This repository contains a modified version of TIsigner, adapted for batch processing of DNA sequences. TIsigner was developed for designing coding regions for optimal translation initiation.
This work was conducted as part of a US Department of Energy SCGSR Fellowship (details) at the National Renewable Energy Laboratory with additional support from the US National Science Foundation (grant).
The current version has been modified to:
- Process batches of DNA sequences rapidly.
- Enhance compatibility with Google Colab for improved accessibility and ease of use.
- Optimize the output format for simple analysis.
These modifications aim to streamline the process of analyzing and optimizing large sets of DNA sequences, making it more efficient for researchers working with bulk genomic data.
This repository originally contained source for the following:
- TIsigner command line version (TIsigner_cmd).
- TIsigner website (TIsigner_web).
This paper describes TIsigner.
Instructions for setting up the modified command line version and using it with Google Colab are available in the TIsigner_cmd directory.
© Bikash Kumar Bhandari, Chun Shem Lim, Paul P Gardner (2019-)
This work builds upon the original TIsigner project. We acknowledge the contributions of the original authors and maintain their citations to ensure proper attribution of the foundational work.