z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW116 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi +R_PALMITOLEICBETAOX0006 Enoyl-CoA-hydratase (C14:2(2E,7Z), mitochondrial) M_coa14_2_2e7z_m + M_h2o_m <=> M_coa14_1_7z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW116 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0007 (S)-3-hydroxyacyl-CoA-dehydrogenase (C14:1(7Z,3(S)OH), mitochondrial) M_nad_m + M_coa14_1_7z3oh__S_m <=> M_h_m + M_nadh_m + M_coa14_1_7z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0008 3-ketothiolase (C14:1(7Z,3O), mitochondrial) M_coa14_1_7z3o_m + M_coa_m <=> M_accoa_m + M_coa12_1_5z_m m FALSE WBGene00009952 or WBGene00015125 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0009 Acyl-CoA-dehydrogenase (C12:1(5Z), mitochondrial) M_h_m + M_fad_m + M_coa12_1_5z_m <=> M_fadh2_m + M_coa12_2_2e5z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW116 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi -R_PALMITOLEICBETAOX0010 Enoyl-CoA-hydratase (C12:2(2E,5Z), mitochondrial) M_coa12_2_2e5z_m + M_h2o_m <=> M_coa12_1_5z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW116 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi +R_PALMITOLEICBETAOX0010 Enoyl-CoA-hydratase (C12:2(2E,5Z), mitochondrial) M_coa12_2_2e5z_m + M_h2o_m <=> M_coa12_1_5z3oh__S_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW116 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0011 (S)-3-hydroxyacyl-CoA-dehydrogenase (C12:1(5Z,3(S)OH), mitochondrial) M_nad_m + M_coa12_1_5z3oh__S_m <=> M_h_m + M_nadh_m + M_coa12_1_5z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0012 3-ketothiolase (C12:1(5Z,3O), mitochondrial) M_coa12_1_5z3o_m + M_coa_m <=> M_accoa_m + M_coa10_1_3z_m m FALSE WBGene00009952 or WBGene00015125 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi R_PALMITOLEICBETAOX0013 Enoyl-CoA delta isomerase (C10:1(3Z), mitochondrial) M_coa10_1_3z_m <=> M_coa10_1_2e_m m FALSE WBGene00001153 PW116 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0088 wimi @@ -1994,10 +1994,10 @@ R_Pantothenate_transport Pantothenate transport M_pnto_R_c <=> M_pnto_R_e ce TRU R_PC_m Pyruvate carboxylase M_hco3_m + M_atp_m + M_pyr_m <=> M_oaa_m + M_pi_m + 2.0 M_h_m + M_adp_m m FALSE (WBGene00004258) PW023 SPW004 RHEA:20844 R_PCLAD_c Aminocarboxymuconate-semialdehyde decarboxylase M_cmusa_c + M_h_c <=> M_co2_c + M_am6sa_c c FALSE (WBGene00022104) PW072 RHEA:16557 R_PCRNtm O-Palmitoylcarnitine transport into mitochondria via diffusion M_carn16_0__L_c <=> M_carn16_0__L_m cm FALSE WBGene00000996 or WBGene00008320 PW106 -R_PDE4_c 3′,5′-cyclic-GMP phosphodiesterase M_h2o_c + M_35cgmp_c <=> M_h_c + M_gmp_c c FALSE (WBGene00016328) or (WBGene00003966) or (WBGene00011433) or (WBGene00020114) or (WBGene00022389) or (WBGene00008443) or (WBGene00011146) PW034;PW042 RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653 -R_PDE4_m 3′,5′-cyclic-GMP phosphodiesterase M_h2o_m + M_35cgmp_m <=> M_h_m + M_gmp_m m FALSE (WBGene00003966) PW034;PW042 -R_PDE4_n 3′,5′-cyclic-GMP phosphodiesterase M_h2o_n + M_35cgmp_n <=> M_h_n + M_gmp_n n FALSE (WBGene00016328) or (WBGene00003966) or (WBGene00011433) or (WBGene00020114) or (WBGene00022389) PW034;PW042 RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653 -R_PDH_m pyruvate dehydrogenase M_coa_m + M_nad_m + M_pyr_m <=> M_co2_m + M_nadh_m + M_accoa_m m FALSE (WBGene00010794 and WBGene00007824 and WBGene00009082 and WBGene00015413 and WBGene00011510) PW018;PW022;PW023;PW030 RHEA:19189;RHEA:17017;RHEA:15045;RHEA:19189 +R_PDE4_c "3′,5′-cyclic-GMP phosphodiesterase" M_h2o_c + M_35cgmp_c <=> M_h_c + M_gmp_c c FALSE (WBGene00016328) or (WBGene00003966) or (WBGene00011433) or (WBGene00020114) or (WBGene00022389) or (WBGene00008443) or (WBGene00011146) "PW034;PW042" "RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653" +R_PDE4_m "3′,5′-cyclic-GMP phosphodiesterase" M_h2o_m + M_35cgmp_m <=> M_h_m + M_gmp_m m FALSE (WBGene00003966) "PW034;PW042" +R_PDE4_n "3′,5′-cyclic-GMP phosphodiesterase" M_h2o_n + M_35cgmp_n <=> M_h_n + M_gmp_n n FALSE (WBGene00016328) or (WBGene00003966) or (WBGene00011433) or (WBGene00020114) or (WBGene00022389) "PW034;PW042" "RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653" +R_PDH_m pyruvate dehydrogenase M_coa_m + M_nad_m + M_pyr_m <=> M_co2_m + M_nadh_m + M_accoa_m m FALSE (WBGene00010794 and WBGene00007824 and WBGene00009082 and WBGene00015413 and WBGene00011510) "PW018;PW022;PW023;PW030" "RHEA:19189;RHEA:17017;RHEA:15045;RHEA:19189" R_PEPCARBOX_RXN_c Phosphoenolpyruvate carboxylase M_oaa_c + M_pi_c + M_h_c <=> M_co2_c + M_h2o_c + M_pep_c c TRUE PW018 SPW004 R_PEPCK_c Phosphoenolpyruvate carboxykinase (GTP) M_oaa_c + M_gtp_c <=> M_co2_c + M_pep_c + M_gdp_c c TRUE (WBGene00021043) or (WBGene00011232) or (WBGene00019151) PW018 SPW004 set to reversible janna R_PEPCK_m Phosphoenolpyruvate carboxykinase (GTP) M_oaa_m + M_gtp_m <=> M_co2_m + M_pep_m + M_gdp_m m FALSE (WBGene00021043) PW018 SPW004 @@ -2025,37 +2025,37 @@ R_PEPLYStn peptide (lysine) nuclear transport via diffusion M_peplys_c <=> M_pep R_peptide_te peptide te <=> M_peptide_c c TRUE PW111 [DELETION] Merge into R_Peptides_transport jpnh R_Peptides_Exchange_reactions_e Peptides transport M_peptide_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Peptides_transport Peptides transport M_peptide_c <=> M_peptide_e ce TRUE PW107 Merged [ALT ID] R_peptide_te and R_TCE1150 to here jpnh -R_PEROXID_RXN_c Peroxidase M_h2o2_c + M_donor_h2_c <=> 2.0 M_h2o_c + M_acceptor_c c TRUE (WBGene00017968) or (WBGene00004257) or (WBGene00020692) or (WBGene00009811) or (WBGene00008627) or (WBGene00004256) or (WBGene00019970) or (WBGene00021572) or (WBGene00005148) or (WBGene00016700) or (WBGene00011530) or (WBGene00009897) or (WBGene00022743) or (WBGene00020471) or (WBGene00019613) PW098 RHEA:56136;RHEA:56136;RHEA:56136 [CHECKME] this reaction is generic and looks disconnected lenov +R_PEROXID_RXN_c Peroxidase M_h2o2_c + M_donor_h2_c <=> 2.0 M_h2o_c + M_acceptor_c c TRUE (WBGene00017968) or (WBGene00004257) or (WBGene00020692) or (WBGene00009811) or (WBGene00008627) or (WBGene00004256) or (WBGene00019970) or (WBGene00021572) or (WBGene00005148) or (WBGene00016700) or (WBGene00011530) or (WBGene00009897) or (WBGene00022743) or (WBGene00020471) or (WBGene00019613) PW098 "RHEA:56136;RHEA:56136;RHEA:56136" [CHECKME] this reaction is generic and looks disconnected lenov R_PEROXID_RXN_m Peroxidase M_h2o2_m + M_donor_h2_m <=> 2.0 M_h2o_m + M_acceptor_m m TRUE (WBGene00011530) or (WBGene00022743) or (WBGene00021845) PW098 RHEA:56136 [CHECKME] this reaction is generic and looks disconnected lenov R_PEROXID_RXN_n Peroxidase M_h2o2_n + M_donor_h2_n <=> 2.0 M_h2o_n + M_acceptor_n n TRUE (WBGene00017968) or (WBGene00019970) or (WBGene00016700) PW098 [CHECKME] this reaction is generic and looks disconnected lenov R_PETHCT_c ethanolamine-phosphate cytidylyltransferase M_ethamp_c + M_h_c + M_ctp_c <=> M_ppi_c + M_cdpea_c c TRUE (WBGene00021352) or (WBGene00016531) PW056 set to reversible janna -R_PFK_c 6-phosphofructokinase M_f6p_c + M_atp_c <=> M_fdp_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00022199) or (WBGene00008230) PW031;PW018 RHEA:16109;RHEA:16109 -R_PFK_n 6-phosphofructokinase M_f6p_n + M_atp_n <=> M_fdp_n + 2.0 M_h_n + M_adp_n n FALSE (WBGene00022199) or (WBGene00008230) PW031;PW018 RHEA:16109;RHEA:16109 +R_PFK_c 6-phosphofructokinase M_f6p_c + M_atp_c <=> M_fdp_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00022199) or (WBGene00008230) "PW031;PW018" "RHEA:16109;RHEA:16109" +R_PFK_n 6-phosphofructokinase M_f6p_n + M_atp_n <=> M_fdp_n + 2.0 M_h_n + M_adp_n n FALSE (WBGene00022199) or (WBGene00008230) "PW031;PW018" "RHEA:16109;RHEA:16109" R_PGCD_c Phosphoglycerate dehydrogenase M_nad_c + M_3pg_c <=> M_3php_c + M_h_c + M_nadh_c c TRUE (WBGene00007836) PW074 set to reversible janna -R_PGI_c Glucose-6-phosphate isomerase M_g6p_B_c <=> M_f6p_c c TRUE (WBGene00013597) PW031;PW018;PW025 RHEA:11816;RHEA:11816 -R_PGI_m Glucose-6-phosphate isomerase M_g6p_B_m <=> M_f6p_m m TRUE (WBGene00013597) PW031;PW018;PW025 RHEA:11816;RHEA:11816 +R_PGI_c Glucose-6-phosphate isomerase M_g6p_B_c <=> M_f6p_c c TRUE (WBGene00013597) "PW031;PW018;PW025" "RHEA:11816;RHEA:11816" +R_PGI_m Glucose-6-phosphate isomerase M_g6p_B_m <=> M_f6p_m m TRUE (WBGene00013597) "PW031;PW018;PW025" "RHEA:11816;RHEA:11816" R_PGK_c Phosphoglycerate kinase M_atp_c + M_3pg_c <=> M_adp_c + M_13dpg_c c TRUE (WBGene00020185) PW018 SPW004 RHEA:14801 R_PGL_c 6-phosphogluconolactonase M_h2o_c + M_6pgl_c <=> M_6pgc_c + M_h_c c TRUE (WBGene00013301) PW027 SPW004 R_PGM_c Phosphoglycerate mutase M_3pg_c <=> M_2pg_c c TRUE (WBGene00019001) PW018 SPW004 RHEA:15901 -R_PHEAMINOTRANS_DEG_RXN_c Aromatic amino acid transferase M_glu__L_c + M_phpyr_c <=> M_akg_c + M_phe__L_c c TRUE (WBGene00020146) or (WBGene00020145) or (WBGene00015778) or (WBGene00015771) or (WBGene00009628) PW076 RHEA:21824;RHEA:21824 [DELETION] Dupe of R_RXN909_57_c jpnh -R_PHEAMINOTRANS_DEG_RXN_m Aromatic amino acid transferase M_glu__L_m + M_phpyr_m <=> M_akg_m + M_phe__L_m m TRUE (WBGene00016652) or (WBGene00015778) PW076 RHEA:21824;RHEA:21824 [DELETION] Dupe of R_RXN909_57_m jpnh +R_PHEAMINOTRANS_DEG_RXN_c Aromatic amino acid transferase M_glu__L_c + M_phpyr_c <=> M_akg_c + M_phe__L_c c TRUE (WBGene00020146) or (WBGene00020145) or (WBGene00015778) or (WBGene00015771) or (WBGene00009628) PW076 "RHEA:21824;RHEA:21824" [DELETION] Dupe of R_RXN909_57_c jpnh +R_PHEAMINOTRANS_DEG_RXN_m Aromatic amino acid transferase M_glu__L_m + M_phpyr_m <=> M_akg_m + M_phe__L_m m TRUE (WBGene00016652) or (WBGene00015778) PW076 "RHEA:21824;RHEA:21824" [DELETION] Dupe of R_RXN909_57_m jpnh R_PHEMEABCte R_PHEMEABCte M_h2o_c + M_atp_c + M_pheme_c <=> M_pi_c + M_h_c + M_adp_c + M_pheme_e c FALSE WBGene00003412 PW107 R_PHEMEe release of heme into the blood M_pheme_c <=> M_pheme_e ce TRUE WBGene00019830 or WBGene00009493 PW107 R_PHEMEtm Heme transport to cytosol M_pheme_m <=> M_pheme_c mc TRUE ND PW106 -R_PHENYLALANINE_4_MONOOXYGENASE_RXN_c Phenylalanine 4-monooxygenase M_phe__L_c + M_thbpt_c + M_o2_c <=> M_thbpt4acam_c + M_tyr__L_c c FALSE (WBGene00006600) or (WBGene00000296) or (WBGene00000240) PW073;PW078 RHEA:20309;RHEA:18201;RHEA:20273;RHEA:16709 -R_PHENYLALANINE_4_MONOOXYGENASE_RXN_n Phenylalanine 4-monooxygenase M_phe__L_n + M_thbpt_n + M_o2_n <=> M_thbpt4acam_n + M_tyr__L_n n FALSE (WBGene00000240) PW073;PW078 RHEA:20273;RHEA:16709 +R_PHENYLALANINE_4_MONOOXYGENASE_RXN_c Phenylalanine 4-monooxygenase M_phe__L_c + M_thbpt_c + M_o2_c <=> M_thbpt4acam_c + M_tyr__L_c c FALSE (WBGene00006600) or (WBGene00000296) or (WBGene00000240) "PW073;PW078" "RHEA:20309;RHEA:18201;RHEA:20273;RHEA:16709" +R_PHENYLALANINE_4_MONOOXYGENASE_RXN_n Phenylalanine 4-monooxygenase M_phe__L_n + M_thbpt_n + M_o2_n <=> M_thbpt4acam_n + M_tyr__L_n n FALSE (WBGene00000240) "PW073;PW078" "RHEA:20273;RHEA:16709" R_Phenylalanine_Exchange_reactions_e Phenylalanine transport M_phe__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Phenylalanine_transport Phenylalanine transport M_phe__L_c <=> M_phe__L_e ce TRUE ND PW107 -R_PHOSPHAGLYPSYN_RXN_c CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase M_glyc3p_c + M_cdpdag_c <=> M_h_c + M_cmp_c + M_1ac2acg3pg3p_c c FALSE (WBGene00021677) PW056 RHEA:12593;RHEA:12593 [DELETION] Dupe of R_RC01801 jpnh +R_PHOSPHAGLYPSYN_RXN_c CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase M_glyc3p_c + M_cdpdag_c <=> M_h_c + M_cmp_c + M_1ac2acg3pg3p_c c FALSE (WBGene00021677) PW056 "RHEA:12593;RHEA:12593" [DELETION] Dupe of R_RC01801 jpnh R_PHOSPHATIDATE_PHOSPHATASE_RXN_c Phosphatidate phosphatase M_h2o_c + M_1ac2acglyc3p_c <=> M_pi_c + M_1ac2acglyc_c c FALSE (WBGene00018756) PW056 -R_PHOSPHOGLUCMUT_RXN_c Phosphoglucomutase M_g1p_c <=> M_g6p_A_c c TRUE WBGene00019890 or WBGene00012803 PW031;PW017;PW018;PW019 -R_PHOSPHOLIPASE_C_RXN_c Phospholipase C M_h2o_c + M_1ac2acg3pc_c <=> M_cholp_c + M_1ac2acglyc_c + M_h_c c FALSE (WBGene00004037) or (WBGene00004039) PW056 RHEA:33179;RHEA:33179 replaced pathway phospholipases by glycerophospholipid metabolism lenov +R_PHOSPHOGLUCMUT_RXN_c Phosphoglucomutase M_g1p_c <=> M_g6p_A_c c TRUE WBGene00019890 or WBGene00012803 "PW031;PW017;PW018;PW019" +R_PHOSPHOLIPASE_C_RXN_c Phospholipase C M_h2o_c + M_1ac2acg3pc_c <=> M_cholp_c + M_1ac2acglyc_c + M_h_c c FALSE (WBGene00004037) or (WBGene00004039) PW056 "RHEA:33179;RHEA:33179" replaced pathway phospholipases by glycerophospholipid metabolism lenov R_Pi_Exchange_reactions_e Pi transport M_pi_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Pi_transport Phosphate transport M_pi_c <=> M_pi_e ce TRUE ND PW107 R_PIBIOSYNTH0001 CDP-diacylglycerol inositol transferase M_inost_c + M_cdpdag_c <=> M_h_c + M_cmp_c + M_1ac2acg3pi_c c FALSE WBGene00012897 PW145 SPW003 [CHECKME] replaces R_2_7_8_11_RXN_c / R_RC01802 wimi -R_PIBIOSYNTH0002 phosphatidylinositol nuclear transport (diffusion) M_1ac2acg3pi_c <=> M_1ac2acg3pi_n cn TRUE PW108;PW145 SPW003 -R_PIBIOSYNTH0003 phosphatidylinositol phospholipase C M_h2o_c + M_1ac2acg3pi_c <=> M_h_c + M_1ac2acglyc_c + M_mi1p_D_c c FALSE WBGene00004036 or WBGene00004037 or WBGene00004038 or WBGene00004039 or WBGene00001177 PW145 SPW003 RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179 -R_PIBIOSYNTH0004 1-phosphatidylinositol 3-kinase M_atp_c + M_1ac2acg3pi_c <=> M_adp_c + M_h_c + M_1ac2acg3pi3p_c c FALSE (WBGene00000001 and WBGene00000090) or (WBGene00006932) or (WBGene00009552) PW145 SPW003 RHEA:12709;RHEA:12709;RHEA:12709 +R_PIBIOSYNTH0002 phosphatidylinositol nuclear transport (diffusion) M_1ac2acg3pi_c <=> M_1ac2acg3pi_n cn TRUE "PW108;PW145" SPW003 +R_PIBIOSYNTH0003 phosphatidylinositol phospholipase C M_h2o_c + M_1ac2acg3pi_c <=> M_h_c + M_1ac2acglyc_c + M_mi1p_D_c c FALSE WBGene00004036 or WBGene00004037 or WBGene00004038 or WBGene00004039 or WBGene00001177 PW145 SPW003 "RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179" +R_PIBIOSYNTH0004 1-phosphatidylinositol 3-kinase M_atp_c + M_1ac2acg3pi_c <=> M_adp_c + M_h_c + M_1ac2acg3pi3p_c c FALSE (WBGene00000001 and WBGene00000090) or (WBGene00006932) or (WBGene00009552) PW145 SPW003 "RHEA:12709;RHEA:12709;RHEA:12709" R_PIBIOSYNTH0005 1-phosphatidylinositol 3-kinase M_atp_n + M_1ac2acg3pi_n <=> M_adp_n + M_h_n + M_1ac2acg3pi3p_n n FALSE (WBGene00009552) PW145 SPW003 RHEA:12709 R_PIBIOSYNTH0006 1-phosphatidylinositol 4-kinase M_atp_c + M_1ac2acg3pi_c <=> M_adp_c + M_h_c + M_1ac2acg3pi4p_c c FALSE (WBGene00008346 or WBGene00022501) or (WBGene00013557 or WBGene00018076) PW145 SPW003 R_PIBIOSYNTH0007 1-phosphatidylinositol 4-kinase M_atp_n + M_1ac2acg3pi_n <=> M_adp_n + M_h_n + M_1ac2acg3pi4p_n n FALSE (WBGene00018076) or (WBGene00013557) PW145 SPW003 @@ -2071,26 +2071,26 @@ R_PIBIOSYNTH0016 Phosphatidylinositol-bisphosphatase M_h2o_n + M_1ac2acg3pi4p5p R_PIBIOSYNTH0017 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase M_h2o_c + M_1ac2acg3pi3p4p_c <=> M_pi_c + M_1ac2acg3pi3p_c c FALSE WBGene00010975 PW145 SPW003 R_PIBIOSYNTH0018 1-phosphatidylinositol-5-phosphate 4-kinase M_atp_c + M_1ac2acg3pi5p_c <=> M_adp_c + M_1ac2acg3pi4p5p_c c FALSE (WBGene00004088) PW145 SPW003 R_PIBIOSYNTH0019 1-phosphatidylinositol-5-phosphate 4-kinase M_atp_n + M_1ac2acg3pi5p_n <=> M_adp_n + M_1ac2acg3pi4p5p_n n FALSE (WBGene00004088) PW145 SPW003 -R_PIBIOSYNTH0020 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_mi145p_c + M_1ac2acglyc_c + M_h_c c FALSE (WBGene00001177) or (WBGene00004037) or (WBGene00004039) PW145 SPW003 RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179 -R_PIBIOSYNTH0021 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase M_h2o_n + M_1ac2acg3pi4p5p_n <=> M_mi145p_n + M_1ac2acglyc_n + M_h_n n FALSE (WBGene00001177) or (WBGene00004036) or (WBGene00004037) or (WBGene00004039) or (WBGene00004038) PW145 SPW003 RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179 -R_PIBIOSYNTH0022 1-Phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_h_c + M_mi145p_c + M_1ac2acglyc_c c FALSE WBGene00004036 or WBGene00004037 or WBGene00004038 or WBGene00004039 or WBGene00001177 PW145 SPW003 RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179 +R_PIBIOSYNTH0020 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_mi145p_c + M_1ac2acglyc_c + M_h_c c FALSE (WBGene00001177) or (WBGene00004037) or (WBGene00004039) PW145 SPW003 "RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179" +R_PIBIOSYNTH0021 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase M_h2o_n + M_1ac2acg3pi4p5p_n <=> M_mi145p_n + M_1ac2acglyc_n + M_h_n n FALSE (WBGene00001177) or (WBGene00004036) or (WBGene00004037) or (WBGene00004039) or (WBGene00004038) PW145 SPW003 "RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179" +R_PIBIOSYNTH0022 1-Phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_h_c + M_mi145p_c + M_1ac2acglyc_c c FALSE WBGene00004036 or WBGene00004037 or WBGene00004038 or WBGene00004039 or WBGene00001177 PW145 SPW003 "RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179;RHEA:33179" R_PIBIOSYNTH0023 Phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_pi_c + M_1ac2acg3pi4p_c c FALSE WBGene00012016 or WBGene00007620 or WBGene00006763 PW145 SPW003 RHEA:22764 [DELETION] Merge into R_PHOSPHATIDYLINOSITOL_BISPHOSPHATASE_RXN_c jpnh R_PIBIOSYNTH0024 Phosphatidylinositol-4,5-bisphosphate 3-kinase M_atp_c + M_1ac2acg3pi4p5p_c <=> M_adp_c + M_1ac2acg3pi3p4p5p_c c FALSE (WBGene00000090 and WBGene00000001) PW145 SPW003 RHEA:12709 -R_PIBIOSYNTH0026 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase M_h2o_c + M_1ac2acg3pi3p4p5p_c <=> M_pi_c + M_1ac2acg3pi4p5p_c c FALSE WBGene00000913 PW145 SPW003 RHEA:25017;RHEA:20629;RHEA:47004;RHEA:10684 +R_PIBIOSYNTH0026 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase M_h2o_c + M_1ac2acg3pi3p4p5p_c <=> M_pi_c + M_1ac2acg3pi4p5p_c c FALSE WBGene00000913 PW145 SPW003 "RHEA:25017;RHEA:20629;RHEA:47004;RHEA:10684" R_PIBIOSYNTH0027 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_pi_c + M_1ac2acg3pi5p_c c FALSE WBGene00022167 PW145 SPW003 [DELETION] Merge into R_RCN_9779_c jpnh R_PIt2m phosphate transporter, mitochondrial M_pi_c + M_h_c <=> M_pi_m + M_h_m cm TRUE (WBGene00008505) or (WBGene00011493) or (WBGene00016358) or (WBGene00007584) or (WBGene00020422) or (ND) PW106 R_PIt7 phosphate transport in/out via three Na+ symporter M_pi_e + 3.0 M_na1_e <=> M_pi_c + 3.0 M_na1_c ec TRUE (WBGene00022767) PW107 R_PIt8 phosphate transport in/out via Na+ symporter M_pi_e + 1.5 M_na1_e <=> M_pi_c + 1.5 M_na1_c ec TRUE (WBGene00016739) or (WBGene00017312) or (WBGene00015055) or (WBGene00015054) PW107 R_PItn phosphate transport, nuclear M_pi_n <=> M_pi_c nc TRUE PW108 R_PMEVK_c Phosphomevalonate kinase M_5pmev_c + M_atp_c <=> M_5dpmev_c + M_h_c + M_adp_c c TRUE (WBGene00009335) PW001 R03245 added KEGGID, ChEBI ms -R_PMPOXI_RXN_m pyridoxal 5′-phosphate synthase M_h2o_m + M_o2_m + M_pyam5p_m <=> M_h2o2_m + M_nh3_m + M_h_m + M_pydx5p_m m FALSE (WBGene00018996) PW039 +R_PMPOXI_RXN_m "pyridoxal 5′-phosphate synthase" M_h2o_m + M_o2_m + M_pyam5p_m <=> M_h2o2_m + M_nh3_m + M_h_m + M_pydx5p_m m FALSE (WBGene00018996) PW039 R_PMTFATPtc R_PMTFATPtc M_atp_c + M_coa_c + M_fa16_0_e <=> M_ppi_c + M_amp_c + M_coa16_0_c c FALSE (WBGene00017012 or WBGene00009218) PW107 -R_PNANM_c Phosphomannomutase M_man1p_c <=> M_man6p_c c TRUE (WBGene00009925) PW031;PW025 -R_PNANM_m Phosphomannomutase M_man1p_m <=> M_man6p_m m TRUE (WBGene00009925) PW031;PW025 -R_PNANM_n Phosphomannomutase M_man1p_n <=> M_man6p_n n TRUE (WBGene00009925) PW031;PW025 +R_PNANM_c Phosphomannomutase M_man1p_c <=> M_man6p_c c TRUE (WBGene00009925) "PW031;PW025" +R_PNANM_m Phosphomannomutase M_man1p_m <=> M_man6p_m m TRUE (WBGene00009925) "PW031;PW025" +R_PNANM_n Phosphomannomutase M_man1p_n <=> M_man6p_n n TRUE (WBGene00009925) "PW031;PW025" R_PNKIN_RXN_c R_PNKIN_RXN_c M_atp_c + M_pydxn_c <=> M_h_c + M_adp_c + M_pdx5p_c c FALSE (WBGene00019008) PW039 RHEA:10224 R_PNKIN_RXN_m R_PNKIN_RXN_m M_atp_m + M_pydxn_m <=> M_h_m + M_adp_m + M_pdx5p_m m FALSE (WBGene00019008) PW039 RHEA:10224 -R_PNPOXI_RXN_m pyridoxal 5′-phosphate synthase M_o2_m + M_pdx5p_m <=> M_h2o2_m + M_pydx5p_m m FALSE (WBGene00018996) PW039 +R_PNPOXI_RXN_m "pyridoxal 5′-phosphate synthase" M_o2_m + M_pdx5p_m <=> M_h2o2_m + M_pydx5p_m m FALSE (WBGene00018996) PW039 R_PNTK_c Pantothenate kinase M_pnto_R_c + M_atp_c <=> M_4ppan_c + 2.0 M_h_c + M_adp_c c FALSE WBGene00004068 or WBGene00006862 PW037 RHEA:16373 R_PPA_c Inorganic pyrophosphatase M_h2o_c + M_ppi_c <=> 2.0 M_pi_c + M_h_c c TRUE (WBGene00007548) or (WBGene00008149) PW007 RHEA:24576 R_PPA_m Inorganic pyrophosphatase M_h2o_m + M_ppi_m <=> 2.0 M_pi_m + M_h_m m TRUE (WBGene00007548) or (WBGene00008149) PW007 RHEA:24576 @@ -2098,24 +2098,24 @@ R_PPA_n Inorganic pyrophosphatase M_h2o_n + M_ppi_n <=> 2.0 M_pi_n + M_h_n n TR R_PPA2_c Triphosphatase M_h2o_c + M_pppi_c <=> M_pi_c + M_ppi_c c TRUE Unknown PW007 R_PPCDC_c Phosphopantothenoylcysteine decarboxylase M_4ppcys_c + M_h_c <=> M_co2_c + M_pan4p_c c TRUE (WBGene00009138) PW037 R_PPCK_c Phosphoenolpyruvate carboxykinase (ATP) M_oaa_c + M_atp_c <=> M_co2_c + M_pep_c + M_h_c + M_adp_c c FALSE (WBGene00019151) PW018 SPW004 -R_PPCOAC_c Propionyl-CoA carboxylase M_hco3_c + M_atp_c + M_ppcoa_c <=> M_pi_c + 2.0 M_h_c + M_adp_c + M_mmcoa_S_c c FALSE (WBGene00018701 and WBGene00017864) PW001;PW010 RHEA:23720 -R_PPCOAC_m Propionyl-CoA carboxylase M_hco3_m + M_atp_m + M_ppcoa_m <=> M_pi_m + 2.0 M_h_m + M_adp_m + M_mmcoa_S_m m FALSE (WBGene00018701 and WBGene00017864) PW001;PW010 RHEA:23720 +R_PPCOAC_c Propionyl-CoA carboxylase M_hco3_c + M_atp_c + M_ppcoa_c <=> M_pi_c + 2.0 M_h_c + M_adp_c + M_mmcoa_S_c c FALSE (WBGene00018701 and WBGene00017864) "PW001;PW010" RHEA:23720 +R_PPCOAC_m Propionyl-CoA carboxylase M_hco3_m + M_atp_m + M_ppcoa_m <=> M_pi_m + 2.0 M_h_m + M_adp_m + M_mmcoa_S_m m FALSE (WBGene00018701 and WBGene00017864) "PW001;PW010" RHEA:23720 R_PPItn Inorganic diphosphate transport through nuclear pore M_ppi_c <=> M_ppi_n cn TRUE PW108 -R_PPM_c phosphoglucomutase M_r1p_c <=> M_r5p_c c TRUE (WBGene00012803) or (WBGene00019890) PW027;PW042 removed PRPP biosynthesis and PW043 pathways, added PW027 lenov -R_PPM_n phosphoglucomutase M_r1p_n <=> M_r5p_n n TRUE (WBGene00019890) PW027;PW042 removed PRPP biosynthesis and PW043 pathways, added PW027 lenov +R_PPM_c phosphoglucomutase M_r1p_c <=> M_r5p_c c TRUE (WBGene00012803) or (WBGene00019890) "PW027;PW042" removed PRPP biosynthesis and PW043 pathways, added PW027 lenov +R_PPM_n phosphoglucomutase M_r1p_n <=> M_r5p_n n TRUE (WBGene00019890) "PW027;PW042" removed PRPP biosynthesis and PW043 pathways, added PW027 lenov R_PPNCL2_c Phosphopantothenate--cysteine ligase M_4ppan_c + M_cys__L_c + M_ctp_c <=> M_4ppcys_c + M_ppi_c + M_h_c + M_cmp_c c TRUE (WBGene00022171) PW037 R_PPPItn Inorganic triphosphate transport through nuclear pore M_pppi_c <=> M_pppi_n cn TRUE PW108 R_PPS_c Pyruvate,water dikinase M_h2o_c + M_atp_c + M_pyr_c <=> M_pep_c + M_pi_c + 3.0 M_h_c + M_amp_c c FALSE (WBGene00011893) PW018 SPW004 -R_PRAGS_c Phosphoribosylamine--glycine ligase M_pram_c + M_gly_c + M_atp_c <=> M_pi_c + 2.0 M_h_c + M_gar_c + M_adp_c c TRUE (WBGene00018174) PW042 set to reversible;Removed the redundant 5-aminoimidazole ribonucleotide biosynthesis pathway janna; lenov +R_PRAGS_c Phosphoribosylamine--glycine ligase M_pram_c + M_gly_c + M_atp_c <=> M_pi_c + 2.0 M_h_c + M_gar_c + M_adp_c c TRUE (WBGene00018174) PW042 "set to reversible;Removed the redundant 5-aminoimidazole ribonucleotide biosynthesis pathway" "janna; lenov" R_PRAIS_c phosphoribosylformylglycinamidine cyclo-ligase M_fpram_c + M_atp_c <=> M_air_c + M_pi_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00018174) PW042 Removed the redundant 5-aminoimidazole ribonucleotide biosynthesis pathway lenov -R_PRASCS_c Phosphoribosylaminoimidazole-succinocarboxamide synthetase M_5aizc_c + M_asp__L_c + M_atp_c <=> M_25aics_c + M_pi_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00015116) PW042 RHEA:22628;RHEA:10792 [DELETION] Incorrect stoich when using model charges. Merge with R_RC04591;change M_asp__L_c into M_asp_c jpnh; lenov +R_PRASCS_c Phosphoribosylaminoimidazole-succinocarboxamide synthetase M_5aizc_c + M_asp__L_c + M_atp_c <=> M_25aics_c + M_pi_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00015116) PW042 "RHEA:22628;RHEA:10792" "[DELETION] Incorrect stoich when using model charges. Merge with R_RC04591;change M_asp__L_c into M_asp_c" "jpnh; lenov" R_PRFGS_c phosphoribosylformylglycinamidine synthetase M_h2o_c + M_gln__L_c + M_fgam_c + M_atp_c <=> M_pi_c + 2.0 M_h_c + M_glu__L_c + M_fpram_c + M_adp_c c FALSE (WBGene00008654) PW042 Removed the redundant 5-aminoimidazole ribonucleotide biosynthesis pathway lenov -R_PROAKGOX1_c proline,2-oxoglutarate-4-dioxygenase M_akg_c + M_pro__L_c + M_o2_c <=> M_co2_c + M_4hpro_LT_c + M_succ_c c TRUE (WBGene00003963 and WBGene00001077) or (WBGene00003963 and WBGene00004025) or WBGene00015773 or WBGene00077688 or WBGene00004026 or WBGene00012815 PW081 RHEA:18945;RHEA:18945 -R_PROB0AT2tc R_PROB0AT2tc M_pro__L_e + M_na1_e <=> M_pro__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 RHEA:21824;RHEA:21824 -R_PROCOLLAGEN_LYSINE_5_DIOXYGENASE_RXN_c Procollagen-lysine 5-dioxygenase M_akg_c + M_o2_c + M_pcollglys_c <=> M_co2_c + M_succ_c + M_pcollg5hlys_c c TRUE (WBGene00002497) PW089 RHEA:16569;RHEA:12637;RHEA:12576 +R_PROAKGOX1_c proline,2-oxoglutarate-4-dioxygenase M_akg_c + M_pro__L_c + M_o2_c <=> M_co2_c + M_4hpro_LT_c + M_succ_c c TRUE (WBGene00003963 and WBGene00001077) or (WBGene00003963 and WBGene00004025) or WBGene00015773 or WBGene00077688 or WBGene00004026 or WBGene00012815 PW081 "RHEA:18945;RHEA:18945" +R_PROB0AT2tc R_PROB0AT2tc M_pro__L_e + M_na1_e <=> M_pro__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 "RHEA:21824;RHEA:21824" +R_PROCOLLAGEN_LYSINE_5_DIOXYGENASE_RXN_c Procollagen-lysine 5-dioxygenase M_akg_c + M_o2_c + M_pcollglys_c <=> M_co2_c + M_succ_c + M_pcollg5hlys_c c TRUE (WBGene00002497) PW089 "RHEA:16569;RHEA:12637;RHEA:12576" R_Proline_transport Proline transport M_pro__L_c <=> M_pro__L_e ce TRUE ND PW107 R_PROPCOASYN_RXN_c propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase M_fadh2_c + M_prpncoa_c <=> M_h_c + M_fad_c + M_ppcoa_c c TRUE (WBGene00010336) or (WBGene00009104) or (WBGene00019599) or (WBGene00019060) or (WBGene00015326) or (WBGene00022300) or (WBGene00008167) or (WBGene00010052) or (WBGene00019406) or (WBGene00017874) or (WBGene00008567) or (WBGene00008566) or (WBGene00008565) or (WBGene00016491) or (WBGene00020419) PW086 R00924 RHEA:38959 Added Rxn Name jpnh -R_PROPCOASYN_RXN_m propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase M_fadh2_m + M_prpncoa_m <=> M_h_m + M_fad_m + M_ppcoa_m m TRUE (WBGene00020812) or (WBGene00020366) or (WBGene00015326) or (WBGene00022300) or (WBGene00015335) or (WBGene00010052) or (WBGene00019406) or (WBGene00017874) or (WBGene00008567) or (WBGene00016491) or (WBGene00019433) PW086 R00924 RHEA:12276;RHEA:14477 Added Rxn Name jpnh +R_PROPCOASYN_RXN_m propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase M_fadh2_m + M_prpncoa_m <=> M_h_m + M_fad_m + M_ppcoa_m m TRUE (WBGene00020812) or (WBGene00020366) or (WBGene00015326) or (WBGene00022300) or (WBGene00015335) or (WBGene00010052) or (WBGene00019406) or (WBGene00017874) or (WBGene00008567) or (WBGene00016491) or (WBGene00019433) PW086 R00924 "RHEA:12276;RHEA:14477" Added Rxn Name jpnh R_PROPCOASYN_RXN_n propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase M_fadh2_n + M_prpncoa_n <=> M_h_n + M_fad_n + M_ppcoa_n n TRUE (WBGene00010336) or (WBGene00009104) or (WBGene00019060) or (WBGene00022300) or (WBGene00008167) or (WBGene00010052) or (WBGene00008567) or (WBGene00008566) or (WBGene00008565) or (WBGene00020419) PW086 R00924 RHEA:38959 Added Rxn Name jpnh R_PROSTAGLANDIN_E_SYNTHASE_RXN_c prostaglandin-E synthase M_prostgh2_c <=> M_prostge2_c c TRUE WBGene00011239 or WBGene00022599 PW068 set to reversible janna R_PROSTAGLANDIN_E_SYNTHASE_RXN_m prostaglandin-E synthase M_prostgh2_m <=> M_prostge2_m m TRUE (WBGene00011239) PW068 set to reversible janna @@ -2123,9 +2123,9 @@ R_PROtm L-proline transport, mitochondrial M_pro__L_c <=> M_pro__L_m cm TRUE ND R_Proton_Exchange_reactions_e Proton transport M_h_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Proton_transport Proton transport M_h_c <=> M_h_e ce TRUE PW107 R_PRPNCOAHYD_c 3-Hydroxypropionyl-CoA hydro-lyase M_h2o_c + M_prpncoa_c <=> M_3hpcoa_c c TRUE (WBGene00001150) PW086 R02963 Added Rxn Name jpnh -R_PRPNCOAHYD_m 3-Hydroxypropionyl-CoA hydro-lyase M_h2o_m + M_prpncoa_m <=> M_3hpcoa_m m TRUE (WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152 PW086;PW010 R02963 RHEA:16105;RHEA:20724 Added Rxn Name jpnh -R_PRPPS_c ribose-phosphate diphosphokinase M_r5p_c + M_atp_c <=> M_prpp_c + 2.0 M_h_c + M_amp_c c TRUE (WBGene00020107) PW042;PW027 set to reversible; changed the pathway annotation janna; lenov -R_PRPPS_n ribose-phosphate diphosphokinase M_r5p_n + M_atp_n <=> M_prpp_n + 2.0 M_h_n + M_amp_n n TRUE (WBGene00020107) PW042;PW027 set to reversible; changed the pathway annotation lenov +R_PRPNCOAHYD_m 3-Hydroxypropionyl-CoA hydro-lyase M_h2o_m + M_prpncoa_m <=> M_3hpcoa_m m TRUE (WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152 "PW086;PW010" R02963 "RHEA:16105;RHEA:20724" Added Rxn Name jpnh +R_PRPPS_c ribose-phosphate diphosphokinase M_r5p_c + M_atp_c <=> M_prpp_c + M_h_c + M_amp_c c TRUE (WBGene00020107) "PW042;PW027" "set to reversible; changed the pathway annotation" "janna; lenov" +R_PRPPS_n ribose-phosphate diphosphokinase M_r5p_n + M_atp_n <=> M_prpp_n + M_h_n + M_amp_n n TRUE (WBGene00020107) "PW042;PW027" "set to reversible; changed the pathway annotation" lenov R_PSERT_c Phosphoserine aminotransferase M_akg_c + M_pser_L_c <=> M_3php_c + M_glu__L_c c TRUE (WBGene00009177) PW074 [DELETION] Same reaction as R_RC04173 jpnh R_PSFLIPm phosphatidylserine flippase M_h2o_c + M_atp_c + M_1ac2acg3ps_c <=> M_pi_c + 2.0 M_h_c + M_adp_c + M_1ac2acg3ps_m c FALSE (WBGene00013034) or (ND) PW106 R_PTHPS_c 6-pyruvoyltetrahydropterin synthase M_ahdt_c <=> M_6pthp_c + M_pppi_c c FALSE (WBGene00015010) PW091 RHEA:22048 @@ -2146,37 +2146,37 @@ R_pydx_e Pyridoxaltransport M_pydx_e <=> e TRUE PW111 R_pydxn_e Pyridoxine transport M_pydxn_e <=> e TRUE PW111 R_pydxnt Pyridoxine transport M_pydxn_c <=> M_pydxn_e ce TRUE ND PW107 R_pydxt Pyridoxal transport M_pydx_c <=> M_pydx_e ce TRUE ND PW107 -R_PYK_c Pyruvate kinase M_pep_c + 2.0 M_h_c + M_adp_c <=> M_atp_c + M_pyr_c c FALSE (WBGene00009126) or (WBGene00014001) PW018 SPW004 RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157 -R_PYNP2_c Uridine phosphorylase M_pi_c + M_uri_c <=> M_r1p_c + M_ura_c c TRUE (WBGene00022817) PW043 RHEA:24388;RHEA:16037;RHEA:22824 +R_PYK_c Pyruvate kinase M_pep_c + 2.0 M_h_c + M_adp_c <=> M_atp_c + M_pyr_c c FALSE (WBGene00009126) or (WBGene00014001) PW018 SPW004 "RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157" +R_PYNP2_c Uridine phosphorylase M_pi_c + M_uri_c <=> M_r1p_c + M_ura_c c TRUE (WBGene00022817) PW043 "RHEA:24388;RHEA:16037;RHEA:22824" R_PYRAMKIN_RXN_c R_PYRAMKIN_RXN_c M_atp_c + M_pydam_c <=> M_h_c + M_adp_c + M_pyam5p_c c FALSE (WBGene00019008) PW039 RHEA:10224 R_PYRAMKIN_RXN_m R_PYRAMKIN_RXN_m M_atp_m + M_pydam_m <=> M_h_m + M_adp_m + M_pyam5p_m m FALSE (WBGene00019008) PW039 RHEA:10224 R_PYRIDOXKIN_RXN_c pyridoxal kinase M_atp_c + M_pydx_c <=> M_h_c + M_adp_c + M_pydx5p_c c FALSE (WBGene00019008) PW039 RHEA:10224 R_PYRIDOXKIN_RXN_m pyridoxal kinase M_atp_m + M_pydx_m <=> M_h_m + M_adp_m + M_pydx5p_m m FALSE (WBGene00019008) PW039 RHEA:10224 -R_PYRROLINECARBDEHYDROG_RXN_c 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_c + M_1pyr5c_c + M_nad_c <=> M_h_c + M_glu__L_c + M_nadh_c c TRUE (WBGene00000112) PW081;PW073 -R_PYRROLINECARBDEHYDROG_RXN_m 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_m + M_1pyr5c_m + M_nad_m <=> M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00000112) PW081;PW073 +R_PYRROLINECARBDEHYDROG_RXN_c 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_c + M_1pyr5c_c + M_nad_c <=> M_h_c + M_glu__L_c + M_nadh_c c TRUE (WBGene00000112) "PW081;PW073" +R_PYRROLINECARBDEHYDROG_RXN_m 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_m + M_1pyr5c_m + M_nad_m <=> M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00000112) "PW081;PW073" R_PYRt2m pyruvate mitochondrial transport via proton symport M_h_c + M_pyr_c <=> M_h_m + M_pyr_m cm TRUE ND PW111 R_QUILSYN_c Quinolinate Synthase M_cmusa_c <=> M_h2o_c + M_quln_c c FALSE PW036 R_r0941 Bicarbonate Exchange reactions M_hco3_c <=> M_hco3_m cm TRUE PW111 R_r1291 Propanoyl CoA transport CM M_ppcoa_c <=> M_ppcoa_m cm TRUE PW111 added rxn name jpnh -R_r1435 Serine transport CM M_ser__L_c <=> M_ser__L_m cm TRUE ND PW111 added rxn name; set to reversible janna;jpnh +R_r1435 Serine transport CM M_ser__L_c <=> M_ser__L_m cm TRUE ND PW111 "added rxn name; set to reversible" "janna;jpnh" R_R146_RXN_c 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) M_dhmtp_c + M_o2_c <=> M_co_c + M_for_c + M_h_c + M_mtpp_c c TRUE (WBGene00009636) PW082 R07363 Added rxn name jpnh R_R147_RXN_c Acireductone dioxygenase (Fe(2+)-requiring) M_dhmtp_c + M_o2_c <=> M_for_c + M_h_c + M_2kmb_c c FALSE (WBGene00009636) PW082 R_r2408 Mitochondrial Carrier (MC) TCDB:2.A.29.19.1 M_h_c + M_orn_c + M_his__L_m <=> M_h_m + M_orn_m + M_his__L_c cm FALSE (WBGene00015186) PW106 R_r2472 Glycerol 3-phosphate transport CM M_glyc3p_c + M_pi_m <=> M_glyc3p_m + M_pi_c cm FALSE PW111 added rxn name jpnh R_RBFK_c ATP-dependent riboflavin kinase M_atp_c + M_ribflv_c <=> 2.0 M_h_c + M_adp_c + M_fmn_c c FALSE (WBGene00011224) PW040 -R_RC00078 Fe(II):oxygen oxidoreductase 4.0 M_h_c + M_o2_c + 4.0 M_fe2_c <=> 2.0 M_h2o_c + 4.0 M_fe3_c c FALSE