Deep Embedded Single-cell RNA-seq Clustering implementation with pytorch, you can find implementation of tensorflow version of DESC in https://github.com/eleozzr/desc. We will try more complicated network structure and loss function base on DESCtorch in the future!!! I try my best to reproduce result of this paper in https://github.com/yuxiaokang-source/DESC_reproduce.
conda create -n DESCtorch python=3.6.10
conda activate DESCtorch
pip install DESCtorch
run paul15_tutorial.ipynb for more detail
Li, X., Wang, K., Lyu, Y., Pan, H., Zhang, J., Stambolian, D., ... & Li, M. (2020). Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis. Nature communications, 11(1), 1-14.