Wellness KP

Multiomics Wellness KP

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Wellness is a KP created and maintained by the Multiomics Provider. Wellness KP provides significant correlations between various blood analytes. The dataset was created as a result of a wellness study that monitored the blood analytes and general wellness of a cohort of individuals that were largely healthy. The KP presents statistical metrics like the Spearman correlation and the Bonferroni corrected p-value among clinical labs, proteins and metabolites. Upcoming versions will include regression models for analytes with maximum connections and models that represent interactions among community of analytes that make biological networks.

Edge Attribute: weighted p-value:

The graph currently uses the biolink:correlated_with predicate and biolink:ClinicalFinding, and the deprecated biolink:Protein and biolink:Metabolite as nodes.

• Modes of Access - Reasoner API v.#.#.#, SmartAPI registry, KGX - formatted Knowledge Graph
  • Smart API: https://biothings.ncats.io/multiomics_wellness_kp
  • TRAPI: https://api.bte.ncats.io/v1/smartapi/02af7d098ab304e80d6f4806c3527027/query
  • KGX - upcoming

Use Cases- A sample TRAPI formatted query:

• { "message": { "query_graph": { "edges": { "e0": { "predicate": "biolink:correlated_with", "subject": "n00", "object": "n01" } }, "nodes": { "n00": { "category": "biolink:ClinicalFinding", "id": "LOINC:1759-0" }, "n01": { "category": "biolink:ChemicalSubstance" } } } } }

Knowledge Sources Accessed -

• ISB's Wellness dataset

Source Code - (include links to your source code). See example below

• Upcoming