WBGene00001500 or WBGene00001501 PW005 RHEA:11148;RHEA:11148 +R_RC00078 Fe(II):oxygen oxidoreductase 4.0 M_h_c + M_o2_c + 4.0 M_fe2_c <=> 2.0 M_h2o_c + 4.0 M_fe3_c c FALSE WBGene00001500 or WBGene00001501 PW005 "RHEA:11148;RHEA:11148" R_RC00089 ATP diphosphate-lyase (cyclizing, 3',5'-cyclic-AMP-forming) M_atp_c <=> M_ppi_c + M_camp_c c FALSE (WBGene00000068 or WBGene00000071) or WBGene00000069 PW042 RHEA:15389 R_RC00100 NADH:ferricytochrome-b5 oxidoreductase M_h_c + M_nadh_c + 2.0 M_ficytb5_c <=> M_nad_c + 2.0 M_focytb5_c c TRUE (WBGene00020267 or WBGene00020268) PW098 RHEA:46680 -R_RC00102 NAD nucleosidase M_h2o_c + M_nad_c <=> M_h_c + M_ncam_c + M_adprib_c c FALSE WBGene00004800 or WBGene00004801 or WBGene00004802 or WBGene00004803 PW035 RHEA:43636;RHEA:43636;RHEA:43636;RHEA:43636 +R_RC00102 NAD nucleosidase M_h2o_c + M_nad_c <=> M_h_c + M_ncam_c + M_adprib_c c FALSE WBGene00004800 or WBGene00004801 or WBGene00004802 or WBGene00004803 PW035 "RHEA:43636;RHEA:43636;RHEA:43636;RHEA:43636" R_RC00103 NAD+ phosphohydrolase M_h2o_c + M_nad_c <=> M_nmn_c + 2.0 M_h_c + M_amp_c c FALSE WBGene00007753 or WBGene00007755 PW035 -R_RC00137 ATP:nicotinamide-nucleotide adenylyltransferase M_nmn_c + M_h_c + M_atp_c <=> M_ppi_c + M_nad_c c TRUE WBGene00012295 or WBGene00009176 PW035 RHEA:21360;RHEA:22860;RHEA:22860;RHEA:21360 +R_RC00137 ATP:nicotinamide-nucleotide adenylyltransferase M_nmn_c + M_h_c + M_atp_c <=> M_ppi_c + M_nad_c c TRUE WBGene00012295 or WBGene00009176 PW035 "RHEA:21360;RHEA:22860;RHEA:22860;RHEA:21360" R_RC00160 FAD diphosphatase M_h2o_c + M_fad_c <=> 2.0 M_h_c + M_amp_c + M_fmn_c c FALSE WBGene00007753 or WBGene00007755 PW040 -R_RC00181 AMP aminohydrolase M_h2o_c + M_h_c + M_amp_c <=> M_imp_c + M_nh4_c c FALSE WBGene00016415 PW042 RHEA:14777;RHEA:14777;RHEA:14777;RHEA:14777 +R_RC00181 AMP aminohydrolase M_h2o_c + M_h_c + M_amp_c <=> M_imp_c + M_nh4_c c FALSE WBGene00016415 PW042 "RHEA:14777;RHEA:14777;RHEA:14777;RHEA:14777" R_RC00220 L-serine ammonia-lyase M_ser__L_c <=> M_pyr_c + M_nh4_c c FALSE WBGene00010456 or WBGene00021787 PW074 R_RC00233 malonyl-CoA carboxy-lyase (acetyl-CoA-forming) M_h_c + M_malcoa_c <=> M_co2_c + M_accoa_c c FALSE WBGene00009439 PW010 R_RC00248 L-Glutamate:NADP+ oxidoreductase (deaminating) M_h2o_c + M_glu__L_c + M_nadp_c <=> M_akg_c + M_h_c + M_nadph_c + M_nh4_c c TRUE WBGene00012326 PW073 -R_RC00253 L-Glutamate:ammonia ligase (ADP-forming) M_glu__L_c + M_atp_c + M_nh4_c <=> M_pi_c + M_h_c + M_gln__L_c + M_adp_c c FALSE WBGene00001602 or WBGene00001603 or WBGene00001604 or WBGene00001606 or WBGene00001607 PW073 RHEA:16169;RHEA:16169;RHEA:16169 -R_RC00256 L-Glutamine amidohydrolase M_h2o_c + M_gln__L_c <=> M_glu__L_c + M_nh4_c c FALSE WBGene00007480 or WBGene00008435 or WBGene00009271 PW073 RHEA:15889;RHEA:15889 +R_RC00253 L-Glutamate:ammonia ligase (ADP-forming) M_glu__L_c + M_atp_c + M_nh4_c <=> M_pi_c + M_h_c + M_gln__L_c + M_adp_c c FALSE WBGene00001602 or WBGene00001603 or WBGene00001604 or WBGene00001606 or WBGene00001607 PW073 "RHEA:16169;RHEA:16169;RHEA:16169" +R_RC00256 L-Glutamine amidohydrolase M_h2o_c + M_gln__L_c <=> M_glu__L_c + M_nh4_c c FALSE WBGene00007480 or WBGene00008435 or WBGene00009271 PW073 "RHEA:15889;RHEA:15889" R_RC00261 L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) M_h_c + M_glu__L_c <=> M_co2_c + M_4abut_c c FALSE WBGene00006762 PW073 R_RC00277 Pyridoxamine-5-phosphate:oxygen oxidoreductase (deaminating) M_h2o_c + M_o2_c + M_pyam5p_c <=> M_h2o2_c + M_pydx5p_c + M_nh4_c c FALSE WBGene00018996 PW039 R_RC00278 Pyridoxine 5-phosphate:oxygen oxidoreductase M_o2_c + M_pdx5p_c <=> M_h2o2_c + M_pydx5p_c c FALSE WBGene00018996 PW039 @@ -2184,15 +2184,15 @@ R_RC00287 UDP-glucose glucophosphohydrolase M_h2o_c + M_udpg_c <=> M_g1p_c + 2. R_RC00293 UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming) M_udpg_c <=> M_h2o_c + M_udp4k6dg_c c FALSE WBGene00015298 PW031 R_RC00306 cellobiose glucohydrolase M_h2o_c + M_clb_c <=> 2.0 M_glc_bD_c c FALSE WBGene00016848 or WBGene00017103 PW019 R_RC00335 GTP phosphohydrolase M_h2o_c + M_gtp_c <=> M_pi_c + M_h_c + M_gdp_c c FALSE WBGene00001093 or WBGene00001130 PW042 RHEA:19669 -R_RC00355 L-Aspartate:2-oxoglutarate aminotransferase M_akg_c + M_asp__L_c <=> M_oaa_c + M_glu__L_c c TRUE WBGene00020145 or WBGene00020146 or WBGene00015771 or WBGene00015778 PW073 R00355 RHEA:21824;RHEA:21824 added gene from A_ASPTA_c, which is marked for deletion jpnh -R_RC00359 D-Aspartate:oxygen oxidoreductase (deaminating) M_h2o_c + M_o2_c + M_asp__D_c <=> M_oaa_c + M_h2o2_c + M_nh4_c c FALSE (WBGene00008127 or WBGene00017565 or WBGene00017648) PW073 RHEA:12512;RHEA:12512;RHEA:12512 +R_RC00355 L-Aspartate:2-oxoglutarate aminotransferase M_akg_c + M_asp__L_c <=> M_oaa_c + M_glu__L_c c TRUE WBGene00020145 or WBGene00020146 or WBGene00015771 or WBGene00015778 PW073 R00355 "RHEA:21824;RHEA:21824" added gene from A_ASPTA_c, which is marked for deletion jpnh +R_RC00359 D-Aspartate:oxygen oxidoreductase (deaminating) M_h2o_c + M_o2_c + M_asp__D_c <=> M_oaa_c + M_h2o2_c + M_nh4_c c FALSE (WBGene00008127 or WBGene00017565 or WBGene00017648) PW073 "RHEA:12512;RHEA:12512;RHEA:12512" R_RC00366 glycine:oxygen oxidoreductase (deaminating) M_h2o_c + M_gly_c + M_o2_c <=> M_h2o2_c + M_glx_c + M_nh4_c c FALSE WBGene00022076 PW074 RHEA:21816 -R_RC00369 L-Alanine:glyoxylate aminotransferase M_glx_c + M_ala__L_c <=> M_gly_c + M_pyr_c c TRUE WBGene00020382 or WBGene00011767 PW073 RHEA:22852;RHEA:24248 +R_RC00369 L-Alanine:glyoxylate aminotransferase M_glx_c + M_ala__L_c <=> M_gly_c + M_pyr_c c TRUE WBGene00020382 or WBGene00011767 PW073 "RHEA:22852;RHEA:24248" R_RC00383 Acyl-CoA hydrolase M_h2o_c + M_ppcoa_c <=> M_ppa_c + M_h_c + M_coa_c c FALSE Unknown PW010 R_RC00417 protein N-acetylglucosaminyltransferase M_uacgam_c + M_pepasn_c <=> M_h_c + M_udp_c + M_pepasp_acBgamam_c c TRUE Unknown PW100 -R_RC00426 GTP diphosphohydrolase (diphosphate-forming) M_h2o_c + M_gtp_c <=> M_ppi_c + M_h_c + M_gmp_c c FALSE WBGene00001823 PW042 RHEA:23996;RHEA:44644 +R_RC00426 GTP diphosphohydrolase (diphosphate-forming) M_h2o_c + M_gtp_c <=> M_ppi_c + M_h_c + M_gmp_c c FALSE WBGene00001823 PW042 "RHEA:23996;RHEA:44644" R_RC00471 D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase M_4h2oglt_c <=> M_pyr_c + M_glx_c c TRUE Unknown PW081 -R_RC00479 isocitrate lyase M_icit_c <=> M_glx_c + M_succ_c c TRUE WBGene00001564 PW030 RHEA:13245;RHEA:18181 +R_RC00479 isocitrate lyase M_icit_c <=> M_glx_c + M_succ_c c TRUE WBGene00001564 PW030 "RHEA:13245;RHEA:18181" R_RC00485 L-Asparagine amidohydrolase M_h2o_c + M_asn__L_c <=> M_asp__L_c + M_nh4_c c FALSE WBGene00007756 PW073 R_RC00489 L-aspartate 1-carboxy-lyase (beta-alanine-forming) M_h_c + M_asp__L_c <=> M_co2_c + M_ala_B_c c FALSE WBGene00006762 PW086 R_RC00494 glutathione gamma-glutamylaminopeptidase M_h2o_c + M_gthrd_c <=> M_glu__L_c + M_cgly_c c TRUE WBGene00016906 or WBGene00019204 or WBGene00011393 or WBGene00020590 or WBGene00012416 or WBGene00022397 PW070 @@ -2204,15 +2204,15 @@ R_RC00571 UTP:ammonia ligase (ADP-forming) M_atp_c + M_utp_c + M_nh4_c <=> M_p R_RC00578 L-aspartate:L-glutamine amido-ligase (AMP-forming) M_h2o_c + M_gln__L_c + M_atp_c + M_asp__L_c <=> M_ppi_c + M_h_c + M_glu__L_c + M_amp_c + M_asn__L_c c FALSE WBGene00003816 or WBGene00019730 PW073 [DELETION] Merge into R_ANSN1_c R_RC00578_new L-aspartate:L-glutamine amido-ligase (AMP-forming) M_h2o_c + M_gln__L_c + M_atp_c + M_asp__L_c <=> M_ppi_c + M_glu__L_c + M_amp_c + M_asn__L_c c FALSE WBGene00003816 or WBGene00019730 PW073 [CHECK ME] Fixed stoichiometry of RC00578 and ASNS1_c please remove the new from !Reaction post merge jpnh R_RC00582 O-phospho-L-serine phosphohydrolase M_h2o_c + M_pser_L_c <=> M_pi_c + M_ser__L_c c TRUE WBGene00013379 PW074 Set reversibility to true jpnh -R_RC00585 L-Serine:pyruvate aminotransferase M_ser__L_c + M_pyr_c <=> M_hpyr_c + M_ala__L_c c TRUE WBGene00011767 PW074 RHEA:22852;RHEA:24248 -R_RC00602 methanol:hydrogen-peroxide oxidoreductase M_h2o2_c + M_meoh_c <=> 2.0 M_h2o_c + M_fald_c c FALSE (WBGene00000830 or WBGene00000831 or WBGene00013220) or (WBGene00021401) PW094 RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309 +R_RC00585 L-Serine:pyruvate aminotransferase M_ser__L_c + M_pyr_c <=> M_hpyr_c + M_ala__L_c c TRUE WBGene00011767 PW074 "RHEA:22852;RHEA:24248" +R_RC00602 methanol:hydrogen-peroxide oxidoreductase M_h2o2_c + M_meoh_c <=> 2.0 M_h2o_c + M_fald_c c FALSE (WBGene00000830 or WBGene00000831 or WBGene00013220) or (WBGene00021401) PW094 "RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309" R_RC00631 aldehyde:NAD+ oxidoreductase M_h2o_c + M_nad_c + M_fattyald_c <=> 2.0 M_h_c + M_nadh_c + M_Rtotal7_c c TRUE (WBGene00000108 or WBGene00000110) or WBGene00000118 PW065 R_RC00650 S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase M_hcys__L_c + M_amet_c <=> M_h_c + M_ahcys_c + M_met__L_c c FALSE WBGene00020491 PW082 -R_RC00662 Uridine triphosphate pyrophosphohydrolase M_h2o_c + M_utp_c <=> M_ppi_c + M_h_c + M_ump_c c FALSE WBGene00001823 PW043 RHEA:23996;RHEA:44644 +R_RC00662 Uridine triphosphate pyrophosphohydrolase M_h2o_c + M_utp_c <=> M_ppi_c + M_h_c + M_ump_c c FALSE WBGene00001823 PW043 "RHEA:23996;RHEA:44644" R_RC00678 L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) M_trp__L_c + M_o2_c <=> M_Lfmkynr_c c FALSE WBGene00016201 PW072 RHEA:24536 -R_RC00685 L-Tryptophan decarboxy-lyase M_h_c + M_trp__L_c <=> M_co2_c + M_trypta_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW072 RHEA:14345;RHEA:12272;RHEA:18533 +R_RC00685 L-Tryptophan decarboxy-lyase M_h_c + M_trp__L_c <=> M_co2_c + M_trypta_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW072 "RHEA:14345;RHEA:12272;RHEA:18533" R_RC00698 L-phenylalanine:oxygen oxidoreductase (decarboxylating) M_phe__L_c + M_o2_c <=> M_co2_c + M_h2o_c + M_pad_c c TRUE WBGene00021401 PW075 -R_RC00699 L-phenylalanine carboxy-lyase (phenylethylamine-forming) M_h_c + M_phe__L_c <=> M_co2_c + M_peamn_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW075 RHEA:14345;RHEA:12272;RHEA:18533 +R_RC00699 L-phenylalanine carboxy-lyase (phenylethylamine-forming) M_h_c + M_phe__L_c <=> M_co2_c + M_peamn_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW075 "RHEA:14345;RHEA:12272;RHEA:18533" R_RC00711 Acetaldehyde:NADP+ oxidoreductase M_h2o_c + M_nadp_c + M_acald_c <=> 2.0 M_h_c + M_nadph_c + M_ac_c c FALSE WBGene00000111 PW018 SPW004 R_RC00731 L-Tyrosine:oxygen oxidoreductase 2.0 M_tyr__L_c + M_o2_c <=> 2.0 M_34dhphe_c c FALSE WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231 PW077 R_RC00748 ethanolamine-phosphate phosphate-lyase (deaminating) (acetaldehyde-forming) M_h2o_c + M_ethamp_c <=> M_pi_c + M_acald_c + M_nh4_c c FALSE WBGene00020139 PW056 @@ -2229,9 +2229,9 @@ R_RC00963 Uridine 5-monophosphate phosphohydrolase M_h2o_c + M_ump_c <=> M_pi_c R_RC00987 L-Kynurenine hydrolase M_Lkynr_c + M_h2o_c <=> M_h_c + M_ala__L_c + M_anth_c c FALSE (WBGene00015802) PW072 R_RC00988 N-Formylanthranilate amidohydrolase M_h2o_c + M_nformanth_c <=> M_for_c + M_h_c + M_anth_c c TRUE WBGene00017051 PW072 R_RC00996 L-threonine ammonia-lyase (2-oxobutanoate-forming) M_thr__L_c <=> M_2obut_c + M_nh4_c c FALSE WBGene00010456 or WBGene00021787 PW074 -R_RC01000 2-Hydroxybutyrate:NAD+ oxidoreductase M_nad_c + M_2hb_c <=> M_h_c + M_nadh_c + M_2obut_c c TRUE WBGene00002262 PW010 RHEA:23444;RHEA:23444 +R_RC01000 2-Hydroxybutyrate:NAD+ oxidoreductase M_nad_c + M_2hb_c <=> M_h_c + M_nadh_c + M_2obut_c c TRUE WBGene00002262 PW010 "RHEA:23444;RHEA:23444" R_RC01005 UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase M_udpg_c + M_dolp_c <=> M_udp_c + M_dolglcp_c c FALSE WBGene00019276 PW011 -R_RC01010 Glycerone phosphate phosphohydrolase M_h2o_c + M_dhap_c <=> M_dha_c + M_pi_c c FALSE WBGene00013646 or ((WBGene00009146 or WBGene00014076 or WBGene00007328 or WBGene00007331) or (WBGene00020471 or WBGene00015161 or WBGene00011262) or WBGene00022379 or WBGene00008531) or (WBGene00206373 or WBGene00008802 or WBGene00008801 or WBGene00022246 or WBGene00004020 or WBGene00016152 or WBGene00004023 or WBGene00018696 or WBGene00011879 or WBGene00022181) PW052 RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017 +R_RC01010 Glycerone phosphate phosphohydrolase M_h2o_c + M_dhap_c <=> M_dha_c + M_pi_c c FALSE WBGene00013646 or ((WBGene00009146 or WBGene00014076 or WBGene00007328 or WBGene00007331) or (WBGene00020471 or WBGene00015161 or WBGene00011262) or WBGene00022379 or WBGene00008531) or (WBGene00206373 or WBGene00008802 or WBGene00008801 or WBGene00022246 or WBGene00004020 or WBGene00016152 or WBGene00004023 or WBGene00018696 or WBGene00011879 or WBGene00022181) PW052 "RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017" R_RC01016 methylglyoxal synthase M_dhap_c <=> M_pi_c + M_mthgxl_c c FALSE Unknown PW022 SPW004 R_RC01041 Glycerol:NADP+ oxidoreductase M_glyald_c + M_h_c + M_nadph_c <=> M_glyc_c + M_nadp_c c TRUE WBGene00012722 or WBGene00016985 PW052 R_RC01054 ADP-ribose ribophosphohydrolase M_h2o_c + M_adprib_c <=> M_r5p_c + 2.0 M_h_c + M_amp_c c FALSE WBGene00003579 or WBGene00003583 PW042 @@ -2244,17 +2244,17 @@ R_RC01103 Raffinose galactohydrolase M_h2o_c + M_raffin_c <=> M_gal_c + M_sucr_ R_RC01108 glutathione dehydrogenase (ascorbate) M_dhdascb_c + 2.0 M_gthrd_c <=> M_gthox_c + M_ascb__L_c c FALSE Unknown PW070 R_RC01134 inosine-5-phosphate:NADP+ oxidoreductase (aminating) 2.0 M_h_c + M_gmp_c + M_nadph_c <=> M_imp_c + M_nadp_c + M_nh4_c c FALSE WBGene00017984 PW042 R_RC01135 IMP:L-aspartate ligase (GDP-forming) M_imp_c + M_gtp_c + M_asp__L_c <=> M_pi_c + 2.0 M_h_c + M_dcamp_c + M_gdp_c c FALSE WBGene00016509 PW042 RHEA:15753 [DELETION] Merged into R_ADSS_c jpnh -R_RC01138 dATP:pyruvate 2-O-phosphotransferase M_pep_c + M_h_c + M_dadp_c <=> M_datp_c + M_pyr_c c FALSE WBGene00009126 or WBGene00014001 PW042 RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157 +R_RC01138 dATP:pyruvate 2-O-phosphotransferase M_pep_c + M_h_c + M_dadp_c <=> M_datp_c + M_pyr_c c FALSE WBGene00009126 or WBGene00014001 PW042 "RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157;RHEA:18157" R_RC01168 L-histidine ammonia-lyase (urocanate-forming) M_his__L_c <=> M_urcan_c + M_nh4_c c FALSE WBGene00009813 PW084 RHEA:21232 -R_RC01185 1D-myo-Inositol 1-phosphate phosphohydrolase M_h2o_c + M_mi1p_D_c <=> M_pi_c + M_inost_c c FALSE (WBGene00008765 or WBGene00012390) PW029 RHEA:24056;RHEA:29315 -R_RC01186 1D-myo-Inositol 4-phosphate phosphohydrolase M_h2o_c + M_mi4p_D_c <=> M_pi_c + M_inost_c c FALSE (WBGene00008765 or WBGene00012390) PW029 RHEA:24056;RHEA:29315 -R_RC01187 1D-myo-Inositol 3-phosphate phosphohydrolase M_h2o_c + M_mi3p_D_c <=> M_pi_c + M_inost_c c FALSE (WBGene00008765 or WBGene00012390) PW029 RHEA:24056;RHEA:29315 replaced streptomycin biosynthesis with inositol phosphate metabolism lenov +R_RC01185 1D-myo-Inositol 1-phosphate phosphohydrolase M_h2o_c + M_mi1p_D_c <=> M_pi_c + M_inost_c c FALSE (WBGene00008765 or WBGene00012390) PW029 "RHEA:24056;RHEA:29315" +R_RC01186 1D-myo-Inositol 4-phosphate phosphohydrolase M_h2o_c + M_mi4p_D_c <=> M_pi_c + M_inost_c c FALSE (WBGene00008765 or WBGene00012390) PW029 "RHEA:24056;RHEA:29315" +R_RC01187 1D-myo-Inositol 3-phosphate phosphohydrolase M_h2o_c + M_mi3p_D_c <=> M_pi_c + M_inost_c c FALSE (WBGene00008765 or WBGene00012390) PW029 "RHEA:24056;RHEA:29315" replaced streptomycin biosynthesis with inositol phosphate metabolism lenov R_RC01206 [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase M_h2o_c + M_chtn_c <=> M_acgam_c c FALSE WBGene00007425 or WBGene00016666 or WBGene00011170 or WBGene00011196 or WBGene00020270 or WBGene00044807 or WBGene00012057 or WBGene00007465 or WBGene00016665 or WBGene00010799 or WBGene00010945 or WBGene00011157 or WBGene00011158 or WBGene00011159 or WBGene00011161 or WBGene00011162 or WBGene00007466 or WBGene00011163 or WBGene00011164 or WBGene00011166 or WBGene00011167 or WBGene00020407 or WBGene00011846 or WBGene00011848 or WBGene00008842 or WBGene00007467 or WBGene00007469 or WBGene00007470 or WBGene00007471 or WBGene00007472 or WBGene00007473 or WBGene00014162 or WBGene00000503 or WBGene00011757 or WBGene00021252 or WBGene00017233 or WBGene00020141 PW031 R_RC01220 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase M_mlthf_c + M_nadp_c <=> M_nadph_c + M_methf_c c TRUE WBGene00019492 PW095 -R_RC01224 5-methyltetrahydrofolate:NADP+ oxidoreductase 2.0 M_h_c + M_mlthf_c + M_nadph_c <=> M_5mthf_c + M_nadp_c c TRUE WBGene00015512 PW095 RHEA:19817;RHEA:19821 +R_RC01224 5-methyltetrahydrofolate:NADP+ oxidoreductase 2.0 M_h_c + M_mlthf_c + M_nadph_c <=> M_5mthf_c + M_nadp_c c TRUE WBGene00015512 PW095 "RHEA:19817;RHEA:19821" R_RC01230 Xanthosine-5-phosphate:ammonia ligase (AMP-forming) M_xmp_c + M_atp_c + M_nh4_c <=> M_ppi_c + 2.0 M_h_c + M_gmp_c + M_amp_c c FALSE WBGene00010912 PW042 RHEA:11680 R_RC01248 L-Proline:NAD+ 5-oxidoreductase M_1pyr5c_c + 2.0 M_h_c + M_nadh_c <=> M_pro__L_c + M_nad_c c TRUE WBGene00018904 PW081 -R_RC01252 L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) M_akg_c + M_pro__L_c + M_o2_c <=> M_co2_c + M_4hpro_LT_c + M_succ_c c FALSE WBGene00015773 or WBGene00077688 or WBGene00001077 or WBGene00004025 or WBGene00004026 or WBGene00012815 PW081 RHEA:18945;RHEA:18945 [DELETION] Merge into R_PROAKGOX1_c_c jpnh +R_RC01252 L-Proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) M_akg_c + M_pro__L_c + M_o2_c <=> M_co2_c + M_4hpro_LT_c + M_succ_c c FALSE WBGene00015773 or WBGene00077688 or WBGene00001077 or WBGene00004025 or WBGene00004026 or WBGene00012815 PW081 "RHEA:18945;RHEA:18945" [DELETION] Merge into R_PROAKGOX1_c_c jpnh R_RC01262 glutathione:L-amino-acid 5-glutamyltransferase M_gthrd_c + M_ala__L_c <=> M_cgly_c + M_gluala_c c FALSE WBGene00016906 or WBGene00019204 or WBGene00011393 or WBGene00020590 or WBGene00012416 or WBGene00022397 PW070 R_RC01266 beta-aspartyl-N-acetylglucosaminidase M_h2o_c + M_acBgamamAsn_c <=> M_acgam_c + M_asn__L_c c TRUE Unknown PW100 R_RC01268 nicotinamidase M_h2o_c + M_ncam_c <=> M_nac_c + M_nh4_c c FALSE WBGene00021395 or WBGene00013336 PW035 @@ -2263,7 +2263,7 @@ R_RC01334 phosphoglycolate phosphatase M_h2o_c + M_2pglyc_c <=> M_glyclt_c + M_ R_RC01375 L-Glutamine:phenylpyruvate aminotransferase M_gln__L_c + M_phpyr_c <=> M_phe__L_c + M_akgm_c c TRUE WBGene00009232 PW075 R_RC01378 Phenylpyruvate keto-enol-isomerase M_phpyr_c <=> M_enphpyr_c c TRUE WBGene00003234 PW075 R_RC01393 hydroxypyruvate decarboxylase M_hpyr_c + M_h_c <=> M_co2_c + M_gcald_c c FALSE Unknown PW030 -R_RC01397 carbamoyl-phosphate:L-aspartate carbamoyltransferase M_cbp_c + M_asp__L_c <=> M_pi_c + M_h_c + M_cbasp_c c FALSE WBGene00004259 PW043 RHEA:18633;RHEA:20013;RHEA:24296 [DELETION] Dupe of R_ASPCT_c jpnh +R_RC01397 carbamoyl-phosphate:L-aspartate carbamoyltransferase M_cbp_c + M_asp__L_c <=> M_pi_c + M_h_c + M_cbasp_c c FALSE WBGene00004259 PW043 "RHEA:18633;RHEA:20013;RHEA:24296" [DELETION] Dupe of R_ASPCT_c jpnh R_RC01410 cyanide conversion to alpha-Aminopropiononitrile M_acald_c + M_cyan_c + M_nh4_c <=> M_h2o_c + M_aprop_c c TRUE Unknown PW087 R_RC01431 xylitol:NADP+ oxidoreductase M_h_c + M_nadph_c + M_xyl_D_c <=> M_xylt_c + M_nadp_c c TRUE WBGene00012722 PW033 R_RC01463 Cholesterol,NADPH:oxygen oxidoreductase M_h_c + M_nadph_c + M_o2_c + M_chsterol_c <=> M_h2o_c + M_nadp_c + M_xol7a_c c FALSE TBD PW066 @@ -2287,14 +2287,14 @@ R_RC01759 L-Arabitol:NADP+ 1-oxidoreductase M_h_c + M_nadph_c + M_arab__L_c <= R_RC01769 Hypoxanthine:oxygen oxidoreductase M_h2o_c + M_hxan_c + M_o2_c <=> M_h2o2_c + M_xan_c c FALSE WBGene00010083 PW042 R_RC01787 D-sorbitol reductase M_glc_bD_c + M_h_c + M_nadph_c <=> M_nadp_c + M_sbt__D_c c TRUE WBGene00012722 PW025 ms R_RC01794 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase M_h_c + M_dhbpt_c + M_nadph_c <=> M_thbpt_c + M_nadp_c c FALSE WBGene00011398 PW091 -R_RC01795 L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) M_phe__L_c + M_thbpt_c + M_o2_c <=> M_h2o_c + M_tyr__L_c + M_dhbpt_c c FALSE WBGene00000240 PW075 RHEA:20273;RHEA:16709 +R_RC01795 L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) M_phe__L_c + M_thbpt_c + M_o2_c <=> M_h2o_c + M_tyr__L_c + M_dhbpt_c c FALSE WBGene00000240 PW075 "RHEA:20273;RHEA:16709" R_RC01814 L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) (Dihydrobiopterin forming) M_trp__L_c + M_thbpt_c + M_o2_c <=> M_h2o_c + M_5htrp_c + M_dhbpt_c c FALSE WBGene00006600 PW072 -R_RC01815 L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (Dihydrobiopterin forming) M_tyr__L_c + M_thbpt_c + M_o2_c <=> M_h2o_c + M_34dhphe_c + M_dhbpt_c c FALSE WBGene00000296 PW077 RHEA:20309;RHEA:18201 +R_RC01815 L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating) (Dihydrobiopterin forming) M_tyr__L_c + M_thbpt_c + M_o2_c <=> M_h2o_c + M_34dhphe_c + M_dhbpt_c c FALSE WBGene00000296 PW077 "RHEA:20309;RHEA:18201" R_RC01816 anthranilate 3-monooxygenase M_h_c + M_thbpt_c + M_o2_c + M_anth_c <=> M_h2o_c + M_3hanthrn_c + M_dhbpt_c c FALSE Unknown PW072 -R_RC01829 Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase M_s17bp_c <=> M_dhap_c + M_e4p_c c TRUE WBGene00017166 or WBGene00011474 PW027 SPW004 RHEA:14729;RHEA:14729;RHEA:14729 -R_RC01843 ATP:Sedoheptulose 7-phosphate 1-phosphotransferase M_s7p_c + M_atp_c <=> M_h_c + M_adp_c + M_s17bp_c c FALSE WBGene00008230 or WBGene00022199 PW027 SPW004 RHEA:16109;RHEA:16109 +R_RC01829 Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase M_s17bp_c <=> M_dhap_c + M_e4p_c c TRUE WBGene00017166 or WBGene00011474 PW027 SPW004 "RHEA:14729;RHEA:14729;RHEA:14729" +R_RC01843 ATP:Sedoheptulose 7-phosphate 1-phosphotransferase M_s7p_c + M_atp_c <=> M_h_c + M_adp_c + M_s17bp_c c FALSE WBGene00008230 or WBGene00022199 PW027 SPW004 "RHEA:16109;RHEA:16109" R_RC01844 ATP:sedoheptulose 7-phosphate M_atp_c + M_sedh_c <=> M_s7p_c + M_h_c + M_adp_c c TRUE WBGene00012017 PW027 SPW004 -R_RC01878 Cytidine aminohydrolase M_h2o_c + M_h_c + M_cytd_c <=> M_uri_c + M_nh4_c c FALSE WBGene00000391 or WBGene00000392 PW043 RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069 +R_RC01878 Cytidine aminohydrolase M_h2o_c + M_h_c + M_cytd_c <=> M_uri_c + M_nh4_c c FALSE WBGene00000391 or WBGene00000392 PW043 "RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069" R_RC01896 xylitol dehydrogenase (D-xyulose-forming) M_xylt_c + M_nad_c <=> M_xylu_D_c + M_h_c + M_nadh_c c TRUE WBGene00011003 or WBGene00011004 PW033 R_RC01903 L-arabinitol 4-dehydrogenase M_nad_c + M_abt_c <=> M_xylu_L_c + M_h_c + M_nadh_c c TRUE Unknown PW033 R_RC01938 2-aminomuconate reductase M_h2o_c + M_amuco_c + M_h_c + M_nadph_c <=> M_2oxoadp_c + M_nadp_c + M_nh4_c c FALSE Unknown PW072 @@ -2302,16 +2302,16 @@ R_RC01956 L-Kynurenine:2-oxoglutarate aminotransferase M_akg_c + M_Lkynr_c <=> R_RC01961 ATP:D-glucosamine 6-phosphotransferase M_atp_c + M_gam_c <=> M_h_c + M_adp_c + M_gam6p_c c FALSE WBGene00008780 or WBGene00010416 or WBGene00022306 PW031 R_RC01968 2-Deoxyguanosine 5-monophosphate phosphohydrolase M_h2o_c + M_dgmp_c <=> M_pi_c + M_dgsn_c c FALSE WBGene00017775 or WBGene00012423 or WBGene00022201 PW042 R_RC02016 NADPH:oxidized-thioredoxin oxidoreductase M_h_c + M_nadph_c + M_trdox_c <=> M_nadp_c + M_trdrd_c c FALSE WBGene00015553 PW043 RHEA:20345 -R_RC02017 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase M_adp_c + M_trdrd_c <=> M_h2o_c + M_dadp_c + M_trdox_c c TRUE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW042 RHEA:23252;RHEA:23252 set to reversible janna -R_RC02018 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase M_udp_c + M_trdrd_c <=> M_h2o_c + M_dudp_c + M_trdox_c c FALSE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW043 RHEA:23252;RHEA:23252 -R_RC02019 2-Deoxyguanosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase M_gdp_c + M_trdrd_c <=> M_h2o_c + M_dgdp_c + M_trdox_c c FALSE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW042 RHEA:23252;RHEA:23252 -R_RC02024 2-Deoxycytidine diphosphate:oxidized-thioredoxin 2-oxidoreductase M_cdp_c + M_trdrd_c <=> M_h2o_c + M_dcdp_c + M_trdox_c c FALSE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW043 RHEA:23252;RHEA:23252 +R_RC02017 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase M_adp_c + M_trdrd_c <=> M_h2o_c + M_dadp_c + M_trdox_c c TRUE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW042 "RHEA:23252;RHEA:23252" set to reversible janna +R_RC02018 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase M_udp_c + M_trdrd_c <=> M_h2o_c + M_dudp_c + M_trdox_c c FALSE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW043 "RHEA:23252;RHEA:23252" +R_RC02019 2-Deoxyguanosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase M_gdp_c + M_trdrd_c <=> M_h2o_c + M_dgdp_c + M_trdox_c c FALSE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW042 "RHEA:23252;RHEA:23252" +R_RC02024 2-Deoxycytidine diphosphate:oxidized-thioredoxin 2-oxidoreductase M_cdp_c + M_trdrd_c <=> M_h2o_c + M_dcdp_c + M_trdox_c c FALSE WBGene00004391 and WBGene00004392 and (WBGene00017610 or WBGene00019055) PW043 "RHEA:23252;RHEA:23252" R_RC02037 S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase M_ethamp_c + M_amet_c <=> M_h_c + M_ahcys_c + M_methamp_c c FALSE WBGene00022781 PW056 R_RC02061 geranylgeranyl diphosphate synthase M_ipdp_c + M_frdp_c <=> M_ppi_c + M_ttc_ggdp_c c TRUE WBGene00000761 or WBGene00011058 PW001 R02061 added KEGGID, ChEBI ms R_RC02098 ATP:dUMP phosphotransferase M_atp_c + M_dump_c <=> M_adp_c + M_dudp_c c TRUE WBGene00011272 PW043 RHEA:13517 R_RC02102 2-Deoxyuridine 5-monophosphate phosphohydrolase M_h2o_c + M_dump_c <=> M_pi_c + M_duri_c c FALSE WBGene00017775 or WBGene00012423 or WBGene00022201 PW043 R_RC02107 Xanthine:oxygen oxidoreductase M_h2o_c + M_xan_c + M_o2_c <=> M_h2o2_c + M_urate_c c FALSE WBGene00010083 PW042 -R_RC02124 retinol:NAD+ oxidoreductase M_nad_c + M_retinol_c <=> M_h_c + M_nadh_c + M_retinal_c c TRUE ((WBGene00019240 or WBGene00021747) or (WBGene00017060 or WBGene00010790 or WBGene00010791)) or (WBGene00000982 or WBGene00000967) PW069 RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740 +R_RC02124 retinol:NAD+ oxidoreductase M_nad_c + M_retinol_c <=> M_h_c + M_nadh_c + M_retinal_c c TRUE ((WBGene00019240 or WBGene00021747) or (WBGene00017060 or WBGene00010790 or WBGene00010791)) or (WBGene00000982 or WBGene00000967) PW069 "RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740" R_RC02173 Tryptamine:oxygen oxidoreductase (deaminating) M_h2o_c + M_o2_c + M_trypta_c <=> M_h2o2_c + M_id3acald_c + M_nh4_c c FALSE WBGene00000138 PW072 R_RC02186 Dolichyl-diphosphate:polyphosphate phosphotransferase M_pi_c + M_doldp_c <=> M_ppi_c + M_dolp_c c TRUE Unknown PW011 R_RC02222 steroyl-CoA,hydrogen-donor:oxygen oxidoreductase M_o2_c + M_coa18_0_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + M_coa18_1_9z_c + 2.0 M_ficytb5_c c FALSE WBGene00001399 or WBGene00001398 PW061 [DELETION] Dupe of R_1_14_19_1_RXN_c jpnh @@ -2319,15 +2319,15 @@ R_RC02235 dihydrofolate:NAD+ oxidoreductase M_fol_c + M_nadh_c <=> M_dhf_c + M_ R_RC02266 Prostaglandin-H2 D-isomerase (Precursor) M_prostgh2_c <=> M_prostgd2_c c TRUE WBGene00001759 PW068 R_RC02286 formimidoylglutamate deiminase M_h2o_c + 3.0 M_h_c + M_forglu_c <=> M_Nforglu_c + M_nh4_c c FALSE WBGene00000775 PW084 R_RC02295 Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase M_r1p_c + M_h_c + M_nac_c <=> M_pi_c + M_nicrns_c c TRUE WBGene00019298 PW035 -R_RC02335 UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase M_uacgam_c <=> M_h_c + M_udp_c + M_chtn_c c FALSE WBGene00000496 or WBGene00000497 PW031 RHEA:16637;RHEA:16637 +R_RC02335 UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase M_uacgam_c <=> M_h_c + M_udp_c + M_chtn_c c FALSE WBGene00000496 or WBGene00000497 PW031 "RHEA:16637;RHEA:16637" R_RC02364 NADPH2:qui oxidoreductase M_h_c + M_nadph_c + M_q_c <=> M_nadp_c + M_qh2_c c FALSE WBGene00009554 PW098 R_RC02382 Tyramine:oxygen oxidoreductase (deaminating) (flavin-containing) M_tym_c + M_h2o_c + M_o2_c <=> M_h2o2_c + M_4hoxpacd_c + M_nh4_c c FALSE WBGene00000138 PW077 R_RC02383 Monophenol,L-dopa:oxygen oxidoreductase M_tym_c + M_h_c + M_nadh_c + M_o2_c <=> M_h2o_c + M_dopa_c + M_nad_c c FALSE WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231 PW077 -R_RC02389 UDP-glucuronate-bilirubin glucuronyltransferase 2.0 M_udpglcur_c + M_bilirub_c <=> 2.0 M_udp_c + M_bildglcur_c c FALSE WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587 PW005 RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032 +R_RC02389 UDP-glucuronate-bilirubin glucuronyltransferase 2.0 M_udpglcur_c + M_bilirub_c <=> 2.0 M_udp_c + M_bildglcur_c c FALSE WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587 PW005 "RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032" R_RC02463 2-alkenal reductase M_h_c + M_nadph_c + M_hxdcenal_c <=> M_hxdcal_c + M_nadp_c c FALSE Unknown PW098 R_RC02466 3-Sulfino-L-alanine carboxy-lyase M_h_c + M_3sala_c <=> M_co2_c + M_hyptaur_c c FALSE WBGene00006762 PW090 -R_RC02478 UDP-glucuronate-androsterone glucuronyltransferase M_udpglcur_c + M_andrstrn_c <=> M_udp_c + M_andrstrnglc_c c FALSE WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587 PW049 RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032 -R_RC02485 Deoxycytidine aminohydrolase M_h2o_c + M_h_c + M_dcyt_c <=> M_duri_c + M_nh4_c c FALSE WBGene00000391 or WBGene00000392 PW043 RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069 +R_RC02478 UDP-glucuronate-androsterone glucuronyltransferase M_udpglcur_c + M_andrstrn_c <=> M_udp_c + M_andrstrnglc_c c FALSE WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587 PW049 "RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032" +R_RC02485 Deoxycytidine aminohydrolase M_h2o_c + M_h_c + M_dcyt_c <=> M_duri_c + M_nh4_c c FALSE WBGene00000391 or WBGene00000392 PW043 "RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069" R_RC02497 dihydrotestosterone:NADP+ delta4-oxidoreductase M_h_c + M_nadph_c + M_tststerone_c <=> M_nadp_c + M_5adtststerone_c c FALSE WBGene00007102 or WBGene00009635 PW049 R_RC02529 aminoacetone:oxygen oxidoreductase (deaminating) M_h2o_c + M_o2_c + M_aact_c <=> M_h2o2_c + M_mthgxl_c + M_nh4_c c FALSE WBGene00000138 PW074 R_RC02531 Lactaldehyde:NAD+ 1-oxidoreductase M_nad_c + M_lald_D_c <=> M_h_c + M_nadh_c + M_mthgxl_c c TRUE WBGene00012722 PW022 SPW004 @@ -2336,31 +2336,31 @@ R_RC02535 3,4-dihydroxyphenetylamine,ascorbate:oxygen oxidoreductase (beta-hydro R_RC02556 Deoxyadenosine aminohydrolase M_h2o_c + M_h_c + M_dad_2_c <=> M_din_c + M_nh4_c c FALSE WBGene00015551 or WBGene00016632 PW042 R_RC02577 Propane-1,2-diol:NAD+ 1-oxidoreductase M_nadp_c + M_12ppd_R_c <=> M_h_c + M_nadph_c + M_lald_D_c c TRUE WBGene00012722 PW052 R_RC02668 3-Hydroxy-L-kynurenine hydrolase M_h2o_c + M_hLkynr_c <=> M_3hanthrn_c + M_ala__L_c c FALSE WBGene00015802 PW072 [DELETION] Dupe of R_HKYNH_c jpnh -R_RC02670 Hydroxyanthranilate oxidation 2.0 M_3hanthrn_c + 4.0 M_o2_c <=> 2.0 M_h2o2_c + 2.0 M_o2s_c + 4.0 M_h_c + M_cinnavalininate_c c TRUE WBGene00000830 or WBGene00000831 or WBGene00013220 PW072 RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309 +R_RC02670 Hydroxyanthranilate oxidation 2.0 M_3hanthrn_c + 4.0 M_o2_c <=> 2.0 M_h2o2_c + 2.0 M_o2s_c + 4.0 M_h_c + M_cinnavalininate_c c TRUE WBGene00000830 or WBGene00000831 or WBGene00013220 PW072 "RHEA:20309;RHEA:20309;RHEA:20309;RHEA:20309" R_RC02678 Indole-3-acetaldehyde:NAD+ oxidoreductase M_h2o_c + M_nad_c + M_id3acald_c <=> 2.0 M_h_c + M_nadh_c + M_ind3ac_c c FALSE (WBGene00000108 or WBGene00000110) or WBGene00000118 PW072 R_RC02695 4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase M_h2o_c + M_nad_c + M_4hoxpacd_c <=> 2.0 M_h_c + M_nadh_c + M_4hphac_c c TRUE WBGene00000111 PW077 R_RC02697 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase M_h2o_c + M_nadp_c + M_4hoxpacd_c <=> 2.0 M_h_c + M_nadph_c + M_4hphac_c c TRUE WBGene00000111 PW077 -R_RC02731 D-Fructose-2,6-bisphosphate 2-phosphohydrolase M_h2o_c + M_f26bp_c <=> M_f6p_c + M_pi_c c FALSE WBGene00022456 or WBGene00019295 PW025 RHEA:17289;RHEA:15653 -R_RC02737 trehalose 6-phosphate synthase M_g6p_A_c + M_udpg_c <=> M_h_c + M_udp_c + M_tre6p_c c FALSE WBGene00006602 or WBGene00006603 PW019 RHEA:18889;RHEA:18889 ms -R_RC02739 alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Glucose 6-phosphate) M_g6p_A_c <=> M_g6p_B_c c TRUE WBGene00013597 PW018 SPW004 RHEA:11816;RHEA:11816 +R_RC02731 D-Fructose-2,6-bisphosphate 2-phosphohydrolase M_h2o_c + M_f26bp_c <=> M_f6p_c + M_pi_c c FALSE WBGene00022456 or WBGene00019295 PW025 "RHEA:17289;RHEA:15653" +R_RC02737 trehalose 6-phosphate synthase M_g6p_A_c + M_udpg_c <=> M_h_c + M_udp_c + M_tre6p_c c FALSE WBGene00006602 or WBGene00006603 PW019 "RHEA:18889;RHEA:18889" ms +R_RC02739 alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Glucose 6-phosphate) M_g6p_A_c <=> M_g6p_B_c c TRUE WBGene00013597 PW018 SPW004 "RHEA:11816;RHEA:11816" R_RC02743 (5-L-Glutamyl)-L-cysteine 5-glutamyltransferase (cyclizing) M_glucys_c <=> M_5oxpro_c + M_cys__L_c c FALSE WBGene00016629 PW070 R_RC02750 2-Deoxy-D-ribose 5-phosphate + ADP = Deoxyribose + ATP M_atp_c + M_2doxrib_c <=> M_h_c + M_adp_c + M_2dr5p_c c FALSE WBGene00008548 PW027 SPW004 R_RC02778 Trehalose-6-phosphate phosphohydrolase M_h2o_c + M_tre6p_c <=> M_tre_c + M_pi_c c FALSE WBGene00001649 PW019 RHEA:23420 ms R_RC02869 S-adenosylmethioninamine:spermidine 3-aminopropyltransferase M_ametam_c + M_spmd_c <=> M_5mta_c + M_h_c + M_sprm_c c FALSE WBGene00012909 PW082 -R_RC02902 UDP-glucuronate-retinol glucuronyltransferase M_udpglcur_c + M_retn_c <=> M_udp_c + M_retnglc_c c FALSE WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587 PW069 RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032 +R_RC02902 UDP-glucuronate-retinol glucuronyltransferase M_udpglcur_c + M_retn_c <=> M_udp_c + M_retnglc_c c FALSE WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587 PW069 "RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032" R_RC02908 5-Hydroxytryptamine:oxygen oxidoreductase (deaminating) (flavin-containing) M_h2o_c + M_srtn_c + M_o2_c <=> M_h2o2_c + M_5hoxindact_c + M_nh4_c c FALSE WBGene00000138 PW072 -R_RC02918 L-Tyrosine:tRNA(Tyr) ligase (AMP-forming) M_tyr__L_c + M_atp_c + M_trnatyr_c <=> M_ppi_c + M_amp_c + M_tyrtrna_c c FALSE WBGene00013677 PW085 RHEA:10220;RHEA:10220;RHEA:10220 +R_RC02918 L-Tyrosine:tRNA(Tyr) ligase (AMP-forming) M_tyr__L_c + M_atp_c + M_trnatyr_c <=> M_ppi_c + M_amp_c + M_tyrtrna_c c FALSE WBGene00013677 PW085 "RHEA:10220;RHEA:10220;RHEA:10220" R_RC02957 D-Glucuronolactone:NAD+ oxidoreductase 2.0 M_h2o_c + M_nad_c + M_glac_c <=> 3.0 M_h_c + M_nadh_c + M_glcr_c c TRUE (WBGene00000108 or WBGene00000110) or WBGene00000118 PW045 replaced L-ascorbate biosynthesis with ascorbate and aldarate metabolism lenov R_RC03004 Deaminido NAD diphosphatase M_h2o_c + M_dnad_c <=> M_nicrnt_c + 2.0 M_h_c + M_amp_c c FALSE WBGene00007753 or WBGene00007755 PW035 R_RC03020 pseudouridine synthase M_uri_c <=> M_psduri_c c FALSE WBGene00022250 or WBGene00004248 PW043 RHEA:22376 R_RC03038 L-Alanine:tRNA(Ala) ligase (AMP-forming) M_atp_c + M_ala__L_c + M_trnaala_c <=> M_ppi_c + M_amp_c + M_alatrna_c c FALSE WBGene00000197 PW085 RHEA:12540 R_RC03057 (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate hydrolase M_h2o_c + M_leuktrA4_c <=> M_leuktrB4_c c FALSE WBGene00016589 or WBGene00022610 PW068 R_RC03058 Arachidonate 5-lipoxygenase M_5HPET_c <=> M_h2o_c + M_leuktrA4_c c FALSE TBD PW068 -R_RC03104 3-Mercaptolactate:NAD+ oxidoreductase M_nad_c + M_mercplac_c <=> M_mercppyr_c + M_h_c + M_nadh_c c TRUE WBGene00002262 PW082 RHEA:23444;RHEA:23444 -R_RC03105 3-Mercaptopyruvate:cyanide sulfurtransferase M_mercppyr_c + M_so3_c <=> M_tsul_c + M_pyr_c c TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW082 RHEA:16881;RHEA:16881 -R_RC03219 Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) M_akg_c + M_o2_c + M_pcollgpro_c <=> M_co2_c + M_succ_c + M_pcollg4hpro_c c FALSE WBGene00015773 or WBGene00077688 or WBGene00001077 or WBGene00004025 or WBGene00004026 or WBGene00012815 PW089 RHEA:18945;RHEA:18945 +R_RC03104 3-Mercaptolactate:NAD+ oxidoreductase M_nad_c + M_mercplac_c <=> M_mercppyr_c + M_h_c + M_nadh_c c TRUE WBGene00002262 PW082 "RHEA:23444;RHEA:23444" +R_RC03105 3-Mercaptopyruvate:cyanide sulfurtransferase M_mercppyr_c + M_so3_c <=> M_tsul_c + M_pyr_c c TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW082 "RHEA:16881;RHEA:16881" +R_RC03219 Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) M_akg_c + M_o2_c + M_pcollgpro_c <=> M_co2_c + M_succ_c + M_pcollg4hpro_c c FALSE WBGene00015773 or WBGene00077688 or WBGene00001077 or WBGene00004025 or WBGene00004026 or WBGene00012815 PW089 "RHEA:18945;RHEA:18945" R_RC03291 trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase M_4hpro_LT_c + M_nad_c <=> M_1p3h5c_c + 2.0 M_h_c + M_nadh_c c TRUE WBGene00018904 PW081 -R_RC03315 ATP:pseudouridine 5'-phosphotransferase; pseudouridine kinase M_atp_c + M_psduri_c <=> M_h_c + M_adp_c + M_psd5p_c c FALSE WBGene00020765 PW043 +R_RC03315 "ATP:pseudouridine 5'-phosphotransferase; pseudouridine kinase" M_atp_c + M_psduri_c <=> M_h_c + M_adp_c + M_psd5p_c c FALSE WBGene00020765 PW043 R_RC03346 Nicotinate D-ribonucleotide phosphohydrolase M_nicrnt_c + M_h2o_c <=> M_pi_c + M_nicrns_c c FALSE WBGene00017775 or WBGene00012423 or WBGene00022201 PW035 R_RC03393 inositol-1,4-bisphosphate 1-phosphatase M_h2o_c + M_mi14p_c <=> M_pi_c + M_mi4p_D_c c FALSE ND PW029 R_RC03421 N4-(beta-N-Acetyl-D-glucosaminyl)-L-asparagine amidohydrolase M_h2o_c + M_acBgamamAsn_c <=> M_h_c + M_acBgamam_c + M_asp__L_c c TRUE WBGene00019867 PW100 @@ -2377,15 +2377,15 @@ R_RC03646 L-Arginine:tRNA(Arg) ligase (AMP-forming) M_atp_c + M_arg__L_c + M_t R_RC03648 L-Asparagine:tRNA(Asn) ligase (AMP-forming) M_atp_c + M_asn__L_c + M_trnaasn_c <=> M_ppi_c + M_amp_c + M_asntrna_c c FALSE WBGene00003815 PW085 RHEA:11180 R_RC03650 L-Cysteine:tRNA(Cys) ligase (AMP-forming) M_cys__L_c + M_atp_c + M_trnacys_c <=> M_ppi_c + M_amp_c + M_cystrna_c c FALSE WBGene00000800 PW085 R_RC03652 L-Glutamine:tRNA(Gln) ligase (AMP-forming) M_gln__L_c + M_atp_c + M_trnagln_c <=> M_ppi_c + M_amp_c + M_glntrna_c c FALSE WBGene00001336 PW085 RHEA:20121 -R_RC03654 glycine:tRNA(Gly) ligase (AMP-forming) M_gly_c + M_atp_c + M_trnagly_c <=> M_ppi_c + M_amp_c + M_glytrna_c c FALSE WBGene00001744 PW085 RHEA:16013;RHEA:16014;RHEA:34935;RHEA:34936 +R_RC03654 glycine:tRNA(Gly) ligase (AMP-forming) M_gly_c + M_atp_c + M_trnagly_c <=> M_ppi_c + M_amp_c + M_glytrna_c c FALSE WBGene00001744 PW085 "RHEA:16013;RHEA:16014;RHEA:34935;RHEA:34936" R_RC03655 L-Histidine:tRNA(His) ligase (AMP-forming) M_his__L_c + M_atp_c + M_trnahis_c <=> M_ppi_c + M_amp_c + M_histrna_c c FALSE WBGene00002001 PW085 RHEA:17313 R_RC03656 L-Isoleucine:tRNA(Ile) ligase (AMP-forming) M_ile__L_c + M_atp_c + M_trnaile_c <=> M_ppi_c + M_amp_c + M_iletrna_c c FALSE WBGene00002152 PW085 RHEA:11060 R_RC03657 L-Leucine:tRNA(Leu) ligase (AMP-forming) M_leu__L_c + M_atp_c + M_trnaleu_c <=> M_ppi_c + M_amp_c + M_leutrna_c c FALSE WBGene00003073 PW085 RHEA:11688 -R_RC03658 L-Lysine:tRNALys ligase (AMP-forming) M_lys__L_c + M_atp_c + M_trnalys_c <=> M_ppi_c + M_amp_c + M_lystrna_c c FALSE WBGene00002238 PW085 RHEA:20792;RHEA:20792;RHEA:20792 +R_RC03658 L-Lysine:tRNALys ligase (AMP-forming) M_lys__L_c + M_atp_c + M_trnalys_c <=> M_ppi_c + M_amp_c + M_lystrna_c c FALSE WBGene00002238 PW085 "RHEA:20792;RHEA:20792;RHEA:20792" R_RC03659 L-Methionine:tRNAMet ligase (AMP-forming) M_met__L_c + M_atp_c + M_trnamet_c <=> M_ppi_c + M_amp_c + M_mettrna_c c FALSE WBGene00003415 or WBGene00013678 PW085 RHEA:13481 R_RC03660 L-Phenylalanine:tRNA(Ala) ligase (AMP-forming) M_phe__L_c + M_atp_c + M_trnaphe_c <=> M_ppi_c + M_amp_c + M_phetrna_c c FALSE WBGene00001497 and WBGene00001498 PW085 RHEA:19413 R_RC03661 L-proline:tRNA(Pro) ligase (AMP-forming) M_pro__L_c + M_atp_c + M_trnapro_c <=> M_ppi_c + M_amp_c + M_protrna_c c FALSE WBGene00004189 PW085 -R_RC03662 L-Serine:tRNA(Ser) ligase (AMP-forming) M_ser__L_c + M_atp_c + M_trnaser_c <=> M_ppi_c + M_amp_c + M_sertrna_c c FALSE WBGene00005663 PW085 RHEA:12292;RHEA:42580 +R_RC03662 L-Serine:tRNA(Ser) ligase (AMP-forming) M_ser__L_c + M_atp_c + M_trnaser_c <=> M_ppi_c + M_amp_c + M_sertrna_c c FALSE WBGene00005663 PW085 "RHEA:12292;RHEA:42580" R_RC03663 L-Threonine:tRNA(Thr) ligase (AMP-forming) M_thr__L_c + M_atp_c + M_trnathr_c <=> M_ppi_c + M_amp_c + M_thrtrna_c c FALSE WBGene00006617 PW085 RHEA:24624 R_RC03664 L-Tryptophan -tRNA(Trp) ligase (AMP-forming) M_trp__L_c + M_atp_c + M_trnatrp_c <=> M_ppi_c + M_amp_c + M_trptrna_c c FALSE WBGene00006945 PW085 R_RC03665 L-Valine:tRNAVal ligase (AMP-forming) M_val__L_c + M_atp_c + M_trnaval_c <=> M_ppi_c + M_amp_c + M_valtrna_c c FALSE WBGene00006936 PW085 RHEA:10704 @@ -2403,7 +2403,7 @@ R_RC04025 N-Acetylputrescine:oxygen oxidoreductase (deaminating) (flavin-contain R_RC04073 Peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) M_akg_c + M_o2_c + M_pepasp_c <=> M_co2_c + M_succ_c + M_pepasp3oh_c c FALSE WBGene00010703 PW100 R_RC04171 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase M_akg_c + M_hLkynr_c <=> M_glu__L_c + M_42A3HP24DB_c c TRUE WBGene00009232 PW072 R_RC04173 3-Phosphoserine:2-oxoglutarate aminotransferase M_3php_c + M_glu__L_c <=> M_akg_c + M_pser_L_c c TRUE WBGene00009177 PW074 -R_RC04176 NAD+:poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase (PARP) M_nad_c <=> M_h_c + M_ncam_c + M_polyadprib_c c FALSE WBGene00004049 or WBGene00004050 or WBGene00004053 PW035 RHEA:54424;RHEA:54425;RHEA:58224;RHEA:58225;RHEA:54424;RHEA:54425;RHEA:58224;RHEA:58225;RHEA:54424;RHEA:54425;RHEA:58224;RHEA:58225 +R_RC04176 NAD+:poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase (PARP) M_nad_c <=> M_h_c + M_ncam_c + M_polyadprib_c c FALSE WBGene00004049 or WBGene00004050 or WBGene00004053 PW035 "RHEA:54424;RHEA:54425;RHEA:58224;RHEA:58225;RHEA:54424;RHEA:54425;RHEA:58224;RHEA:58225;RHEA:54424;RHEA:54425;RHEA:58224;RHEA:58225" R_RC04183 alpha-N-Acetyl-D-galactosaminide N-acetylgalactosaminohydrolase M_acgal_c + M_gbside_c <=> M_h2o_c + M_forssman_c c TRUE WBGene00011095 PW098 R_RC04184 Trihexosylceramide N-acetylhexosaminohydrolase M_acgal_c + M_thcrm_c <=> M_h2o_c + M_gbside_c c TRUE WBGene00020509 or WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497 PW098 R_RC04230 (R)-4-Phosphopantothenate:L-cysteine ligase (ATP-dependent) M_4ppan_c + M_cys__L_c + M_atp_c <=> M_4ppcys_c + M_ppi_c + M_h_c + M_amp_c c FALSE WBGene00022171 PW037 @@ -2413,7 +2413,7 @@ R_RC04321 CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase M_cdpch R_RC04326 5'-Phosphoribosyl-N-formylglycinamide formation by 5,10-Methenyltetrahydrofolate M_h2o_c + M_gar_c + M_methf_c <=> 2.0 M_h_c + M_fgam_c + M_thf_c c TRUE WBGene00018174 PW095 R_RC04361 Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferase M_ak2gchol_c + M_Rtotal6coa_c <=> M_coa_c + M_1alk2acglyc_c c FALSE Unknown PW065 R_RC04496 S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase M_amet_c + M_protSfarC_c <=> M_h_c + M_ahcys_c + M_protSfarCmet_c c FALSE WBGene00017673 or WBGene00019710 PW001 RHEA:21672 -R_RC04591 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming) M_5aizc_c + M_atp_c + M_asp__L_c <=> M_25aics_c + M_pi_c + M_h_c + M_adp_c c TRUE WBGene00015116 PW042 RHEA:22628;RHEA:10792 jpnh +R_RC04591 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming) M_5aizc_c + M_atp_c + M_asp__L_c <=> M_25aics_c + M_pi_c + M_h_c + M_adp_c c TRUE WBGene00015116 PW042 "RHEA:22628;RHEA:10792" jpnh R_RC04666 3-Ureidoisobutyrate amidohydrolase M_h2o_c + M_3uib_c + 2.0 M_h_c <=> M_co2_c + M_3aib__D_c + M_nh4_c c FALSE WBGene00017440 PW043 R_RC04674 N-Methylhistamine:oxygen oxidoreductase (deaminating) (copper-containing) M_h2o_c + M_o2_c + M_mhista_c <=> M_h2o2_c + M_3mldz_c + M_nh4_c c FALSE WBGene00000138 PW084 R_RC04770 Selenomethionine methanethiol-lyase (deaminating) M_h2o_c + M_selmeth_c <=> M_h_c + M_2obut_c + M_metsel_c + M_nh4_c c TRUE WBGene00007533 or WBGene00009048 or WBGene00022856 PW088 RHEA:14005 @@ -2421,7 +2421,7 @@ R_RC04807 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreducta R_RC04823 3-oxo-Delta4-steroid 5beta-reductase M_h_c + M_nadph_c + M_xoldiolone_c <=> M_nadp_c + M_xoldioloneh_c c FALSE WBGene00012722 or WBGene00020369 or WBGene00015565 or WBGene00013896 or WBGene00012723 or WBGene00009981 or WBGene00009980 PW066 R_RC04824 3alpha-hydroxysteroid dehydrogenase M_h_c + M_nadh_c + M_xoldioloneh_c <=> M_nad_c + M_xoltriol_c c TRUE WBGene00012722 or WBGene00020369 or WBGene00015565 or WBGene00013896 or WBGene00012723 or WBGene00009981 or WBGene00009980 PW066 R_RC04826 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase M_h_c + M_nadph_c + M_o2_c + M_xol7aone_c <=> M_h2o_c + M_nadp_c + M_xoldiolone_c c FALSE TBD PW066 -R_RC04880 3,4-dihydroxyphenylethyleneglycol:NAD+ oxidoreductase M_nad_c + M_34dhoxpeg_c <=> M_h_c + M_nadh_c + M_34dhmald_c c TRUE WBGene00017060 or WBGene00019240 or WBGene00010790 or WBGene00010791 or WBGene00021747 PW077 RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740 +R_RC04880 3,4-dihydroxyphenylethyleneglycol:NAD+ oxidoreductase M_nad_c + M_34dhoxpeg_c <=> M_h_c + M_nadh_c + M_34dhmald_c c TRUE WBGene00017060 or WBGene00019240 or WBGene00010790 or WBGene00010791 or WBGene00021747 PW077 "RHEA:10736;RHEA:10740;RHEA:10736;RHEA:10740" R_RC04886 melanine biosynthesis (last step) M_o2_c + M_ind56qn_c <=> M_h2o_c + M_eumelanin_c c TRUE Unknown PW077 R_RC04903 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase M_h2o_c + M_nad_c + M_5hoxindact_c <=> 2.0 M_h_c + M_nadh_c + M_5hoxindoa_c c FALSE (WBGene00000108 or WBGene00000110) or WBGene00000118 PW072 R_RC04928 ATP:adenylylsulfate 3'-phosphotransferase M_atp_c + M_adsel_c <=> M_h_c + M_adp_c + M_3padsel_c c TRUE WBGene00004091 PW088 @@ -2432,7 +2432,7 @@ R_RC05052 L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase M_akg_c + R_RC05556 (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10-55 isopentenyl units) 19.0 M_ipdp_c + M_frdp_c <=> 19.0 M_ppi_c + M_dedoldp_c c TRUE WBGene00044025 PW001 R05556 added KEGGID, ChEBI ms R_RC05577 L-Aspartate:tRNA(Asp) ligase (AMP-forming) M_atp_c + M_asp__L_c + M_trnaasp_c <=> M_ppi_c + M_amp_c + M_asptrna_c c FALSE WBGene00001094 PW085 RHEA:19649 R_RC05578 L-glutamate:tRNA(Glu) ligase (AMP-forming) M_glu__L_c + M_atp_c + M_trnaglu_c <=> M_ppi_c + M_amp_c + M_glutrna_c c FALSE WBGene00001337 PW005 -R_RC05623 trimethylamine monooxygenase M_nadph_c + M_o2_c + M_tma_c <=> M_h2o_c + M_nadp_c + M_tmao_c c TRUE WBGene00001476 or WBGene00001477 or WBGene00001478 or WBGene00001479 or WBGene00001480 PW094 RHEA:24468;RHEA:24468;RHEA:24468;RHEA:24468;RHEA:24468 +R_RC05623 trimethylamine monooxygenase M_nadph_c + M_o2_c + M_tma_c <=> M_h2o_c + M_nadp_c + M_tmao_c c TRUE WBGene00001476 or WBGene00001477 or WBGene00001478 or WBGene00001479 or WBGene00001480 PW094 "RHEA:24468;RHEA:24468;RHEA:24468;RHEA:24468;RHEA:24468" R_RC05861 D-alanine:oxygen oxidoreductase (deaminating) M_h2o_c + M_o2_c + M_ala__D_c <=> M_h2o2_c + M_pyr_c + M_nh4_c c FALSE WBGene00022076 PW098 RHEA:21816 R_RC05916 UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase M_uacgam_c + M_1ac2acg3pi_c <=> M_h_c + M_udp_c + M_6nadgpi_c c TRUE WBGene00008504 or WBGene00011860 or WBGene00008431 PW052 replaced pathway Glycosylphosphatidylinositol(GPI)-anchor biosynthesis by glycerolipid metabolism lenov R_RC05972 chitobiosyldiphosphodolichol beta-mannosyltransferase M_gdpmann_c + M_chito2pdol_c <=> M_h_c + M_gdp_c + M_mpdol_c c FALSE WBGene00020820 PW011 @@ -2455,12 +2455,12 @@ R_RC06261 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (8man R_RC06262 dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase M_dolglcp_c + M_m8mpdol_c <=> M_h_c + M_dolp_c + M_g1m8mpdol_c c FALSE WBGene00007435 PW011 R_RC06263 dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase M_dolglcp_c + M_g1m8mpdol_c <=> M_h_c + M_dolp_c + M_g2m8mpdol_c c FALSE WBGene00007464 PW011 R_RC06264 dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase M_dolglcp_c + M_g2m8mpdol_c <=> M_h_c + M_dolp_c + M_g3m8mpdol_c c FALSE WBGene00007043 PW011 RHEA:29543 -R_RC07034 Glutathione: 5-HPETE oxidoreductase 2.0 M_gthrd_c + M_5HPET_c <=> M_h2o_c + M_gthox_c + M_5HETE_c c FALSE WBGene00009165 or WBGene00011045 or WBGene00007517 or WBGene00022377 or WBGene00007516 or WBGene00019846 or WBGene00018850 PW068 RHEA:16833;RHEA:16833;RHEA:16833 +R_RC07034 Glutathione: 5-HPETE oxidoreductase 2.0 M_gthrd_c + M_5HPET_c <=> M_h2o_c + M_gthox_c + M_5HETE_c c FALSE WBGene00009165 or WBGene00011045 or WBGene00007517 or WBGene00022377 or WBGene00007516 or WBGene00019846 or WBGene00018850 PW068 "RHEA:16833;RHEA:16833;RHEA:16833" R_RC07041 Arachidonic acid:oxygen 1-oxidoreductase M_h_c + M_nadph_c + M_o2_c + M_fa20_4_5z8z11z14z_c <=> M_h2o_c + M_nadp_c + M_20HETE_c c FALSE WBGene00008499 or WBGene00009226 PW068 R_RC07050 aryl hydrocarbon hydroxylase M_h_c + M_nadph_c + M_o2_c + M_fa20_4_5z8z11z14z_c <=> M_h2o_c + M_nadp_c + M_eet_c c FALSE WBGene00015399 or WBGene00015400 or WBGene00016786 or WBGene00019473 PW068 -R_RC07109 11,12-EET hydrolase M_h2o_c + M_eet_c <=> M_dhet_c c TRUE WBGene00010628 or WBGene00019329 PW068 RHEA:19037;RHEA:19037 +R_RC07109 11,12-EET hydrolase M_h2o_c + M_eet_c <=> M_dhet_c c TRUE WBGene00010628 or WBGene00019329 PW068 "RHEA:19037;RHEA:19037" R_RC07140 S-(hydroxymethyl)glutathione:NADP+ oxidoreductase M_nadp_c + M_hmgth_c <=> M_Sfglutth_c + M_h_c + M_nadph_c c TRUE WBGene00019240 or WBGene00021747 PW094 -R_RC07171 NADH:oxygen oxidoreductase M_h_c + M_nadh_c + M_o2_c <=> M_h2o2_c + M_nad_c c FALSE WBGene00000253 PW098 RHEA:11264;RHEA:11260 +R_RC07171 NADH:oxygen oxidoreductase M_h_c + M_nadh_c + M_o2_c <=> M_h2o2_c + M_nad_c c FALSE WBGene00000253 PW098 "RHEA:11264;RHEA:11260" R_RC07209 oxysterol 7alpha-hydroxylase (acting on 25-hydroxycholesterol) M_h_c + M_nadph_c + M_o2_c + M_xol25oh_c <=> M_h2o_c + M_nadp_c + M_xoltri25_c c FALSE TBD PW066 R_RC07218 Cholesterol 25-hydroxylase M_h_c + M_nadph_c + M_o2_c + M_chsterol_c <=> M_h2o_c + M_nadp_c + M_xol25oh_c c FALSE WBGene00018036 PW066 R_RC07296 choloyl-CoA hydrolase M_h2o_c + M_cholcoa_c <=> M_h_c + M_coa_c + M_cholate_c c FALSE WBGene00017781 PW066 @@ -2470,11 +2470,11 @@ R_ETHERLIPIDREMODEL0001 Plasmenylethanolamine 2-acylhydrolase M_h2o_c + M_1alke R_RC07380 Lysoplasmalogen ethanolamine phosphohydrolase M_h2o_c + M_alken2gpe_c <=> M_ethamp_c + M_h_c + M_1alkenglyc_c c TRUE WBGene00020195 or WBGene00007753 or WBGene00007755 or WBGene00008776 PW065 R_RC07385 O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine phosphatidohydrolase M_h2o_c + M_1alken2acg3pe_c <=> M_etha_c + M_h_c + M_alkenac2gp_c c TRUE WBGene00004040 or (WBGene00017316 or WBGene00020256 or WBGene00013080) PW065 RHEA:14445 R_ETHERLIPIDREMODEL0002 Plasmanylcholine 2-acylhydrolase M_h2o_c + M_1alk2acg3pc_c <=> M_h_c + M_1alkg3pc_c + M_Rtotal6_c c FALSE WBGene00009801 or WBGene00012319 PW065 SPW003 -R_RC07641 hydrogen-carbonate:ammonia amido-ligase (ADP-forming, carbamate-phosphorylating) M_hco3_c + 2.0 M_atp_c + M_nh4_c <=> M_cbp_c + M_pi_c + 2.0 M_h_c + 2.0 M_adp_c c FALSE WBGene00004259 PW043 RHEA:18633;RHEA:20013;RHEA:24296 +R_RC07641 hydrogen-carbonate:ammonia amido-ligase (ADP-forming, carbamate-phosphorylating) M_hco3_c + 2.0 M_atp_c + M_nh4_c <=> M_cbp_c + M_pi_c + 2.0 M_h_c + 2.0 M_adp_c c FALSE WBGene00004259 PW043 "RHEA:18633;RHEA:20013;RHEA:24296" R_RC07759 very-long-chain 3-oxoacyl-CoA reductase M_h_c + M_nadph_c + M_coa18_0_3o_c <=> M_nadp_c + M_coa18_0_3oh__S_c c TRUE WBGene00002891 PW060 SPW001 RHEA:48680 R_RC07933 DELTA6-fatty-acid desaturase M_o2_c + 2.0 M_focytb5_c + M_coa18_3_9z12z15z_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_strdnccoa_c c FALSE WBGene00001395 PW061 R_RC08198 alphaKG reductase M_nad_c + M_2hglut_c <=> M_akg_c + M_h_c + M_nadh_c c TRUE WBGene00007836 PW046 -R_RC08218 L-serine:tRNASec ligase (AMP-forming) M_ser__L_c + M_atp_c + M_trnasec_c <=> M_ppi_c + M_amp_c + M_sertrna_sec_c c FALSE WBGene00005663 or WBGene00005662 PW085 RHEA:12292;RHEA:42580 fixed gene association lenov +R_RC08218 L-serine:tRNASec ligase (AMP-forming) M_ser__L_c + M_atp_c + M_trnasec_c <=> M_ppi_c + M_amp_c + M_sertrna_sec_c c FALSE WBGene00005663 or WBGene00005662 PW085 "RHEA:12292;RHEA:42580" fixed gene association lenov R_RC08223 L-seryl-tRNA(Sec) kinase M_atp_c + M_sertrna_sec_c <=> M_adp_c + M_serptrna_sec_c c TRUE WBGene00013041 PW088 fixed compound name lenov R_RC08223_m L-seryl-tRNA(Sec) kinase M_atp_m + M_sertrna_sec_m <=> M_adp_m + M_serptrna_sec_m m TRUE WBGene00013041 PW088 added mitochondrial version lenov R_RC08224 selenophosphate:O-phospho-L-seryl-tRNA(Sec) selenium transferase M_selnp_c + M_serptrna_sec_c <=> M_ppi_c + M_h_c + M_sectrna_c c TRUE WBGene00008379 PW088 RHEA:25041 fixed compound name lenov @@ -2493,57 +2493,57 @@ R_RC08734 alpha-methylacyl-CoA racemase M_cholcoar_c <=> M_cholcoas_c c TRUE WBG R_RC08735 Branched-chain acyl-CoA oxidase M_o2_c + M_cholcoas_c <=> M_h2o2_c + M_cholcoads_c c FALSE WBGene00008564 or WBGene00008565 or WBGene00008566 or WBGene00008567 or WBGene00010336 or WBGene00008167 PW066 RHEA:38959 R_RC08759 cholestanetriol 26-monooxygenase M_nadp_c + M_xoltetrol_c <=> M_h_c + M_nadph_c + M_thcholst_c c TRUE WBGene00000905 PW066 RHEA:34631 R_RC08761 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate,NADPH:oxygen oxidoreductase (26-hydroxylating) M_nadph_c + M_o2_c + M_thcholst_c <=> M_h2o_c + M_nadp_c + M_thcholstoic_c c FALSE WBGene00000905 PW066 RHEA:34631 -R_RC09035 acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase M_Rtotal2coa_c + M_1acg3ps_c <=> M_coa_c + M_1ac2acg3ps_c c TRUE WBGene00020115 or WBGene00016934 or WBGene00007446 or WBGene00013995 PW056 RHEA:12937;RHEA:33191;RHEA:32995 -R_RC09036 K13510 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]; K13512 lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]; K13513 lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]; K13514 lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]; K13519 lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-] M_Rtotal2coa_c + M_lpglyc_c <=> M_coa_c + M_1ac2acg3pg_c c TRUE WBGene00020264 or WBGene00022646 or WBGene00044631 or WBGene00019465 or WBGene00008581 PW056 +R_RC09035 acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase M_Rtotal2coa_c + M_1acg3ps_c <=> M_coa_c + M_1ac2acg3ps_c c TRUE WBGene00020115 or WBGene00016934 or WBGene00007446 or WBGene00013995 PW056 "RHEA:12937;RHEA:33191;RHEA:32995" +R_RC09036 "K13510 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase [EC:2.3.1.23 2.3.1.67]; K13512 lysophospholipid acyltransferase [EC:2.3.1.23 2.3.1.-]; K13513 lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51]; K13514 lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]; K13519 lysophospholipid acyltransferase [EC:2.3.1.51 2.3.1.23 2.3.1.-]" M_Rtotal2coa_c + M_lpglyc_c <=> M_coa_c + M_1ac2acg3pg_c c TRUE WBGene00020264 or WBGene00022646 or WBGene00044631 or WBGene00019465 or WBGene00008581 PW056 R_RC09085 ADP:alpha-D-glucose 6-phosphotransferase M_glc_aD_c + M_adp_c <=> M_g6p_A_c + M_h_c + M_amp_c c FALSE WBGene00016810 PW018 SPW004 R_RC09086 ADP:beta-D-glucose 6-phosphotransferase M_glc_bD_c + M_adp_c <=> M_g6p_B_c + M_h_c + M_amp_c c FALSE WBGene00016810 PW018 SPW004 R_RC09319 glycoprotein 6-alpha-L-fucosyltransferase (acting on nm2masn) M_gdpfuc_c + M_nm2masn_c <=> M_h_c + M_gdp_c + M_fnm2masn_c c FALSE WBGene00001508 PW011 RHEA:12985 R_RC09371 S-adenosyl-L-methionine:hydrogen-selenide Se-methyltransferase M_seln_c + M_amet_c <=> M_h_c + M_ahcys_c + M_metsel_c c FALSE WBGene00013151 or WBGene00014228 PW088 RHEA:52808 R_RC09752 GDP:alpha-D-glucose 1-phosphate guanylyltransferase M_pi_c + M_gdpg_c <=> M_g1p_c + M_h_c + M_gdp_c c TRUE WBGene00015678 PW025 RHEA:30387 R_RC09844 farnesyl-diphosphate:protein-cysteine farnesyltransferase M_frdp_c + M_protCys_c <=> M_ppi_c + M_protSfar_c c FALSE WBGene00006465 and WBGene00019823 PW001 RHEA:13345 -R_RC09845 prenyl protein peptidase; Ste24 endopeptidase (acting on farnesyl moiety) M_h2o_c + M_protSfar_c <=> M_peptide_c + M_protSfarC_c c FALSE WBGene00001405 or WBGene00001406 PW001 +R_RC09845 "prenyl protein peptidase; Ste24 endopeptidase (acting on farnesyl moiety)" M_h2o_c + M_protSfar_c <=> M_peptide_c + M_protSfarC_c c FALSE WBGene00001405 or WBGene00001406 PW001 R_RC10059 NADP+:L-tyrosine oxidoreductase (iodinating) M_tyr__L_c + 2.0 M_nadp_c + 2.0 M_i_c <=> 2.0 M_nadph_c + M_35diotyr_c c TRUE WBGene00015334 PW077 R_RC10065 ATP:1D-myo-inositol-1,4,5-trisphosphate 3,6-phosphotransferase 2.0 M_atp_c + M_mi145p_c <=> 2.0 M_h_c + 2.0 M_adp_c + M_mi13456p_c c TRUE WBGene00014081 PW029 R_RC10306 S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] methyltransferase 3.0 M_amet_c + M_caphis_c <=> 3.0 M_h_c + 3.0 M_ahcys_c + M_pdipht_c c TRUE WBGene00007194 PW099 -R_RC10633 NAD-dependent histone deacetylase M_h2o_c + M_nad_c + M_Naclys_c <=> M_ncam_c + M_Nlys_c + M_ac_adprib_c c TRUE WBGene00004800 or WBGene00004801 or WBGene00004802 or WBGene00004803 PW035 RHEA:43636;RHEA:43636;RHEA:43636;RHEA:43636 +R_RC10633 NAD-dependent histone deacetylase M_h2o_c + M_nad_c + M_Naclys_c <=> M_ncam_c + M_Nlys_c + M_ac_adprib_c c TRUE WBGene00004800 or WBGene00004801 or WBGene00004802 or WBGene00004803 PW035 "RHEA:43636;RHEA:43636;RHEA:43636;RHEA:43636" R_RCC0001 citrate hydro-lyase (cis-aconitate-forming) M_cit_c <=> M_icit_c c TRUE WBGene00000040 PW023 SPW004 RHEA:10336 R_RCC0005 maintenance atp M_h2o_c + M_atp_c <=> M_pi_c + M_h_c + M_adp_c c FALSE PW098 -R_RCC0010 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing); 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming) M_dkmpp_c + M_h2o_c + M_o2_c <=> M_for_c + M_pi_c + 2.0 M_h_c + M_2kmb_c c FALSE WBGene00010286 and (WBGene00009636 or WBGene00020149) PW082 +R_RCC0010 "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing); 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" M_dkmpp_c + M_h2o_c + M_o2_c <=> M_for_c + M_pi_c + 2.0 M_h_c + M_2kmb_c c FALSE WBGene00010286 and (WBGene00009636 or WBGene00020149) PW082 R_RCC0018 melanine biosynthesis (merged) 2.0 M_dopaqn_c + 0.5 M_o2_c <=> M_co2_c + M_h2o_c + M_34dhphe_c + M_ind56qn_c c FALSE WBGene00015332 or WBGene00010661 or WBGene00009001 or WBGene00016419 or WBGene00021553 or WBGene00022231 PW077 R_RCC0021 S-Adenosyl-L-methionine:methylethanolamine-phosphate N-methyltransferase 2.0 M_amet_c + M_methamp_c <=> M_cholp_c + 2.0 M_h_c + 2.0 M_ahcys_c c FALSE WBGene00018811 PW056 R_RCC0029 dehydrodolichol diphosphate phosphatase M_h2o_c + M_dedoldp_c <=> M_pi_c + M_h_c + M_dedolp_c c FALSE Unknown PW011 R_RCC0030 dehydrodolichol phosphate phosphatase M_h2o_c + M_dedolp_c <=> M_pi_c + M_dedol_c c FALSE Unknown PW011 R_RCC0031 Polyprenol reductase M_h_c + M_nadph_c + M_dedol_c <=> M_nadp_c + M_dolichol_c c FALSE WBGene00007102 PW011 R_RCC0032 geranylgeranyltransferase M_protCys_c + M_ttc_ggdp_c <=> M_ppi_c + M_protSger_c c TRUE WBGene00013002 or (WBGene00019778 and WBGene00015099) PW001 RHEA:21240 -R_RCC0033 prenyl protein peptidase; Ste24 endopeptidase (acting on geranyl-geranyl moiety) M_h2o_c + M_protSger_c <=> M_peptide_c + M_protSgerC_c c FALSE WBGene00001405 or WBGene00001406 PW001 +R_RCC0033 "prenyl protein peptidase; Ste24 endopeptidase (acting on geranyl-geranyl moiety)" M_h2o_c + M_protSger_c <=> M_peptide_c + M_protSgerC_c c FALSE WBGene00001405 or WBGene00001406 PW001 R_RCC0034 S-Adenosyl-L-methionine:protein-C-terminal-S-geranylgeranyl-L-cysteine O-methyltransferase M_amet_c + M_protSgerC_c <=> M_h_c + M_ahcys_c + M_protSgerCmet_c c FALSE WBGene00017673 or WBGene00019710 PW001 RHEA:21672 -R_RCC0037 GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase; GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase 2.0 M_gdpmann_c + M_m2mpdol_c <=> 2.0 M_h_c + 2.0 M_gdp_c + M_m4mpdol_c c FALSE WBGene00015162 PW011 RHEA:29523 +R_RCC0037 "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase; GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase" 2.0 M_gdpmann_c + M_m2mpdol_c <=> 2.0 M_h_c + 2.0 M_gdp_c + M_m4mpdol_c c FALSE WBGene00015162 PW011 RHEA:29523 R_RCC0038 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (acting on nm4masn) M_h2o_c + M_nm4masn_c <=> M_man_c + M_nm3masn_c c FALSE WBGene00010284 PW011 R_RCC0039 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (acting on nm3masn) M_h2o_c + M_nm3masn_c <=> M_man_c + M_nm2masn_c c FALSE WBGene00010284 PW011 R_RCC0040 beta-N-acetylglucosaminidase (acting on nm3masn) M_h2o_c + M_nm3masn_c <=> M_acgam_c + M_m3masn_c c FALSE WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497 PW011 R_RCC0041 beta-N-acetylglucosaminidase (acting on nm2masn) M_h2o_c + M_nm2masn_c <=> M_acgam_c + M_m2masn_c c FALSE WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497 PW011 R_RCC0042 beta-N-acetylglucosaminidase (acting on fnm2masn) M_h2o_c + M_fnm2masn_c <=> M_acgam_c + M_fm2masn_c c FALSE WBGene00015767 or WBGene00012663 or WBGene00021766 or WBGene00013497 PW011 -R_RCC0045 Debranching enzyme activity M_h2o_c + M_ldex_c <=> M_glc_bD_c + M_ggn_c c FALSE WBGene00011050 PW019;PW053 RHEA:55988 Changed name, replaced M_dxtrn2_c by M_ldex_c, replaced M_dxtrn3_c by M_ggn_c, fixed the stoichiometry, added group lenov -R_RCC0046 dextrin phosphorylase 8 M_pi_c + M_ggn_c <=> 8 M_g1p_c + M_HC02136_c c FALSE WBGene00020696 PW019;PW053 Replaced M_dxtrn3_c by M_ggn_c. Changed stoichiometry to produce 8 G1P. Added M_HC02136_c on the right, but coordinate with reaction R_GLYCOGENIN_GLUCOSYLTRANSFERASE_RXN_c, added group +R_RCC0045 Debranching enzyme activity M_h2o_c + M_ldex_c <=> M_glc_bD_c + M_ggn_c c FALSE WBGene00011050 "PW019;PW053" RHEA:55988 Changed name, replaced M_dxtrn2_c by M_ldex_c, replaced M_dxtrn3_c by M_ggn_c, fixed the stoichiometry, added group lenov +R_RCC0046 dextrin phosphorylase 8 M_pi_c + M_ggn_c <=> 8 M_g1p_c + M_HC02136_c c FALSE WBGene00020696 "PW019;PW053" Replaced M_dxtrn3_c by M_ggn_c. Changed stoichiometry to produce 8 G1P. Added M_HC02136_c on the right, but coordinate with reaction R_GLYCOGENIN_GLUCOSYLTRANSFERASE_RXN_c, added group R_RCC0050 D-bifunctional protein M_h2o_c + M_nad_c + M_cholcoads_c <=> M_h_c + M_nadh_c + M_cholcoaone_c c TRUE WBGene00000988 or WBGene00000991 or WBGene00017123 PW066 -R_RCC0051 poly(ADP-ribose) glycohydrolase (PARG) M_h2o_c + M_polyadprib_c <=> M_adprib_c c FALSE WBGene00004051 or WBGene00004052 PW035 RHEA:52216;RHEA:52216 +R_RCC0051 poly(ADP-ribose) glycohydrolase (PARG) M_h2o_c + M_polyadprib_c <=> M_adprib_c c FALSE WBGene00004051 or WBGene00004052 PW035 "RHEA:52216;RHEA:52216" R_RCC0061 DELTA12-fatty-acid desaturase M_o2_c + M_coa18_1_9z_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_coa18_2_9z12z_c c FALSE WBGene00001394 PW061 R_RCC0062 OMEGA3-fatty acid desaturase M_o2_c + 2.0 M_focytb5_c + M_coa18_2_9z12z_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_coa18_3_9z12z15z_c c FALSE WBGene00001393 PW061 -R_RCC0063 long chain Fatty acid biosynthesis (Stearidonoyl-CoA to Icosatetraenoyl-CoA) 3.0 M_h_c + 2.0 M_nadph_c + M_malcoa_c + M_strdnccoa_c <=> M_co2_c + M_h2o_c + M_coa_c + 2.0 M_nadp_c + M_coa20_4_8z11z14z17z_c c FALSE (WBGene00001239 or WBGene00001240) and WBGene00002891 and WBGene00020517 and WBGene00000198 PW061 RHEA:14473;RHEA:48680;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:45812 -R_RCC0064 long chain Fatty acid biosynthesis (Linolenoyl-CoA to Eicosatrienoyl-CoA) 3.0 M_h_c + 2.0 M_nadph_c + M_malcoa_c + M_coa18_3_6z9z12_c <=> M_co2_c + M_h2o_c + M_coa_c + 2.0 M_nadp_c + M_dlnlcgcoa_c c FALSE (WBGene00001239 or WBGene00001240) and WBGene00002891 and WBGene00020517 and WBGene00000198 PW061 RHEA:14473;RHEA:48680;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:45812 +R_RCC0063 long chain Fatty acid biosynthesis (Stearidonoyl-CoA to Icosatetraenoyl-CoA) 3.0 M_h_c + 2.0 M_nadph_c + M_malcoa_c + M_strdnccoa_c <=> M_co2_c + M_h2o_c + M_coa_c + 2.0 M_nadp_c + M_coa20_4_8z11z14z17z_c c FALSE (WBGene00001239 or WBGene00001240) and WBGene00002891 and WBGene00020517 and WBGene00000198 PW061 "RHEA:14473;RHEA:48680;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:45812" +R_RCC0064 long chain Fatty acid biosynthesis (Linolenoyl-CoA to Eicosatrienoyl-CoA) 3.0 M_h_c + 2.0 M_nadph_c + M_malcoa_c + M_coa18_3_6z9z12_c <=> M_co2_c + M_h2o_c + M_coa_c + 2.0 M_nadp_c + M_dlnlcgcoa_c c FALSE (WBGene00001239 or WBGene00001240) and WBGene00002891 and WBGene00020517 and WBGene00000198 PW061 "RHEA:14473;RHEA:48680;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:45812" R_RCC0065 DELTA5-fatty-acid desaturase M_o2_c + M_dlnlcgcoa_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + M_coa20_4_5z8z11z14z_c + 2.0 M_ficytb5_c c FALSE WBGene00001396 PW061 R_RCC0066 OMEGA3-fatty acid desaturase M_o2_c + M_dlnlcgcoa_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + M_coa20_4_8z11z14z17z_c + 2.0 M_ficytb5_c c FALSE WBGene00001393 PW061 R_RCC0067 OMEGA3-fatty acid desaturase M_o2_c + M_coa20_4_8z11z14z17z_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_tmndnccoa_c c FALSE WBGene00001393 PW061 R_RCC0068 DELTA5-fatty-acid desaturase M_coa20_4_5z8z11z14z_c + M_o2_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + 2.0 M_ficytb5_c + M_tmndnccoa_c c FALSE WBGene00001396 PW061 R_RCC0069 DELTA9-fatty-acid desaturase M_o2_c + M_coa16_0_c + 2.0 M_focytb5_c <=> 2.0 M_h2o_c + M_coa16_1_9z_c + 2.0 M_ficytb5_c c FALSE WBGene00001397 PW061 -R_RCC0070 long chain Fatty acid biosynthesis (Palmitoleyl-coA to Vaccenyl-coA) 3.0 M_h_c + 2.0 M_nadph_c + M_malcoa_c + M_coa16_1_9z_c <=> M_co2_c + M_h2o_c + M_coa_c + 2.0 M_nadp_c + M_coa18_1_11z_c c FALSE (WBGene00001239 or WBGene00001240 or WBGene00001241 or WBGene00001242 or WBGene00001243 or WBGene00001244 or WBGene00001245 or WBGene00001247) and WBGene00002891 and WBGene00020517 and WBGene00000198 PW061 RHEA:14473;RHEA:32727;RHEA:48680;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:45812;RHEA:32727 +R_RCC0070 long chain Fatty acid biosynthesis (Palmitoleyl-coA to Vaccenyl-coA) 3.0 M_h_c + 2.0 M_nadph_c + M_malcoa_c + M_coa16_1_9z_c <=> M_co2_c + M_h2o_c + M_coa_c + 2.0 M_nadp_c + M_coa18_1_11z_c c FALSE (WBGene00001239 or WBGene00001240 or WBGene00001241 or WBGene00001242 or WBGene00001243 or WBGene00001244 or WBGene00001245 or WBGene00001247) and WBGene00002891 and WBGene00020517 and WBGene00000198 PW061 "RHEA:14473;RHEA:32727;RHEA:48680;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:32727;RHEA:45812;RHEA:32727" R_RCC0074 sulfinic acid oxidation M_h2o2_c + M_h_c + M_3sala_c <=> M_h2o_c + M_Lcyst_c c FALSE PW090 R_RCC0076 heme protein synthesis M_pheme_c + M_apohemeprotein_c <=> M_hemeprotein_c c TRUE PW005 R_RCC0078 Prostaglandin G/H synthase M_h_c + M_nadph_c + 2.0 M_o2_c + M_fa20_4_5z8z11z14z_c <=> M_h2o_c + M_nadp_c + M_prostgh2_c c FALSE TBD PW068 R_RCC0079 acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase (acting on Rtotal4 group) M_glyc3p_c + M_Rtotal4coa_c <=> M_coa_c + M_1acglyc3p_c c FALSE WBGene00017261 or (WBGene00018657 or WBGene00011106) PW052 RHEA:15325 -R_RCC0080 acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase (Rtotal5 group) M_Rtotal5coa_c + M_1acglyc3p_c <=> M_coa_c + M_1ac2acglyc3p_c c FALSE ((WBGene00020264 or WBGene00022646 or WBGene00044631) or (WBGene00010339 or WBGene00011543) or (WBGene00016934 or WBGene00007446 or WBGene00013995)) or WBGene00017888 PW052 RHEA:19709;RHEA:19709 +R_RCC0080 acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase (Rtotal5 group) M_Rtotal5coa_c + M_1acglyc3p_c <=> M_coa_c + M_1ac2acglyc3p_c c FALSE ((WBGene00020264 or WBGene00022646 or WBGene00044631) or (WBGene00010339 or