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# Workflow | ||
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Exemplary data harmonization: Existing data sources are used to compute embeddings that | ||
are stored in a database. New data by users is being mapped based on the shortest embedding distances. | ||
An end user curates data based on suggestions and may store mappings to improve the next mapping | ||
iteration. | ||
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 | ||
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1. New data sources consisting of the raw study data and corresponding data dictionaries are collected and pre-processed by the end-user | ||
2. The user can then specify the context in which the new data should be harmonized - this could be any kind of terminology that has been used for previous mappings or has been stored for retrieval in any terminology server, e.g. Ontology Lookup Service (OLS)^[1] | ||
3. Using a general purpose public LLM such as ChatGPT, a local variant such as LLaMA^[2] or a domain-specific model like BioBERT^[3], a high dimensional embedding can be computed for each of the previously curated data sources as well as for all relevant terminology sources | ||
4. After the same embedding calculation is done for the unseen data, the data is then mapped to a concept of either the curated data or any terminology concept term in the matching pre-selected context based on its smallest Euclidean distance | ||
5. The end-user will receive a list of the closest matching candidates, which can then again be manually curated with little additional effort compared to a full manual curation | ||
6. The resulting mappings and embeddings are then stored together with the previously curated data | ||
7. Based on the updated mappings, the upcoming iteration of mapping can benefit from an expanded baseline of underlying vector embeddings, thus potentially being able to utilize a more detailed and granular mapping model | ||
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[1]: [EMBL-EBI Ontology Lookup Service](https://www.ebi.ac.uk/) | ||
[2]: [LLaMA: Open and Efficient Foundation Language Models](https://arxiv.org/abs/2302.13971) | ||
[3]: [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://arxiv.org/abs/1901.08746) |
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