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| # covid19-ace2-variants | ||
| Author: Stuart MacGowan ([s.macgowan@dundee.ac.uk](mailto:s.macgowan@dundee.ac.uk)) | ||
| # COVID-19 ACE2 Variants | ||
| **Author:** Stuart MacGowan ([smacgowan@dundee.ac.uk](mailto:smacgowan@dundee.ac.uk)) | ||
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| Research code and data to interpret the effect of ACE2 variants on SARS-CoV-2 infection | ||
| ## Overview | ||
| This repository contains research code and data used to analyse the impact of ACE2 variants on SARS-CoV-2 infection. The primary focus is on exploring how missense variants in ACE2 influence interaction with the SARS-CoV-2 Spike protein and their potential contribution to genetic risk factors in COVID-19. | ||
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| The analysis and figures for the paper *"Missense variants in ACE2 are predicted to encourage and inhibit | ||
| interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19"* | ||
| [preprint on bioRxiv](https://www.biorxiv.org/content/10.1101/2020.05.03.074781v1) can be found in the | ||
| notebook [ACE2-variants-structure-and-assays.ipynb](ACE2-variants-structure-and-assays.ipynb). | ||
| ## Research Paper | ||
| The detailed analysis and figures related to this study are available in the paper titled: | ||
| - "Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19". | ||
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| This work is available as a [preprint on bioRxiv](https://www.biorxiv.org/content/10.1101/2020.05.03.074781v1). | ||
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| ## Published Work | ||
| The findings of this research have been published in the following journal: | ||
| - MacGowan SA, Barton MI, Kutuzov M, Dushek O, van der Merwe PA, et al. (2022). "Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants." PLOS Computational Biology 18(3): e1009922. [Link to Publication](https://doi.org/10.1371/journal.pcbi.1009922) | ||
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| ## Repository Contents | ||
| - `ACE2-variants-structure-and-assays.ipynb`: Jupyter notebook containing the analysis and figures related to the study. |