WBGene00011543) or (WBGene00016934 or WBGene00007446 or WBGene00013995)) or WBGene00017888 PW052 "RHEA:19709;RHEA:19709" R_RCC0081 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase (acting on TAG) M_h2o_c + M_1ac2acglyc3p_c <=> M_pi_c + M_1ac2acglyc_c c FALSE (WBGene00008749 or WBGene00018756 or WBGene00020895) or WBGene00010425 PW052 -R_RCC0082 ATP:1,2-diacylglycerol 3-phosphotransferase (acting on neutral lipid components) M_atp_c + M_1ac2acglyc_c <=> M_h_c + M_adp_c + M_1ac2acglyc3p_c c FALSE WBGene00000958 or WBGene00000959 or WBGene00000960 or WBGene00006483 or WBGene00019428 PW052 RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272 +R_RCC0082 ATP:1,2-diacylglycerol 3-phosphotransferase (acting on neutral lipid components) M_atp_c + M_1ac2acglyc_c <=> M_h_c + M_adp_c + M_1ac2acglyc3p_c c FALSE WBGene00000958 or WBGene00000959 or WBGene00000960 or WBGene00006483 or WBGene00019428 PW052 "RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272;RHEA:10272" R_RCC0101 fatty-acid--CoA ligase (fa15p0iso) M_atp_c + M_coa_c + M_fa14_0_13me_c <=> M_ppi_c + M_amp_c + M_coa14_0_13me_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 R_RCC0101_c13 fatty-acid--CoA ligase (fa15p0iso) M_atp_c + M_coa_c + M_fa12_0_11me_c <=> M_ppi_c + M_amp_c + M_coa12_0_11me_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 R_RCC0102 fatty-acid--CoA ligase (fa17p0iso) M_atp_c + M_coa_c + M_fa16_0_15me_c <=> M_ppi_c + M_amp_c + M_coa16_0_15me_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 @@ -2551,13 +2551,13 @@ R_RCC0127 fatty-acid--CoA ligase (Rtotal6) M_atp_c + M_coa_c + M_Rtotal6_c <=> R_RCC0129 fatty-acid--CoA ligase (Rtotal3) M_atp_c + M_coa_c + M_Rtotal3_c <=> M_ppi_c + M_amp_c + M_Rtotal3coa_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 R_RCC0130 fatty-acid--CoA ligase (vacc) M_atp_c + M_coa_c + M_vacc_c <=> M_ppi_c + M_amp_c + M_coa18_1_11z_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 R_RCC0131 methylglyoxal synthase M_g3p_c <=> M_pi_c + M_mthgxl_c c FALSE Unknown PW022 SPW004 -R_RCC0134 (S) 3-hydroxybutyryl-CoA hydrolase M_h2o_c + M_3hbcoa_c <=> M_h_c + M_coa_c + M_S3hb_c c FALSE WBGene00017301 PW046 RHEA:20888;RHEA:20888 +R_RCC0134 (S) 3-hydroxybutyryl-CoA hydrolase M_h2o_c + M_3hbcoa_c <=> M_h_c + M_coa_c + M_S3hb_c c FALSE WBGene00017301 PW046 "RHEA:20888;RHEA:20888" R_RCC0136 synthesis of peptide with asparagine M_asn__L_c <=> M_Asn_X_Ser_Thr_c c FALSE PW011 R_RCC0139 GTP:alpha-D-glucose-1-phosphate guanylyltransferase M_g1p_c + M_h_c + M_gtp_c <=> M_ppi_c + M_gdpg_c c TRUE WBGene00016583 or WBGene00021628 PW025 RHEA:15229 R_RCC0140 glyceryl-ether monoxygenase M_thbpt_c + M_o2_c + M_1alkg3pc_c <=> M_h2o_c + M_dhbpt_c + M_hak2lgchol_c c FALSE WBGene00007210 PW065 RHEA:36255 R_RCC0141 Hydroxyalkyl-sn-glycerol decomposition M_hak2lgchol_c <=> M_g3pc_c + M_fattyald_c c FALSE PW065 -R_RCC0142 molybdopterin synthesis-merged M_h2o_c + M_cpmp_c + 2.0 M_cys__L_c + 2.0 M_atp_c + 2.0 M_trdrd_c <=> 2.0 M_ppi_c + 4.0 M_h_c + 2.0 M_amp_c + M_mpt_c + 2.0 M_trdox_c + 2.0 M_ala__L_c c FALSE WBGene00015021 and WBGene00018357 and (WBGene00020842 and WBGene00019633) PW092 RHEA:43616;RHEA:48612;RHEA:26333 -R_RCC0143 molybdopterin adenylyl transferase; molybdopterin molybdotransferase M_mobd_c + 2.0 M_h_c + M_atp_c + M_mpt_c <=> M_h2o_c + M_mptamp_c + M_ppi_c + M_amp_c c FALSE WBGene00003031 or WBGene00003384 or WBGene00003385 PW092 RHEA:31331;RHEA:35047;RHEA:31331;RHEA:35047 +R_RCC0142 molybdopterin synthesis-merged M_h2o_c + M_cpmp_c + 2.0 M_cys__L_c + 2.0 M_atp_c + 2.0 M_trdrd_c <=> 2.0 M_ppi_c + 4.0 M_h_c + 2.0 M_amp_c + M_mpt_c + 2.0 M_trdox_c + 2.0 M_ala__L_c c FALSE WBGene00015021 and WBGene00018357 and (WBGene00020842 and WBGene00019633) PW092 "RHEA:43616;RHEA:48612;RHEA:26333" +R_RCC0143 "molybdopterin adenylyl transferase; molybdopterin molybdotransferase" M_mobd_c + 2.0 M_h_c + M_atp_c + M_mpt_c <=> M_h2o_c + M_mptamp_c + M_ppi_c + M_amp_c c FALSE WBGene00003031 or WBGene00003384 or WBGene00003385 PW092 "RHEA:31331;RHEA:35047;RHEA:31331;RHEA:35047" R_RCC0144 retinol isomerase (9-cis) M_retinol_c <=> M_retinol_9_cis_c c TRUE Unknown PW069 R_RCC0147 fatty-acid--CoA ligase (fa16_1_9z) M_atp_c + M_coa_c + M_fa16_1_9z_c <=> M_ppi_c + M_amp_c + M_coa16_1_9z_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 R_RCC0148 fatty-acid--CoA ligase (fa17c9) M_atp_c + M_coa_c + M_fa17c9_c <=> M_ppi_c + M_amp_c + M_fa17c9coa_c c FALSE WBGene00011174 or WBGene00009221 or WBGene00020343 or WBGene00018152 or WBGene00013575 or WBGene00022037 or WBGene00019920 or WBGene00016716 or WBGene00011173 PW057 @@ -2576,13 +2576,13 @@ R_RCC0171 Procollagen synthesis (modified protein) 0.006239 M_pcollg5hlys_c + 0. R_RCC0172 Procollagen registration M_pcollg_mod_c <=> M_pcollg_diS_c c FALSE WBGene00003962 or WBGene00003963 or WBGene00003964 or WBGene00015168 or WBGene00015752 or WBGene00014807 or WBGene00013030 or WBGene00022836 PW089 R_RCC0173 Procollagen trimerization 3.0 M_pcollg_diS_c <=> M_pcollg_tri_c c FALSE TBD PW089 R_RCC0174 Tropocollagen formation M_pcollg_tri_c <=> 0.99814 M_tropcollg_rest_c + 0.00186 M_tropcollgtyr_c c FALSE WBGene00006592 and WBGene00000254 PW089 -R_RCC0175 Tropocollagen crosslinking by dual oxidase M_h_c + M_nadph_c + M_o2_c + 2.0 M_tropcollgtyr_c <=> 2.0 M_h2o_c + M_nadp_c + 2.0 M_tropcollgtyrX_c c FALSE WBGene00000253 PW089 RHEA:11264;RHEA:11260 +R_RCC0175 Tropocollagen crosslinking by dual oxidase M_h_c + M_nadph_c + M_o2_c + 2.0 M_tropcollgtyr_c <=> 2.0 M_h2o_c + M_nadp_c + 2.0 M_tropcollgtyrX_c c FALSE WBGene00000253 PW089 "RHEA:11264;RHEA:11260" R_RCC0176 Collagen formation 0.99814 M_tropcollg_rest_c + 0.00186 M_tropcollgtyrX_c <=> M_collg_c c FALSE PW089 -R_RCC0177 Protein-lysine methylase M_peplys_c + 3.0 M_amet_c <=> 3.0 M_h_c + 3.0 M_ahcys_c + M_peptmelys_c c FALSE (WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206) PW099 RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024 +R_RCC0177 Protein-lysine methylase M_peplys_c + 3.0 M_amet_c <=> 3.0 M_h_c + 3.0 M_ahcys_c + M_peptmelys_c c FALSE (WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206) PW099 "RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024" R_RCC0178 artificial transformation of peptide to peptidyl-aspartate M_asp__L_c + M_pepX_c <=> M_h2o_c + M_pepasp_c c FALSE PW100 R_RCC0179 artificial transformation of peptide to peptidyl-asparagine M_asn__L_c + M_pepX_c <=> M_h2o_c + M_pepasn_c c FALSE PW100 R_RCC0180 Peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) M_akg_c + M_o2_c + M_pepasn_c <=> M_co2_c + M_succ_c + M_pepasn3oh_c c FALSE WBGene00010703 PW100 -R_RCC0185 (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units) 6.0 M_ipdp_c + M_frdp_c <=> 6.0 M_ppi_c + M_nonadp_c c TRUE WBGene00000761 PW001 R02003;R02061;R07475;R05613;R05612;R05611;R07267 chain reactions ms +R_RCC0185 (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units) 6.0 M_ipdp_c + M_frdp_c <=> 6.0 M_ppi_c + M_nonadp_c c TRUE WBGene00000761 PW001 "R02003;R02061;R07475;R05613;R05612;R05611;R07267" chain reactions ms R_RE00160 FAD diphosphatase M_h2o_e + M_fad_e <=> 2.0 M_h_e + M_amp_e + M_fmn_e e FALSE WBGene00007753 or WBGene00007755 PW040 R_RE00548 riboflavin-5-phosphate phosphohydrolase (acid optimum) M_h2o_e + M_fmn_e <=> M_pi_e + M_ribflv_e e FALSE WBGene00022770 PW040 RHEA:15017 R_RE10092 carbonate hydro-lyase (carbon-dioxide-forming) M_co2_e + M_h2o_e <=> M_hco3_e + M_h_e e TRUE WBGene00000283 PW098 RHEA:10748 Changed pathway annotation from nitrogen metabolism to miscellaneous lenov @@ -2591,10 +2591,10 @@ R_Riboflavin_transport Riboflavin transport M_ribflv_c <=> M_ribflv_e ce TRUE WB R_RIBOKIN_RXN_c Ribokinase M_atp_c + M_rib_D_c <=> M_r5p_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00008548) PW027 SPW004 R_RIBOKIN_RXN_m Ribokinase M_atp_m + M_rib_D_m <=> M_r5p_m + 2.0 M_h_m + M_adp_m m FALSE (WBGene00008548) PW027 SPW004 R_RIBONUCLEOSIDE_DIP_REDUCTII_RXN_c R_RIBONUCLEOSIDE_DIP_REDUCTII_RXN_c M_cdp_c + M_nrdh_ox_c <=> M_h2o_c + M_dcdp_c + M_nrdh_rd_c c FALSE PW043 -R_RM00081 Ferrocytochrome-c:oxygen oxidoreductase 8.0 M_h_m + M_o2_m + 4.0 M_focytC_m <=> 2.0 M_h2o_m + 4.0 M_h_c + 4.0 M_ficytC_m m FALSE (WBGene00010964 and WBGene00010965 and WBGene00010962) and WBGene00000371 and WBGene00012553 and WBGene00006519 and WBGene00022170 and WBGene00017926 and WBGene00009161 PW007 RHEA:11436;RHEA:11436;RHEA:11436 +R_RM00081 Ferrocytochrome-c:oxygen oxidoreductase 8.0 M_h_m + M_o2_m + 4.0 M_focytC_m <=> 2.0 M_h2o_m + 4.0 M_h_c + 4.0 M_ficytC_m m FALSE (WBGene00010964 and WBGene00010965 and WBGene00010962) and WBGene00000371 and WBGene00012553 and WBGene00006519 and WBGene00022170 and WBGene00017926 and WBGene00009161 PW007 "RHEA:11436;RHEA:11436;RHEA:11436" R_RM00130 ATP:dephospho-CoA 3-phosphotransferase M_atp_m + M_dpcoa_m <=> M_h_m + M_adp_m + M_coa_m m FALSE WBGene00011500 or WBGene00022031 PW037 R_RM00138 inorganic triphosphatase (mitochondrial) M_h2o_m + M_pppi_m <=> M_pi_m + M_ppi_m + M_h_m m FALSE Unknown PW098 -R_RM00161 ATP:FMN adenylyltransferase M_h_m + M_atp_m + M_fmn_m <=> M_ppi_m + M_fad_m m FALSE WBGene00011271 PW040 RHEA:17237;RHEA:17237 +R_RM00161 ATP:FMN adenylyltransferase M_h_m + M_atp_m + M_fmn_m <=> M_ppi_m + M_fad_m m FALSE WBGene00011271 PW040 "RHEA:17237;RHEA:17237" R_RM00197 (R)-Lactate:ferricytochrome-c 2-oxidoreductase M_lac__D_m + 2.0 M_ficytC_m <=> 2.0 M_h_m + M_pyr_m + 2.0 M_focytC_m m FALSE WBGene00009334 PW022 SPW004 R_RM00199 ATP:pyruvate,water phosphotransferase M_h2o_m + M_atp_m + M_pyr_m <=> M_pep_m + M_pi_m + 2.0 M_h_m + M_amp_m m FALSE WBGene00011893 PW022 SPW004 R_RM00243 L-glutamate:NAD+ oxidoreductase (deaminating) M_h2o_m + M_glu__L_m + M_nad_m <=> M_akg_m + M_h_m + M_nadh_m + M_nh4_m m TRUE WBGene00014095 PW073 @@ -2602,21 +2602,21 @@ R_RM00245 L-Glutamate 5-semialdehyde:NAD+ oxidoreductase M_h2o_m + M_glu5sa_m + R_RM00248 L-Glutamate:NADP+ oxidoreductase (deaminating) M_h2o_m + M_glu__L_m + M_nadp_m <=> M_akg_m + M_h_m + M_nadph_m + M_nh4_m m TRUE WBGene00014095 PW073 R_RM00258 L-Alanine:2-oxoglutarate aminotransferase M_akg_m + M_ala__L_m <=> M_glu__L_m + M_pyr_m m TRUE WBGene00016333 PW073 R_RM00335 GTP phosphohydrolase M_h2o_m + M_gtp_m <=> M_pi_m + M_h_m + M_gdp_m m FALSE WBGene00001093 or WBGene00001134 PW042 -R_RM00355 L-Aspartate:2-oxoglutarate aminotransferase M_akg_m + M_asp__L_m <=> M_oaa_m + M_glu__L_m m TRUE WBGene00016652 or WBGene00015778 PW073 RHEA:21824;RHEA:21824 -R_RM00369 L-Alanine:glyoxylate aminotransferase M_glx_m + M_ala__L_m <=> M_gly_m + M_pyr_m m TRUE WBGene00020382 or WBGene00011767 PW073 RHEA:22852;RHEA:24248 +R_RM00355 L-Aspartate:2-oxoglutarate aminotransferase M_akg_m + M_asp__L_m <=> M_oaa_m + M_glu__L_m m TRUE WBGene00016652 or WBGene00015778 PW073 "RHEA:21824;RHEA:21824" +R_RM00369 L-Alanine:glyoxylate aminotransferase M_glx_m + M_ala__L_m <=> M_gly_m + M_pyr_m m TRUE WBGene00020382 or WBGene00011767 PW073 "RHEA:22852;RHEA:24248" R_RM00383 Acyl-CoA hydrolase M_h2o_m + M_ppcoa_m <=> M_h_m + M_coa_m + M_ppa_m m FALSE Unknown PW010 R_RM00471 D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase M_4h2oglt_m <=> M_pyr_m + M_glx_m m TRUE Unknown PW081 R_RM00489 L-aspartate 1-carboxy-lyase (beta-alanine-forming) M_h_m + M_asp__L_m <=> M_co2_m + M_ala_B_m m FALSE WBGene00006762 PW086 R_RM00513 ATP:cytidine 5-phosphotransferase M_atp_m + M_cytd_m <=> M_h_m + M_adp_m + M_cmp_m m FALSE WBGene00008948 PW043 R_RM00533 Sulfite:oxygen oxidoreductase M_h2o_c + M_so3_c + M_o2_m <=> M_h2o2_m + M_so4_c c FALSE WBGene00010397 PW096 R_RM00549 riboflavin kinase M_atp_m + M_ribflv_m <=> M_h_m + M_adp_m + M_fmn_m m FALSE WBGene00011224 PW040 -R_RM00585 L-Serine:pyruvate aminotransferase M_ser__L_m + M_pyr_m <=> M_hpyr_m + M_ala__L_m m TRUE WBGene00011767 PW074 RHEA:22852;RHEA:24248 +R_RM00585 L-Serine:pyruvate aminotransferase M_ser__L_m + M_pyr_m <=> M_hpyr_m + M_ala__L_m m TRUE WBGene00011767 PW074 "RHEA:22852;RHEA:24248" R_RM00708 (S)-1-pyrroline-5-carboxylate:NADP+ oxidoreductase 2.0 M_h2o_m + M_1pyr5c_m + M_nadp_m <=> M_h_m + M_glu__L_m + M_nadph_m m FALSE WBGene00000112 PW073 R_RM00711 Acetaldehyde:NADP+ oxidoreductase M_h2o_m + M_nadp_m + M_acald_m <=> 2.0 M_h_m + M_nadph_m + M_ac_m m FALSE WBGene00000111 PW018 SPW004 R_RM00716 N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming) M_akg_m + M_h_m + M_lys__L_m + M_nadph_m <=> M_h2o_m + M_nadp_m + M_saccrp__L_m m TRUE WBGene00019819 PW080 [DELETION] Uncharge balanced version of R_SACCD3_m jpnh R_RM00781 sulfur dioxygenase M_h2o_m + M_o2_m + M_s_m <=> M_so3_m + 2.0 M_h_m m FALSE WBGene00007886 PW096 -R_RM00842 sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase M_dhap_m + M_h_m + M_nadh_m <=> M_glyc3p_m + M_nad_m m TRUE WBGene00010778 PW056 RHEA:11092;RHEA:11092;RHEA:11092;RHEA:11092 -R_RM00935 (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) M_coa_m + M_nad_m + M_2mop_m <=> M_co2_m + M_nadh_m + M_ppcoa_m m FALSE WBGene00000114 PW083 RHEA:20804;RHEA:22992;RHEA:22988 +R_RM00842 sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase M_dhap_m + M_h_m + M_nadh_m <=> M_glyc3p_m + M_nad_m m TRUE WBGene00010778 PW056 "RHEA:11092;RHEA:11092;RHEA:11092;RHEA:11092" +R_RM00935 (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase (CoA-propanoylating) M_coa_m + M_nad_m + M_2mop_m <=> M_co2_m + M_nadh_m + M_ppcoa_m m FALSE WBGene00000114 PW083 "RHEA:20804;RHEA:22992;RHEA:22988" R_RM01025 choline:acceptor 1-oxidoreductase M_chol_m + M_fad_m <=> M_betald_m + M_fadh2_m m TRUE WBGene00007917 PW074 R_RM01175 Butanoyl-CoA:oxygen 2-oxidoreductase M_btcoa_m + M_etfox_m <=> M_b2coa_m + M_etfrd_m m TRUE (WBGene00020812 or WBGene00019406 or WBGene00020366) or (WBGene00016943 or WBGene00015894) PW057 RHEA:14477 R_RM01220 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase M_mlthf_m + M_nadp_m <=> M_nadph_m + M_methf_m m TRUE WBGene00019492 PW095 @@ -2630,15 +2630,15 @@ R_RM01608 3-hydroxypropionate dehydrogenase M_3hpp_m + M_nad_m <=> M_msa_m + M_ R_RM01736 (R)-S-Lactoylglutathione hydrolase M_h2o_m + M_lgt_S_m <=> M_h_m + M_lac__D_m + M_gthrd_m m FALSE WBGene00012459 PW022 SPW004 R_RM01868 (S)-dihydroorotate:qui oxidoreductase M_dhor_S_c + M_q_m <=> M_orot_c + M_qh2_m cm FALSE WBGene00020932 PW043 RHEA:30187 R_RM01875 Thiosulfate:thiol sulfurtransferase M_gthox_m + M_so3_m + M_h2s_m <=> M_tsul_m + 2.0 M_gthrd_m m TRUE Unknown PW096 -R_RM02016 NADPH:oxidized-thioredoxin oxidoreductase M_h_m + M_nadph_m + M_trdox_m <=> M_nadp_m + M_trdrd_m m FALSE WBGene00015553 or (WBGene00014028) PW043 RHEA:20345;RHEA:11740 +R_RM02016 NADPH:oxidized-thioredoxin oxidoreductase M_h_m + M_nadph_m + M_trdox_m <=> M_nadp_m + M_trdrd_m m FALSE WBGene00015553 or (WBGene00014028) PW043 "RHEA:20345;RHEA:11740" R_RM02050 (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase M_pyr_m + M_3aib__D_m <=> M_2mop_m + M_ala__L_m m TRUE WBGene00020382 PW043 R_RM02055 Phsophatidyl-L-serine carboxy-lyase M_h_m + M_1ac2acg3ps_m <=> M_co2_m + M_1ac2acg3pe_m m FALSE WBGene00015159 PW056 RHEA:20828 [DELETION] Replaced by R_PEPCPSBIOSYNTH0005 R_RM02161 Ubiquinol:ferricytochrome-c oxidoreductase 2.0 M_h_m + 2.0 M_ficytC_m + M_qh2_m <=> 4.0 M_h_c + 2.0 M_focytC_m + M_q_m m TRUE WBGene00002162 and WBGene00000829 and WBGene00000869 and (WBGene00020757 or WBGene00012158 or WBGene00011679) and WBGene00012094 and WBGene00020181 and (WBGene00009739 or WBGene00019937) and WBGene00019007 PW007 RHEA:11484 -R_RM02164 Succinate:ubiqui oxidoreductase M_succ_m + M_q_m <=> M_fum_m + M_qh2_m m FALSE ((WBGene00015391 or WBGene00016392) and WBGene00006433) and WBGene00003225 and WBGene00009353 PW023 SPW004 RHEA:40523;RHEA:40523;RHEA:40523 +R_RM02164 Succinate:ubiqui oxidoreductase M_succ_m + M_q_m <=> M_fum_m + M_qh2_m m FALSE ((WBGene00015391 or WBGene00016392) and WBGene00006433) and WBGene00003225 and WBGene00009353 PW023 SPW004 "RHEA:40523;RHEA:40523;RHEA:40523" R_RM02300 S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) M_h2o_m + M_methf_m <=> M_h_m + M_5fthf_m m TRUE WBGene00017765 PW095 RHEA:16945 R_RM02301 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) M_atp_m + M_5fthf_m <=> M_pi_m + M_adp_m + M_methf_m m FALSE WBGene00013708 PW095 R_RM02313 N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase M_h2o_m + M_nad_m + M_saccrp__L_m <=> M_L2aadp6sa_m + M_h_m + M_glu__L_m + M_nadh_m m TRUE WBGene00019819 PW080 [DELETION] Uncharge balanced version of R_1_5_1_9_RXN_m jpnh -R_RM02433 L-cysteate:2-oxoglutarate aminotransferase M_akg_m + M_Lcyst_m <=> M_glu__L_m + M_3spyr_m m TRUE WBGene00016652 or WBGene00015778 PW082 RHEA:21824;RHEA:21824 +R_RM02433 L-cysteate:2-oxoglutarate aminotransferase M_akg_m + M_Lcyst_m <=> M_glu__L_m + M_3spyr_m m TRUE WBGene00016652 or WBGene00015778 PW082 "RHEA:21824;RHEA:21824" R_RM02480 Cytochrome c apocytochrome-c-lyase M_pheme_m + M_apocytc_m <=> M_focytC_m m TRUE WBGene00011527 PW005 RHEA:22648 R_RM02488 Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) M_h_m + M_glutcoa_m + M_etfox_m <=> M_co2_m + M_b2coa_m + M_etfrd_m m FALSE WBGene00010052 PW057 R_RM02529 aminoacetone:oxygen oxidoreductase(deaminating) M_h2o_m + M_o2_m + M_aact_m <=> M_h2o2_m + M_mthgxl_m + M_nh4_m m FALSE WBGene00000138 PW074 @@ -2647,29 +2647,29 @@ R_RM02565 p-Cumic alcohol:NADP+ oxidoreductase M_betald_m + M_h2o_m + M_nad_m R_RM02566 p-Cumic alcohol:NADP+ oxidoreductase M_betald_m + M_h2o_m + M_nadp_m <=> 2.0 M_h_m + M_nadph_m + M_glyb_m m FALSE WBGene00000115 PW074 RHEA:16185 R_RM02661 2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase M_ibcoa_m + M_etfox_m <=> M_2mp2coa_m + M_etfrd_m m TRUE (WBGene00016943 or WBGene00015894 or WBGene00019433) or WBGene00017874 PW083 R_RM02678 Indole-3-acetaldehyde:NAD+ oxidoreductase M_h2o_m + M_nad_m + M_id3acald_m <=> 2.0 M_h_m + M_nadh_m + M_ind3ac_m m FALSE (WBGene00000107 or WBGene00000108 or WBGene00000110) or WBGene00000115 PW072 RHEA:16185 -R_RM02918 L-Tyrosine:tRNA(Tyr) ligase (AMP-forming) M_tyr__L_m + M_atp_m + M_trnatyr_m <=> M_ppi_m + M_amp_m + M_tyrtrna_m m FALSE WBGene00013677 PW085 RHEA:10220;RHEA:10220;RHEA:10220 +R_RM02918 L-Tyrosine:tRNA(Tyr) ligase (AMP-forming) M_tyr__L_m + M_atp_m + M_trnatyr_m <=> M_ppi_m + M_amp_m + M_tyrtrna_m m FALSE WBGene00013677 PW085 "RHEA:10220;RHEA:10220;RHEA:10220" R_RM03035 ATP:pantetheine-4-phosphate adenylyltransferase M_h_m + M_atp_m + M_pan4p_m <=> M_ppi_m + M_dpcoa_m m TRUE WBGene00022031 PW037 R_RM03038 L-Alanine:tRNA(Ala) ligase (AMP-forming) M_atp_m + M_ala__L_m + M_trnaala_m <=> M_ppi_m + M_amp_m + M_alatrna_m m FALSE WBGene00000196 PW085 RHEA:12540 R_RM03102 L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase M_L2aadp6sa_m + M_h2o_m + M_nad_m <=> M_L2aadp_m + 2.0 M_h_m + M_nadh_m m FALSE WBGene00000115 PW080 RHEA:16185 R_RM03103 L-2-Aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase M_L2aadp6sa_m + M_h2o_m + M_nadp_m <=> M_L2aadp_m + 2.0 M_h_m + M_nadph_m m FALSE WBGene00000115 PW080 RHEA:16185 R_RM03172 (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase M_2mbcoa_m + M_etfox_m <=> M_2mb2coa_m + M_etfrd_m m TRUE WBGene00016943 or WBGene00015894 or WBGene00019433 PW083 -R_RM03225 (S)-3-Hydroxybutanoate:2-oxoglutarate oxidoreductase M_akg_m + M_S3hb_m <=> M_acac_m + M_2hglut_m m TRUE WBGene00012608 PW046 RHEA:23048;RHEA:24734 +R_RM03225 (S)-3-Hydroxybutanoate:2-oxoglutarate oxidoreductase M_akg_m + M_S3hb_m <=> M_acac_m + M_2hglut_m m TRUE WBGene00012608 PW046 "RHEA:23048;RHEA:24734" R_RM03291 trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase M_nad_m + M_4hpro_LT_m <=> 2.0 M_h_m + M_nadh_m + M_1p3h5c_m m TRUE WBGene00010924 PW081 R_RM03293 trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase M_nadp_m + M_4hpro_LT_m <=> 2.0 M_h_m + M_nadph_m + M_1p3h5c_m m TRUE WBGene00010924 PW081 -R_RM03381 Methylmalonate semialdehyde dehydrogenase (CoA-acylating) M_coa_m + M_nad_m + M_2mop_m <=> M_h_m + M_nadh_m + M_mmcoa_R_m m TRUE WBGene00000114 PW010 RHEA:20804;RHEA:22992;RHEA:22988 -R_RM03425 glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) M_h_m + M_gly_m + M_lpro_m <=> M_co2_m + M_alpro_m m FALSE WBGene00020022 and (WBGene00008354 or WBGene00009918) PW074 RHEA:24304;RHEA:24304 +R_RM03381 Methylmalonate semialdehyde dehydrogenase (CoA-acylating) M_coa_m + M_nad_m + M_2mop_m <=> M_h_m + M_nadh_m + M_mmcoa_R_m m TRUE WBGene00000114 PW010 "RHEA:20804;RHEA:22992;RHEA:22988" +R_RM03425 glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating) M_h_m + M_gly_m + M_lpro_m <=> M_co2_m + M_alpro_m m FALSE WBGene00020022 and (WBGene00008354 or WBGene00009918) PW074 "RHEA:24304;RHEA:24304" R_RM03451 trimethyllysine dioxygenase M_akg_m + M_o2_m + M_tmlys_m <=> M_co2_m + M_succ_m + M_3htmelys_m m FALSE WBGene00001523 PW099 Why do we have this reaction in the mitochondrion, and all the others in the cytosol? lenov -R_RM03524 L-cysteine hydrogen-sulfide-lyase (adding HCN) M_cys__L_m + M_cyan_m <=> M_h_m + M_cyanala_m + M_h2s_m m TRUE WBGene00010759 PW087 RHEA:17821;RHEA:14829 +R_RM03524 L-cysteine hydrogen-sulfide-lyase (adding HCN) M_cys__L_m + M_cyan_m <=> M_h_m + M_cyanala_m + M_h2s_m m TRUE WBGene00010759 PW087 "RHEA:17821;RHEA:14829" R_RM03534 2-Hydroxyglutarate:(acceptor) 2-oxidoreductase M_fad_m + M_2hglut_m <=> M_akg_m + M_fadh2_m m TRUE WBGene00021564 PW046 R_RM03646 L-Arginine:tRNA(Arg) ligase (AMP-forming) M_atp_m + M_arg__L_m + M_trnaarg_m <=> M_ppi_m + M_amp_m + M_argtrna_m m FALSE WBGene00004680 PW085 R_RM03648 L-Asparagine:tRNA(Asn) ligase (AMP-forming) M_atp_m + M_asn__L_m + M_trnaasn_m <=> M_ppi_m + M_amp_m + M_asntrna_m m FALSE WBGene00013447 PW085 R_RM03650 L-Cysteine:tRNA(Cys) ligase (AMP-forming) M_cys__L_m + M_atp_m + M_trnacys_m <=> M_ppi_m + M_amp_m + M_cystrna_m m FALSE WBGene00000800 PW085 R_RM03651 L-Glutamate:tRNA(Gln) ligase M_glu__L_m + M_atp_m + M_trnagln_m <=> M_ppi_m + M_amp_m + M_glutrna_gln_m m FALSE Unknown PW085 -R_RM03654 glycine:tRNA(Gly) ligase (AMP-forming) M_gly_m + M_atp_m + M_trnagly_m <=> M_ppi_m + M_amp_m + M_glytrna_m m FALSE WBGene00001744 PW085 RHEA:16013;RHEA:16014;RHEA:34935;RHEA:34936 +R_RM03654 glycine:tRNA(Gly) ligase (AMP-forming) M_gly_m + M_atp_m + M_trnagly_m <=> M_ppi_m + M_amp_m + M_glytrna_m m FALSE WBGene00001744 PW085 "RHEA:16013;RHEA:16014;RHEA:34935;RHEA:34936" R_RM03655 L-Histidine:tRNA(His) ligase (AMP-forming) M_atp_m + M_his__L_m + M_trnahis_m <=> M_ppi_m + M_amp_m + M_histrna_m m FALSE WBGene00002001 PW085 RHEA:17313 R_RM03656 L-Isoleucine:tRNA(Ile) ligase (AMP-forming) M_ile__L_m + M_atp_m + M_trnaile_m <=> M_ppi_m + M_amp_m + M_iletrna_m m FALSE WBGene00002153 PW085 R_RM03657 L-Leucine:tRNA(Leu) ligase (AMP-forming) M_leu__L_m + M_atp_m + M_trnaleu_m <=> M_ppi_m + M_amp_m + M_leutrna_m m FALSE WBGene00003074 PW085 -R_RM03658 L-Lysine:tRNALys ligase (AMP-forming) M_lys__L_m + M_atp_m + M_trnalys_m <=> M_ppi_m + M_amp_m + M_lystrna_m m FALSE WBGene00002238 PW085 RHEA:20792;RHEA:20792;RHEA:20792 +R_RM03658 L-Lysine:tRNALys ligase (AMP-forming) M_lys__L_m + M_atp_m + M_trnalys_m <=> M_ppi_m + M_amp_m + M_lystrna_m m FALSE WBGene00002238 PW085 "RHEA:20792;RHEA:20792;RHEA:20792" R_RM03659 L-Methionine:tRNAMet ligase (AMP-forming) M_met__L_m + M_atp_m + M_trnamet_m <=> M_ppi_m + M_amp_m + M_mettrna_m m FALSE WBGene00013678 PW085 R_RM03660 L-Phenylalanine:tRNA(Ala) ligase (AMP-forming) M_phe__L_m + M_atp_m + M_trnaphe_m <=> M_ppi_m + M_amp_m + M_phetrna_m m FALSE WBGene00013361 PW085 R_RM03661 L-proline:tRNA(Pro) ligase (AMP-forming) M_pro__L_m + M_atp_m + M_trnapro_m <=> M_ppi_m + M_amp_m + M_protrna_m m FALSE WBGene00004190 PW085 @@ -2688,7 +2688,7 @@ R_RM03989 trans-Tetradec-2-enoyl-CoA reductase M_h_m + M_nadph_m + M_coa14_1_2 R_RM03990 Tetradecanoyl-CoA:(acceptor) 2,3-oxidoreductase M_coa14_0_m + M_etfox_m <=> M_coa14_1_2e_m + M_etfrd_m m TRUE (WBGene00020812 or WBGene00019406 or WBGene00020366) or WBGene00017125 PW057 RHEA:14477 R_RM04096 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase M_ivcoa_m + M_etfox_m <=> M_3mb2coa_m + M_etfrd_m m FALSE WBGene00015326 PW083 R_RM04125 S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) M_thf_m + M_alpro_m <=> M_mlthf_m + M_dhlpro_m + M_nh4_m m FALSE WBGene00017765 and (WBGene00008354 or WBGene00009918) PW074 RHEA:16945 -R_RM04188 L-3-amino-isobutanoate:2-oxoglutarate aminotransferase M_glu__L_m + M_2mop_m <=> M_akg_m + M_3aib_m m TRUE WBGene00001794 PW083 RHEA:23352;RHEA:13993 +R_RM04188 L-3-amino-isobutanoate:2-oxoglutarate aminotransferase M_glu__L_m + M_2mop_m <=> M_akg_m + M_3aib_m m TRUE WBGene00001794 PW083 "RHEA:23352;RHEA:13993" R_RM04432 Propanoyl-CoA:(acceptor) 2,3-oxidoreductase M_ppcoa_m + M_etfox_m <=> M_prpncoa_m + M_etfrd_m m TRUE WBGene00016943 or WBGene00015894 PW010 R_RM04433 Electron-transferring-flavoprotein:ubiqui oxidoreductase M_etfrd_m + M_q_m <=> M_etfox_m + M_qh2_m m FALSE WBGene00002855 and (WBGene00009187 and WBGene00017734) PW098 RHEA:24052 R_RM04444 L-1-Pyrroline-3-hydroxy-5-carboxylate:NAD+ oxidoreductase 2.0 M_h2o_m + M_nad_m + M_1p3h5c_m <=> M_h_m + M_nadh_m + M_e4hglu_m m FALSE WBGene00000112 PW081 @@ -2698,13 +2698,13 @@ R_RM04753 trans-Dec-2-enoyl-CoA reductase M_h_m + M_nadph_m + M_coa10_1_2e_m < R_RM04754 Decanoyl-CoA:(acceptor) 2,3-oxidoreductase M_coa10_0_m + M_etfox_m <=> M_coa10_1_2e_m + M_etfrd_m m TRUE (WBGene00020812 or WBGene00019406 or WBGene00020366) PW057 RHEA:14477 R_RM04807 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) M_h_m + M_nadph_m + M_o2_m + M_xoltriol_m <=> M_h2o_m + M_nadp_m + M_xoltetrol_m m FALSE WBGene00000905 PW066 RHEA:34631 R_RM05051 L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase M_h2o_m + M_nad_m + M_4hglusa_m <=> 2.0 M_h_m + M_nadh_m + M_e4hglu_m m TRUE WBGene00000112 PW081 -R_RM05052 L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase M_akg_m + M_e4hglu_m <=> M_glu__L_m + M_4h2oglt_m m FALSE WBGene00016652 or WBGene00015778 PW081 RHEA:21824;RHEA:21824 +R_RM05052 L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase M_akg_m + M_e4hglu_m <=> M_glu__L_m + M_4h2oglt_m m FALSE WBGene00016652 or WBGene00015778 PW081 "RHEA:21824;RHEA:21824" R_RM05066 3-Hydroxy-2-methylpropanoate:NAD+ oxidoreductase M_nad_m + M_3hmp_m <=> M_h_m + M_nadh_m + M_2mop_m m TRUE WBGene00007122 or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978) PW083 R_RM05373 methylmalonyl-CoA carboxy-lyase M_h_m + M_mmcoa_S_m <=> M_co2_m + M_ppcoa_m m FALSE WBGene00009439 PW010 R_RM05577 L-Aspartate:tRNA(Asp) ligase (AMP-forming) M_atp_m + M_asp__L_m + M_trnaasp_m <=> M_ppi_m + M_amp_m + M_asptrna_m m FALSE WBGene00001095 PW085 R_RM05578 L-glutamate:tRNA(Glu) ligase (AMP-forming) M_glu__L_m + M_atp_m + M_trnaglu_m <=> M_ppi_m + M_amp_m + M_glutrna_m m FALSE WBGene00001338 PW005 R_RM06985 trans-Hex-2-enoyl-CoA reductase M_h_m + M_nadph_m + M_coa6_1_2e_m <=> M_nadp_m + M_coa6_0_m m FALSE WBGene00012375 or WBGene00012970 PW060 SPW001 -R_RM07136 L-sulfolactate dehydrogenase M_nad_m + M_sl__L_m <=> M_h_m + M_nadh_m + M_3spyr_m m TRUE WBGene00018491 or WBGene00003162 PW082 RHEA:21432;RHEA:21432;RHEA:21432 +R_RM07136 L-sulfolactate dehydrogenase M_nad_m + M_sl__L_m <=> M_h_m + M_nadh_m + M_3spyr_m m TRUE WBGene00018491 or WBGene00003162 PW082 "RHEA:21432;RHEA:21432;RHEA:21432" R_RM07273 nonaprenyl-4-hydroxybenzoate transferase M_4hbz_m + M_nonadp_m <=> M_ppi_m + M_3nphb_m m FALSE WBGene00000762 PW004 RHEA:44504 R_RM07411 protoheme farnesyltransferase M_h2o_m + M_frdp_c + M_pheme_m <=> M_ppi_m + M_hemeo_m m FALSE WBGene00012895 PW005 R_RM07412 heme A synthase M_o2_m + M_hemeo_m <=> M_h2o_m + M_hemea_m m TRUE WBGene00011526 PW005 @@ -2713,19 +2713,19 @@ R_RM08657 sn-glycerol 3-phosphate:qui oxidoreductase M_glyc3p_c + M_q_m <=> M_d R_RM08759 cholestanetriol 26-monooxygenase M_nadp_m + M_xoltetrol_m <=> M_h_m + M_nadph_m + M_thcholst_m m TRUE WBGene00000905 PW066 RHEA:34631 R_RM08761 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate,NADPH:oxygen oxidoreductase (26-hydroxylating) M_nadph_m + M_o2_m + M_thcholst_m <=> M_h2o_m + M_nadp_m + M_thcholstoic_m m FALSE WBGene00000905 PW066 RHEA:34631 R_RM08770 Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NAD) M_h_m + M_nadh_m + M_o2_m + M_3nphb_m <=> M_h2o_m + M_nad_m + M_3npdhb_m m FALSE Unknown PW004 -R_RM08771 dihydroxydecaprenylbenzoate methyltransferase M_amet_m + M_3npdhb_m <=> M_h_m + M_ahcys_m + M_me3dhnpdh_m m FALSE WBGene00000763 PW004 RHEA:44452;RHEA:44380 +R_RM08771 dihydroxydecaprenylbenzoate methyltransferase M_amet_m + M_3npdhb_m <=> M_h_m + M_ahcys_m + M_me3dhnpdh_m m FALSE WBGene00000763 PW004 "RHEA:44452;RHEA:44380" R_RM08772 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation M_h_m + M_me3dhnpdh_m <=> M_co2_m + M_2np6mep_m m FALSE Unknown PW004 R_RM08773 Ubiqui biosynthesis monooxgenase COQ6 M_o2_m + M_2np6mep_m <=> M_h2o_m + M_2np6mobq_m m FALSE WBGene00000766 PW004 R_RM08774 Ubiqui biosynthesis methyltransferase COQ5 M_amet_m + M_2np6mobq_m <=> M_h_m + M_ahcys_m + M_me2np6mobq_m m FALSE WBGene00000765 PW004 RHEA:28286 R_RM08775 Ubiqui biosynthesis COQ7 M_h_m + M_nadph_m + M_o2_m + M_me2np6mobq_m <=> M_h2o_m + M_nadp_m + M_2npmhobq_m m FALSE WBGene00000536 PW004 -R_RM08781 methyltransferase COQ3 M_amet_m + M_2npmhobq_m <=> M_h_m + M_ahcys_m + M_q9_m m FALSE WBGene00000763 PW004 RHEA:44452;RHEA:44380 +R_RM08781 methyltransferase COQ3 M_amet_m + M_2npmhobq_m <=> M_h_m + M_ahcys_m + M_q9_m m FALSE WBGene00000763 PW004 "RHEA:44452;RHEA:44380" R_RM10151 Thiosulfate oxidation (cytochrome c reducing) 5.0 M_h2o_m + M_tsul_m + 8.0 M_ficytC_m <=> 2.0 M_so4_m + 10.0 M_h_m + 8.0 M_focytC_m m FALSE WBGene00017121 or WBGene00013854 PW096 R_RMC0001 isocitrate hydro-lyase (cis-aconitate-forming) M_cit_m <=> M_icit_m m TRUE WBGene00000041 PW023 SPW004 RHEA:10336 -R_RMC0004 ATP phosphohydrolase M_pi_m + 4.0 M_h_i + M_adp_m <=> M_h2o_m + 3.0 M_h_m + M_atp_m m FALSE ((WBGene00010419 or WBGene00012040) and WBGene00000229 and WBGene00022089 and WBGene00019061 and (WBGene00017982 or WBGene00019880 or WBGene00022582) and WBGene00000230 and WBGene00010960 and (WBGene00000207 or WBGene00000206) and WBGene00022336 and WBGene00007385 and WBGene00011015 and WBGene00011273 and (WBGene00000210 or WBGene00000209)) and (WBGene00013025 and (WBGene00006921 or WBGene00004959) and WBGene00006920 and WBGene00010130 and WBGene00006917 and WBGene00006918 and WBGene00006919 and (WBGene00018698 or WBGene00020507) and (WBGene00006916 or WBGene00006914 or WBGene00006915 or WBGene00006768) and (WBGene00006911 or WBGene00006910 or WBGene00006913 or WBGene00006912) and WBGene00009882 and WBGene00021952) PW007 RHEA:57720;RHEA:57720 -R_RMC0005 ATP phosphohydrolase M_pi_m + 3.0 M_h_i + M_adp_m <=> M_h2o_m + 2.0 M_h_m + M_atp_m m FALSE ((WBGene00010419 or WBGene00012040) and WBGene00000229 and WBGene00022089 and WBGene00019061 and (WBGene00017982 or WBGene00019880 or WBGene00022582) and WBGene00000230 and WBGene00010960 and (WBGene00000207 or WBGene00000206) and WBGene00022336 and WBGene00007385 and WBGene00011015 and WBGene00011273 and (WBGene00000210 or WBGene00000209)) and (WBGene00013025 and (WBGene00006921 or WBGene00004959) and WBGene00006920 and WBGene00010130 and WBGene00006917 and WBGene00006918 and WBGene00006919 and (WBGene00018698 or WBGene00020507) and (WBGene00006916 or WBGene00006914 or WBGene00006915 or WBGene00006768) and (WBGene00006911 or WBGene00006910 or WBGene00006913 or WBGene00006912) and WBGene00009882 and WBGene00021952) PW007 RHEA:57720;RHEA:57720 -R_RMC0006 NADH:ubiqui oxidoreductase 5.0 M_h_m + M_nadh_m + M_q_m <=> 4.0 M_h_c + M_nad_m + M_qh2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356 -R_RMC0007 NADH:ubiqui oxidoreductase M_h_c + M_nadh_m + M_q_m <=> M_nad_m + M_qh2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356 -R_RMC0008 NADH:ubiqui oxidoreductase M_h_m + M_nadh_m + M_q_m <=> M_nad_m + M_qh2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356 +R_RMC0004 ATP phosphohydrolase M_pi_m + 4.0 M_h_i + M_adp_m <=> M_h2o_m + 3.0 M_h_m + M_atp_m m FALSE ((WBGene00010419 or WBGene00012040) and WBGene00000229 and WBGene00022089 and WBGene00019061 and (WBGene00017982 or WBGene00019880 or WBGene00022582) and WBGene00000230 and WBGene00010960 and (WBGene00000207 or WBGene00000206) and WBGene00022336 and WBGene00007385 and WBGene00011015 and WBGene00011273 and (WBGene00000210 or WBGene00000209)) and (WBGene00013025 and (WBGene00006921 or WBGene00004959) and WBGene00006920 and WBGene00010130 and WBGene00006917 and WBGene00006918 and WBGene00006919 and (WBGene00018698 or WBGene00020507) and (WBGene00006916 or WBGene00006914 or WBGene00006915 or WBGene00006768) and (WBGene00006911 or WBGene00006910 or WBGene00006913 or WBGene00006912) and WBGene00009882 and WBGene00021952) PW007 "RHEA:57720;RHEA:57720" +R_RMC0005 ATP phosphohydrolase M_pi_m + 3.0 M_h_i + M_adp_m <=> M_h2o_m + 2.0 M_h_m + M_atp_m m FALSE ((WBGene00010419 or WBGene00012040) and WBGene00000229 and WBGene00022089 and WBGene00019061 and (WBGene00017982 or WBGene00019880 or WBGene00022582) and WBGene00000230 and WBGene00010960 and (WBGene00000207 or WBGene00000206) and WBGene00022336 and WBGene00007385 and WBGene00011015 and WBGene00011273 and (WBGene00000210 or WBGene00000209)) and (WBGene00013025 and (WBGene00006921 or WBGene00004959) and WBGene00006920 and WBGene00010130 and WBGene00006917 and WBGene00006918 and WBGene00006919 and (WBGene00018698 or WBGene00020507) and (WBGene00006916 or WBGene00006914 or WBGene00006915 or WBGene00006768) and (WBGene00006911 or WBGene00006910 or WBGene00006913 or WBGene00006912) and WBGene00009882 and WBGene00021952) PW007 "RHEA:57720;RHEA:57720" +R_RMC0006 NADH:ubiqui oxidoreductase 5.0 M_h_m + M_nadh_m + M_q_m <=> 4.0 M_h_c + M_nad_m + M_qh2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 "RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356" +R_RMC0007 NADH:ubiqui oxidoreductase M_h_c + M_nadh_m + M_q_m <=> M_nad_m + M_qh2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 "RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356" +R_RMC0008 NADH:ubiqui oxidoreductase M_h_m + M_nadh_m + M_q_m <=> M_nad_m + M_qh2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 "RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356" R_RMC0016 L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial M_h2o_m + M_h_m + M_1p3h5c_m <=> M_4hglusa_m m TRUE PW081 R_RMC0023 Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 5thf) 4.0 M_glu__L_m + 4.0 M_atp_m + M_thf_m <=> 4.0 M_pi_m + 4.0 M_h_m + 4.0 M_adp_m + M_5thf_m m FALSE WBGene00017777 PW091 R_RMC0024 Tetrahydrofolyl-[Glu](n):L-glutamate gamma-ligase (ADP-forming) (producing 7thf) 2.0 M_glu__L_m + 2.0 M_atp_m + M_5thf_m <=> 2.0 M_pi_m + 2.0 M_h_m + 2.0 M_adp_m + M_7thf_m m FALSE WBGene00017777 PW091 @@ -2736,25 +2736,25 @@ R_RMC0054 Sulfite:ferricytochrome-c oxidoreductase M_h2o_c + M_so3_c + 2.0 M_fi R_RMC0074 sulfinic acid oxidation M_h2o2_m + M_h_m + M_3sala_m <=> M_h2o_m + M_Lcyst_m m FALSE PW090 R_RMC0075 thioredoxin peroxidase M_h2o2_m + M_trdrd_m <=> 2.0 M_h2o_m + M_trdox_m m FALSE WBGene00006434 or WBGene00011110 PW093 RHEA:10008 R_RMC0077 Sulfide:qui oxidoreductase M_h2s_m + M_q_m <=> M_qh2_m + M_s_m m FALSE WBGene00008538 PW096 -R_RMC0106 Beta oxidation of fa19c11 (mitochondrial) M_h2o_m + M_coa_m + M_fad_m + M_nad_m + M_fa19c11coa_m <=> M_h_m + M_fadh2_m + M_nadh_m + M_accoa_m + M_fa17c9coa_m m FALSE (WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952) PW064 RHEA:16105;RHEA:20724;RHEA:14477 -R_RMC0107 Beta oxidation of fa17c9 (mitochondrial) 3.0 M_h2o_m + 3.0 M_coa_m + 3.0 M_fad_m + 3.0 M_nad_m + M_fa17c9coa_m <=> 3.0 M_h_m + 3.0 M_fadh2_m + 3.0 M_nadh_m + 3.0 M_accoa_m + M_fa11c3coa_m m FALSE (WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952) PW064 RHEA:16105;RHEA:20724;RHEA:14477 +R_RMC0106 Beta oxidation of fa19c11 (mitochondrial) M_h2o_m + M_coa_m + M_fad_m + M_nad_m + M_fa19c11coa_m <=> M_h_m + M_fadh2_m + M_nadh_m + M_accoa_m + M_fa17c9coa_m m FALSE (WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952) PW064 "RHEA:16105;RHEA:20724;RHEA:14477" +R_RMC0107 Beta oxidation of fa17c9 (mitochondrial) 3.0 M_h2o_m + 3.0 M_coa_m + 3.0 M_fad_m + 3.0 M_nad_m + M_fa17c9coa_m <=> 3.0 M_h_m + 3.0 M_fadh2_m + 3.0 M_nadh_m + 3.0 M_accoa_m + M_fa11c3coa_m m FALSE (WBGene00020812 or WBGene00019406 or WBGene00020366 or WBGene00017125) and ((WBGene00001155 or WBGene00001156) or (WBGene00020347 or WBGene00001150) or WBGene00001152) and ((WBGene00020347 or WBGene00001150) or (WBGene00007129 or WBGene00010035 or WBGene00001157 or WBGene00001158 or WBGene00019978)) and (WBGene00015125 or WBGene00009952) PW064 "RHEA:16105;RHEA:20724;RHEA:14477" R_RMC0132 PW097 M_h2o_m + 2.0 M_cys__L_m + M_atp_m + M_apoISclustprot_m + 2.0 M_fe3_m <=> M_pi_m + M_h_m + M_adp_m + M_ISclustprot_m + 2.0 M_ala__L_m m FALSE WBGene00015021 and WBGene00012885 and (WBGene00001486 or WBGene00012666) and WBGene00001033 and WBGene00002010 PW097 RHEA:11148 -R_RMC0133 branched-chain 2-oxo acid dehydrogenase M_coa_m + M_nad_m + M_2obut_m <=> M_co2_m + M_nadh_m + M_ppcoa_m m FALSE ((WBGene00012713 or WBGene00012799) and WBGene00006518) and WBGene00010794 and WBGene00014054 PW010 RHEA:15045;RHEA:13457;RHEA:13457;RHEA:18865 +R_RMC0133 branched-chain 2-oxo acid dehydrogenase M_coa_m + M_nad_m + M_2obut_m <=> M_co2_m + M_nadh_m + M_ppcoa_m m FALSE ((WBGene00012713 or WBGene00012799) and WBGene00006518) and WBGene00010794 and WBGene00014054 PW010 "RHEA:15045;RHEA:13457;RHEA:13457;RHEA:18865" R_RMC0154 Propionyl-CoA:carnitine O-propionyltransferase II M_coa_m + M_pcrn_m <=> M_crn_m + M_ppcoa_m m FALSE WBGene00011122 PW010 R_RMC0155 electron transfer flavoprotein M_fadh2_m + M_etfox_m <=> M_fad_m + M_etfrd_m m FALSE PW098 R_RMC0182 rhodoqui-9 biosynthesis M_h2o_m + M_q9_m + 3.0 M_nad_m + M_nh4_m <=> M_co2_m + 4.0 M_h_m + 3.0 M_nadh_m + M_rq9_m m FALSE Unknown PW004 R_RMC0183 fumarate reductase M_fum_m + M_rq9h2_m <=> M_succ_m + M_rq9_m m FALSE WBGene00018610 PW023 SPW004 -R_RMC0184 NADH:rhodoqui oxidoreductase 5.0 M_h_m + M_nadh_m + M_rq9_m <=> 4.0 M_h_c + M_nad_m + M_rq9h2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356 FALSE -R_rnasynth_m RNA polymerisation in mitochondria 0.406 M_h2o_m + 0.406 M_atp_m + 0.381 M_datp_m + 0.119 M_gtp_m + 0.381 M_utp_m + 0.119 M_ctp_m <=> 0.406 M_pi_m + M_ppi_m + 0.406 M_h_m + 0.406 M_adp_m + 0.381 M_adnr_m + 0.119 M_guar_m + 0.381 M_urir_m + 0.119 M_cytr_m m FALSE ((WBGene00009658 or WBGene00011791 or WBGene00012528) and WBGene00001596 and WBGene00014115) and (WBGene00012999 and WBGene00008781 and WBGene00000123 and WBGene00016140 and WBGene00004411 and WBGene00017300 and WBGene00013680) PW044 RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:11332;RHEA:11332 replace the generic production of DNA to represent each nucleotide residue lenov -R_rnasynth_n RNA polymerisation in nucleus 0.406 M_h2o_n + 0.731 M_atp_n + 0.175 M_gtp_n + 0.325 M_utp_n + 0.175 M_ctp_n <=> 0.406 M_pi_n + M_ppi_n + 0.406 M_h_n + 0.406 M_adp_n + 0.325 M_adnr_n + 0.175 M_guar_n + 0.325 M_urir_n + 0.175 M_cytr_n n FALSE ((WBGene00009658 or WBGene00011791 or WBGene00012528) and WBGene00001596 and WBGene00014115) and (WBGene00012999 and WBGene00008781 and WBGene00000123 and WBGene00016140 and WBGene00004411 and WBGene00017300 and WBGene00013680) PW044 RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:11332;RHEA:11332 replace the generic production of DNA to represent each nucleotide residue lenov -R_RNDR1_m R_RNDR1_m M_h2o_m + M_dadp_m + M_trdox_m <=> M_adp_m + M_trdrd_m m TRUE (WBGene00004391 and WBGene00004392) PW042 RHEA:23252;RHEA:23252 -R_RNDR1_n R_RNDR1_n M_h2o_n + M_dadp_n + M_trdox_n <=> M_adp_n + M_trdrd_n n TRUE (WBGene00004391 and WBGene00004392) PW042 RHEA:23252;RHEA:23252 -R_RNDR2_m R_RNDR2_m M_gdp_m + M_trdrd_m <=> M_h2o_m + M_dgdp_m + M_trdox_m m FALSE (WBGene00004391 and WBGene00004392) PW042 RHEA:23252;RHEA:23252 -R_RNDR2_n R_RNDR2_n M_gdp_n + M_trdrd_n <=> M_h2o_n + M_dgdp_n + M_trdox_n n FALSE (WBGene00004391 and WBGene00004392) PW042 RHEA:23252;RHEA:23252 -R_RNDR3_m R_RNDR3_m M_cdp_m + M_trdrd_m <=> M_h2o_m + M_dcdp_m + M_trdox_m m FALSE (WBGene00004391 and WBGene00004392) PW043 RHEA:23252;RHEA:23252 -R_RNDR3_n R_RNDR3_n M_cdp_n + M_trdrd_n <=> M_h2o_n + M_dcdp_n + M_trdox_n n FALSE (WBGene00004391 and WBGene00004392) PW043 RHEA:23252;RHEA:23252 -R_RNDR4_m R_RNDR4_m M_udp_m + M_trdrd_m <=> M_h2o_m + M_dudp_m + M_trdox_m m FALSE (WBGene00004391 and WBGene00004392) PW043 RHEA:23252;RHEA:23252 -R_RNDR4_n R_RNDR4_n M_udp_n + M_trdrd_n <=> M_h2o_n + M_dudp_n + M_trdox_n n FALSE (WBGene00004391 and WBGene00004392) PW043 RHEA:23252;RHEA:23252 +R_RMC0184 NADH:rhodoqui oxidoreductase 5.0 M_h_m + M_nadh_m + M_rq9_m <=> 4.0 M_h_c + M_nad_m + M_rq9h2_m m FALSE (WBGene00010959 and WBGene00010961 and WBGene00010966 and WBGene00010963 and WBGene00010967 and WBGene00010957 and WBGene00010958) and (WBGene00009992 and (WBGene00001520 or WBGene00006463) and WBGene00020417 and WBGene00003831 and WBGene00021562 and WBGene00012376 and WBGene00020636 and WBGene00003061 and WBGene00021839 and WBGene00009051) and (WBGene00009294 and WBGene00013406 and WBGene00007880 and WBGene00013308 and WBGene00009740 and WBGene00021849 and WBGene00021800 and WBGene00019401 and (WBGene00018151 or WBGene00013237) and WBGene00016393) and (WBGene00009712 and WBGene00007684 and WBGene00012166 and WBGene00016118 and WBGene00014086 and WBGene00008414 and WBGene00013094 and WBGene00015810 and WBGene00010326 and WBGene00022169 and WBGene00018361) PW007 "RHEA:11356;RHEA:29091;RHEA:29091;RHEA:11356;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:29091;RHEA:11356" FALSE +R_rnasynth_m RNA polymerisation in mitochondria 0.406 M_h2o_m + 0.406 M_atp_m + 0.381 M_datp_m + 0.119 M_gtp_m + 0.381 M_utp_m + 0.119 M_ctp_m <=> 0.406 M_pi_m + M_ppi_m + 0.406 M_h_m + 0.406 M_adp_m + 0.381 M_adnr_m + 0.119 M_guar_m + 0.381 M_urir_m + 0.119 M_cytr_m m FALSE ((WBGene00009658 or WBGene00011791 or WBGene00012528) and WBGene00001596 and WBGene00014115) and (WBGene00012999 and WBGene00008781 and WBGene00000123 and WBGene00016140 and WBGene00004411 and WBGene00017300 and WBGene00013680) PW044 "RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:11332;RHEA:11332" replace the generic production of DNA to represent each nucleotide residue lenov +R_rnasynth_n RNA polymerisation in nucleus 0.406 M_h2o_n + 0.731 M_atp_n + 0.175 M_gtp_n + 0.325 M_utp_n + 0.175 M_ctp_n <=> 0.406 M_pi_n + M_ppi_n + 0.406 M_h_n + 0.406 M_adp_n + 0.325 M_adnr_n + 0.175 M_guar_n + 0.325 M_urir_n + 0.175 M_cytr_n n FALSE ((WBGene00009658 or WBGene00011791 or WBGene00012528) and WBGene00001596 and WBGene00014115) and (WBGene00012999 and WBGene00008781 and WBGene00000123 and WBGene00016140 and WBGene00004411 and WBGene00017300 and WBGene00013680) PW044 "RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:21248;RHEA:11332;RHEA:11332" replace the generic production of DNA to represent each nucleotide residue lenov +R_RNDR1_m R_RNDR1_m M_h2o_m + M_dadp_m + M_trdox_m <=> M_adp_m + M_trdrd_m m TRUE (WBGene00004391 and WBGene00004392) PW042 "RHEA:23252;RHEA:23252" +R_RNDR1_n R_RNDR1_n M_h2o_n + M_dadp_n + M_trdox_n <=> M_adp_n + M_trdrd_n n TRUE (WBGene00004391 and WBGene00004392) PW042 "RHEA:23252;RHEA:23252" +R_RNDR2_m R_RNDR2_m M_gdp_m + M_trdrd_m <=> M_h2o_m + M_dgdp_m + M_trdox_m m FALSE (WBGene00004391 and WBGene00004392) PW042 "RHEA:23252;RHEA:23252" +R_RNDR2_n R_RNDR2_n M_gdp_n + M_trdrd_n <=> M_h2o_n + M_dgdp_n + M_trdox_n n FALSE (WBGene00004391 and WBGene00004392) PW042 "RHEA:23252;RHEA:23252" +R_RNDR3_m R_RNDR3_m M_cdp_m + M_trdrd_m <=> M_h2o_m + M_dcdp_m + M_trdox_m m FALSE (WBGene00004391 and WBGene00004392) PW043 "RHEA:23252;RHEA:23252" +R_RNDR3_n R_RNDR3_n M_cdp_n + M_trdrd_n <=> M_h2o_n + M_dcdp_n + M_trdox_n n FALSE (WBGene00004391 and WBGene00004392) PW043 "RHEA:23252;RHEA:23252" +R_RNDR4_m R_RNDR4_m M_udp_m + M_trdrd_m <=> M_h2o_m + M_dudp_m + M_trdox_m m FALSE (WBGene00004391 and WBGene00004392) PW043 "RHEA:23252;RHEA:23252" +R_RNDR4_n R_RNDR4_n M_udp_n + M_trdrd_n <=> M_h2o_n + M_dudp_n + M_trdox_n n FALSE (WBGene00004391 and WBGene00004392) PW043 "RHEA:23252;RHEA:23252" R_RNTR1_c R_RNTR1_c M_atp_c + M_etfrd_c <=> M_h2o_c + M_datp_c + M_etfox_c c FALSE PW042 R_RNTR2_c R_RNTR2_c M_gtp_c + M_etfrd_c <=> M_h2o_c + M_dgtp_c + M_etfox_c c FALSE PW042 R_RNTR3_c R_RNTR3_c M_ctp_c + M_etfrd_c <=> M_h2o_c + M_dctp_c + M_etfox_c c FALSE PW043 @@ -2763,7 +2763,7 @@ R_RPE_c ribulose phosphate 3-epimerase M_ru5p_D_c <=> M_xu5p_D_c c TRUE (WBGene0 R_RPI_c Ribose 5-phosphate epimerase M_r5p_c <=> M_ru5p_D_c c TRUE (WBGene00015101) PW027 SPW004 RHEA:14657 R_RPI_m Ribose 5-phosphate epimerase M_r5p_m <=> M_ru5p_D_m m TRUE (WBGene00015101) PW027 SPW004 RHEA:14657 R_Rthioredtn Red Thioredoxin nuclear transport (diffusion) M_trdrd_c <=> M_trdrd_n cn TRUE PW108 -R_RXN_10841_c NADP-retinol dehydrogenase M_nadp_c + M_retinol_c <=> M_h_c + M_nadph_c + M_retinal_c c TRUE (WBGene00000967) or (WBGene00000982) or (WBGene00000976) or (WBGene00007780) or (WBGene00010063) PW069 RHEA:19257;RHEA:10736;RHEA:10740 +R_RXN_10841_c NADP-retinol dehydrogenase M_nadp_c + M_retinol_c <=> M_h_c + M_nadph_c + M_retinal_c c TRUE (WBGene00000967) or (WBGene00000982) or (WBGene00000976) or (WBGene00007780) or (WBGene00010063) PW069 "RHEA:19257;RHEA:10736;RHEA:10740" R_RXN_10938_c R_RXN_10938_c M_h2o_c + M_1ac2acg3pi3p5p_c <=> M_pi_c + 2.0 M_h_c + M_1ac2acg3pi3p_c c FALSE PW029 R_RXN_10945_c R_RXN_10945_c M_h2o_c + M_mi13456p_c <=> M_pi_c + M_mi1456p_c c FALSE PW029 R_RXN_10958_c R_RXN_10958_c M_h2o_c + M_1ac2acg3pi3p5p_c <=> M_pi_c + 2.0 M_h_c + M_1ac2acg3pi5p_c c FALSE PW029 @@ -2778,8 +2778,8 @@ R_RXN_10974_n R_RXN_10974_n M_atp_n + M_dpminol_n <=> M_adp_n + M_6bppoldm_n n R_RXN_10979_c R_RXN_10979_c M_atp_c + M_ppmi12346p_c <=> M_adp_c + M_8bppoldm_c c FALSE (WBGene00018508) PW029 R_RXN_10979_n R_RXN_10979_n M_atp_n + M_ppmi12346p_n <=> M_adp_n + M_8bppoldm_n n FALSE (WBGene00018508) PW029 R_RXN_11325_c R_RXN_11325_c M_oh_c + M_nadp_c + M_fa10_0_c <=> M_fa10_0_10oh_c + M_nadph_c c FALSE PW060 SPW001 -R_RXN_11361_c molybdopterin-synthase adenylyltransferase M_atp_c + M_small_mpts_c <=> M_ppi_c + M_crboxad_c c FALSE (WBGene00018357) PW092 RHEA:43616;RHEA:48612 -R_RXN_11361_n molybdopterin-synthase adenylyltransferase M_atp_n + M_small_mpts_n <=> M_ppi_n + M_crboxad_n n FALSE (WBGene00018357) PW092 RHEA:43616;RHEA:48612 +R_RXN_11361_c molybdopterin-synthase adenylyltransferase M_atp_c + M_small_mpts_c <=> M_ppi_c + M_crboxad_c c FALSE (WBGene00018357) PW092 "RHEA:43616;RHEA:48612" +R_RXN_11361_n molybdopterin-synthase adenylyltransferase M_atp_n + M_small_mpts_n <=> M_ppi_n + M_crboxad_n n FALSE (WBGene00018357) PW092 "RHEA:43616;RHEA:48612" R_RXN_11369_c R_RXN_11369_c M_dopaqn_c + M_2c23dh56dhoxin_c <=> M_L_dpchrm_c + M_34dhphe_c c FALSE PW077 R_RXN_12473_c molybdopterin synthase sulfurtransferase M_prot_scyst_c + M_crboxad_c <=> M_amp_c + M_cysdesase_c + M_thiocarb_mpt_c c FALSE PW092 R_RXN_12547_c Palmitoyl-CoA:retinol O-acyltransferase M_coa_c + M_retpalm_c <=> M_coa16_0_c + M_retinol_c c TRUE (WBGene00010408) PW069 set to reversible janna @@ -2789,34 +2789,34 @@ R_RXN_12579_c R_RXN_12579_c M_h2o_c + M_retest_c <=> M_retinol_c + M_long_fatac R_RXN_12579_n R_RXN_12579_n M_h2o_n + M_retest_n <=> M_retinol_n + M_long_fatacid_n n FALSE (WBGene00015241) PW069 R_RXN_12623_c N,N'-diacetylchitobiose synthase M_h2o_c + M_chdex_c <=> M_chtbs_c c FALSE (WBGene00000503) PW021 R_RXN_12624_c chitotriose synthase M_h2o_c + M_chdex_c <=> M_chttr_c c FALSE (WBGene00000503) PW021 -R_RXN_12625_c N,N'-diacetylchitobioseβ-N-acetylglucosaminidase M_h2o_c + M_chtbs_c <=> 2.0 M_acgam_c c FALSE (WBGene00020509) PW021 -R_RXN_12626_c chitotriose β-N-acetylglucosaminidase M_h2o_c + M_chttr_c <=> M_acgam_c + M_chtbs_c c FALSE (WBGene00020509) PW021 +R_RXN_12625_c "N,N'-diacetylchitobioseβ-N-acetylglucosaminidase" M_h2o_c + M_chtbs_c <=> 2.0 M_acgam_c c FALSE (WBGene00020509) PW021 +R_RXN_12626_c "chitotriose β-N-acetylglucosaminidase" M_h2o_c + M_chttr_c <=> M_acgam_c + M_chtbs_c c FALSE (WBGene00020509) PW021 R_RXN_1685_c alpha-D-glucokinase M_glc_aD_c + M_atp_c <=> M_g6p_A_c + 2.0 M_h_c + M_adp_c c FALSE (WBGene00008780) or (WBGene00022306) or (WBGene00010416) PW018 SPW004 R_RXN_1685_m alpha-D-glucokinase M_glc_aD_m + M_atp_m <=> M_g6p_A_m + 2.0 M_h_m + M_adp_m m FALSE (WBGene00010416) PW018 SPW004 why only one hexokinase associated? Are the two others not in mitochondria? R_RXN_1685_n alpha-D-glucokinase M_glc_aD_n + M_atp_n <=> M_g6p_A_n + 2.0 M_h_n + M_adp_n n FALSE (WBGene00008780) or (WBGene00022306) or (WBGene00010416) PW018 SPW004 R_RXN_2881_c Non enzymatic 5,10-Methylenetetrahydrofolate production M_thf_c + M_fald_c <=> M_h2o_c + M_mlthf_c c TRUE PW091 added rxn name jpnh R_RXN_2961_c Non enzymatic 5,10-Methylenetetrahydrofolate production M_hmgth_c <=> M_fald_c + M_gthrd_c c TRUE PW091 added rxn name jpnh -R_RXN_3521_c L-ascorbate:hydrogen-peroxide oxidoreductase M_h2o2_c + 4.0 M_h_c + 2.0 M_ascb__L_c <=> 2.0 M_h2o_c + 2.0 M_mdascb_c c FALSE PW070 added rxn name; replaced M_ascb__L_c with M_ascb__L_c jpnh; lenov +R_RXN_3521_c L-ascorbate:hydrogen-peroxide oxidoreductase M_h2o2_c + 4.0 M_h_c + 2.0 M_ascb__L_c <=> 2.0 M_h2o_c + 2.0 M_mdascb_c c FALSE PW070 "added rxn name; replaced M_ascb__L_c with M_ascb__L_c" "jpnh; lenov" R_RXN_3522_c monodehydroascorbate reductase (NADPH) M_nadph_c + 2.0 M_mdascb_c <=> 3.0 M_h_c + M_nadp_c + 2.0 M_ascb__L_c c FALSE PW070 replace M_ascb__L_c with M_ascb__L_c lenov -R_RXN_3523_c 2nd step of L-ascorbate:hydrogen-peroxide oxidoreductase 2.0 M_mdascb_c <=> M_dhdascb_c + 3.0 M_h_c + M_ascb__L_c c FALSE PW070 added rxn name; replaced M_ascb__L_c with M_ascb__L_c jpnh; lenov +R_RXN_3523_c 2nd step of L-ascorbate:hydrogen-peroxide oxidoreductase 2.0 M_mdascb_c <=> M_dhdascb_c + 3.0 M_h_c + M_ascb__L_c c FALSE PW070 "added rxn name; replaced M_ascb__L_c with M_ascb__L_c" "jpnh; lenov" R_RXN_3541_c R_RXN_3541_c 5.0 M_h_c + M_o2_c + M_ascb__L_c <=> 2.0 M_h2o_c + M_mdascb_c c FALSE PW070 replaced M_ascb__L_c with M_ascb__L_c lenov R_RXN_3741_c Folatepolyglutamate(n) M_h2o_c <=> M_glu__L_c + M_Folatepolyglutamate_n_c c FALSE PW091 R_RXN_3742_c Folatepolyglutamate synthesis M_glu__L_c + M_atp_c <=> M_pi_c + M_adp_c + M_Folatepolyglutamate_n_c c FALSE (WBGene00017777) PW091 added rxn name jpnh R_RXN_3742_m Folatepolyglutamate synthesis M_glu__L_m + M_atp_m <=> M_pi_m + M_adp_m + M_Folatepolyglutamate_n_m m FALSE (WBGene00017777) PW091 added rxn name jpnh R_RXN_4941_c R_RXN_4941_c M_atp_c + M_mi13456p_c <=> M_h_c + M_adp_c + M_ppmi1346p_c c FALSE (WBGene00018508) PW029 R_RXN_4941_n R_RXN_4941_n M_atp_n + M_mi13456p_n <=> M_h_n + M_adp_n + M_ppmi1346p_n n FALSE (WBGene00018508) PW029 -R_RXN_5462_c GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase M_gdpmann_c + M_admnsyl_c <=> M_h_c + M_gdp_c + M_m2nag2dp_c c FALSE (WBGene00017282) PW011 -R_RXN_5462_m GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase M_gdpmann_m + M_admnsyl_m <=> M_h_m + M_gdp_m + M_m2nag2dp_m m FALSE (WBGene00017282) PW011 -R_RXN_5463_c GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase M_gdpmann_c + M_m2nag2dp_c <=> M_h_c + M_gdp_c + M_m3nag2dp_c c FALSE (WBGene00017282) PW011 -R_RXN_5463_m GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase M_gdpmann_m + M_m2nag2dp_m <=> M_h_m + M_gdp_m + M_m3nag2dp_m m FALSE (WBGene00017282) PW011 -R_RXN_5464_c GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase M_gdpmann_c + M_m3nag2dp_c <=> 2.0 M_h_c + 2.0 M_gdp_c + M_m5nag2dp_c c FALSE (WBGene00015162) PW011 RHEA:29523 -R_RXN_5466_c Dol-P-Man:Man5GlcNAc2 -PP-Dol α-1,3-mannosyltransferase M_dolmanp_c + M_m5nag2dp_c <=> M_h_c + M_dolp_c + M_m6nag2dp_c c FALSE PW011 -R_RXN_5467_c Dol-P-Man:Man6GlcNAc2 -PP-Dol α-1,2-mannosyltransferase M_dolmanp_c + M_m6nag2dp_c <=> M_h_c + M_dolp_c + M_m7nag2dp_c c FALSE (WBGene00007556) PW011 -R_RXN_5468_c Dol-P-Man:Man7GlcNAc2 -PP-Dol α-1,6-mannosyltransferase M_dolmanp_c + M_m7nag2dp_c <=> M_h_c + M_dolp_c + M_m8nag2dp_c c FALSE (WBGene00022629) PW011 -R_RXN_5469_c Dol-P-Man:Man8GlcNAc2 -PP-Dol α-1,2-mannosyltransferase M_dolmanp_c + M_m8nag2dp_c <=> M_h_c + M_dolp_c + M_m9nag2dp_c c FALSE (WBGene00007556) PW011 -R_RXN_5470_c Dol-P-Glc:Man9GlcNAc2 -PP-Dol α-1,3-glucosyltransferase M_m9nag2dp_c + M_dolglcp_c <=> M_h_c + M_dolp_c + M_gmadph_c c FALSE (WBGene00007435) PW011 -R_RXN_5471_c Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dolα-1,3-glucosyltransferase M_gmadph_c + M_dolglcp_c <=> M_h_c + M_dolp_c + M_g2madph_c c FALSE PW011 -R_RXN_5472_c Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dolα-1,2-glucosyltransferase M_dolglcp_c + M_g2madph_c <=> M_h_c + M_dolp_c + M_oligo_dpdolichol_c c FALSE PW011 +R_RXN_5462_c "GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase" M_gdpmann_c + M_admnsyl_c <=> M_h_c + M_gdp_c + M_m2nag2dp_c c FALSE (WBGene00017282) PW011 +R_RXN_5462_m "GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase" M_gdpmann_m + M_admnsyl_m <=> M_h_m + M_gdp_m + M_m2nag2dp_m m FALSE (WBGene00017282) PW011 +R_RXN_5463_c "GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase" M_gdpmann_c + M_m2nag2dp_c <=> M_h_c + M_gdp_c + M_m3nag2dp_c c FALSE (WBGene00017282) PW011 +R_RXN_5463_m "GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase" M_gdpmann_m + M_m2nag2dp_m <=> M_h_m + M_gdp_m + M_m3nag2dp_m m FALSE (WBGene00017282) PW011 +R_RXN_5464_c "GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase" M_gdpmann_c + M_m3nag2dp_c <=> 2.0 M_h_c + 2.0 M_gdp_c + M_m5nag2dp_c c FALSE (WBGene00015162) PW011 RHEA:29523 +R_RXN_5466_c "Dol-P-Man:Man5GlcNAc2 -PP-Dol α-1,3-mannosyltransferase" M_dolmanp_c + M_m5nag2dp_c <=> M_h_c + M_dolp_c + M_m6nag2dp_c c FALSE PW011 +R_RXN_5467_c "Dol-P-Man:Man6GlcNAc2 -PP-Dol α-1,2-mannosyltransferase" M_dolmanp_c + M_m6nag2dp_c <=> M_h_c + M_dolp_c + M_m7nag2dp_c c FALSE (WBGene00007556) PW011 +R_RXN_5468_c "Dol-P-Man:Man7GlcNAc2 -PP-Dol α-1,6-mannosyltransferase" M_dolmanp_c + M_m7nag2dp_c <=> M_h_c + M_dolp_c + M_m8nag2dp_c c FALSE (WBGene00022629) PW011 +R_RXN_5469_c "Dol-P-Man:Man8GlcNAc2 -PP-Dol α-1,2-mannosyltransferase" M_dolmanp_c + M_m8nag2dp_c <=> M_h_c + M_dolp_c + M_m9nag2dp_c c FALSE (WBGene00007556) PW011 +R_RXN_5470_c "Dol-P-Glc:Man9GlcNAc2 -PP-Dol α-1,3-glucosyltransferase" M_m9nag2dp_c + M_dolglcp_c <=> M_h_c + M_dolp_c + M_gmadph_c c FALSE (WBGene00007435) PW011 +R_RXN_5471_c "Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dolα-1,3-glucosyltransferase" M_gmadph_c + M_dolglcp_c <=> M_h_c + M_dolp_c + M_g2madph_c c FALSE PW011 +R_RXN_5472_c "Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dolα-1,2-glucosyltransferase" M_dolglcp_c + M_g2madph_c <=> M_h_c + M_dolp_c + M_oligo_dpdolichol_c c FALSE PW011 R_RXN_5641_c Serine decarboxylase M_h_c + M_ser__L_c <=> M_co2_c + M_etha_c c FALSE PW056 added rxn names jpnh R_RXN_5642_c S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase M_methamp_c + M_amet_c <=> M_dmeap_c + M_h_c + M_ahcys_c c FALSE (WBGene00018811) PW056 added rxn names jpnh R_RXN_5642_m S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase M_methamp_m + M_amet_m <=> M_dmeap_m + M_h_m + M_ahcys_m m FALSE (WBGene00018811) PW056 added rxn names jpnh @@ -2826,17 +2826,17 @@ R_RXN_5841_c R_RXN_5841_c M_nmn_c + M_h2o_c <=> M_rnam_c + M_pi_c c FALSE WBGen R_RXN_6461_c R_RXN_6461_c M_amet_c + M_ala_B_c <=> M_h_c + M_ahcys_c + M_mbala_c c FALSE (WBGene00011573) PW086 R_RXN_6462_c R_RXN_6462_c M_amet_c + M_mbala_c <=> M_h_c + M_ahcys_c + M_dmbala_c c FALSE (WBGene00011573) PW086 R_RXN_6464_c R_RXN_6464_c M_amet_c + M_dmbala_c <=> M_h_c + M_ahcys_c + M_balab_c c FALSE (WBGene00011573) PW086 -R_RXN_6902_m 4-aminobutanoate:pyruvate aminotransferase M_4abut_m + M_pyr_m <=> M_sucsal_m + M_ala__L_m m TRUE (WBGene00001794) PW073 RHEA:23352;RHEA:13993 Added Rxn Name; Changed M_ala__L_m into M_ala_L_m jpnh; lenov +R_RXN_6902_m 4-aminobutanoate:pyruvate aminotransferase M_4abut_m + M_pyr_m <=> M_sucsal_m + M_ala__L_m m TRUE (WBGene00001794) PW073 "RHEA:23352;RHEA:13993" "Added Rxn Name; Changed M_ala__L_m into M_ala_L_m" "jpnh; lenov" R_RXN_7587_c Non ezymatic Formylisoglutamine conversion production M_4izp_c + M_h2o_c + M_h_c <=> M_for_isogln_c c FALSE PW084 added rxn name jpnh -R_RXN_7592_c Formylisoglutamine degradation to Isoglutamine M_for_isogln_c + M_h2o_c <=> M_for_c + M_isogln_L_c c FALSE PW084 added rxn name; replace M_isogln__L_c with M_isogln_L_c jpnh; lenov +R_RXN_7592_c Formylisoglutamine degradation to Isoglutamine M_for_isogln_c + M_h2o_c <=> M_for_c + M_isogln_L_c c FALSE PW084 "added rxn name; replace M_isogln__L_c with M_isogln_L_c" "jpnh; lenov" R_RXN_7593_c Non enzymatic Isoglutamine degradation to 4-Oxoglutaramate M_4izp_c + M_h2o_c + 2.0 M_h_c + M_o2_c <=> M_nh3_c + M_4ogm_c + M_for_c c FALSE PW084 R_RXN_7594_c non-enzymatic hydrolysis of Oxoglutamarate M_h2o_c + M_4ogm_c <=> M_akg_c + M_nh3_c + M_h_c c TRUE PW084 R_RXN_7605_c 5-Methyltetrahydrofolate:Adenosyl-L-homocysteine S-methyltransferase M_amet_c + M_thf_c <=> M_h_c + M_ahcys_c + M_5mthf_c c TRUE PW082 -R_RXN_7667_c glucosyl-glycogenin self-glycosylation 7 M_udpg_c + M_glucosyl_glycogenin_c <=> M_ggn_c + 7 M_udp_c c FALSE (WBGene00006863) or (WBGene00012020) PW019;PW053 RHEA:23360;RHEA:56560 Changed the stoichiometry of UDP-glucose from 1 to 8, update name, added group. lenov +R_RXN_7667_c glucosyl-glycogenin self-glycosylation 7 M_udpg_c + M_glucosyl_glycogenin_c <=> M_ggn_c + 7 M_udp_c c FALSE (WBGene00006863) or (WBGene00012020) "PW019;PW053" "RHEA:23360;RHEA:56560" Changed the stoichiometry of UDP-glucose from 1 to 8, update name, added group. lenov R_RXN_7719_m dihydrolipoyl-dehydrogenase M_nad_m + M_bcaadh_m <=> M_h_m + M_nadh_m + M_bcaalip_m m FALSE (WBGene00010794) PW083 RHEA:15045 updated !Name to be more descriptive (was just !Reaction copied) hjs R_RXN_7908_c 4a-hydroxytetrahydrobiopterin dehydratase M_thbpt4acam_c <=> M_h2o_c + M_dhbpt_c c FALSE (WBGene00020397) PW091 RHEA:11920 added rxn name jpnh R_RXN_7908_m 4a-hydroxytetrahydrobiopterin dehydratase M_thbpt4acam_m <=> M_h2o_m + M_dhbpt_m m FALSE (WBGene00020397) PW091 RHEA:11920 added rxn name jpnh -R_RXN_7909_c 5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase M_h_c + M_dhbpt_c + M_nadh_c <=> M_thbpt_c + M_nad_c c TRUE (WBGene00011398) PW091;PW073 added rxn name jpnh +R_RXN_7909_c 5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase M_h_c + M_dhbpt_c + M_nadh_c <=> M_thbpt_c + M_nad_c c TRUE (WBGene00011398) "PW091;PW073" added rxn name jpnh R_RXN_8162_c R_RXN_8162_c 2.0 M_h2o_c + M_nad_c + M_thp2c_c <=> M_h_c + M_nadh_c + M_L2aadp_c c TRUE (WBGene00000115) PW079 RHEA:16185 R_RXN_8162_m R_RXN_8162_m 2.0 M_h2o_m + M_thp2c_m + M_nad_m <=> M_L2aadp_m + M_h_m + M_nadh_m m TRUE (WBGene00000115) PW079 RHEA:16185 R_RXN_821_c Proline dehydrogenase M_pro__L_c + M_fad_c <=> M_1pyr5c_c + M_fadh2_c c FALSE (WBGene00007197) PW081 @@ -2844,39 +2844,39 @@ R_RXN_821_m Proline dehydrogenase M_pro__L_m + M_fad_m <=> M_1pyr5c_m + M_fadh2 R_RXN_8340_c cyclic pyranopterin monophosphate synthase M_gtp_c <=> M_cpmp_c + M_ppi_c c FALSE (WBGene00009885) or (WBGene00009908) PW092 R_RXN_8340_m cyclic pyranopterin monophosphate synthase M_gtp_m <=> M_cpmp_m + M_ppi_m m FALSE (WBGene00009885) PW092 R_RXN_8342_c molybdopterin synthase M_h2o_c + M_cpmp_c + 2.0 M_thiocarb_mpt_c <=> M_mpt_c + 2.0 M_small_mpts_c c FALSE (WBGene00019633 and WBGene00020842) PW092 RHEA:26333 -R_RXN_8344_c molybdopterin adenylyltransferase 2.0 M_h_c + M_atp_c + M_mpt_c <=> M_mptamp_c + M_ppi_c c FALSE (WBGene00003384) PW092 RHEA:31331;RHEA:35047 -R_RXN_8344_n molybdopterin adenylyltransferase 2.0 M_h_n + M_atp_n + M_mpt_n <=> M_mptamp_n + M_ppi_n n FALSE (WBGene00003384) PW092 RHEA:31331;RHEA:35047 Inserted correct reaction, previous was M_asn_L_c + M_gthrd_c = M_gluasp_c + M_cgly_c jpnh -R_RXN_8348_c molybdopterin molybdotransferase M_mptamp_c + M_mobd_c <=> M_moco_c + M_h2o_c + M_amp_c c FALSE (WBGene00003384) PW092 RHEA:31331;RHEA:35047 -R_RXN_8348_n molybdopterin molybdotransferase M_mptamp_n + M_mobd_n <=> M_moco_n + M_h2o_n + M_amp_n n FALSE (WBGene00003384) PW092 RHEA:31331;RHEA:35047 +R_RXN_8344_c molybdopterin adenylyltransferase 2.0 M_h_c + M_atp_c + M_mpt_c <=> M_mptamp_c + M_ppi_c c FALSE (WBGene00003384) PW092 "RHEA:31331;RHEA:35047" +R_RXN_8344_n molybdopterin adenylyltransferase 2.0 M_h_n + M_atp_n + M_mpt_n <=> M_mptamp_n + M_ppi_n n FALSE (WBGene00003384) PW092 "RHEA:31331;RHEA:35047" Inserted correct reaction, previous was M_asn_L_c + M_gthrd_c = M_gluasp_c + M_cgly_c jpnh +R_RXN_8348_c molybdopterin molybdotransferase M_mptamp_c + M_mobd_c <=> M_moco_c + M_h2o_c + M_amp_c c FALSE (WBGene00003384) PW092 "RHEA:31331;RHEA:35047" +R_RXN_8348_n molybdopterin molybdotransferase M_mptamp_n + M_mobd_n <=> M_moco_n + M_h2o_n + M_amp_n n FALSE (WBGene00003384) PW092 "RHEA:31331;RHEA:35047" R_RXN_8629_c [glycine-cleavage complex H protein] N6-(dihydrolipoyl)lysine oxidoreductase M_nad_c + M_dhlip_gcvh_c <=> M_h_c + M_nadh_c + M_lip_gcvh_c c FALSE (WBGene00010794) PW074 RHEA:15045 added rxn name jpnh R_RXN_8629_m [glycine-cleavage complex H protein] N6-(dihydrolipoyl)lysine oxidoreductase M_nad_m + M_dhlip_gcvh_m <=> M_h_m + M_nadh_m + M_lip_gcvh_m m FALSE (WBGene00010794) PW074 RHEA:15045 added rxn name -R_RXN_8635_c R_RXN_8635_c M_h2o2_c <=> 2.0 M_h2o_c + M_betnd_c + M_betqu_c c FALSE (WBGene00004257) or (WBGene00020692) or (WBGene00009811) or (WBGene00008627) or (WBGene00004256) or (WBGene00019970) or (WBGene00021572) or (WBGene00005148) or (WBGene00016700) or (WBGene00011530) or (WBGene00009897) or (WBGene00022743) or (WBGene00020471) or (WBGene00019613) PW098 RHEA:56136;RHEA:56136;RHEA:56136 [CHECKME] this reaction looks odd and unbalanced lenov +R_RXN_8635_c R_RXN_8635_c M_h2o2_c <=> 2.0 M_h2o_c + M_betnd_c + M_betqu_c c FALSE (WBGene00004257) or (WBGene00020692) or (WBGene00009811) or (WBGene00008627) or (WBGene00004256) or (WBGene00019970) or (WBGene00021572) or (WBGene00005148) or (WBGene00016700) or (WBGene00011530) or (WBGene00009897) or (WBGene00022743) or (WBGene00020471) or (WBGene00019613) PW098 "RHEA:56136;RHEA:56136;RHEA:56136" [CHECKME] this reaction looks odd and unbalanced lenov R_RXN_8635_m R_RXN_8635_m M_h2o2_m <=> 2.0 M_h2o_m + M_betnd_m + M_betqu_m m FALSE (WBGene00011530) or (WBGene00022743) or (WBGene00021845) PW098 RHEA:56136 [CHECKME] this reaction looks odd and unbalanced lenov R_RXN_8635_n R_RXN_8635_n M_h2o2_n <=> 2.0 M_h2o_n + M_betnd_n + M_betqu_n n FALSE (WBGene00019970) or (WBGene00016700) PW098 [CHECKME] this reaction looks odd and unbalanced lenov -R_RXN_8654_c lipoate—protein ligase M_h_c + M_atp_c + M_lipoate_c <=> M_lipoamp_c + M_ppi_c c FALSE PW051 -R_RXN_8655_c lipoate—protein ligase M_lipoamp_c + M_nlipo_domain_c <=> M_amp_c + M_lipo_domain_c c FALSE (WBGene00044008) PW051 +R_RXN_8654_c "lipoate—protein ligase" M_h_c + M_atp_c + M_lipoate_c <=> M_lipoamp_c + M_ppi_c c FALSE PW051 +R_RXN_8655_c "lipoate—protein ligase" M_lipoamp_c + M_nlipo_domain_c <=> M_amp_c + M_lipo_domain_c c FALSE (WBGene00044008) PW051 R_RXN_8672_c glycine oxidase M_h2o_c + M_ala__D_c + M_o2_c <=> M_h2o2_c + M_nh3_c + M_h_c + M_pyr_c c FALSE (WBGene00022076) PW073 RHEA:21816 Changed M_ala__D_c into M_ala_D_c lenov R_RXN_8853_n Sepiapterin reductase M_6pthp_n + 2.0 M_nadph_n <=> M_thbpt_n + 2.0 M_nadp_n n FALSE PW091 R_RXN_9241_m R_RXN_9241_m 4.0 M_h_m + M_o2_m + M_npmoxph_m <=> M_h2o_m + M_npmoxbq_m m FALSE (WBGene00000766) PW003 R_RXN_9242_m R_RXN_9242_m M_npmoxbq_m + M_amet_m <=> M_h_m + M_npmmoxbq_m + M_ahcys_m m FALSE (WBGene00000765) PW003 RHEA:28286 R_RXN_9243_m R_RXN_9243_m M_h_m + M_npmmoxbq_m + M_o2_m <=> M_h2o_m + M_3dmub_m m FALSE (WBGene00000536) PW003 R_RXN_9278_m R_RXN_9278_m 2.0 M_h_m + M_npr4hben_m + M_o2_m <=> M_h2o_m + M_3npdhb_m m FALSE PW003 -R_RXN_9281_m nonaprenyldihydroxybenzoate methyltransferase M_3npdhb_m + M_amet_m <=> M_h_m + M_me3dhnpdh_m + M_ahcys_m m FALSE (WBGene00000763) PW003 RHEA:44452;RHEA:44380 +R_RXN_9281_m nonaprenyldihydroxybenzoate methyltransferase M_3npdhb_m + M_amet_m <=> M_h_m + M_me3dhnpdh_m + M_ahcys_m m FALSE (WBGene00000763) PW003 "RHEA:44452;RHEA:44380" R_RXN_9284_m R_RXN_9284_m M_h_m + M_me3dhnpdh_m <=> M_co2_m + M_npmoxph_m m FALSE PW003 R_RXN_969_c R_RXN_969_c M_glyclt_c + M_o2_c <=> M_h2o2_c + M_glx_c c FALSE (WBGene00018286) PW030 R_RXN_969_n R_RXN_969_n M_glyclt_n + M_o2_n <=> M_h2o2_n + M_glx_n n FALSE (WBGene00018286) PW030 R_RXN_9779_c phosphatidylinositol-4,5-bisphosphate 4-phosphatase M_h2o_c + M_1ac2acg3pi4p5p_c <=> M_pi_c + M_1ac2acg3pi5p_c c FALSE WBGene00022167 PW029 R_RXN_982_c arsenate reductase (glutaredoxin) M_aso4_c + M_grxrd_c <=> M_h2o_c + M_aso3_c + M_grxox_c c FALSE PW070 replaced arsenate detoxification by glutathione metabolism lenov -R_RXN_9927_2 Glycerol-3-phosphate dehydrogenase M_glyc3p_c + M_q9_m <=> M_dhap_c + M_q9h2_m cm FALSE (WBGene00013049) or (WBGene00009824) or (WBGene00012031) PW052;PW056 RHEA:11092 +R_RXN_9927_2 Glycerol-3-phosphate dehydrogenase M_glyc3p_c + M_q9_m <=> M_dhap_c + M_q9h2_m cm FALSE (WBGene00013049) or (WBGene00009824) or (WBGene00012031) "PW052;PW056" RHEA:11092 R_RXN_9969_c di-trans,poly-cis-polyprenyl diphosphate synthase[(2E,6E)-farnesyl diphosphate specific] 13.0 M_ipdp_c + M_frdp_c <=> 13.0 M_ppi_c + M_dtpcpprd_c c TRUE (WBGene00044025) PW001 R06447 added KEGGID, ChEBI ms R_RXN_9969_n di-trans,poly-cis-polyprenyl diphosphate synthase[(2E,6E)-farnesyl diphosphate specific] 13.0 M_ipdp_n + M_frdp_n <=> 13.0 M_ppi_n + M_dtpcpprd_n n TRUE (WBGene00044025) PW001 R06447 added KEGGID, ChEBI ms R_RXN_9970_c R_RXN_9970_c M_h2o_c + M_dtpcpprd_c <=> M_dtpcppr_c + M_ppi_c c FALSE PW001 R_RXN_9971_c R_RXN_9971_c M_dtpcppr_c + M_h_c + M_nadph_c <=> M_nadp_c + M_dolichol_c c FALSE PW001 -R_RXN0_2161_m L-Seryl-tRNA(Sec) formation M_ser__L_m + M_atp_m + M_trnasec_m <=> M_ppi_m + M_amp_m + M_sertrna_sec_m m FALSE WBGene00005663 or WBGene00005662 PW082 RHEA:12292;RHEA:42580 added name; replaced M_SEC__tRNAs_m by M_trnasec_m and M_sertrna_LPAREN_sec_RPAREN__m by M_sertrna_sec_m; fixed gene assication jpnh; lenov +R_RXN0_2161_m L-Seryl-tRNA(Sec) formation M_ser__L_m + M_atp_m + M_trnasec_m <=> M_ppi_m + M_amp_m + M_sertrna_sec_m m FALSE WBGene00005663 or WBGene00005662 PW082 "RHEA:12292;RHEA:42580" "added name; replaced M_SEC__tRNAs_m by M_trnasec_m and M_sertrna_LPAREN_sec_RPAREN__m by M_sertrna_sec_m; fixed gene assication" "jpnh; lenov" R_RXN0_276_c S-(hydroxymethyl)glutathione dehydrogenase M_nad_c + M_hmgth_c <=> M_Sfglutth_c + M_h_c + M_nadh_c c TRUE WBGene00019240 or WBGene00021747 PW091 set to reversible janna -R_RXN0_308_c cysteine desulfurase M_cys__L_c + M_cysdesase_c <=> M_ala__L_c + M_prot_scyst_c c FALSE (WBGene00015021) PW092;PW073 replaced M_ala__L_c with M_ala_L_c lenov -R_RXN0_5114_m O-phospho-L-serine phosphohydrolase M_h2o_m + M_pser_L_m <=> M_pi_m + M_ser__L_m m TRUE (WBGene00013379) PW074 added name to rxn; replaced M_pser__L_m with M_pser_L_m jpnh; lenov -R_RXN0_5224_c Bicarbonate formation (cytosol) M_co2_c + M_h2o_c <=> M_hco3_c + M_h_c c TRUE (WBGene00000282) or (WBGene00000281) or (WBGene00077690) or (WBGene00000284) or (WBGene00000245) or (WBGene00000279) or (WBGene00000280) or (WBGene00000283) or (WBGene00013805) PW098 RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748 Updated rxn name jpnh +R_RXN0_308_c cysteine desulfurase M_cys__L_c + M_cysdesase_c <=> M_ala__L_c + M_prot_scyst_c c FALSE (WBGene00015021) "PW092;PW073" replaced M_ala__L_c with M_ala_L_c lenov +R_RXN0_5114_m O-phospho-L-serine phosphohydrolase M_h2o_m + M_pser_L_m <=> M_pi_m + M_ser__L_m m TRUE (WBGene00013379) PW074 "added name to rxn; replaced M_pser__L_m with M_pser_L_m" "jpnh; lenov" +R_RXN0_5224_c Bicarbonate formation (cytosol) M_co2_c + M_h2o_c <=> M_hco3_c + M_h_c c TRUE (WBGene00000282) or (WBGene00000281) or (WBGene00077690) or (WBGene00000284) or (WBGene00000245) or (WBGene00000279) or (WBGene00000280) or (WBGene00000283) or (WBGene00013805) PW098 "RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748;RHEA:10748" Updated rxn name jpnh R_RXN0_5224_m Bicarbonate formation (mitochondrial) M_co2_m + M_h2o_m <=> M_hco3_m + M_h_m m TRUE WBGene00000245 or WBGene00000282 PW098 RHEA:10748 Updated rxn name jpnh R_RXN0_5224_n Bicarbonate formation (nucleus) M_co2_n + M_h2o_n <=> M_hco3_n + M_h_n n TRUE (WBGene00000281) or (WBGene00077690) or (WBGene00000284) PW098 RHEA:10748 Updated rxn name jpnh R_RXN0_6491_c dihydroorotate dehydrogenase M_dhor_S_c + M_q9_m <=> M_orot_c + M_q9h2_m cm FALSE (WBGene00020932) PW043 RHEA:30187 @@ -2886,7 +2886,7 @@ R_RXN0_902_c R_RXN0_902_c M_h2o_c + M_hxan_c <=> M_xan_c + 2.0 M_h_c c TRUE PW R_RXN0_947_c Lipoyl(octanoyl) transferase M_acp8_0_c + M_nlipo_domain_c <=> M_ACP_c + M_octlipo_domain_c c FALSE PW051 R_RXN0_949_c R_RXN0_949_c 2.0 M_s2_c + 2.0 M_amet_c + M_octlipo_domain_c <=> 2.0 M_met__L_c + 2.0 M_dad_5_c + M_lipo_domain_c c FALSE (WBGene00010809) PW051 R_RXN3DJ_11100_c R_RXN3DJ_11100_c M_c17isodhcrm_c <=> M_c17isocrm_c c FALSE PW055 [CHECK ME] changed to C17 iso sphingosine wimi -R_RXN3DJ_13_c R_RXN3DJ_13_c M_lxhexll_c <=> 2.0 M_h_c + M_ascb__L_c c FALSE PW045 replaced M_ascb__L_c with M_ascb__L_c; replaced L-ascorbate biosynthesis with ascorbate and aldarate metabolism lenov +R_RXN3DJ_13_c R_RXN3DJ_13_c M_lxhexll_c <=> 2.0 M_h_c + M_ascb__L_c c FALSE PW045 "replaced M_ascb__L_c with M_ascb__L_c; replaced L-ascorbate biosynthesis with ascorbate and aldarate metabolism" lenov R_RXN3O_11_c R_RXN3O_11_c M_doldpglcnacglcnacman_manmanman_manmanman_c + M_dolmanp_c <=> M_m8gnpp_c + M_dolp_c c FALSE (WBGene00022629) PW011 R_RXN3O_1120_m R_RXN3O_1120_m M_4cmcoa_m + M_h2o_m + M_coa_m + M_nad_m <=> M_h_m + M_nadh_m + M_accoa_m + M_4hbzcoa_m m FALSE Unknown PW003 R_RXN3O_143_c R_RXN3O_143_c M_atp_c + M_ppmi12346p_c <=> M_adp_c + M_ppip_c c FALSE (WBGene00018508) PW029 @@ -2913,7 +2913,7 @@ R_RXN3O_786_n R_RXN3O_786_n M_h2o_n + M_ppip_n <=> M_pi_n + M_dpolpkp_n n FALSE R_RXN66_28_c R_RXN66_28_c M_h_c + M_nadph_c + M_dsmsterol_c <=> M_nadp_c + M_chsterol_c c FALSE (WBGene00018718) PW047 R_RXN66_281_c squalene synthase M_psqldp_c + M_h_c + M_nadph_c <=> M_sql_c + M_ppi_c + M_nadp_c c FALSE PW002 R_RXN66_321_c R_RXN66_321_c M_h_c + M_nadph_c + M_chlstol_c <=> M_lthstrl_c + M_nadp_c c FALSE (WBGene00018718) PW047 -R_RXN909_10_m ubiquinol-cytochrome c reductase 2.0 M_h_m + M_q9h2_m + 2.0 M_cytc_m <=> 4.0 M_h_i + M_q9_m + 2.0 M_cytc_red_m m FALSE (WBGene00009739 and WBGene00020181 and WBGene00011679 and WBGene00018963 and WBGene00000869 and WBGene00000829 and WBGene00002162 and WBGene00012094 and WBGene00019937) PW007 RHEA:11484 added name; replaced aerobic respiration with oxidative phosphorylation jpnh; lenov +R_RXN909_10_m ubiquinol-cytochrome c reductase 2.0 M_h_m + M_q9h2_m + 2.0 M_cytc_m <=> 4.0 M_h_i + M_q9_m + 2.0 M_cytc_red_m m FALSE (WBGene00009739 and WBGene00020181 and WBGene00011679 and WBGene00018963 and WBGene00000869 and WBGene00000829 and WBGene00002162 and WBGene00012094 and WBGene00019937) PW007 RHEA:11484 "added name; replaced aerobic respiration with oxidative phosphorylation" "jpnh; lenov" R_RXN909_107_c Glycerol:NAD+ oxidoreductase M_glyald_c + M_h_c + M_nadh_c <=> M_glyc_c + M_nad_c c TRUE (WBGene00012722) PW052 set to reversible janna R_RXN909_108_m D-Glyceraldehyde:NAD+ oxidoreductase 2.0 M_h_m + M_nadh_m + M_glyc_R_m <=> M_h2o_m + M_glyald_m + M_nad_m m FALSE (WBGene00000115) PW052 RHEA:16185 added rxn name jpnh R_RXN909_109_c ATP:(R)-glycerate 3-phosphotransferase M_atp_c + M_glyc_R_c <=> 2.0 M_h_c + M_adp_c + M_3pg_c c FALSE (WBGene00015733) PW052 @@ -2921,10 +2921,10 @@ R_RXN909_109_m ATP:(R)-glycerate 3-phosphotransferase M_atp_m + M_glyc_R_m <=> R_RXN909_110_c sucrose glucohydrolase M_h2o_c + M_sucr_c <=> M_glc_aD_c + M_fru_B_c c FALSE (WBGene00019895) or (WBGene00017071) PW020 R_RXN909_112_c alkaline phosphatase M_ahdt_c + 3.0 M_h2o_c <=> M_dhnpt_c + 3.0 M_pi_c + 3.0 M_h_c c TRUE (WBGene00013646) PW091 R_RXN909_113_c R_RXN909_113_c M_m2emgacpail_c + M_1ac2acg3pe_c <=> M_em2emgacpail_c + M_1ac2acglyc_c c FALSE (WBGene00016159) PW028 -R_RXN909_114_c L-Cysteine:2-oxoglutarate aminotransferase M_akg_c + M_cys__L_c <=> M_mercppyr_c + M_glu__L_c c TRUE WBGene00020145 or WBGene00020146 or WBGene00015771 or WBGene00016652 or WBGene00015778 PW082 RHEA:21824;RHEA:21824;RHEA:21824 -R_RXN909_114_m L-Cysteine:2-oxoglutarate aminotransferase M_akg_m + M_cys__L_m <=> M_mercppyr_m + M_glu__L_m m TRUE (WBGene00016652) or (WBGene00015778) PW082 RHEA:21824;RHEA:21824 -R_RXN909_115_c 3-mercaptopyruvate sulfurtransferase M_mercppyr_c + M_cyan_c <=> M_h_c + M_pyr_c + M_tcynt_c c FALSE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW082 RHEA:16881;RHEA:16881 -R_RXN909_117_m L-3-amino-isobutanoate:2-oxoglutarate aminotransferase M_glu__L_m + M_mmtsa_m <=> M_akg_m + M_3aib_m m FALSE (WBGene00001794) PW083 RHEA:23352;RHEA:13993 +R_RXN909_114_c L-Cysteine:2-oxoglutarate aminotransferase M_akg_c + M_cys__L_c <=> M_mercppyr_c + M_glu__L_c c TRUE WBGene00020145 or WBGene00020146 or WBGene00015771 or WBGene00016652 or WBGene00015778 PW082 "RHEA:21824;RHEA:21824;RHEA:21824" +R_RXN909_114_m L-Cysteine:2-oxoglutarate aminotransferase M_akg_m + M_cys__L_m <=> M_mercppyr_m + M_glu__L_m m TRUE (WBGene00016652) or (WBGene00015778) PW082 "RHEA:21824;RHEA:21824" +R_RXN909_115_c 3-mercaptopyruvate sulfurtransferase M_mercppyr_c + M_cyan_c <=> M_h_c + M_pyr_c + M_tcynt_c c FALSE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW082 "RHEA:16881;RHEA:16881" +R_RXN909_117_m L-3-amino-isobutanoate:2-oxoglutarate aminotransferase M_glu__L_m + M_mmtsa_m <=> M_akg_m + M_3aib_m m FALSE (WBGene00001794) PW083 "RHEA:23352;RHEA:13993" R_RXN909_118_c myristate:CoA ligase M_atp_c + M_coa_c + M_fa14_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa14_0_c c FALSE (WBGene00016716) or (WBGene00018579) or (WBGene00009221) or (WBGene00018579) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) or (WBGene00020343) or (WBGene00022037) or (WBGene00008669) or (WBGene00013575) or (WBGene00018152) PW136 SPW001 R_RXN909_118_m myristate:CoA ligase M_atp_m + M_coa_m + M_fa14_0_m <=> M_ppi_m + M_h_m + M_amp_m + M_coa14_0_m m FALSE (WBGene00009221) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) PW120 R_RXN909_119_c laurate:CoA-ligase M_atp_c + M_coa_c + M_fa12_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa12_0_c c FALSE (WBGene00016716) or (WBGene00009221) or (WBGene00018579) or (WBGene00018579) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) or (WBGene00020343) or (WBGene00022037) or (WBGene00008669) or (WBGene00013575) or (WBGene00018152) PW136 SPW001 @@ -2932,11 +2932,11 @@ R_RXN909_120_c caprate:CoA-ligase M_atp_c + M_coa_c + M_fa10_0_c <=> M_ppi_c + R_RXN909_121_c octanoate:CoA-ligase M_atp_c + M_coa_c + M_fa8_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa8_0_c c FALSE (WBGene00016716) or (WBGene00009221) or (WBGene00018579) or (WBGene00018579) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) or (WBGene00020343) or (WBGene00022037) or (WBGene00008669) PW136 SPW001 R_RXN909_122_c Hexanoate CoA-ligase M_atp_c + M_coa_c + M_fa6_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa6_0_c c FALSE (WBGene00016716) or (WBGene00009221) or (WBGene00018579) or (WBGene00018579) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) or (WBGene00020343) or (WBGene00022037) or (WBGene00008669) PW136 SPW001 added rxn name jpnh R_RXN909_123_c butyrate:CoA-ligase M_atp_c + M_coa_c + M_but_c <=> M_ppi_c + M_h_c + M_amp_c + M_btcoa_c c FALSE (WBGene00016716) or (WBGene00009221) or (WBGene00018579) or (WBGene00018579) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) or (WBGene00020343) or (WBGene00022037) or (WBGene00008669) PW136 SPW001 Added extra genes from (R_BUTYRATE__COA_LIGASE_RXN_c) which is marked for deletion jpnh -R_RXN909_130_n histone-L-lysine N6-methyltransferase (acting on dimethylated residues) M_Ndmelys_n + M_amet_n <=> M_Ntmelys_n + M_h_n + M_ahcys_n n FALSE (WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206) PW101 RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024 Added all the GeneAssociation that were in cytoplasm lenov +R_RXN909_130_n histone-L-lysine N6-methyltransferase (acting on dimethylated residues) M_Ndmelys_n + M_amet_n <=> M_Ntmelys_n + M_h_n + M_ahcys_n n FALSE (WBGene00011729 or WBGene00003040 or (WBGene00016603 or WBGene00019584) or WBGene00004782 or WBGene00019883 or WBGene00018023 or WBGene00003220 or WBGene00021515 or (WBGene00021474 or WBGene00010067 or WBGene00012302 or WBGene00010120 or WBGene00022512) or WBGene00016313 or WBGene00004781) or (WBGene00019690 or WBGene00020006 or WBGene00021282 or WBGene00008062 or WBGene00022431 or WBGene00008206) PW101 "RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024" Added all the GeneAssociation that were in cytoplasm lenov R_RXN909_132_c S-Adenosyl-L-methionine M_peplys_c + M_amet_c <=> M_pmllys_c + M_h_c + M_ahcys_c c FALSE (WBGene00016313) PW080 RHEA:10024 -R_RXN909_132_n S-Adenosyl-L-methionine M_peplys_n + M_amet_n <=> M_pmllys_n + M_h_n + M_ahcys_n n FALSE (WBGene00004781) or (WBGene00021515) or (WBGene00016313) or (WBGene00004782) PW080 RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024 +R_RXN909_132_n S-Adenosyl-L-methionine M_peplys_n + M_amet_n <=> M_pmllys_n + M_h_n + M_ahcys_n n FALSE (WBGene00004781) or (WBGene00021515) or (WBGene00016313) or (WBGene00004782) PW080 "RHEA:10024;RHEA:10024;RHEA:10024;RHEA:10024" R_RXN909_135_c R_RXN909_135_c M_lys__L_c + M_peptide_c <=> M_peplys_c c FALSE PW099 -R_RXN909_136_c dopamine beta-hydroxylase M_tym_c + M_h_c + M_o2_c + M_ascb__L_c <=> M_dhdascb_c + M_h2o_c + M_octpam_c c FALSE (WBGene00006541) PW077 replaced M_ascb__L_c with M_ascb__L_c; replaced octopamine biosynthesis by tyrosine metabolism lenov +R_RXN909_136_c dopamine beta-hydroxylase M_tym_c + M_h_c + M_o2_c + M_ascb__L_c <=> M_dhdascb_c + M_h2o_c + M_octpam_c c FALSE (WBGene00006541) PW077 "replaced M_ascb__L_c with M_ascb__L_c; replaced octopamine biosynthesis by tyrosine metabolism" lenov R_RXN909_137_c peroxiredoxin M_h2o2_c + M_trdrd_c <=> 2.0 M_h2o_c + M_trdox_c c FALSE (WBGene00011110) or (WBGene00006434) PW093 RHEA:10008 R_RXN909_139_c stearoyl-CoA synthase M_atp_c + M_coa_c + M_fa18_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa18_0_c c FALSE (WBGene00018579) or (WBGene00016716) or (WBGene00009221) or (WBGene00018579) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) or (WBGene00020343) or (WBGene00022037) or (WBGene00008669) PW136 SPW001 R_RXN909_139_m stearoyl-CoA synthase M_atp_m + M_coa_m + M_fa18_0_m <=> M_ppi_m + M_h_m + M_amp_m + M_coa18_0_m m FALSE (WBGene00009221) or (WBGene00019920) or (WBGene00011173) or (WBGene00011174) PW120 wimi @@ -2946,7 +2946,7 @@ R_RXN909_150_c R_RXN909_150_c M_em2emgacpail_c + M_dolmanp_c <=> M_mem2emgacpai R_RXN909_151_c R_RXN909_151_c M_pre_prot_c + M_gpi_c <=> M_gpi_sig_c + M_gpi_prot_c c FALSE (WBGene00008918) or (WBGene00011776) or (WBGene00018006) or (WBGene00011914) or (WBGene00011482) PW028 R_RXN909_154_c R_RXN909_154_c M_gpi_c + M_1ac2acglyc_c <=> M_em2emgacpail_c + M_1ac2acg3pe_c c FALSE PW028 R_RXN909_155_c R_RXN909_155_c M_gpi_sig_c + M_m_em_3gacpail_prot_hs_c <=> M_pre_prot_c + M_m_em_3gacpail_c c FALSE (WBGene00008918) or (WBGene00011482) or (WBGene00018006) or (WBGene00011776) or (WBGene00011914) PW028 -R_RXN909_156_c R_RXN909_156_c M_ethamp_c + M_c15isoal_c <=> M_c17isosph1p_c c TRUE (WBGene00006418) or (WBGene00004981) PW055 RHEA:18593 [CHECK ME] changed to C17 iso sphingosine; set to reversible wimi;janna +R_RXN909_156_c R_RXN909_156_c M_ethamp_c + M_c15isoal_c <=> M_c17isosph1p_c c TRUE (WBGene00006418) or (WBGene00004981) PW055 RHEA:18593 "[CHECK ME] changed to C17 iso sphingosine; set to reversible" "wimi;janna" R_RXN909_174_c glutamic phenylpyruvic aminotransferase M_glu__L_c + M_2kmb_c <=> M_akg_c + M_met__L_c c FALSE (WBGene00009628) PW082 R_RXN909_174_m glutamic phenylpyruvic aminotransferase M_glu__L_m + M_2kmb_m <=> M_akg_m + M_met__L_m m FALSE (WBGene00009628) PW082 R_RXN909_175_c purine-nucleoside phosphorylase M_rnam_c + M_pi_c <=> M_r1p_c + M_h_c + M_ncam_c c TRUE (WBGene00019298) PW036 set to reversible janna @@ -2954,7 +2954,7 @@ R_RXN909_175_n purine-nucleoside phosphorylase M_rnam_n + M_pi_n <=> M_r1p_n + R_RXN909_18_c L-1-Pyrroline-3-hydroxy-5-carboxylate hydrolytic ring opening M_1p3h5c_c + M_h2o_c <=> M_4hglusa_c c FALSE PW081 R04443 Added a name to the reaction jpnh R_RXN909_180_c arachidoyl-CoA synthase M_atp_c + M_coa_c + M_fa20_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa20_0_c c FALSE (WBGene00022037) or (WBGene00008669) or (WBGene00020343) or (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00018579) or (WBGene00009221) or (WBGene00016716) or (WBGene00018579) PW136 SPW001 R_RXN909_181_c Behenoyl-CoA synthase M_atp_c + M_coa_c + M_fa22_0_c <=> M_coa22_0_c + M_ppi_c + M_h_c + M_amp_c c FALSE (WBGene00009218) or (WBGene00008669) or (WBGene00022037) or (WBGene00020343) or (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00018579) or (WBGene00009221) or (WBGene00016716) or (WBGene00018579) PW136 SPW001 -R_RXN909_182_c R_RXN909_182_c M_h2o_c + M_camp_c <=> M_h_c + M_amp_c c FALSE (WBGene00016328) or (WBGene00003966) or (WBGene00011433) or (WBGene00020114) or (WBGene00022389) or (WBGene00008443) or (WBGene00011146) PW034 RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653 +R_RXN909_182_c R_RXN909_182_c M_h2o_c + M_camp_c <=> M_h_c + M_amp_c c FALSE (WBGene00016328) or (WBGene00003966) or (WBGene00011433) or (WBGene00020114) or (WBGene00022389) or (WBGene00008443) or (WBGene00011146) PW034 "RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653;RHEA:14653" R_RXN909_182_m R_RXN909_182_m M_h2o_m + M_camp_m <=> M_h_m + M_amp_m m FALSE (WBGene00003966) PW034 R_RXN909_182_n R_RXN909_182_n M_h2o_n + M_camp_n <=> M_h_n + M_amp_n n FALSE (WBGene00016328) or (WBGene00003966) PW034 RHEA:14653 R_RXN909_183_c lignoceroyl-CoA synthase M_atp_c + M_coa_c + M_fa24_0_c <=> M_coa24_0_c + M_ppi_c + M_h_c + M_amp_c c FALSE (WBGene00009218) or (WBGene00008669) or (WBGene00022037) or (WBGene00020343) or (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00018579) or (WBGene00009221) or (WBGene00016716) or (WBGene00018579) PW136 SPW001 @@ -2979,8 +2979,8 @@ R_RXN909_194_c R_RXN909_194_c M_h2o_c + M_fecost_c <=> M_etoh_c + M_dsmsterol_c R_RXN909_195_c R_RXN909_195_c 2.0 M_h_c + M_ddsmsterol_c <=> M_7dhchsterol_c c FALSE PW047 R_RXN909_196_c R_RXN909_196_c M_lthstrl_c + M_5mthf_c <=> M_lphol_c + M_thf_c c FALSE (WBGene00019198) PW047 19531354 abraham R_RXN909_197_c R_RXN909_197_c M_lphol_c <=> M_amchb_c c FALSE PW047 -R_RXN909_20_c propionyl-CoA synthetase M_ppa_c + M_atp_c + M_coa_c <=> M_ppi_c + M_h_c + M_amp_c + M_ppcoa_c c FALSE (WBGene00007969) PW086 R00925 RHEA:23176;RHEA:23176 Added Rxn name jpnh -R_RXN909_20_n propionyl-CoA synthetase M_ppa_n + M_atp_n + M_coa_n <=> M_ppi_n + M_h_n + M_amp_n + M_ppcoa_n n FALSE (WBGene00007969) PW086 R00925 RHEA:23176;RHEA:23176 Added Rxn name jpnh +R_RXN909_20_c propionyl-CoA synthetase M_ppa_c + M_atp_c + M_coa_c <=> M_ppi_c + M_h_c + M_amp_c + M_ppcoa_c c FALSE (WBGene00007969) PW086 R00925 "RHEA:23176;RHEA:23176" Added Rxn name jpnh +R_RXN909_20_n propionyl-CoA synthetase M_ppa_n + M_atp_n + M_coa_n <=> M_ppi_n + M_h_n + M_amp_n + M_ppcoa_n n FALSE (WBGene00007969) PW086 R00925 "RHEA:23176;RHEA:23176" Added Rxn name jpnh R_RXN909_200_c phosphoethanolamine N-methyltransferase M_ethamp_c + M_amet_c <=> M_methamp_c + M_h_c + M_ahcys_c c FALSE (WBGene00022781) PW056 removed pathway N-methyltransferases lenov R_RXN909_204_c R_RXN909_204_c 2.0 M_h2o_c + M_nadp_c + M_ddsmsterol_c <=> M_h_c + M_nadph_c + M_o2_c + M_chlstol_c c FALSE PW047 R_RXN909_205_c R_RXN909_205_c 2.0 M_h2o_c + M_nad_c + M_ddsmsterol_c <=> M_h_c + M_nadh_c + M_o2_c + M_chlstol_c c FALSE PW047 @@ -2995,7 +2995,7 @@ R_RXN909_216_m R_RXN909_216_m M_b2coa_m <=> M_fataccoa_m m TRUE PW038 cl R_RXN909_217_c R_RXN909_217_c M_coa6_0_c <=> M_fataccoa_c c TRUE PW038 clarification needed Weeghel R_RXN909_217_m R_RXN909_217_m M_coa6_0_m <=> M_fataccoa_m m TRUE PW038 clarification needed Weeghel R_RXN909_22_c dihydrofolate reductase M_thf_c + 2.0 M_nadp_c <=> 2.0 M_h_c + M_fol_c + 2.0 M_nadph_c c FALSE (WBGene00007974) PW091 RHEA:15009 -R_RXN909_220_c riboflavin-5-phosphate phosphohydrolase (acid optimum) M_pi_c + M_ribflv_c <=> M_h2o_c + M_fmn_c c TRUE ((WBGene00009146 or WBGene00014076 or WBGene00007328 or WBGene00007331) or (WBGene00020471 or WBGene00015161 or WBGene00011262) or WBGene00022379 or WBGene00008531) or (WBGene00206373 or WBGene00008802 or WBGene00008801 or WBGene00022246 or WBGene00004020 or WBGene00016152 or WBGene00004023 or WBGene00018696 or WBGene00011879 or WBGene00022181) PW040 RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017 set to reversible janna +R_RXN909_220_c riboflavin-5-phosphate phosphohydrolase (acid optimum) M_pi_c + M_ribflv_c <=> M_h2o_c + M_fmn_c c TRUE ((WBGene00009146 or WBGene00014076 or WBGene00007328 or WBGene00007331) or (WBGene00020471 or WBGene00015161 or WBGene00011262) or WBGene00022379 or WBGene00008531) or (WBGene00206373 or WBGene00008802 or WBGene00008801 or WBGene00022246 or WBGene00004020 or WBGene00016152 or WBGene00004023 or WBGene00018696 or WBGene00011879 or WBGene00022181) PW040 "RHEA:15017;RHEA:15017;RHEA:15017;RHEA:15017" set to reversible janna R_RXN909_221_c 7,8-dihydropteroate:L-glutamate ligase (ADP-forming) M_glu__L_c + M_atp_c + M_dhpt_c <=> M_pi_c + M_adp_c + M_dhf_c c FALSE (WBGene00017777) PW091 R_RXN909_221_m 7,8-dihydropteroate:L-glutamate ligase (ADP-forming) M_glu__L_m + M_atp_m + M_dhpt_m <=> M_pi_m + M_adp_m + M_dhf_m m FALSE (WBGene00017777) PW091 R_RXN909_227_c R_RXN909_227_c M_coa12_0_c <=> M_fataccoa_c c FALSE PW038 clarification needed Weeghel @@ -3009,12 +3009,12 @@ R_RXN909_230_c R_RXN909_230_c M_coa18_0_c <=> M_fataccoa_c c FALSE PW038 R_RXN909_230_m R_RXN909_230_m M_coa18_0_m <=> M_fataccoa_m m FALSE PW038 clarification needed Weeghel R_RXN909_231_c R_RXN909_231_c M_coa14_0_c <=> M_fataccoa_c c FALSE PW038 clarification needed Weeghel R_RXN909_231_m R_RXN909_231_m M_coa14_0_m <=> M_fataccoa_m m FALSE PW038 clarification needed Weeghel -R_RXN909_232_c glutathione:L-alanine 5-glutamyltransferase M_h_c + M_ala__L_c + M_gthrd_c <=> M_LgluDala_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 added rxn name - fixed an error in the reaction; replace M_ala__L_c with M_ala_L_c jpnh; lenov +R_RXN909_232_c glutathione:L-alanine 5-glutamyltransferase M_h_c + M_ala__L_c + M_gthrd_c <=> M_LgluDala_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 "added rxn name - fixed an error in the reaction; replace M_ala__L_c with M_ala_L_c" "jpnh; lenov" R_RXN909_233_c glutathione:L-cysteine 5-glutamyltransferase M_h_c + M_cys__L_c + M_gthrd_c <=> M_glucys_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 added rxn name jpnh R_RXN909_234_c glutathione:L-glutamine 5-glutamyltransferase M_h_c + M_gln__L_c + M_gthrd_c <=> M_gluglu_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 added rxn name jpnh R_RXN909_235_c glutathione:L-methionine 5-glutamyltransferase M_h_c + M_met__L_c + M_gthrd_c <=> M_glumet_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 added rxn name jpnh -R_RXN909_236_c glutathione:L-asparaginine 5-glutamyltransferase M_asn__L_c + M_gthrd_c <=> M_gluasp_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 added rxn name; replaced M_asn__L_c with M_asn_L_c jpnh;lenov -R_RXN909_237_c (5-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxoproline-forming) M_LgluDala_c <=> M_5oxpro_c + M_h_c + M_ala__L_c c FALSE (WBGene00016629) PW071 added rxn name; reolaced M_ala__L_c with M_ala_L_c jpnh; lenov +R_RXN909_236_c glutathione:L-asparaginine 5-glutamyltransferase M_asn__L_c + M_gthrd_c <=> M_gluasp_c + M_cgly_c c FALSE (WBGene00016906) or (WBGene00012416) or (WBGene00020590) or (WBGene00011393) PW070 "added rxn name; replaced M_asn__L_c with M_asn_L_c" "jpnh;lenov" +R_RXN909_237_c (5-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxoproline-forming) M_LgluDala_c <=> M_5oxpro_c + M_h_c + M_ala__L_c c FALSE (WBGene00016629) PW071 "added rxn name; reolaced M_ala__L_c with M_ala_L_c" "jpnh; lenov" R_RXN909_238_c (5-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxoproline-forming) M_gluser_c <=> M_5oxpro_c + M_h_c + M_ser__L_c c FALSE (WBGene00016629) PW071 added rxn name jpnh R_RXN909_24_c R_RXN909_24_c M_h_c + M_fad_c + M_ibcoa_c <=> M_fadh2_c + M_2mp2coa_c c FALSE (WBGene00019599) or (WBGene00019406) PW083 R_RXN909_24_m R_RXN909_24_m M_h_m + M_fad_m + M_ibcoa_m <=> M_fadh2_m + M_2mp2coa_m m FALSE (WBGene00020812) or (WBGene00020366) or (WBGene00019406) or (WBGene00019433) or (WBGene00019599) PW083 RHEA:14477 @@ -3025,30 +3025,30 @@ R_RXN909_243_c R_RXN909_243_c M_didp_c + M_atp_c <=> M_ditp_c + M_adp_c c FALSE R_RXN909_243_n R_RXN909_243_n M_didp_n + M_atp_n <=> M_ditp_n + M_adp_n n FALSE (WBGene00009119) PW042 RHEA:44640 R_RXN909_244_c ATP:GDP phosphotransferase M_atp_c + M_idp_c <=> M_h_c + M_itp_c + M_adp_c c TRUE WBGene00019899 or WBGene00021692 or WBGene00009119 PW042 RHEA:44640 set to reversible janna R_RXN909_244_n R_RXN909_244_n M_atp_n + M_idp_n <=> M_h_n + M_itp_n + M_adp_n n TRUE (WBGene00009119) PW042 RHEA:44640 set to reversible janna -R_RXN909_246_c R_RXN909_246_c M_h2o_c + M_itp_c <=> M_ppi_c + M_imp_c + M_h_c c FALSE (WBGene00001823) PW042 RHEA:23996;RHEA:44644 -R_RXN909_246_n R_RXN909_246_n M_h2o_n + M_itp_n <=> M_ppi_n + M_imp_n + M_h_n n FALSE (WBGene00001823) PW042 RHEA:23996;RHEA:44644 +R_RXN909_246_c R_RXN909_246_c M_h2o_c + M_itp_c <=> M_ppi_c + M_imp_c + M_h_c c FALSE (WBGene00001823) PW042 "RHEA:23996;RHEA:44644" +R_RXN909_246_n R_RXN909_246_n M_h2o_n + M_itp_n <=> M_ppi_n + M_imp_n + M_h_n n FALSE (WBGene00001823) PW042 "RHEA:23996;RHEA:44644" R_RXN909_247_c R_RXN909_247_c M_pi_c + M_dad_2_c <=> M_h2o_c + M_damp_c c TRUE WBGene00017775 or WBGene00012423 or WBGene00022201 PW042 set to reversible janna R_RXN909_247_n R_RXN909_247_n M_pi_n + M_dad_2_n <=> M_h2o_n + M_damp_n n TRUE (WBGene00022201) PW042 set to reversible janna R_RXN909_248_c R_RXN909_248_c M_damp_c + M_atp_c <=> M_h_c + M_dadp_c + M_adp_c c TRUE WBGene00008458 or (WBGene00009531 or WBGene00014058 or WBGene00002879) PW042 RHEA:12973 set to reversible janna R_RXN909_248_m R_RXN909_248_m M_damp_m + M_atp_m <=> M_h_m + M_dadp_m + M_adp_m m TRUE (WBGene00014058) or (WBGene00009531) or (WBGene00002879) PW042 RHEA:12973 set to reversible janna R_RXN909_248_n R_RXN909_248_n M_damp_n + M_atp_n <=> M_h_n + M_dadp_n + M_adp_n n TRUE (WBGene00002879) PW042 RHEA:12973 set to reversible janna -R_RXN909_249_c R_RXN909_249_c M_pi_c + M_h_c + M_imp_c <=> M_h2o_c + M_idp_c c TRUE (WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697 PW042 RHEA:36799;RHEA:36799;RHEA:36799 set to reversible janna -R_RXN909_251_c R_RXN909_251_c M_gtp_c + M_cmp_c <=> M_h_c + M_gdp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW042;PW043 -R_RXN909_251_n R_RXN909_251_n M_gtp_n + M_cmp_n <=> M_h_n + M_gdp_n + M_cdp_n n TRUE (WBGene00007812) PW042;PW043 +R_RXN909_249_c R_RXN909_249_c M_pi_c + M_h_c + M_imp_c <=> M_h2o_c + M_idp_c c TRUE (WBGene00044355 or WBGene00017244) or WBGene00003254 or WBGene00010697 PW042 "RHEA:36799;RHEA:36799;RHEA:36799" set to reversible janna +R_RXN909_251_c R_RXN909_251_c M_gtp_c + M_cmp_c <=> M_h_c + M_gdp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) "PW042;PW043" +R_RXN909_251_n R_RXN909_251_n M_gtp_n + M_cmp_n <=> M_h_n + M_gdp_n + M_cdp_n n TRUE (WBGene00007812) "PW042;PW043" R_RXN909_252_c R_RXN909_252_c M_ctp_c + M_cmp_c <=> 2.0 M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW043 R_RXN909_252_n R_RXN909_252_n M_ctp_n + M_cmp_n <=> 2.0 M_cdp_n n TRUE (WBGene00007812) PW043 R_RXN909_253_c R_RXN909_253_c M_utp_c + M_cmp_c <=> M_udp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW043 R_RXN909_253_n R_RXN909_253_n M_utp_n + M_cmp_n <=> M_udp_n + M_cdp_n n TRUE (WBGene00007812) PW043 -R_RXN909_254_c R_RXN909_254_c M_datp_c + M_cmp_c <=> M_h_c + M_dadp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW042;PW043 -R_RXN909_254_n R_RXN909_254_n M_datp_n + M_cmp_n <=> M_h_n + M_dadp_n + M_cdp_n n TRUE (WBGene00007812) PW042;PW043 +R_RXN909_254_c R_RXN909_254_c M_datp_c + M_cmp_c <=> M_h_c + M_dadp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) "PW042;PW043" +R_RXN909_254_n R_RXN909_254_n M_datp_n + M_cmp_n <=> M_h_n + M_dadp_n + M_cdp_n n TRUE (WBGene00007812) "PW042;PW043" R_RXN909_255_c R_RXN909_255_c M_dctp_c + M_cmp_c <=> M_dcdp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW043 R_RXN909_255_n R_RXN909_255_n M_dctp_n + M_cmp_n <=> M_dcdp_n + M_cdp_n n TRUE (WBGene00007812) PW043 -R_RXN909_256_c R_RXN909_256_c M_dgtp_c + M_cmp_c <=> M_dgdp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) PW042;PW043 -R_RXN909_256_n R_RXN909_256_n M_dgtp_n + M_cmp_n <=> M_dgdp_n + M_cdp_n n TRUE (WBGene00007812) PW042;PW043 +R_RXN909_256_c R_RXN909_256_c M_dgtp_c + M_cmp_c <=> M_dgdp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) "PW042;PW043" +R_RXN909_256_n R_RXN909_256_n M_dgtp_n + M_cmp_n <=> M_dgdp_n + M_cdp_n n TRUE (WBGene00007812) "PW042;PW043" R_RXN909_259_c R_RXN909_259_c M_atp_c + M_thm_c <=> M_thmpp_c + M_amp_c c FALSE (WBGene00014027) PW041 RHEA:11576 R_RXN909_26_c 3-hydroxyisobutyrate dehydrogenase M_nad_c + M_3hmp_c <=> M_h_c + M_nadh_c + M_mmtsa_c c FALSE (WBGene00019978) or (WBGene00010035) or (WBGene00001158) or (WBGene00001157) or (WBGene00007129) PW083 R_RXN909_26_m 3-hydroxyisobutyrate dehydrogenase M_nad_m + M_3hmp_m <=> M_h_m + M_nadh_m + M_mmtsa_m m TRUE (WBGene00001157) or (WBGene00010035) or (WBGene00001158) or (WBGene00007129) or (WBGene00000181) or (WBGene00019978) or (WBGene00007122) PW083 Added extra genes from R_3_HYDROXYISOBUTYRATE_DEHYDROGENASE_RXN_m, set to reversible -> revise later jpnh -R_RXN909_260_c (5-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxoproline-forming) M_gluasp_c <=> M_5oxpro_c + M_asn__L_c c FALSE (WBGene00016629) PW071 added rxn name; replaced M_asn__L_c by M_asn_L_c jpnh; lenov +R_RXN909_260_c (5-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxoproline-forming) M_gluasp_c <=> M_5oxpro_c + M_asn__L_c c FALSE (WBGene00016629) PW071 "added rxn name; replaced M_asn__L_c by M_asn_L_c" "jpnh; lenov" R_RXN909_261_c ATP:dGMP phosphotransferase M_h_c + M_dgdp_c + M_adp_c <=> M_atp_c + M_dgmp_c c TRUE (WBGene00020190) PW042 set to reversible janna R_RXN909_261_m R_RXN909_261_m M_h_m + M_dgdp_m + M_adp_m <=> M_atp_m + M_dgmp_m m TRUE (WBGene00020190) PW042 set to reversible janna R_RXN909_266_c R_RXN909_266_c M_gpail_c + M_coa16_0_c <=> M_gacpail_c + M_coa_c c FALSE (WBGene00022447) PW028 @@ -3062,8 +3062,8 @@ R_RXN909_272_n R_RXN909_272_n M_h2o_n + M_ap4a_n <=> M_h_n + M_atp_n + M_amp_n R_RXN909_278_c R_RXN909_278_c M_h2o_c + M_chtn_c <=> M_acgam_c c FALSE (WBGene00000503) PW021 [DELETION] DUPE of R_RC01206 jpnh R_RXN909_28_c (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase M_h2o_c + M_nad_c + M_mmtsa_c <=> M_mm_c + 2.0 M_h_c + M_nadh_c c FALSE (WBGene00000108) or (WBGene00000107) PW083 R_RXN909_28_m (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase M_h2o_m + M_nad_m + M_mmtsa_m <=> M_mm_m + 2.0 M_h_m + M_nadh_m m FALSE (WBGene00000115) or (WBGene00000108) or (WBGene00000107) PW083 RHEA:16185 -R_RXN909_280_c alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Fructose 6-phosphate) M_g6p_A_c <=> M_f6p_c c TRUE (WBGene00013597) PW031 RHEA:11816;RHEA:11816 set to reversible janna -R_RXN909_280_m alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Fructose 6-phosphate) M_g6p_A_m <=> M_f6p_m m TRUE (WBGene00013597) PW031 RHEA:11816;RHEA:11816 updated name; set to reversible jpnh; janna +R_RXN909_280_c alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Fructose 6-phosphate) M_g6p_A_c <=> M_f6p_c c TRUE (WBGene00013597) PW031 "RHEA:11816;RHEA:11816" set to reversible janna +R_RXN909_280_m alpha-D-Glucose 6-phosphate ketol-isomerase (producing beta-D-Fructose 6-phosphate) M_g6p_A_m <=> M_f6p_m m TRUE (WBGene00013597) PW031 "RHEA:11816;RHEA:11816" "updated name; set to reversible" "jpnh; janna" R_RXN909_281_c R_RXN909_281_c M_glc1Man9GlcNac2Asn_c + M_h2o_c <=> M_man9GlcNac2Asn_c + M_glc_bD_c c FALSE (WBGene00018682) or (WBGene00009583) PW011 R_RXN909_282_c R_RXN909_282_c M_glc2Man9GlcNac2Asn_c + M_h2o_c <=> M_glc1Man9GlcNac2Asn_c + M_glc_bD_c c FALSE (WBGene00009583) or (WBGene00018682) PW011 R_RXN909_283_c R_RXN909_283_c M_h2o_c + M_man9GlcNac2Asn_c <=> M_man8GlcNac2Asn_c + M_man_c c FALSE (WBGene00020197) or (WBGene00013881) or (WBGene00008411) PW011 @@ -3078,7 +3078,7 @@ R_RXN909_290_c R_RXN909_290_c M_MGn_c + M_gdpfuc_c <=> M_MGnF6_c + M_h_c + M_gd R_RXN909_290_m R_RXN909_290_m M_MGn_m + M_gdpfuc_m <=> M_MGnF6_m + M_h_m + M_gdp_m m FALSE (WBGene00001508) PW112 RHEA:12985 R_RXN909_291_c R_RXN909_291_c M_man5_c + M_uacgam_c <=> M_man5Gn_c + M_h_c + M_udp_c c FALSE (WBGene00001639) or (WBGene00001637) or (WBGene00001638) PW011 RHEA:11456 R_RXN909_291_n R_RXN909_291_n M_man5_n + M_uacgam_n <=> M_man5Gn_n + M_h_n + M_udp_n n FALSE (WBGene00001639) PW011 -R_RXN909_292_c R_RXN909_292_c 2.0 M_h2o_c + M_man5Gn_c <=> M_MGn_c + 2.0 M_man_c c FALSE (WBGene00010284) PW011;PW112 +R_RXN909_292_c R_RXN909_292_c 2.0 M_h2o_c + M_man5Gn_c <=> M_MGn_c + 2.0 M_man_c c FALSE (WBGene00010284) "PW011;PW112" R_RXN909_294_c R_RXN909_294_c M_h2o_c + M_MGnF6_c <=> M_acgam_c + M_MMF6_c c FALSE (WBGene00015767) PW112 R_RXN909_294_m R_RXN909_294_m M_h2o_m + M_MGnF6_m <=> M_acgam_m + M_MMF6_m m FALSE (WBGene00015767) PW112 R_RXN909_295_c R_RXN909_295_c M_MMF6_c + M_gdpfuc_c <=> M_mmf3f6_c + M_h_c + M_gdp_c c FALSE (WBGene00001505) PW112 RHEA:24444 @@ -3086,8 +3086,8 @@ R_RXN909_296_c R_RXN909_296_c M_MGnF6_c + M_udpgal_c <=> M_mgf6g_c + M_h_c + M_ R_RXN909_297_c R_RXN909_297_c M_MGnF6_c + M_gdpfuc_c <=> M_mgf3f6b_c + M_h_c + M_gdp_c c FALSE (WBGene00020222) PW112 R_RXN909_298_c R_RXN909_298_c M_MM_c + M_gdpfuc_c <=> M_mmf3b_c + M_h_c + M_gdp_c c FALSE (WBGene00020222) PW112 R_RXN909_299_c R_RXN909_299_c M_MM_c + M_gdpfuc_c <=> M_mmf3_c + M_h_c + M_gdp_c c FALSE (WBGene00001505) PW112 RHEA:24444 -R_RXN909_3_c nucleoside-triphosphate diphosphatase M_h2o_c + M_dgtp_c <=> M_ppi_c + M_dgmp_c + M_h_c c TRUE (WBGene00001823) PW042 RHEA:23996;RHEA:44644 -R_RXN909_3_n nucleoside-triphosphate diphosphatase M_h2o_n + M_dgtp_n <=> M_ppi_n + M_dgmp_n + M_h_n n TRUE (WBGene00001823) PW042 RHEA:23996;RHEA:44644 +R_RXN909_3_c nucleoside-triphosphate diphosphatase M_h2o_c + M_dgtp_c <=> M_ppi_c + M_dgmp_c + M_h_c c TRUE (WBGene00001823) PW042 "RHEA:23996;RHEA:44644" +R_RXN909_3_n nucleoside-triphosphate diphosphatase M_h2o_n + M_dgtp_n <=> M_ppi_n + M_dgmp_n + M_h_n n TRUE (WBGene00001823) PW042 "RHEA:23996;RHEA:44644" R_RXN909_30_c R_RXN909_30_c M_selcys_c + M_dtt_c <=> M_dttOX_c + M_seln_c + M_h_c + M_ala__L_c c FALSE (WBGene00017442) PW088 replaced M_ala__L_c with M_ala_L_c lenov R_RXN909_30_n R_RXN909_30_n M_selcys_n + M_dtt_n <=> M_dttOX_n + M_seln_n + M_h_n + M_ala__L_n n FALSE (WBGene00017442) PW088 replaced M_ala__L_n with M_ala_L_n lenov R_RXN909_300_c R_RXN909_300_c M_mmf3f6_c + M_gdpfuc_c <=> M_mmf3f3f6_c + M_h_c + M_gdp_c c FALSE (WBGene00020222) PW112 @@ -3111,20 +3111,20 @@ R_RXN909_315_c R_RXN909_315_c M_T_antigen_c + M_uacgam_c <=> M_core2_c + M_udp_ R_RXN909_316_c R_RXN909_316_c M_tn_antigen_c + M_uacgam_c <=> M_core6_c + M_udp_c c FALSE (WBGene00001641) PW113 R_RXN909_317_c R_RXN909_317_c M_m2mn_c + 2.0 M_h2o_c <=> M_mn_c + 2.0 M_man_c c FALSE PW012 R_RXN909_318_c R_RXN909_318_c 2.0 M_h2o_c + M_man5_c <=> M_acBgamamAsn_c + M_man5gn_c + 2.0 M_peptide_c c FALSE (WBGene00017164) PW012 -R_RXN909_319_c asparagine recovery (hydrolytic) M_h2o_c + M_prot_asp_c <=> M_asn__L_c + M_peptide_c c TRUE PW098 added rxn name; replaced M_asn__L_c with M_asn_L_c; replaced demand reaction with miscellaneous jpnh; lenov -R_RXN909_32_c 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_4mop_c + M_bcaalip_c <=> M_co2_c + M_3meb_lipact_c c FALSE (WBGene00012713) or (WBGene00006518) PW083 RHEA:13457;RHEA:13457 -R_RXN909_32_m 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_4mop_m + M_bcaalip_m <=> M_co2_m + M_3meb_lipact_m m FALSE (WBGene00012713) or (WBGene00006518) PW083 RHEA:13457;RHEA:13457 +R_RXN909_319_c asparagine recovery (hydrolytic) M_h2o_c + M_prot_asp_c <=> M_asn__L_c + M_peptide_c c TRUE PW098 "added rxn name; replaced M_asn__L_c with M_asn_L_c; replaced demand reaction with miscellaneous" "jpnh; lenov" +R_RXN909_32_c 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_4mop_c + M_bcaalip_c <=> M_co2_c + M_3meb_lipact_c c FALSE (WBGene00012713) or (WBGene00006518) PW083 "RHEA:13457;RHEA:13457" +R_RXN909_32_m 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_4mop_m + M_bcaalip_m <=> M_co2_m + M_3meb_lipact_m m FALSE (WBGene00012713) or (WBGene00006518) PW083 "RHEA:13457;RHEA:13457" R_RXN909_320_c R_RXN909_320_c M_tn_antigen_c + M_h_c + M_udp_c <=> M_udpacgal_c + M_polypeptide_c c FALSE (WBGene00011095) PW015 -R_RXN909_321_c R_RXN909_321_c M_h_c + M_nadph_c + M_o2_c <=> M_h2o2_c + M_nadp_c c FALSE (WBGene00000253) or (WBGene00018771) PW098 RHEA:11264;RHEA:11260 +R_RXN909_321_c R_RXN909_321_c M_h_c + M_nadph_c + M_o2_c <=> M_h2o2_c + M_nadp_c c FALSE (WBGene00000253) or (WBGene00018771) PW098 "RHEA:11264;RHEA:11260" R_RXN909_323_c R_RXN909_323_c M_mgacpail_c + M_dolmanp_c <=> M_m2gacpail_c + M_h_c + M_dolp_c c FALSE (WBGene00020375) PW028 R_RXN909_33_c 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase M_coa_c + M_3meb_lipact_c <=> M_ivcoa_c + M_bcaadh_c c FALSE (WBGene00014054) PW083 RHEA:18865 R_RXN909_33_m 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase M_coa_m + M_3meb_lipact_m <=> M_ivcoa_m + M_bcaadh_m m FALSE (WBGene00014054) PW083 RHEA:18865 -R_RXN909_333_c L-arginine:oxygen oxidoreductase (deaminating) M_h2o_c + M_arg__D_c + M_o2_c <=> M_h2o2_c + M_nh3_c + M_5g2oxpt_c + M_h_c c FALSE (WBGene00022076) PW073 RHEA:21816 Added Rxn Name; changed M_arg__D_c into M_arg_D_c jpnh; lenov -R_RXN909_336_c Glycosaminoglycan Chain extension M_udpglcur_c + M_cs_pre_c <=> M_h_c + M_udp_c + M_cs_pre1_c c FALSE (WBGene00005023 and WBGene00003253) PW013 RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996 Added generic rxn name jpnh -R_RXN909_339_c Glycosaminoglycan Chain extension M_udpglcur_c + M_cs_pre2_c <=> M_h_c + M_udp_c + M_cs_pre3_c c FALSE (WBGene00005023 and WBGene00003253) PW013 RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996 Added generic rxn name jpnh +R_RXN909_333_c L-arginine:oxygen oxidoreductase (deaminating) M_h2o_c + M_arg__D_c + M_o2_c <=> M_h2o2_c + M_nh3_c + M_5g2oxpt_c + M_h_c c FALSE (WBGene00022076) PW073 RHEA:21816 "Added Rxn Name; changed M_arg__D_c into M_arg_D_c" "jpnh; lenov" +R_RXN909_336_c Glycosaminoglycan Chain extension M_udpglcur_c + M_cs_pre_c <=> M_h_c + M_udp_c + M_cs_pre1_c c FALSE (WBGene00005023 and WBGene00003253) PW013 "RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996" Added generic rxn name jpnh +R_RXN909_339_c Glycosaminoglycan Chain extension M_udpglcur_c + M_cs_pre2_c <=> M_h_c + M_udp_c + M_cs_pre3_c c FALSE (WBGene00005023 and WBGene00003253) PW013 "RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996" Added generic rxn name jpnh R_RXN909_34_c 3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase M_h_c + M_fad_c + M_ivcoa_c <=> M_fadh2_c + M_3mb2coa_c c FALSE (WBGene00019599) or (WBGene00019406) or (WBGene00015326) PW083 Renamed and added genes from deprecated R_RXN909_35_c R_RXN909_34_m 3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase M_h_m + M_fad_m + M_ivcoa_m <=> M_fadh2_m + M_3mb2coa_m m FALSE (WBGene00020812) or (WBGene00020366) or (WBGene00019406) or (WBGene00015326) or (WBGene00019599) PW083 RHEA:14477 Renamed -R_RXN909_340_c Glycosaminoglycan Chain extension M_udpacgal_c + M_cs_pre3_c <=> M_h_c + M_udp_c + M_cs_pre4_c c FALSE (WBGene00005023 and WBGene00003253) PW013 RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996 Added generic rxn name jpnh +R_RXN909_340_c Glycosaminoglycan Chain extension M_udpacgal_c + M_cs_pre3_c <=> M_h_c + M_udp_c + M_cs_pre4_c c FALSE (WBGene00005023 and WBGene00003253) PW013 "RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996;RHEA:23464;RHEA:20800;RHEA:55000;RHEA:23428;RHEA:54996" Added generic rxn name jpnh R_RXN909_341_c R_RXN909_341_c M_gdpmann_c + M_admnsyl_c <=> M_doldpglcnacglcnacmanman_c + M_gdp_c c FALSE PW011 R_RXN909_343_c R_RXN909_343_c M_h2o_c + M_ala_L_lys__L_c <=> M_lys__L_c + M_ala__L_c c FALSE PW107 replaced M_ala__L_c with M_ala_L_c lenov R_RXN909_344_c R_RXN909_344_c M_h2o_c + M_ala_L_val__L_c <=> M_val__L_c + M_ala__L_c c FALSE PW107 replaced M_ala_L_val__L_c and M_ala__L_c with M_ala_L_val_L_c and M_ala_L_c lenov @@ -3135,61 +3135,61 @@ R_RXN909_351_c R_RXN909_351_c 2.0 M_h2o_c + M_lys_tyr_glu_c <=> M_lys__L_c + M_ R_RXN909_352_c R_RXN909_352_c 2.0 M_h2o_c + M_glu_gly_phe_c <=> M_phe__L_c + M_gly_c + M_glu__L_c c FALSE PW107 R_RXN909_353_c R_RXN909_353_c M_adp_c + M_dcdp_c <=> M_atp_c + M_dcmp_c c TRUE WBGene00007812 or WBGene00009575 PW043 set to reversible janna R_RXN909_353_n R_RXN909_353_n M_adp_n + M_dcdp_n <=> M_atp_n + M_dcmp_n n TRUE (WBGene00007812) PW043 set to reversible janna -R_RXN909_36_c 3-Hydroxyisopentyl-CoA hydro-lyase M_h2o_c + M_3mb2coa_c <=> M_3hivcoa_c c FALSE (WBGene00001156) or (WBGene00020347) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 RHEA:16105;RHEA:20724 -R_RXN909_36_m 3-Hydroxyisopentyl-CoA hydro-lyase M_h2o_m + M_3mb2coa_m <=> M_3hivcoa_m m FALSE (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 RHEA:16105;RHEA:20724 +R_RXN909_36_c 3-Hydroxyisopentyl-CoA hydro-lyase M_h2o_c + M_3mb2coa_c <=> M_3hivcoa_c c FALSE (WBGene00001156) or (WBGene00020347) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 "RHEA:16105;RHEA:20724" +R_RXN909_36_m 3-Hydroxyisopentyl-CoA hydro-lyase M_h2o_m + M_3mb2coa_m <=> M_3hivcoa_m m FALSE (WBGene00001156) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW083 "RHEA:16105;RHEA:20724" R_RXN909_37_c 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) M_hco3_c + M_atp_c + M_3mb2coa_c <=> M_pi_c + 2.0 M_h_c + M_adp_c + M_3mgcoa_c c FALSE (WBGene00009319 and WBGene00008514) PW083 R_RXN909_37_m 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) M_hco3_m + M_atp_m + M_3mb2coa_m <=> M_pi_m + 2.0 M_h_m + M_adp_m + M_3mgcoa_m m FALSE (WBGene00009319 and WBGene00008514) PW083 R_RXN909_38_c succinyl-CoA:acetoacetate CoA-transferase M_acac_c + M_succoa_c <=> M_succ_c + M_aacoa_c c TRUE (WBGene00007330) PW083 R_RXN909_38_m succinyl-CoA:acetoacetate CoA-transferase M_acac_m + M_succoa_m <=> M_succ_m + M_aacoa_m m TRUE (WBGene00007330) PW083 -R_RXN909_39_c (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_3mop_c + M_bcaalip_c <=> M_co2_c + M_2meb_lipact_c c FALSE (WBGene00012713) or (WBGene00006518) PW098 R04225 RHEA:13457;RHEA:13457 -R_RXN909_39_m (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_3mop_m + M_bcaalip_m <=> M_co2_m + M_2meb_lipact_m m FALSE (WBGene00012713) or (WBGene00006518) PW083 RHEA:13457;RHEA:13457 -R_RXN909_4_c dUTP nucleotidohydrolase M_h2o_c + M_dutp_c <=> M_ppi_c + M_dump_c + M_h_c c TRUE WBGene00001823 or WBGene00010609 PW043 RHEA:23996;RHEA:44644 +R_RXN909_39_c (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_3mop_c + M_bcaalip_c <=> M_co2_c + M_2meb_lipact_c c FALSE (WBGene00012713) or (WBGene00006518) PW098 R04225 "RHEA:13457;RHEA:13457" +R_RXN909_39_m (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) M_3mop_m + M_bcaalip_m <=> M_co2_m + M_2meb_lipact_m m FALSE (WBGene00012713) or (WBGene00006518) PW083 "RHEA:13457;RHEA:13457" +R_RXN909_4_c dUTP nucleotidohydrolase M_h2o_c + M_dutp_c <=> M_ppi_c + M_dump_c + M_h_c c TRUE WBGene00001823 or WBGene00010609 PW043 "RHEA:23996;RHEA:44644" R_RXN909_40_c (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase M_coa_c + M_2meb_lipact_c <=> M_2mbcoa_c + M_bcaadh_c c FALSE (WBGene00014054) PW083 RHEA:18865 R_RXN909_40_m (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase M_coa_m + M_2meb_lipact_m <=> M_2mbcoa_m + M_bcaadh_m m FALSE (WBGene00014054) PW083 RHEA:18865 R_RXN909_41_c L-ornithine carboxy-lyase (putrescine-forming) M_h_c + M_orn_c <=> M_co2_c + M_ptrc_c c TRUE WBGene00018764 or WBGene00003844 PW081 R00670 RHEA:22964 -R_RXN909_42_c L-histidine carboxy-lyase M_h_c + M_his__L_c <=> M_hista_c + M_co2_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW084 RHEA:14345;RHEA:12272;RHEA:18533 +R_RXN909_42_c L-histidine carboxy-lyase M_h_c + M_his__L_c <=> M_hista_c + M_co2_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW084 "RHEA:14345;RHEA:12272;RHEA:18533" R_RXN909_44_c L-serine ammonia-lyase M_ser__L_c <=> M_nh3_c + M_h_c + M_pyr_c c TRUE (WBGene00010456) PW074 -R_RXN909_45_c O3-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide) M_acser_c + M_seln_c <=> M_selcys_c + M_ac_c c TRUE WBGene00008490 or WBGene00008732 or WBGene00019094 or WBGene00020797 or WBGene00007653 or WBGene00010759 or WBGene00019962 or WBGene00019096 PW088 RHEA:14829;RHEA:14829;RHEA:17821;RHEA:14829;RHEA:14829 set to reversible janna +R_RXN909_45_c O3-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide) M_acser_c + M_seln_c <=> M_selcys_c + M_ac_c c TRUE WBGene00008490 or WBGene00008732 or WBGene00019094 or WBGene00020797 or WBGene00007653 or WBGene00010759 or WBGene00019962 or WBGene00019096 PW088 "RHEA:14829;RHEA:14829;RHEA:17821;RHEA:14829;RHEA:14829" set to reversible janna R_RXN909_46_c Selenocystathionine Lysteine-lyase (deaminating) M_selcyst_c + M_h2o_c <=> M_nh3_c + 2.0 M_h_c + M_selcys_c + M_2obut_c c FALSE (WBGene00022856) or (WBGene00009048) or (WBGene00007533) PW088 RHEA:14005 R_RXN909_47_c L-Serine hydro-lyase (adding homocysteine) M_selhcys_c + M_h_c + M_ser__L_c <=> M_selcyst_c + M_h2o_c c FALSE (WBGene00013866) or (WBGene00018783) PW088 R_RXN909_49_c Se-Adenosylselenohomocysteine hydrolase M_h2o_c + M_asehcys_c <=> M_selhcys_c + M_adn_c c FALSE (WBGene00019322) PW088 RHEA:21708 R_RXN909_50_c R_RXN909_50_c M_seasmet_c + M_thf_c <=> M_asehcys_c + M_h_c + M_5mthf_c c FALSE PW088 -R_RXN909_51_c ATP:L-selenomethione S-adenosyltransferase M_h2o_c + M_selmeth_c + M_atp_c <=> M_seasmet_c + M_pi_c + M_ppi_c + M_h_c c FALSE (WBGene00006416) or (WBGene00008205) or (WBGene00015540) or (WBGene00015538) PW088 RHEA:21080;RHEA:21080;RHEA:21080;RHEA:21080 +R_RXN909_51_c ATP:L-selenomethione S-adenosyltransferase M_h2o_c + M_selmeth_c + M_atp_c <=> M_seasmet_c + M_pi_c + M_ppi_c + M_h_c c FALSE (WBGene00006416) or (WBGene00008205) or (WBGene00015540) or (WBGene00015538) PW088 "RHEA:21080;RHEA:21080;RHEA:21080;RHEA:21080" R_RXN909_52_c Selenomethionine:tRNAMet ligase (AMP-forming) M_selmeth_c + M_atp_c + M_mettrna_c <=> M_ppi_c + M_amp_c + M_chtrna_c c FALSE (WBGene00003415) PW088 RHEA:13481 R_RXN909_52_m Selenomethionine:tRNAMet ligase (AMP-forming) M_selmeth_m + M_atp_m + M_mettrna_m <=> M_ppi_m + M_amp_m + M_chtrna_m m FALSE (WBGene00013678) or (WBGene00003415) PW088 RHEA:13481 R_RXN909_53_c S-Adenosyl-L-methionine:thiol S-methyltransferase M_selcys_c + M_amet_c <=> M_smscys_c + M_ahcys_c c FALSE PW088 R_RXN909_54_c (5-L-glutamyl)-peptide:Se-Methylselenocysteine 5-glutamyltransferase M_smscys_c + M_5lglup_c <=> M_gglsmsc_c + M_peptide_c c FALSE (WBGene00012416) or (WBGene00011393) or (WBGene00016906) PW088 R_RXN909_55_c Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating) M_phpyr_c + M_o2_c <=> M_2hyoxplac_c + M_co2_c c FALSE WBGene00016294 or WBGene00001993 PW076 RHEA:16189 R_RXN909_56_c R_RXN909_56_c M_2hyoxplac_c + M_h_c + M_nadh_c + M_o2_c <=> M_h2o_c + M_hgentis_c + M_nad_c c FALSE PW076 -R_RXN909_57_c L-Phenylalanine:2-oxoglutarate aminotransferase M_akg_c + M_phe__L_c <=> M_glu__L_c + M_phpyr_c c TRUE (WBGene00020146) or (WBGene00020145) or (WBGene00015778) or (WBGene00015771) or (WBGene00009628) PW076 rn:R00694 RHEA:21824;RHEA:21824 Added Genes from deprecated R_PHEAMINOTRANS_DEG_RXN_c jpnh -R_RXN909_57_m L-Phenylalanine:2-oxoglutarate aminotransferase M_akg_m + M_phe__L_m <=> M_glu__L_m + M_phpyr_m m TRUE (WBGene00009628) or (WBGene00016652) or (WBGene00015778) PW076 rn:R00694 RHEA:21824;RHEA:21824 Added Genes from deprecated R_PHEAMINOTRANS_DEG_RXN_m jpnh +R_RXN909_57_c L-Phenylalanine:2-oxoglutarate aminotransferase M_akg_c + M_phe__L_c <=> M_glu__L_c + M_phpyr_c c TRUE (WBGene00020146) or (WBGene00020145) or (WBGene00015778) or (WBGene00015771) or (WBGene00009628) PW076 rn:R00694 "RHEA:21824;RHEA:21824" Added Genes from deprecated R_PHEAMINOTRANS_DEG_RXN_c jpnh +R_RXN909_57_m L-Phenylalanine:2-oxoglutarate aminotransferase M_akg_m + M_phe__L_m <=> M_glu__L_m + M_phpyr_m m TRUE (WBGene00009628) or (WBGene00016652) or (WBGene00015778) PW076 rn:R00694 "RHEA:21824;RHEA:21824" Added Genes from deprecated R_PHEAMINOTRANS_DEG_RXN_m jpnh R_RXN909_58_c R_RXN909_58_c M_gpail_c + M_coa16_0_c <=> M_gacpail_c + M_coa_c c FALSE PW028 -R_RXN909_59_c (S)-3-Hydroxybutanoyl-CoA hydro-lyase M_h2o_c + M_b2coa_c <=> M_3hbcoa_c c TRUE (WBGene00001156) or (WBGene00020347) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) PW072;PW062 RHEA:16105;RHEA:20724 -R_RXN909_6_c 2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase M_h2o_c + M_ditp_c <=> M_dimp_c + M_ppi_c + M_h_c c TRUE (WBGene00001823) PW042 RHEA:23996;RHEA:44644 -R_RXN909_6_n 2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase M_h2o_n + M_ditp_n <=> M_dimp_n + M_ppi_n + M_h_n n TRUE (WBGene00001823) PW042 RHEA:23996;RHEA:44644 -R_RXN909_60_c (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase M_nad_c + M_3hbcoa_c <=> M_h_c + M_nadh_c + M_aacoa_c c TRUE (WBGene00019978) or (WBGene00010035) or (WBGene00001158) or (WBGene00001157) or (WBGene00007129) PW072;PW062 -R_RXN909_60_m (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase M_nad_m + M_3hbcoa_m <=> M_h_m + M_nadh_m + M_aacoa_m m TRUE (WBGene00010035) or (WBGene00001158) or (WBGene00007129) or (WBGene00001157) PW072;PW062 -R_RXN909_61_c Palmitate:CoA ligase M_atp_c + M_coa_c + M_fa16_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa16_0_c c FALSE (WBGene00008669) or (WBGene00022037) or (WBGene00020343) or (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00018579) or (WBGene00018579) or (WBGene00009221) or (WBGene00016716) or (WBGene00013575) or (WBGene00018152) PW124;PW062 -R_RXN909_61_m Palmitate:CoA ligase M_atp_m + M_coa_m + M_fa16_0_m <=> M_ppi_m + M_h_m + M_amp_m + M_coa16_0_m m FALSE (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00009221) fatty acid biosynthesis;PW062 +R_RXN909_59_c (S)-3-Hydroxybutanoyl-CoA hydro-lyase M_h2o_c + M_b2coa_c <=> M_3hbcoa_c c TRUE (WBGene00001156) or (WBGene00020347) or (WBGene00001155) or (WBGene00001154) or (WBGene00001152) or (WBGene00001150) "PW072;PW062" "RHEA:16105;RHEA:20724" +R_RXN909_6_c 2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase M_h2o_c + M_ditp_c <=> M_dimp_c + M_ppi_c + M_h_c c TRUE (WBGene00001823) PW042 "RHEA:23996;RHEA:44644" +R_RXN909_6_n 2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase M_h2o_n + M_ditp_n <=> M_dimp_n + M_ppi_n + M_h_n n TRUE (WBGene00001823) PW042 "RHEA:23996;RHEA:44644" +R_RXN909_60_c (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase M_nad_c + M_3hbcoa_c <=> M_h_c + M_nadh_c + M_aacoa_c c TRUE (WBGene00019978) or (WBGene00010035) or (WBGene00001158) or (WBGene00001157) or (WBGene00007129) "PW072;PW062" +R_RXN909_60_m (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase M_nad_m + M_3hbcoa_m <=> M_h_m + M_nadh_m + M_aacoa_m m TRUE (WBGene00010035) or (WBGene00001158) or (WBGene00007129) or (WBGene00001157) "PW072;PW062" +R_RXN909_61_c Palmitate:CoA ligase M_atp_c + M_coa_c + M_fa16_0_c <=> M_ppi_c + M_h_c + M_amp_c + M_coa16_0_c c FALSE (WBGene00008669) or (WBGene00022037) or (WBGene00020343) or (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00018579) or (WBGene00018579) or (WBGene00009221) or (WBGene00016716) or (WBGene00013575) or (WBGene00018152) "PW124;PW062" +R_RXN909_61_m Palmitate:CoA ligase M_atp_m + M_coa_m + M_fa16_0_m <=> M_ppi_m + M_h_m + M_amp_m + M_coa16_0_m m FALSE (WBGene00011174) or (WBGene00011173) or (WBGene00019920) or (WBGene00009221) "fatty acid biosynthesis;PW062" R_RXN909_67_c R_RXN909_67_c M_gacpail_c + M_dolmanp_c <=> M_mgacpail_c + M_h_c + M_dolp_c c FALSE (WBGene00007189) PW028 R_RXN909_78_c R_RXN909_78_c M_mgacpail_c + M_1ac2acg3pe_c <=> M_emgacpail_c + M_1ac2acglyc_c c FALSE (WBGene00021840) PW028 R_RXN909_79_c R_RXN909_79_c M_emgacpail_c + M_dolmanp_c <=> M_memgacpail_c + M_h_c + M_dolp_c c FALSE (WBGene00020375) PW028 -R_RXN909_8_m R_RXN909_8_m M_q9_m + M_succ_m <=> M_q9h2_m + M_fum_m m FALSE (WBGene00006433 and WBGene00009353 and WBGene00003225 and WBGene00016392 and WBGene00015391) PW023 SPW004 RHEA:40523;RHEA:40523;RHEA:40523 +R_RXN909_8_m R_RXN909_8_m M_q9_m + M_succ_m <=> M_q9h2_m + M_fum_m m FALSE (WBGene00006433 and WBGene00009353 and WBGene00003225 and WBGene00016392 and WBGene00015391) PW023 SPW004 "RHEA:40523;RHEA:40523;RHEA:40523" R_RXN909_80_c R_RXN909_80_c M_memgacpail_c + M_dolmanp_c <=> M_m2emgacpail_c + M_h_c + M_dolp_c c FALSE PW028 -R_RXN909_9_m R_RXN909_9_m M_q8_m + M_succ_m <=> M_q8h2_m + M_fum_m m FALSE (WBGene00006433 and WBGene00009353 and WBGene00003225 and WBGene00016392 and WBGene00015391) PW023 SPW004 RHEA:40523;RHEA:40523;RHEA:40523 +R_RXN909_9_m R_RXN909_9_m M_q8_m + M_succ_m <=> M_q8h2_m + M_fum_m m FALSE (WBGene00006433 and WBGene00009353 and WBGene00003225 and WBGene00016392 and WBGene00015391) PW023 SPW004 "RHEA:40523;RHEA:40523;RHEA:40523" R_RXtm RX transport M_RX_c <=> M_RX_m cm TRUE PW111 R_SACCD3_c Saccharopine dehydrogenase (NADP+, L-lysine forming) M_akg_c + 5.0 M_h_c + M_lys__L_c + M_nadph_c <=> M_h2o_c + M_saccrp__L_c + M_nadp_c c FALSE (WBGene00019819) PW079 replaced M_saccrp__L_c with M_saccrp_L_c lenov R_SACCD3_m Saccharopine dehydrogenase (NADP+, L-lysine forming) M_akg_m + 5.0 M_h_m + M_lys__L_m + M_nadph_m <=> M_h2o_m + M_saccrp__L_m + M_nadp_m m TRUE (WBGene00019819) PW079 Set to reversible, as per kegg jpnh -R_SADT_c Sulfate adenylyltransferase M_so4_c + M_atp_c + M_h_c <=> M_aps_c + M_ppi_c c TRUE (WBGene00004091) PW096;PW042 set to reversible; replaced annotation sulfate activation for sulfonation with PW096, PW042 janna; lenov +R_SADT_c Sulfate adenylyltransferase M_so4_c + M_atp_c + M_h_c <=> M_aps_c + M_ppi_c c TRUE (WBGene00004091) "PW096;PW042" "set to reversible; replaced annotation sulfate activation for sulfonation with PW096, PW042" "janna; lenov" R_SARCOX_RXN_c sarcosine oxidase M_h2o_c + M_sarcs_c + M_o2_c <=> M_h2o2_c + M_gly_c + M_fald_c c FALSE (WBGene00015783) PW074 R_SARCOX_RXN_m sarcosine oxidase M_h2o_m + M_sarcs_m + M_o2_m <=> M_h2o2_m + M_gly_m + M_fald_m m FALSE (WBGene00015783) PW074 R_SecrRNAtm Sec tRNA transport M_trnasec_c <=> M_trnasec_m cm TRUE PW111 replaced M_SEC__tRNAs_c and M_SEC__tRNAs_m by M_trnasec_c and M_trnasec_m lenov -R_SELNPS_c Selenide,water dikinase M_h2o_c + M_seln_c + M_atp_c <=> M_selnp_c + M_pi_c + M_h_c + M_amp_c c FALSE (WBGene00012867) PW088;PW082 RHEA:18737 +R_SELNPS_c Selenide,water dikinase M_h2o_c + M_seln_c + M_atp_c <=> M_selnp_c + M_pi_c + M_h_c + M_amp_c c FALSE (WBGene00012867) "PW088;PW082" RHEA:18737 R_SERAT_c serine O-acetyltransferase M_ser__L_c + M_accoa_c <=> M_acser_c + M_coa_c c FALSE PW082 -R_SERINE__PYRUVATE_AMINOTRANSFERASE_RXN_c serine—pyruvate transaminase M_ser__L_c + M_pyr_c <=> M_hpyr_c + M_ala__L_c c FALSE (WBGene00011767) PW074 RHEA:22852;RHEA:24248 [DELETION] Dupe of R_RC00585 lenov -R_SERINE__PYRUVATE_AMINOTRANSFERASE_RXN_m serine—pyruvate transaminase M_ser__L_m + M_pyr_m <=> M_hpyr_m + M_ala__L_m m FALSE (WBGene00011767) PW074 RHEA:22852;RHEA:24248 [DELETION] Dupe of R_RM00585 lenov -R_SERINE_GLYOXYLATE_AMINOTRANSFERASE_RXN_c serine—glyoxylate transaminase M_ser__L_c + M_glx_c <=> M_hpyr_c + M_gly_c c FALSE (WBGene00011767) PW074 RHEA:22852;RHEA:24248 -R_SERINE_GLYOXYLATE_AMINOTRANSFERASE_RXN_m serine—glyoxylate transaminase M_ser__L_m + M_glx_m <=> M_hpyr_m + M_gly_m m FALSE (WBGene00011767) PW074 RHEA:22852;RHEA:24248 +R_SERINE__PYRUVATE_AMINOTRANSFERASE_RXN_c "serine—pyruvate transaminase" M_ser__L_c + M_pyr_c <=> M_hpyr_c + M_ala__L_c c FALSE (WBGene00011767) PW074 "RHEA:22852;RHEA:24248" [DELETION] Dupe of R_RC00585 lenov +R_SERINE__PYRUVATE_AMINOTRANSFERASE_RXN_m "serine—pyruvate transaminase" M_ser__L_m + M_pyr_m <=> M_hpyr_m + M_ala__L_m m FALSE (WBGene00011767) PW074 "RHEA:22852;RHEA:24248" [DELETION] Dupe of R_RM00585 lenov +R_SERINE_GLYOXYLATE_AMINOTRANSFERASE_RXN_c "serine—glyoxylate transaminase" M_ser__L_c + M_glx_c <=> M_hpyr_c + M_gly_c c FALSE (WBGene00011767) PW074 "RHEA:22852;RHEA:24248" +R_SERINE_GLYOXYLATE_AMINOTRANSFERASE_RXN_m "serine—glyoxylate transaminase" M_ser__L_m + M_glx_m <=> M_hpyr_m + M_gly_m m FALSE (WBGene00011767) PW074 "RHEA:22852;RHEA:24248" R_Serine_transport Serine transport M_ser__L_c <=> M_ser__L_e ce TRUE ND PW107 R_SERLYSNaex Serine/Lysine Na-dependent Exchange reactions (Ser in) M_lys__L_c + M_ser__L_e + M_na1_e <=> M_ser__L_c + M_lys__L_e + M_na1_c ce FALSE (WBGene00000002 and WBGene00000003) or (WBGene00000002 and WBGene00000004) PW107 R_SFGTH_c S-formylglutathione hydrolase M_Sfglutth_c + M_h2o_c <=> M_for_c + M_h_c + M_gthrd_c c TRUE (WBGene00013018) PW091 @@ -3212,27 +3212,27 @@ R_SNK1002 Peptide histidine sink M_caphis_c <=> c FALSE PW099 R_SNK1003 Peptide diphtine sink M_pdipht_c <=> c FALSE PW099 R_SO4HCOtex sulfate transport via bicarbonate countertransport 2.0 M_hco3_c + M_so4_e <=> 2.0 M_hco3_e + M_so4_c ce FALSE (WBGene00017464) PW107 R_solm M SOLANESYL PYROPHOSPHATE mitochondrial transport M_nonadp_m <=> M_nonadp_c mc TRUE PW106 [DELETION] Dupe of R_TCM5032 jpnh -R_SPHINGOBIOSYNTH0001 Serine C-palmitoyltransferase M_h_c + M_ser__L_c + M_coa14_0_13me_c <=> M_co2_c + M_c17iso3dsphgn_c + M_coa_c c FALSE WBGene00016020 or WBGene00018398 or WBGene00011932 PW055 RHEA:14761;RHEA:14761;RHEA:14761 [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0001 Serine C-palmitoyltransferase M_h_c + M_ser__L_c + M_coa14_0_13me_c <=> M_co2_c + M_c17iso3dsphgn_c + M_coa_c c FALSE WBGene00016020 or WBGene00018398 or WBGene00011932 PW055 "RHEA:14761;RHEA:14761;RHEA:14761" [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0002 3-dehydrosphinganine reductase M_h_c + M_c17iso3dsphgn_c + M_nadph_c <=> M_nadp_c + M_c17isosphgn_c c FALSE WBGene00021367 PW055 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0003 acyl-CoA:sphingosine N-acyltransferase M_fataccoa_c + M_c17isosphgn_c <=> M_coa_c + M_c17isodhcrm_c c TRUE WBGene00006505 or WBGene00002044 or WBGene00002043 PW055 RHEA:23768;RHEA:23768;RHEA:23768 [CHECK ME] changed to C17 iso sphingosine; set to reversible wimi;janna -R_SPHINGOBIOSYNTH0004 Dihydrosphingomyelin synthase M_1ac2acg3pc_c + M_c17isodhcrm_c <=> M_1ac2acglyc_c + M_c17isodhsphmyln_c c FALSE WBGene00004894 or WBGene00004893 or WBGene00004892 PW055 RHEA:18765;RHEA:18765;RHEA:18765 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0005 Dihydrosphingomyelin phosphodiesterase M_cholp_c + M_h_c + M_c17isodhcrm_c <=> M_h2o_c + M_c17isodhsphmyln_c c FALSE WBGene00000213 or WBGene00000212 or (WBGene00000211 PW055 RHEA:19253;RHEA:19253;RHEA:19253;RHEA:19253 [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0003 acyl-CoA:sphingosine N-acyltransferase M_fataccoa_c + M_c17isosphgn_c <=> M_coa_c + M_c17isodhcrm_c c TRUE WBGene00006505 or WBGene00002044 or WBGene00002043 PW055 "RHEA:23768;RHEA:23768;RHEA:23768" "[CHECK ME] changed to C17 iso sphingosine; set to reversible" "wimi;janna" +R_SPHINGOBIOSYNTH0004 Dihydrosphingomyelin synthase M_1ac2acg3pc_c + M_c17isodhcrm_c <=> M_1ac2acglyc_c + M_c17isodhsphmyln_c c FALSE WBGene00004894 or WBGene00004893 or WBGene00004892 PW055 "RHEA:18765;RHEA:18765;RHEA:18765" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0005 Dihydrosphingomyelin phosphodiesterase M_cholp_c + M_h_c + M_c17isodhcrm_c <=> M_h2o_c + M_c17isodhsphmyln_c c FALSE WBGene00000213 or WBGene00000212 or (WBGene00000211 PW055 "RHEA:19253;RHEA:19253;RHEA:19253;RHEA:19253" [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0006 N-acylsphingosine amidohydrolase M_h2o_c + M_c17isodhcrm_c <=> M_c17isosphgn_c + M_fatacid_c c FALSE WBGene00020947 PW055 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0007 sphingolipid delta-4 desaturase M_h_c + M_nadh_c + M_o2_c + M_c17isodhcrm_c <=> 2.0 M_h2o_c + M_nad_c + M_c17isocrm_c c FALSE WBGene00017996 or WBGene00013197 PW055 RHEA:55808;RHEA:46544 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0007 sphingolipid delta-4 desaturase M_h_c + M_nadph_c + M_o2_c + M_c17isodhcrm_c <=> 2.0 M_h2o_c + M_nadp_c + M_c17isocrm_c c FALSE WBGene00017996 or WBGene00013197 PW055 RHEA:55808;RHEA:46544 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0008 Sphingomyelin synthase M_1ac2acg3pc_c + M_c17isocrm_c <=> M_1ac2acglyc_c + M_c17isosphmyln_c c FALSE (WBGene00004894) or (WBGene00004893) or (WBGene00004892) PW055 RHEA:18765;RHEA:18765;RHEA:18765 [DELETION] Dupe of R_RC08969, which is better annotated [CHECK ME] changed to C17 iso sphingosine jpnh; wimi -R_SPHINGOBIOSYNTH0008 ceramide:phosphatidylcholine cholinephosphotransferase M_1ac2acg3pc_c + M_c17isocrm_c <=> M_c17isosphmyln_c + M_1ac2acglyc_c c FALSE WBGene00004892 or WBGene00004893 or WBGene00004894 PW055 RHEA:18765;RHEA:18765;RHEA:18765 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0009 Sphingomyelin phosphodiesterase M_cholp_c + M_h_c + M_c17isocrm_c <=> M_h2o_c + M_c17isosphmyln_c c FALSE (WBGene00000213) or (WBGene00000212) or (WBGene00000211) PW055 RHEA:19253;RHEA:19253;RHEA:19253;RHEA:19253 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0010 N-Acylsphingosine amidohydrolase M_h2o_c + M_c17isocrm_c <=> M_c17isosphings_c + M_fatacid_c c FALSE WBGene00020947 or (WBGene00009192 or WBGene00010769) PW055 RHEA:20856;RHEA:20856 [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0007 sphingolipid delta-4 desaturase M_h_c + M_nadh_c + M_o2_c + M_c17isodhcrm_c <=> 2.0 M_h2o_c + M_nad_c + M_c17isocrm_c c FALSE WBGene00017996 or WBGene00013197 PW055 "RHEA:55808;RHEA:46544" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0007 sphingolipid delta-4 desaturase M_h_c + M_nadph_c + M_o2_c + M_c17isodhcrm_c <=> 2.0 M_h2o_c + M_nadp_c + M_c17isocrm_c c FALSE WBGene00017996 or WBGene00013197 PW055 "RHEA:55808;RHEA:46544" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0008 Sphingomyelin synthase M_1ac2acg3pc_c + M_c17isocrm_c <=> M_1ac2acglyc_c + M_c17isosphmyln_c c FALSE (WBGene00004894) or (WBGene00004893) or (WBGene00004892) PW055 "RHEA:18765;RHEA:18765;RHEA:18765" [DELETION] Dupe of R_RC08969, which is better annotated [CHECK ME] changed to C17 iso sphingosine "jpnh; wimi" +R_SPHINGOBIOSYNTH0008 ceramide:phosphatidylcholine cholinephosphotransferase M_1ac2acg3pc_c + M_c17isocrm_c <=> M_c17isosphmyln_c + M_1ac2acglyc_c c FALSE WBGene00004892 or WBGene00004893 or WBGene00004894 PW055 "RHEA:18765;RHEA:18765;RHEA:18765" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0009 Sphingomyelin phosphodiesterase M_cholp_c + M_h_c + M_c17isocrm_c <=> M_h2o_c + M_c17isosphmyln_c c FALSE (WBGene00000213) or (WBGene00000212) or (WBGene00000211) PW055 "RHEA:19253;RHEA:19253;RHEA:19253;RHEA:19253" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0010 N-Acylsphingosine amidohydrolase M_h2o_c + M_c17isocrm_c <=> M_c17isosphings_c + M_fatacid_c c FALSE WBGene00020947 or (WBGene00009192 or WBGene00010769) PW055 "RHEA:20856;RHEA:20856" [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0011 ATP:ceramide 1-phosphotransferase M_atp_c + M_c17isocrm_c <=> M_h_c + M_adp_c + M_c17isocrmp_c c FALSE WBGene00020398 PW055 RHEA:17929 [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0012 Ceramide 1-phosphate phosphohydrolase M_h2o_c + M_c17isocrmp_c <=> M_pi_c + M_c17isocrm_c c FALSE WBGene00008749 or WBGene00018756 or WBGene00020895 PW055 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0013 Acyl-CoA:sphingosine N-acyltransferase M_c17isosphings_c + M_fataccoa_c <=> M_h_c + M_coa_c + M_c17isocrm_c c TRUE WBGene00002043 or WBGene00002044 or WBGene00006505 PW055 RHEA:23768;RHEA:23768;RHEA:23768 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0014 UDP-glucose:N-acylsphingosine D-glucosyltransferase M_udpg_c + M_c17isocrm_c <=> M_h_c + M_udp_c + M_c17isogluside_c c FALSE WBGene00011517 or WBGene00017625 or WBGene00019127 PW055 RHEA:12088;RHEA:12088;RHEA:12088 [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0013 Acyl-CoA:sphingosine N-acyltransferase M_c17isosphings_c + M_fataccoa_c <=> M_h_c + M_coa_c + M_c17isocrm_c c TRUE WBGene00002043 or WBGene00002044 or WBGene00006505 PW055 "RHEA:23768;RHEA:23768;RHEA:23768" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0014 UDP-glucose:N-acylsphingosine D-glucosyltransferase M_udpg_c + M_c17isocrm_c <=> M_h_c + M_udp_c + M_c17isogluside_c c FALSE WBGene00011517 or WBGene00017625 or WBGene00019127 PW055 "RHEA:12088;RHEA:12088;RHEA:12088" [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0015 UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase M_udpgal_c + M_c17isocrm_c <=> M_h_c + M_udp_c + M_c17isogalside_c c TRUE TBD PW055 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0016 Glucosylceramidase M_h2o_m + M_c17isogluside_m <=> M_glc_bD_m + M_c17isocrm_m m TRUE (WBGene00013670) or (WBGene00019965) PW055 RHEA:13269;RHEA:13269;RHEA:13269 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0017 Glucosylceramidase M_h2o_n + M_c17isogluside_n <=> M_glc_bD_n + M_c17isocrm_n n TRUE (WBGene00013670) PW055 RHEA:13269;RHEA:13269;RHEA:13269 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0018 Glucosylceramidase M_h2o_c + M_c17isogluside_c <=> M_glc_bD_c + M_c17isocrm_c c FALSE (WBGene00019965 or WBGene00013670) or (WBGene00016335 or WBGene00016340 or WBGene00008706 or WBGene00021160) PW055 RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269 [CHECK ME] changed to C17 iso sphingosine wimi -R_SPHINGOBIOSYNTH0019 Galactosylceramidase M_h2o_c + M_c17isogalside_c <=> M_gal_c + M_c17isocrm_c c FALSE WBGene00016207 PW055 [DELETION] Dupe of R_GALACTOSYLCERAMIDASE_RXN_c. [CHECK ME] changed to C17 iso sphingosine jpnh; wimi +R_SPHINGOBIOSYNTH0016 Glucosylceramidase M_h2o_m + M_c17isogluside_m <=> M_glc_bD_m + M_c17isocrm_m m TRUE (WBGene00013670) or (WBGene00019965) PW055 "RHEA:13269;RHEA:13269;RHEA:13269" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0017 Glucosylceramidase M_h2o_n + M_c17isogluside_n <=> M_glc_bD_n + M_c17isocrm_n n TRUE (WBGene00013670) PW055 "RHEA:13269;RHEA:13269;RHEA:13269" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0018 Glucosylceramidase M_h2o_c + M_c17isogluside_c <=> M_glc_bD_c + M_c17isocrm_c c FALSE (WBGene00019965 or WBGene00013670) or (WBGene00016335 or WBGene00016340 or WBGene00008706 or WBGene00021160) PW055 "RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269;RHEA:13269" [CHECK ME] changed to C17 iso sphingosine wimi +R_SPHINGOBIOSYNTH0019 Galactosylceramidase M_h2o_c + M_c17isogalside_c <=> M_gal_c + M_c17isocrm_c c FALSE WBGene00016207 PW055 [DELETION] Dupe of R_GALACTOSYLCERAMIDASE_RXN_c. [CHECK ME] changed to C17 iso sphingosine "jpnh; wimi" R_SPHINGOBIOSYNTH0020 ceramide glucosyltransferase M_h_n + M_udpg_n + M_c17isocrm_n <=> M_udp_n + M_c17isogluside_n n FALSE (WBGene00011517) PW055 RHEA:12088 [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0021 sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming) M_c17isosphs1p_c <=> M_ethamp_c + M_c15isoenal_c c FALSE WBGene00004981 or WBGene00006418 PW055 RHEA:18593 [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0022 2-hexadecenal reductase M_c15isoenal_c+ M_h_c + M_nadph_c <=> M_c15isoal_c + M_nadp_c c FALSE PW055 [CHECK ME] changed to C17 iso sphingosine wimi @@ -3241,8 +3241,8 @@ R_SPHINGOBIOSYNTH0024 sphinganine kinase M_atp_c + M_c17isosphgn_c <=> M_h_c + R_SPHINGOBIOSYNTH0025 Sphinganine 1-phosphate phosphohydrolase M_h2o_c + M_c17isosph1p_c <=> M_pi_c + M_c17isosphgn_c c FALSE WBGene00008749 or WBGene00018756 or WBGene00020895 PW055 [CHECK ME] changed to C17 iso sphingosine wimi R_SPHINGOBIOSYNTH0026 sphingosine 1-phosphatase M_h2o_c + M_c17isosphs1p_c <=> M_pi_c + M_c17isosphings_c c FALSE WBGene00008749 or WBGene00018756 or WBGene00020895 PW055 [CHECK ME] changed to C17 iso sphingosine wimi R_SPMS_c Spermidine synthase M_ametam_c + M_ptrc_c <=> M_5mta_c + M_h_c + M_spmd_c c TRUE (WBGene00012909) PW081 -R_SPODM_c Superoxide dismutase 2.0 M_o2s_c + 2.0 M_h_c <=> M_h2o2_c + M_o2_c c TRUE (WBGene00007036) or (WBGene00004933) or (WBGene00004932) or (WBGene00004930) PW030 RHEA:20696;RHEA:20696;RHEA:20696;RHEA:20696;RHEA:20696 -R_SPODM_m Superoxide dismutase 2.0 M_o2s_m + 2.0 M_h_m <=> M_h2o2_m + M_o2_m m TRUE (WBGene00007036) or (WBGene00004932) or (WBGene00004930) or (WBGene00004931) PW030 RHEA:20696;RHEA:20696;RHEA:20696;RHEA:20696 +R_SPODM_c Superoxide dismutase 2.0 M_o2s_c + 2.0 M_h_c <=> M_h2o2_c + M_o2_c c TRUE (WBGene00007036) or (WBGene00004933) or (WBGene00004932) or (WBGene00004930) PW030 "RHEA:20696;RHEA:20696;RHEA:20696;RHEA:20696;RHEA:20696" +R_SPODM_m Superoxide dismutase 2.0 M_o2s_m + 2.0 M_h_m <=> M_h2o2_m + M_o2_m m TRUE (WBGene00007036) or (WBGene00004932) or (WBGene00004930) or (WBGene00004931) PW030 "RHEA:20696;RHEA:20696;RHEA:20696;RHEA:20696" R_SPODM_n Superoxide dismutase 2.0 M_o2s_n + 2.0 M_h_n <=> M_h2o2_n + M_o2_n n TRUE (WBGene00007036) PW030 RHEA:20696 R_SPONTPRO_RXN_c Non Enzymatic L-Glutamate 5-semialdehyde Ring Closing M_glu5sa_c <=> M_h2o_c + M_1pyr5c_c + M_h_c c TRUE PW081 R03314 Added RXN name jpnh R_SPONTPRO_RXN_m Non Enzymatic L-Glutamate 5-semialdehyde Ring Closing M_glu5sa_m <=> M_h2o_m + M_1pyr5c_m + M_h_m m TRUE PW081 R03314 Added RXN name jpnh @@ -3251,8 +3251,8 @@ R_SSAL_c Succinate-semialdehyde dehydrogenase M_h2o_c + M_sucsal_c + M_nad_c < R_SSAL_m Succinate-semialdehyde dehydrogenase M_h2o_m + M_sucsal_m + M_nad_m <=> 2.0 M_h_m + M_nadh_m + M_succ_m m TRUE (WBGene00000113) PW073 R_SUCCt2m succinate transport, mitochondrial M_pi_m + M_succ_c <=> M_pi_c + M_succ_m mc TRUE (WBGene00019656) or (ND) PW106 R_SUCCt4_2 succinate transport via sodium symport M_succ_e + 2.0 M_na1_e <=> M_succ_c + 2.0 M_na1_c ec TRUE (WBGene00003517) or (WBGene00003519) or (WBGene00003518) PW107 -R_SUCOAS_m Succinate--CoA ligase (ADP-forming) M_atp_m + M_coa_m + M_succ_m <=> M_pi_m + M_adp_m + M_succoa_m m TRUE (WBGene00007350 or WBGene00017759) and WBGene00009812 PW023 SPW004 RHEA:17661;RHEA:22120;RHEA:17661;RHEA:22120;RHEA:17661 -R_SUCOAS1_m Succinate--CoA ligase (GDP-forming) M_gtp_m + M_coa_m + M_succ_m <=> M_pi_m + M_gdp_m + M_succoa_m m TRUE (WBGene00007350 or WBGene00017759) and WBGene00016844 PW023 SPW004 RHEA:17661;RHEA:22120;RHEA:22120;RHEA:17661;RHEA:22120 +R_SUCOAS_m Succinate--CoA ligase (ADP-forming) M_atp_m + M_coa_m + M_succ_m <=> M_pi_m + M_adp_m + M_succoa_m m TRUE (WBGene00007350 or WBGene00017759) and WBGene00009812 PW023 SPW004 "RHEA:17661;RHEA:22120;RHEA:17661;RHEA:22120;RHEA:17661" +R_SUCOAS1_m Succinate--CoA ligase (GDP-forming) M_gtp_m + M_coa_m + M_succ_m <=> M_pi_m + M_gdp_m + M_succoa_m m TRUE (WBGene00007350 or WBGene00017759) and WBGene00016844 PW023 SPW004 "RHEA:17661;RHEA:22120;RHEA:22120;RHEA:17661;RHEA:22120" R_SULFITE_OXIDASE_RXN_c Sulfite oxidase M_h2o_c + M_so3_c + M_o2_c <=> M_h2o2_c + M_so4_c c FALSE (WBGene00010397) PW096 replaced sulfite oxidation with Sulfur metabolism