Wellness KP

Multiomics Wellness KP

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Wellness is a KP created and maintained by the Multiomics Provider. Wellness KP provides significant correlations between various blood analytes. The dataset was created as a result of a wellness study that monitored the blood analytes and general wellness of a cohort of individuals that were largely healthy. The KP presents statistical metrics like the Spearman correlation and the Bonferroni corrected p-value among clinical labs, proteins and metabolites and gut microbiome, along with regression models for blood analytes with maximum connections. Upcoming versions will include models that represent interactions among community of analytes that make biological networks.

Edge Attributes (besides subject, predicate, object):

• N: concept pair count, the number of data instances that help derive the relationship
• Type of relationship: Spearman Correlation, Ridge Regression, it could include any model that was used to derive the relationship
• Strength of relationship: The value of the coefficent obtained
• Bonferroni_pval: The adjusted p-value representing confidence in the strength of the relationship

The graph currently uses the biolink:correlated_with and biolink:related_to as predicates. Node categories include biolink:ClinicalFinding, biolink:Protein, biolink:SmallMolecule and biolink:MolecularActivity.

• Modes of Access - Reasoner API v.#.#.#, SmartAPI registry, KGX - formatted Knowledge Graph
  • Smart API: https://biothings.ncats.io/multiomics_wellness_kp
  • TRAPI: https://api.bte.ncats.io/v1/smartapi/02af7d098ab304e80d6f4806c3527027/query
  • KGX - upcoming

Use Cases- A sample TRAPI formatted query:

• { "message": { "query_graph": { "edges": { "e0": { "predicate": "biolink:correlated_with", "subject": "n00", "object": "n01" } }, "nodes": { "n00": { "category": "biolink:ClinicalFinding", "id": "LOINC:1759-0" }, "n01": { "category": "biolink:ChemicalSubstance" } } } } }

Knowledge Sources Accessed -

• ISB's Wellness dataset

Source Code - (include links to your source code). See example below

• Upcoming