lenov R_SULFITE_OXIDASE_RXN_m Sulfite oxidase M_h2o_m + M_so3_m + M_o2_m <=> M_h2o2_m + M_so4_m m FALSE (WBGene00010397) PW096 replaced sulfite oxidation with Sulfur metabolism lenov R_T4HCINNMFM_m R_T4HCINNMFM_m M_34hpl_m <=> M_h2o_m + M_T4hcinnm_m m FALSE Unknown PW003 @@ -3351,7 +3351,7 @@ R_TCE0788 Deoxyguanosine transport M_dgsn_e <=> M_dgsn_c ec TRUE ND PW105 R_TCE0795 taurocholic acid transport M_tchola_e <=> M_tchola_c ec TRUE ND PW105 R_TCE0797 D-Alanine transport M_ala__D_e <=> M_ala__D_c ec TRUE ND PW105 R_TCE0825 Peptidyl-L-lysine transport M_peplys_e <=> M_peplys_c ec TRUE ND PW105 -R_TCE1117 L-Aspartate transport M_asp__L_e <=> M_asp__L_c ec TRUE ND PW105 [DELETION] Dupe of R_Aspartate_transport; Changed M_asp__L_e and M_asp__L_c into M_asp_L_e and M_asp_L_e jpnh; lenov +R_TCE1117 L-Aspartate transport M_asp__L_e <=> M_asp__L_c ec TRUE ND PW105 "[DELETION] Dupe of R_Aspartate_transport; Changed M_asp__L_e and M_asp__L_c into M_asp_L_e and M_asp_L_e" "jpnh; lenov" R_TCE1121 2-Oxoglutarate transport M_akg_e <=> M_akg_c ec TRUE ND PW105 R_TCE1124 D-Sorbitol transport M_sbt__D_e <=> M_sbt__D_c ec TRUE ND PW105 R_TCE1127 Sulfate transport M_so4_e <=> M_so4_c ec FALSE ND PW105 @@ -3578,74 +3578,74 @@ R_Threonine_transport Threonine transport M_thr__L_c <=> M_thr__L_e ce TRUE ND P R_THYM_PHOSPH_RXN_c Thymidine phosphorylase M_pi_c + M_thymd_c <=> M_thym_c + M_2dr1p_c c TRUE PW043 R_Thymine_Exchange_reactions_e Thymine transport M_thym_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Thymine_transport Thymine transport M_thym_c <=> M_thym_e ce TRUE ND PW107 -R_TKT1_c Transketolase M_s7p_c + M_g3p_c <=> M_xu5p_D_c + M_r5p_c c TRUE (WBGene00012713) or (WBGene00008506) PW027 SPW004 RHEA:13457;RHEA:13457 -R_TKT1_m Transketolase M_s7p_m + M_g3p_m <=> M_xu5p_D_m + M_r5p_m m TRUE (WBGene00012713) PW027 SPW004 RHEA:13457;RHEA:13457 +R_TKT1_c Transketolase M_s7p_c + M_g3p_c <=> M_xu5p_D_c + M_r5p_c c TRUE (WBGene00012713) or (WBGene00008506) PW027 SPW004 "RHEA:13457;RHEA:13457" +R_TKT1_m Transketolase M_s7p_m + M_g3p_m <=> M_xu5p_D_m + M_r5p_m m TRUE (WBGene00012713) PW027 SPW004 "RHEA:13457;RHEA:13457" R_TKT1_n Transketolase M_s7p_n + M_g3p_n <=> M_xu5p_D_n + M_r5p_n n TRUE (WBGene00008506) PW027 SPW004 -R_TKT2_c D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase M_e4p_c + M_xu5p_D_c <=> M_f6p_c + M_g3p_c c TRUE (WBGene00012713) or (WBGene00008506) PW027 SPW004 RHEA:13457;RHEA:13457 -R_TKT2_m D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase M_e4p_m + M_xu5p_D_m <=> M_f6p_m + M_g3p_m m TRUE (WBGene00012713) PW027 SPW004 RHEA:13457;RHEA:13457 +R_TKT2_c D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase M_e4p_c + M_xu5p_D_c <=> M_f6p_c + M_g3p_c c TRUE (WBGene00012713) or (WBGene00008506) PW027 SPW004 "RHEA:13457;RHEA:13457" +R_TKT2_m D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase M_e4p_m + M_xu5p_D_m <=> M_f6p_m + M_g3p_m m TRUE (WBGene00012713) PW027 SPW004 "RHEA:13457;RHEA:13457" R_TKT2_n D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase M_e4p_n + M_xu5p_D_n <=> M_f6p_n + M_g3p_n n TRUE (WBGene00008506) PW027 SPW004 R_TMABADH_c 4-trimethylammoniobutyraldehyde dehydrogenase M_4tmeabut_c + M_h2o_c + M_nad_c <=> 2.0 M_h_c + M_4tmeabutn_c + M_nadh_c c FALSE (WBGene00000108 or WBGene00000110) or WBGene00000118 PW080 -R_TMDK1_c Thymidine kinase M_atp_c + M_thymd_c <=> 2.0 M_h_c + M_adp_c + M_dtmp_c c FALSE (WBGene00006568) PW042;PW043 RHEA:19129;RHEA:19129 +R_TMDK1_c Thymidine kinase M_atp_c + M_thymd_c <=> 2.0 M_h_c + M_adp_c + M_dtmp_c c FALSE (WBGene00006568) "PW042;PW043" "RHEA:19129;RHEA:19129" R_TMDS_c Thymidylate synthase M_dump_c + M_mlthf_c <=> M_dtmp_c + M_dhf_c c TRUE (WBGene00022455) PW043 R_TMDS_n Thymidylate synthase M_dump_n + M_mlthf_n <=> M_dtmp_n + M_dhf_n n TRUE (WBGene00022455) PW043 R_TMLYSOX_c Trimethyllysine dioxygenase M_akg_c + M_tmlys_c + M_o2_c <=> M_co2_c + M_3htmelys_c + M_succ_c c FALSE (WBGene00001522) or (WBGene00001523) PW080 RHEA:24028 R_TMLYSOX_n Trimethyllysine dioxygenase M_akg_n + M_tmlys_n + M_o2_n <=> M_co2_n + M_3htmelys_n + M_succ_n n FALSE (WBGene00001522) or (WBGene00001523) PW080 RHEA:24028 -R_TPI_c Triosephosphate isomerase M_g3p_c <=> M_dhap_c c TRUE (WBGene00006601) PW018;PW020 RHEA:18585;RHEA:17937 +R_TPI_c Triosephosphate isomerase M_g3p_c <=> M_dhap_c c TRUE (WBGene00006601) "PW018;PW020" "RHEA:18585;RHEA:17937" R_TRANS_OCTAPRENYLTRANSTRANSFERASE_RXN_c all-trans-nonaprenyl-diphosphate synthase[geranyl-diphosphate specific] 7.0 M_ipdp_c + M_grdp_c <=> 7.0 M_ppi_c + M_nonadp_c c FALSE (WBGene00000761) PW003 R_TRANS_PENTAPRENYLTRANSFERASE_RXN_c hexaprenyl-diphosphate synthase[(2E,6E)-farnesyl-diphosphate specific] 3.0 M_ipdp_c + M_frdp_c <=> 3.0 M_ppi_c + M_hexdp_c c TRUE (WBGene00000761) PW001 R09245 added KEGGID ms R_TRDR_n Thioredoxin reductase (NADPH) M_h_n + M_nadph_n + M_trdox_n <=> M_nadp_n + M_trdrd_n n FALSE (WBGene00015553) PW093 RHEA:20345 -R_TREHALA_RXN_c α,α-trehalase M_h2o_c + M_tre_c <=> 2.0 M_glc_bD_c c TRUE (WBGene00006610) or (WBGene00006609) or (WBGene00006608) or (WBGene00006611) or (WBGene00006607) PW026 RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675 ms -R_TREHALA_RXN_m α,α-trehalase M_h2o_m + M_tre_m <=> 2.0 M_glc_bD_m m TRUE (WBGene00006610) or (WBGene00006608) PW026 RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675 ms +R_TREHALA_RXN_c "α,α-trehalase" M_h2o_c + M_tre_c <=> 2.0 M_glc_bD_c c TRUE (WBGene00006610) or (WBGene00006609) or (WBGene00006608) or (WBGene00006611) or (WBGene00006607) PW026 "RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675" ms +R_TREHALA_RXN_m "α,α-trehalase" M_h2o_m + M_tre_m <=> 2.0 M_glc_bD_m m TRUE (WBGene00006610) or (WBGene00006608) PW026 "RHEA:32675;RHEA:32675;RHEA:32675;RHEA:32675" ms R_TRIOK_c Triokinase M_glyald_c + M_atp_c <=> M_g3p_c + 2.0 M_h_c + M_adp_c c FALSE PW020 R_TRPHYDRO2_c Tryptophan 5-monooxygenase M_trp__L_c + M_thbpt_c + M_o2_c <=> M_thbpt4acam_c + M_5htrp_c c FALSE (WBGene00006600) PW072 R_Tryptophan_Exchange_reactions_e Tryptophan transport M_trp__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Tryptophan_transport Tryptophan transport M_trp__L_c <=> M_trp__L_e ce TRUE ND PW107 R_TTDCAFATPtc R_TTDCAFATPtc M_atp_c + M_coa_c + M_fa14_0_e <=> M_ppi_c + M_amp_c + M_coa14_0_c c FALSE (WBGene00017012 or WBGene00009218) PW107 R_TTDCAt R_TTDCAt M_fa14_0_e <=> M_fa14_0_c ec FALSE (WBGene00000170 or WBGene00000175 or WBGene00000171 or WBGene00000169 or WBGene00000176) or (ND) PW107 -R_TYRCBOX_c Tyrosine decarboxylase M_h_c + M_tyr__L_c <=> M_tym_c + M_co2_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW077 RHEA:14345;RHEA:12272;RHEA:18533 replaced octopamine biosynthesis by tyrosine metabolism lenov -R_TYROSINE_3_MONOOXYGENASE_RXN_c Tyrosine 3-monooxygenase M_tyr__L_c + M_thbpt_c + M_o2_c <=> M_thbpt4acam_c + M_34dhphe_c c FALSE (WBGene00000296) PW077 RHEA:20309;RHEA:18201 +R_TYRCBOX_c Tyrosine decarboxylase M_h_c + M_tyr__L_c <=> M_tym_c + M_co2_c c FALSE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW077 "RHEA:14345;RHEA:12272;RHEA:18533" replaced octopamine biosynthesis by tyrosine metabolism lenov +R_TYROSINE_3_MONOOXYGENASE_RXN_c Tyrosine 3-monooxygenase M_tyr__L_c + M_thbpt_c + M_o2_c <=> M_thbpt4acam_c + M_34dhphe_c c FALSE (WBGene00000296) PW077 "RHEA:20309;RHEA:18201" R_Tyrosine_transport Tyrosine transport M_tyr__L_c <=> M_tyr__L_e ce TRUE ND PW107 R_TYRTA_c Tyrosine aminotransferase M_akg_c + M_tyr__L_c <=> M_glu__L_c + M_34hpp_c c TRUE (WBGene00013034) or (WBGene00019166) or (WBGene00009628) or (WBGene00015771) or (WBGene00020145) or (WBGene00020146) PW077 RHEA:21824 -R_TYRTA_m Tyrosine aminotransferase M_akg_m + M_tyr__L_m <=> M_glu__L_m + M_34hpp_m m TRUE (WBGene00009628) or (WBGene00015778) or (WBGene00016652) PW077 RHEA:21824;RHEA:21824 -R_tyrtm Tyrosine Transport M_tyr__L_c <=> M_tyr__L_m cm TRUE ND PW111 added reaction name; set to reversible jpnh; janna +R_TYRTA_m Tyrosine aminotransferase M_akg_m + M_tyr__L_m <=> M_glu__L_m + M_34hpp_m m TRUE (WBGene00009628) or (WBGene00015778) or (WBGene00016652) PW077 "RHEA:21824;RHEA:21824" +R_tyrtm Tyrosine Transport M_tyr__L_c <=> M_tyr__L_m cm TRUE ND PW111 "added reaction name; set to reversible" "jpnh; janna" R_UAGDP_c UDP-N-acetylglucosamine pyrophosphorylase M_acgam1p_c + M_h_c + M_utp_c <=> M_uacgam_c + M_ppi_c c TRUE WBGene00007965 or WBGene00019439 PW032 R_Ubiqui8tm Ubiqui-8 transport in mitochondria M_q8_c <=> M_q8_m cm TRUE TBD PW106 R_Ubiquinol8tm Ubiquinol 8 transport M_selmeth_c <=> M_selmeth_m cm FALSE PW111 R_UDP_GLUCURONATE_DECARBOXYLASE_RXN_c UDP-glucuronate decarboxylase M_udpglcur_c + M_h_c <=> M_co2_c + M_udpxyl_c c FALSE (WBGene00005019) PW019 -R_UDP_N_ACETYLGLUCOSAMINE_4_EPIMERASE_RXN_c UDP-N-acetylglucosamine 4-epimerase M_uacgam_c <=> M_udpacgal_c c FALSE (WBGene00008132) PW032 RHEA:22168;RHEA:20517 -R_UDP_N_ACETYLGLUCOSAMINE_4_EPIMERASE_RXN_m UDP-N-acetylglucosamine 4-epimerase M_uacgam_m <=> M_udpacgal_m m FALSE (WBGene00008132) PW032 RHEA:22168;RHEA:20517 -R_UDPGNP_c R_UDPGNP_c M_h2o_c + M_udpglcur_c <=> M_h_c + M_udp_c + M_glcur_c c FALSE (WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587) and (WBGene00013693) PW045 RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032 replaced L-ascorbate biosynthesis with ascorbate and aldarate metabolism -R_UGD_RXN_c UDP-glucose 6-dehydrogenase M_h2o_c + 2.0 M_nad_c + M_udpg_c <=> M_udpglcur_c + 3.0 M_h_c + 2.0 M_nadh_c c TRUE (WBGene00005022) PW031;PW019;PW045;PW017 RHEA:23596 replaced L-ascorbate biosynthesis with PW045 lenov -R_UGLT_c UDP-galactose--hexose-1-phosphate uridylyltransferase M_gal1p_c + M_udpg_c <=> M_g1p_c + M_udpgal_c c TRUE (WBGene00014203) PW031;PW017 [ADDITIONAL CURATION BY JANNA 18/01/2018 CORRECTED TO CYTOSOLIC WAS WRONGLY MITOCHONDRIAL]Corrected reaction name. Only cytosolic in human (https://www.proteinatlas.org/ENSG00000213930-GALT/cell). C. elegans enzyme activity was studied (https://www.ncbi.nlm.nih.gov/pubmed/19858195). Reviewed in C. elegans in https://doi.org/10.1534/genetics.117.300106 nel -R_UMPKI_RXN_c ATP:UMP phosphotransferase M_atp_c + M_ump_c <=> M_adp_c + M_udp_c c TRUE (WBGene00009575) or (WBGene00007812) PW043;PW042 set to be reversible janna -R_UMPKI_RXN_m R_UMPKI_RXN_m M_atp_m + M_ump_m <=> M_adp_m + M_udp_m m FALSE PW042;PW043 -R_UMPKI_RXN_n ATP:UMP phosphotransferase M_atp_n + M_ump_n <=> M_adp_n + M_udp_n n TRUE (WBGene00007812) PW043;PW042 set to reversible janna -R_UPPN_c β-ureidopropionase M_h2o_c + M_cala_c + M_h_c <=> M_co2_c + M_nh3_c + M_ala_B_c c TRUE (WBGene00017440) PW043 -R_UPPRT_c Uracil phosphoribosyltransferase M_ppi_c + M_ump_c <=> M_prpp_c + M_ura_c c TRUE (WBGene00020036) or (WBGene00011559) or (WBGene00008131) PW043 RHEA:10380;RHEA:11596 -R_UPPRT_m Uracil phosphoribosyltransferase M_ppi_m + M_ump_m <=> M_prpp_m + M_ura_m m TRUE (WBGene00011559) PW043 RHEA:10380;RHEA:11596 +R_UDP_N_ACETYLGLUCOSAMINE_4_EPIMERASE_RXN_c UDP-N-acetylglucosamine 4-epimerase M_uacgam_c <=> M_udpacgal_c c FALSE (WBGene00008132) PW032 "RHEA:22168;RHEA:20517" +R_UDP_N_ACETYLGLUCOSAMINE_4_EPIMERASE_RXN_m UDP-N-acetylglucosamine 4-epimerase M_uacgam_m <=> M_udpacgal_m m FALSE (WBGene00008132) PW032 "RHEA:22168;RHEA:20517" +R_UDPGNP_c R_UDPGNP_c M_h2o_c + M_udpglcur_c <=> M_h_c + M_udp_c + M_glcur_c c FALSE (WBGene00015371 or WBGene00016959 or WBGene00017334 or WBGene00018789 or WBGene00019181 or WBGene00019235 or WBGene00019379 or WBGene00007072 or WBGene00020594 or WBGene00020593 or WBGene00020592 or WBGene00019232 or WBGene00019233 or WBGene00008097 or WBGene00013901 or WBGene00007422 or WBGene00013900 or WBGene00019515 or WBGene00007073 or WBGene00019516 or WBGene00007885 or WBGene00007455 or WBGene00007650 or WBGene00016762 or WBGene00015692 or WBGene00015695 or WBGene00015694 or WBGene00021709 or WBGene00013903 or WBGene00011340 or WBGene00021464 or WBGene00018543 or WBGene00007946 or WBGene00009255 or WBGene00044286 or WBGene00017315 or WBGene00017332 or WBGene00017333 or WBGene00017329 or WBGene00013905 or WBGene00017331 or WBGene00017336 or WBGene00017959 or WBGene00008485 or WBGene00008486 or WBGene00021372 or WBGene00015141 or WBGene00011006 or WBGene00015965 or WBGene00007070 or WBGene00013906 or WBGene00011564 or WBGene00015369 or WBGene00018931 or WBGene00020182 or WBGene00012013 or WBGene00011452 or WBGene00011453 or WBGene00009450 or WBGene00011238 or WBGene00013904 or WBGene00007402 or WBGene00018206 or WBGene00010904 or WBGene00015449 or WBGene00015577 or WBGene00008583 or WBGene00015739 or WBGene00019234 or WBGene00020587) and (WBGene00013693) PW045 "RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032;RHEA:21032" replaced L-ascorbate biosynthesis with ascorbate and aldarate metabolism +R_UGD_RXN_c UDP-glucose 6-dehydrogenase M_h2o_c + 2.0 M_nad_c + M_udpg_c <=> M_udpglcur_c + 3.0 M_h_c + 2.0 M_nadh_c c TRUE (WBGene00005022) "PW031;PW019;PW045;PW017" RHEA:23596 replaced L-ascorbate biosynthesis with PW045 lenov +R_UGLT_c UDP-galactose--hexose-1-phosphate uridylyltransferase M_gal1p_c + M_udpg_c <=> M_g1p_c + M_udpgal_c c TRUE (WBGene00014203) "PW031;PW017" [ADDITIONAL CURATION BY JANNA 18/01/2018 CORRECTED TO CYTOSOLIC WAS WRONGLY MITOCHONDRIAL]Corrected reaction name. Only cytosolic in human (https://www.proteinatlas.org/ENSG00000213930-GALT/cell). C. elegans enzyme activity was studied (https://www.ncbi.nlm.nih.gov/pubmed/19858195). Reviewed in C. elegans in https://doi.org/10.1534/genetics.117.300106 nel +R_UMPKI_RXN_c ATP:UMP phosphotransferase M_atp_c + M_ump_c <=> M_adp_c + M_udp_c c TRUE (WBGene00009575) or (WBGene00007812) "PW043;PW042" set to be reversible janna +R_UMPKI_RXN_m R_UMPKI_RXN_m M_atp_m + M_ump_m <=> M_adp_m + M_udp_m m FALSE "PW042;PW043" +R_UMPKI_RXN_n ATP:UMP phosphotransferase M_atp_n + M_ump_n <=> M_adp_n + M_udp_n n TRUE (WBGene00007812) "PW043;PW042" set to reversible janna +R_UPPN_c "β-ureidopropionase" M_h2o_c + M_cala_c + M_h_c <=> M_co2_c + M_nh3_c + M_ala_B_c c TRUE (WBGene00017440) PW043 +R_UPPRT_c Uracil phosphoribosyltransferase M_ppi_c + M_ump_c <=> M_prpp_c + M_ura_c c TRUE (WBGene00020036) or (WBGene00011559) or (WBGene00008131) PW043 "RHEA:10380;RHEA:11596" +R_UPPRT_m Uracil phosphoribosyltransferase M_ppi_m + M_ump_m <=> M_prpp_m + M_ura_m m TRUE (WBGene00011559) PW043 "RHEA:10380;RHEA:11596" R_UPPRT_n Uracil phosphoribosyltransferase M_ppi_n + M_ump_n <=> M_prpp_n + M_ura_n n TRUE (WBGene00020036) PW043 -R_URA_PHOSPH_RXN_c R_URA_PHOSPH_RXN_c M_pi_c + M_duri_c <=> M_ura_c + M_2dr1p_c c TRUE WBGene00019298 or WBGene00022817 PW043 RHEA:24388;RHEA:16037;RHEA:22824 +R_URA_PHOSPH_RXN_c R_URA_PHOSPH_RXN_c M_pi_c + M_duri_c <=> M_ura_c + M_2dr1p_c c TRUE WBGene00019298 or WBGene00022817 PW043 "RHEA:24388;RHEA:16037;RHEA:22824" R_URCN_c Urocanate hydratase M_4izp_c + M_h_c <=> M_urcan_c + M_h2o_c c TRUE (WBGene00013103) PW084 R_Urea_Exchange_reactions_e Urea transport M_urea_e <=> e FALSE PW111 Removed space from reaction ID jpnh R_Urea_transport Urea transport M_urea_c <=> M_urea_e ce TRUE ND PW107 R_Uridine_Exchange_reactions_e Uridine transport M_uri_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Uridine_transport Uridine transport M_uri_c <=> M_uri_e ce TRUE ND PW107 -R_URIH_c Uridine nucleosidase M_h2o_c + M_uri_c <=> M_ura_c + M_rib_D_c c TRUE PW042;PW043 -R_URIK1_c Uridine kinase M_atp_c + M_uri_c <=> 2.0 M_h_c + M_adp_c + M_ump_c c FALSE WBGene00007089 or WBGene00008948 PW042;PW043 +R_URIH_c Uridine nucleosidase M_h2o_c + M_uri_c <=> M_ura_c + M_rib_D_c c TRUE "PW042;PW043" +R_URIK1_c Uridine kinase M_atp_c + M_uri_c <=> 2.0 M_h_c + M_adp_c + M_ump_c c FALSE WBGene00007089 or WBGene00008948 "PW042;PW043" R_URIK2_c GTP:uridine 5'-phosphotransferase M_gtp_c + M_uri_c <=> M_h_c + M_gdp_c + M_ump_c c TRUE PW043 R_URIt2r Uridine transport M_h_e + M_uri_e <=> M_h_c + M_uri_c ec TRUE (WBGene00018716 or WBGene00014092) or (ND) PW107 Added name jpnh R_Uritn uridine transport in nucleus M_uri_c <=> M_uri_n cn TRUE PW108 R_UTPtm UTP transporter, mitochondrial M_utp_c <=> M_utp_m cm TRUE PW106 Added to support RNA synthesis in mitochondrion janna R_UTPtn UTP diffusion in nucleus M_utp_c <=> M_utp_n cn TRUE PW108 added, was missing, blocked nuclear RNA reactions janna R_VACCENICBETAOX0001 Acyl-CoA-dehydrogenase (C18:1(11Z), mitochondrial) M_h_m + M_fad_m + M_coa18_1_11z_m <=> M_fadh2_m + M_coa18_2_2e11z_m m FALSE WBGene00020812 or WBGene00020366 or WBGene00019406 or WBGene00017125 PW115 SPW001 RHEA:14477 [CHECKME] Detailed replacement for lumped reaction R_RMC0090 wimi -R_VACCENICBETAOX0002 Enoyl-CoA-hydratase (C18:2(2E,11Z), mitochondrial) M_coa18_2_2e11z_m + M_h2o_m <=> M_coa18_1_11z3oh__R_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW115 SPW001 RHEA:16105;RHEA:20724 [CHECKME] Detailed replacement for lumped reaction R_RMC0090 wimi +R_VACCENICBETAOX0002 Enoyl-CoA-hydratase (C18:2(2E,11Z), mitochondrial) M_coa18_2_2e11z_m + M_h2o_m <=> M_coa18_1_11z3oh__R_m m TRUE WBGene00001156 or WBGene00001155 or WBGene00001154 or WBGene00001152 or WBGene00001150 or WBGene00020347 PW115 SPW001 "RHEA:16105;RHEA:20724" [CHECKME] Detailed replacement for lumped reaction R_RMC0090 wimi R_VACCENICBETAOX0003 (S)-3-hydroxyacyl-CoA-dehydrogenase (C18:1(11Z,3(S)OH), mitochondrial) M_nad_m + M_coa18_1_11z3oh__R_m <=> M_h_m + M_nadh_m + M_coa18_1_11z3o_m m FALSE WBGene00007129 or WBGene00010035 or WBGene00019978 or WBGene00020347 or WBGene00001150 PW115 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0090 wimi R_VACCENICBETAOX0004 3-ketothiolase (C18:1(11Z,3O), mitochondrial) M_coa18_1_11z3o_m + M_coa_m <=> M_accoa_m + M_coa16_1_9z_m m FALSE WBGene00009952 or WBGene00015125 PW115 SPW001 [CHECKME] Detailed replacement for lumped reaction R_RMC0090 wimi -R_VALB0AT2tc R_VALB0AT2tc M_val__L_e + M_na1_e <=> M_val__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 RHEA:21824;RHEA:21824 +R_VALB0AT2tc R_VALB0AT2tc M_val__L_e + M_na1_e <=> M_val__L_c + M_na1_c ec TRUE (WBGene00015778 or WBGene00016652) PW107 "RHEA:21824;RHEA:21824" R_Valine_Exchange_reactions_e Valine transport M_val__L_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Valine_transport Valine transport M_val__L_c <=> M_val__L_e ce TRUE ND PW107 R_VALt5m Valine reversible mitochondrial transport M_val__L_c <=> M_val__L_m cm TRUE ND PW106 -R_VALTA_c Valine transaminase M_akg_c + M_val__L_c <=> M_3mob_c + M_glu__L_c c TRUE (WBGene00001149) PW083 RHEA:18321;RHEA:24801;RHEA:24813 Corrected gene association ckaleta 2.6.1.42 +R_VALTA_c Valine transaminase M_akg_c + M_val__L_c <=> M_3mob_c + M_glu__L_c c TRUE (WBGene00001149) PW083 "RHEA:18321;RHEA:24801;RHEA:24813" Corrected gene association ckaleta 2.6.1.42 R_VALTA_m Valine transaminase M_akg_m + M_val__L_m <=> M_3mob_m + M_glu__L_m m TRUE (WBGene00012855) PW083 Corrected gene association. ckaleta 2.6.1.42 R_Vitamin_B12_Exchange_reactions_e Vitamin B12 transport M_adocbl_e <=> e TRUE PW111 Removed space from reaction ID jpnh R_Vitamin_B12_transport Vitamin B12 transport M_adocbl_c <=> M_adocbl_e ce TRUE PW107 From 9a33f39c07512bd98579e69f151f50c176b68ad2 Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 11:44:46 +1000 Subject: [PATCH 2/9] fix/R_1PFRUCTPHOSN_RXN_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 42e6d3a..2eba620 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -10,7 +10,7 @@ R_1_2_4_4_RXN_m 2-keto-isovalerate dehydrogenase (lipoamide) M_3mob_m + M_bcaal R_1_5_1_9_RXN_c Saccharopine dehydrogenase (NAD+, L-glutamate forming) M_h2o_c + M_saccrp__L_c + M_nad_c <=> M_L2aadp6sa_c + 6.0 M_h_c + M_glu__L_c + M_nadh_c c TRUE (WBGene00019819) PW079 Set reversibility to true jpnh R_1_5_1_9_RXN_m Saccharopine dehydrogenase (NAD+, L-glutamate forming) M_h2o_m + M_saccrp__L_m + M_nad_m <=> M_L2aadp6sa_m + 6.0 M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00019819) PW079 "set reversibility to true; replaced M_saccrp__L_m with M_saccrp_L_m" "jpnh; lenov" R_1_5_5_1_RXN_m Electron-transferring-flavoprotein dehydrogenase M_q9_m + M_etfrd_m <=> M_q9h2_m + M_etfox_m m FALSE (WBGene00002855) PW098 RHEA:24052 -R_1PFRUCTPHOSN_RXN_c 1-phosphofructokinase M_f1p_c + M_atp_c <=> M_fdp_c + 2.0 M_h_c + M_adp_c c FALSE PW031 +R_1PFRUCTPHOSN_RXN_c 1-phosphofructokinase M_f1p_c + M_atp_c <=> M_fdp_c + M_h_c + M_adp_c c FALSE PW031 R_2_1_1_64_RXN_m 3-Demethylubiqui-9 3-O-methyltransferase M_3dmub_m + M_amet_m <=> 2.0 M_h_m + M_q9h2_m + M_ahcys_m m FALSE PW003 R_2_1_1_77_RXN_c Protein-L-isoaspartate(D-aspartate) O-methyltransferase M_amet_c + M_prot_isoasp_c <=> M_ahcys_c + M_prot_iaspme_c c TRUE (WBGene00020090) PW102 Pathway should be protein methylation lenov R_2_1_1_77_RXN_m Protein-L-isoaspartate(D-aspartate) O-methyltransferase M_amet_m + M_prot_isoasp_m <=> M_ahcys_m + M_prot_iaspme_m m TRUE (WBGene00020090) PW102 Pathway should be protein methylation lenov @@ -2152,8 +2152,8 @@ R_PYRAMKIN_RXN_c R_PYRAMKIN_RXN_c M_atp_c + M_pydam_c <=> M_h_c + M_adp_c + M_p R_PYRAMKIN_RXN_m R_PYRAMKIN_RXN_m M_atp_m + M_pydam_m <=> M_h_m + M_adp_m + M_pyam5p_m m FALSE (WBGene00019008) PW039 RHEA:10224 R_PYRIDOXKIN_RXN_c pyridoxal kinase M_atp_c + M_pydx_c <=> M_h_c + M_adp_c + M_pydx5p_c c FALSE (WBGene00019008) PW039 RHEA:10224 R_PYRIDOXKIN_RXN_m pyridoxal kinase M_atp_m + M_pydx_m <=> M_h_m + M_adp_m + M_pydx5p_m m FALSE (WBGene00019008) PW039 RHEA:10224 -R_PYRROLINECARBDEHYDROG_RXN_c 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_c + M_1pyr5c_c + M_nad_c <=> M_h_c + M_glu__L_c + M_nadh_c c TRUE (WBGene00000112) "PW081;PW073" -R_PYRROLINECARBDEHYDROG_RXN_m 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_m + M_1pyr5c_m + M_nad_m <=> M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00000112) "PW081;PW073" +R_PYRROLINECARBDEHYDROG_RXN_c 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_c + M_1pyr5c_c + M_nad_c <=> 2.0 M_h_c + M_glu__L_c + M_nadh_c c TRUE (WBGene00000112) "PW081;PW073" +R_PYRROLINECARBDEHYDROG_RXN_m 1-pyrroline-5-carboxylate dehydrogenase 2.0 M_h2o_m + M_1pyr5c_m + M_nad_m <=> 2.0 M_h_m + M_glu__L_m + M_nadh_m m TRUE (WBGene00000112) "PW081;PW073" R_PYRt2m pyruvate mitochondrial transport via proton symport M_h_c + M_pyr_c <=> M_h_m + M_pyr_m cm TRUE ND PW111 R_QUILSYN_c Quinolinate Synthase M_cmusa_c <=> M_h2o_c + M_quln_c c FALSE PW036 R_r0941 Bicarbonate Exchange reactions M_hco3_c <=> M_hco3_m cm TRUE PW111 From b61e68f87deb4eb64a9066ed6c7b3e5f7e56076f Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 11:49:15 +1000 Subject: [PATCH 3/9] fix/R_3HAO_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 2eba620..f513ae4 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -86,7 +86,7 @@ R_34HPLFM_m Hydroxyphenylpyruvate reductase M_h_m + M_nadh_m + M_34hpp_m <=> M R_34HPPOR_c 4-hydroxyphenylpyruvate dioxygenase M_o2_c + M_34hpp_c <=> M_co2_c + M_hgentis_c c FALSE (WBGene00016294) or (WBGene00001993) PW077 RHEA:16189 R_34HPPOR_n 4-hydroxyphenylpyruvate dioxygenase M_o2_n + M_34hpp_n <=> M_co2_n + M_hgentis_n n FALSE (WBGene00016294) PW077 R_35CGMPtn 35cGMP nuclear transport M_35cgmp_c <=> M_35cgmp_n cn TRUE PW108 -R_3HAO_c 3-hydroxyanthranilate 3,4-dioxygenase M_3hanthrn_c + M_o2_c <=> M_cmusa_c + M_h_c c FALSE (WBGene00010595) PW072 RHEA:17953 +R_3HAO_c 3-hydroxyanthranilate 3,4-dioxygenase M_3hanthrn_c + M_o2_c <=> M_cmusa_c c FALSE (WBGene00010595) PW072 RHEA:17953 R_3HBCD_c 3-hydroxybutyryl-CoA dehydratase M_h2o_c + M_b2coa_c <=> M_3hbcoa_R_c c FALSE (WBGene00001150) PW080 replaced M_3hbcoa_R_c with M_3hbcoa__R_c lenov R_3HBCD_m 3-hydroxybutyryl-CoA dehydratase M_h2o_m + M_b2coa_m <=> M_3hbcoa_R_m m FALSE (WBGene00001150) PW080 replaced M_3hbcoa_R_m with M_3hbcoa__R_m lenov R_3HLYTCL_c R_3HLYTCL_c M_h_c + M_34dhphe_c <=> M_co2_c + M_dopa_c c TRUE WBGene00000239 or WBGene00015467 or WBGene00001839 or WBGene00006562 PW077 "RHEA:14345;RHEA:12272;RHEA:18533" From 07c18933f1c5998f5f9cd64e261930c8a8b447d3 Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 11:53:05 +1000 Subject: [PATCH 4/9] fix/R_ADSK_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index f513ae4..7348b8a 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -161,7 +161,7 @@ R_ADNK1_m Adenosine kinase M_atp_m + M_adn_m <=> M_h_m + M_amp_m + M_adp_m m FA R_ADNtm adenosine facilated transport in mitochondria M_adn_c <=> M_adn_m cm TRUE (WBGene00001320) or (WBGene00010701) or (ND) PW106 R_ADPSUGPPHOSPHAT_RXN_c ADP-sugar diphosphatase M_h2o_c + M_adpsug_c <=> M_amp_c + M_adaldp_c c FALSE PW034 R_ADPT_c Adenine phosphoribosyltransferase M_prpp_c + M_ade_c <=> M_ppi_c + M_amp_c c FALSE WBGene00020557 or WBGene00013690 PW042 RHEA:17973 -R_ADSK_c Adenylylsulfate kinase M_aps_c + M_atp_c <=> M_paps_c + 2.0 M_h_c + M_adp_c c TRUE (WBGene00004091) "PW096;PW042" "set to reversible; replaced annotation sulfate activation for sulfonation with PW096, PW042" "janna; lenov" +R_ADSK_c Adenylylsulfate kinase M_aps_c + M_atp_c <=> M_paps_c + M_h_c + M_adp_c c TRUE (WBGene00004091) "PW096;PW042" "set to reversible; replaced annotation sulfate activation for sulfonation with PW096, PW042" "janna; lenov" R_ADSL1_c Adenylosuccinate lyase M_dcamp_c <=> M_amp_c + M_fum_c c TRUE (WBGene00011064) PW042 "RHEA:16853;RHEA:23920" R_ADSL2_c Adenylosuccinate lyase M_25aics_c <=> M_aicar_c + M_fum_c c TRUE (WBGene00011064) PW042 "RHEA:16853;RHEA:23920" R_ADSS_c adenylosuccinate synthetase M_asp__L_c + M_imp_c + M_gtp_c <=> M_pi_c + 2.0 M_h_c + M_dcamp_c + M_gdp_c c TRUE (WBGene00016509) or (WBGene00016509) or (WBGene00016509) PW042 20654742 RHEA:15753 "added PMID and merged R_RC01135 into here; changed M_asp__L_c into M_asp_c" "jpnh; lenov" From c2ae9db7256d8e9397a84817fed4c0769b997978 Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 12:07:28 +1000 Subject: [PATCH 5/9] fix/R_ASNS1_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 7348b8a..5196fd4 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -479,7 +479,7 @@ R_ASCRODDBIOSYNTH0068 M_h2o_c + M_bkas_34coa_c <=> M_h_c + M_bkas_34_c + M_coa_ R_ASCRODDBIOSYNTH0069 M_h2o_c + M_bkas_38coa_c <=> M_h_c + M_bkas_38_c + M_coa_c c FALSE PW135 SPW002 [CHECKME] changed pathway and superpathway wimi R_ASCRODDBIOSYNTH0070 M_h2o_c + M_bkas_9coa_c <=> M_h_c + M_bkas_9_c + M_coa_c c FALSE PW135 SPW002 [CHECKME] changed pathway and superpathway wimi R_ASNN_c Asparaginase M_h2o_c + M_asn__L_c <=> M_nh3_c + M_h_c + M_asp__L_c c TRUE (WBGene00007756) PW073 changed M_asp__L_c and M_asn__L_c into M_asp_L_c and M_asn_L_c lenov -R_ASNS1_c asparagine synthetase (glutamine-hydrolysing) M_h2o_c + M_gln__L_c + M_asp__L_c + M_atp_c <=> M_ppi_c + 2.0 M_h_c + M_asn__L_c + M_glu__L_c + M_amp_c c FALSE (WBGene00019730) or (WBGene00003816) PW073 "[DELETION] replaced with R_RC00578_new due to incorrect stoichiometry; changed M_asp__L_c and M_asn__L_c into M_asp_L_c and M_asn_L_c" "jpnh; lenov" +R_ASNS1_c asparagine synthetase (glutamine-hydrolysing) M_h2o_c + M_gln__L_c + M_asp__L_c + M_atp_c <=> M_ppi_c + M_h_c + M_asn__L_c + M_glu__L_c + M_amp_c c FALSE (WBGene00019730) or (WBGene00003816) PW073 "[DELETION] replaced with R_RC00578_new due to incorrect stoichiometry; changed M_asp__L_c and M_asn__L_c into M_asp_L_c and M_asn_L_c" "jpnh; lenov" R_Asparagine_transport Asparagine transport M_asn__L_c <=> M_asn__L_e ce TRUE PW107 replaced M_asn__L_c and M_asn__L_e with M_asn_L_c and M_asn_L_e lenov R_ASPARTATE_RACEMASE_RXN_c aspartate racemase M_asp__L_c <=> M_asp__D_c c FALSE PW073 changed M_asp__L_c and M_asp__D_c into M_asp_L_c and M_asp_D_c lenov R_Aspartate_transport Aspartate transport M_asp__L_c <=> M_asp__L_e ce TRUE PW107 From ced3b9f58df9dd29ccd9c1d85879d65e466b480f Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 12:16:02 +1000 Subject: [PATCH 6/9] fix/ATPH1_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 5196fd4..3c68152 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -489,7 +489,7 @@ R_ASPGLUm aspartate-glutamate mitochondrial shuttle M_h_c + M_glu__L_c + M_asp R_ASPt6 L-aspartate transport via Na, H symport and K antiport M_h_e + M_asp__L_e + 3.0 M_na1_e + M_k_c <=> M_h_c + M_asp__L_c + M_k_e + 3.0 M_na1_c ec FALSE (WBGene00001620) or (WBGene00001625) PW107 changed M_asp__L_e and M_asp__L_c into M_asp_L_e and M_asp_L_e lenov R_ASPTA_c Aspartate aminotransferase M_oaa_c + M_glu__L_c <=> M_akg_c + M_asp__L_c c FALSE (WBGene00020146) or (WBGene00020145) or (WBGene00015771) or (WBGene00015778) "PW073;PW074" "RHEA:21824;RHEA:21824" "[DELETION] merged into R_RC00355; changed M_asp__L_c into M_asp_c" "jpnh;lenov" R_ASPTA_m Aspartate aminotransferase M_oaa_m + M_glu__L_m <=> M_akg_m + M_asp__L_m m FALSE (WBGene00016652) or (WBGene00015778) "PW073;PW074" "RHEA:21824;RHEA:21824" changed M_asp__L_m into M_asp_L_m lenov -R_ATPH1_c Apyrase 2.0 M_h2o_c + M_atp_c <=> 2.0 M_pi_c + 3.0 M_h_c + M_amp_c c FALSE (WBGene00003254) "PW042;PW043" RHEA:36799 +R_ATPH1_c Apyrase 2.0 M_h2o_c + M_atp_c <=> 2.0 M_pi_c + 2.0 M_h_c + M_amp_c c FALSE (WBGene00003254) "PW042;PW043" RHEA:36799 R_ATPtm ADP/ATP transporter, mitochondrial M_atp_m + M_adp_c <=> M_atp_c + M_adp_m mc FALSE (WBGene00010485) or (WBGene00020140) or (WBGene00007057) or (WBGene00006439) or (ND) PW106 R_ATPtn ATP diffusion in nucleus M_atp_c <=> M_atp_n cn TRUE PW108 R_BBHOX_c "γ-butyrobetaine dioxygenase" M_akg_c + M_4tmeabutn_c + M_o2_c <=> M_co2_c + M_crn_c + M_succ_c c FALSE (WBGene00001522) or (WBGene00001523) PW080 RHEA:24028 From c92ad08e152fe8e4567d1ceb84e21521c3f5a2ab Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 13:59:06 +1000 Subject: [PATCH 7/9] fix/R_CMPKI_RXN_n removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 3c68152..97a842d 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -731,7 +731,7 @@ R_CLBIOSYNTH0006 Phospholipase A2 (CL) M_h2o_m + M_clpn_m <=> M_h_c + M_fatacid_ R_CLBIOSYNTH0007 monolysocardiolipin acyltransferase M_mlclpn_m + M_fataccoa_m <=> M_coa_m + M_clpn_m m FALSE WBGene00006491 PW142 SPW003 [CHECKME] added for cardiolipin remodeling wimi R_CMPKI_RXN_c Cytidylate kinase M_atp_c + M_cmp_c <=> M_adp_c + M_cdp_c c TRUE (WBGene00007812) or (WBGene00009575) "PW043;PW042" set to reversible janna R_CMPKI_RXN_m Cytidylate kinase M_atp_m + M_cmp_m <=> M_adp_m + M_cdp_m m TRUE (WBGene00007812) or (WBGene00009575) "PW043;PW042" set to reversible janna -R_CMPKI_RXN_n Cytidylate kinase M_atp_n + M_cmp_n <=> M_h_n + M_adp_n + M_cdp_n n TRUE (WBGene00007812) "PW043;PW042" set to reversible janna +R_CMPKI_RXN_n Cytidylate kinase M_atp_n + M_cmp_n <=> M_adp_n + M_cdp_n n TRUE (WBGene00007812) "PW043;PW042" set to reversible janna R_CMPtm cmp transport to mitochndria M_cmp_c <=> M_cmp_m cm TRUE ND PW106 set to reversible janna R_CO2_Exchange_reactions_e CO2 transport M_co2_e <=> e FALSE PW111 Set directionality to FALSE` jpnh R_CO2_transport CO2 transport M_co2_c <=> M_co2_e ce TRUE ND PW107 From f3e7e2a088d9e266988c094f724854ca8d0b7c05 Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 14:05:35 +1000 Subject: [PATCH 8/9] fix/R_CTPS2_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 97a842d..10c2f1c 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -745,7 +745,7 @@ R_CRNtim L-carnitine transport out of mitochondria via diffusion M_crn_c <=> M_c R_CS_c Citrate (si)-synthase M_oaa_c + M_h2o_c + M_accoa_c <=> M_cit_c + M_h_c + M_coa_c c FALSE (WBGene00000833) "PW023;PW030" RHEA:16845 R_CS_m Citrate (si)-synthase M_oaa_m + M_h2o_m + M_accoa_m <=> M_cit_m + M_h_m + M_coa_m m FALSE (WBGene00000833) "PW023;PW030" RHEA:16845 R_CSND_c Cytosine deaminase M_h2o_c + M_csn_c <=> M_nh3_c + M_ura_c c TRUE PW043 -R_CTPS2_c CTP synthetase M_h2o_c + M_gln__L_c + M_atp_c + M_utp_c <=> M_pi_c + 3.0 M_h_c + M_glu__L_c + M_adp_c + M_ctp_c c FALSE (WBGene00012316) PW043 RHEA:26426 +R_CTPS2_c CTP synthetase M_h2o_c + M_gln__L_c + M_atp_c + M_utp_c <=> M_pi_c + 2.0 M_h_c + M_glu__L_c + M_adp_c + M_ctp_c c FALSE (WBGene00012316) PW043 RHEA:26426 R_CTPtn CTP diffusion in nucleus M_ctp_c <=> M_ctp_n cn TRUE PW108 R_cu2_e copper exchange rxn <=> M_cu2_e e TRUE PW111 Improved rxn name jpnh R_CYANST_c Thiosulfate sulfurtransferase M_tsul_c + M_cyan_c <=> M_so3_c + 2.0 M_h_c + M_tcynt_c c TRUE WBGene00008409 or WBGene00010380 or WBGene00010383 or WBGene00017387 or WBGene00022006 or WBGene00022007 or WBGene00011307 PW096 "RHEA:16881;RHEA:16881" set to reversible janna From 47f648c7ab5341c34dbdedc8fdb391dd5b145f90 Mon Sep 17 00:00:00 2001 From: Marius-uni Date: Mon, 29 Aug 2022 14:06:53 +1000 Subject: [PATCH 9/9] fix/R_CYTDK1_c removed 1 Proton to balance the reaction/found on uniprot --- curation/Reaction-SBtab.tsv | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv index 10c2f1c..679eb74 100644 --- a/curation/Reaction-SBtab.tsv +++ b/curation/Reaction-SBtab.tsv @@ -762,7 +762,7 @@ R_Cystm Cystein reversible mitochondrial transport M_cys__L_c <=> M_cys__L_m cm R_CYSTS_c "Cystathionine β-synthase" M_hcys__L_c + M_ser__L_c <=> M_cyst__L_c + M_h2o_c c TRUE (WBGene00013866) or (WBGene00018783) PW082 R_CYTD_c Cytidine deaminase M_h2o_c + M_cytd_c <=> M_nh3_c + M_uri_c c TRUE (WBGene00000391) or (WBGene00000392) PW043 "RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069" R_CYTD_n Cytidine deaminase M_h2o_n + M_cytd_n <=> M_nh3_n + M_uri_n n TRUE (WBGene00000391) or (WBGene00000392) PW043 "RHEA:13433;RHEA:16069;RHEA:13433;RHEA:16069" -R_CYTDK1_c R_CYTDK1_c M_atp_c + M_cytd_c <=> 2.0 M_h_c + M_adp_c + M_cmp_c c FALSE WBGene00007089 or WBGene00008948 "PW042;PW043" +R_CYTDK1_c R_CYTDK1_c M_atp_c + M_cytd_c <=> M_h_c + M_adp_c + M_cmp_c c FALSE WBGene00007089 or WBGene00008948 "PW042;PW043" R_CYTDK2_c cytidine kinase M_gtp_c + M_cytd_c <=> M_h_c + M_gdp_c + M_cmp_c c TRUE PW043 Added reaction name jpnh R_CYTDt2r Cytidine transport M_h_e + M_cytd_e <=> M_h_c + M_cytd_c ec TRUE (WBGene00018716 or WBGene00014092) or (ND) PW111 Added rxn name jpnh R_CYTDtm cytidine facilated transport in mitochondria M_cytd_c <=> M_cytd_m cm TRUE (WBGene00001320) or (WBGene00010701) or (ND) PW106