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Update TP53 pipeline analysis (greenelab#86)
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* remove args from within disease

remove checkpoint call from tp53 viz

remove checkpoint and convert to pdf

update copy burden analysis

add two additional notebook scripts for tp53 analysis

remove old figure generation script

update name of supplementary figure plot0

update gzip copy burden figures

add back l1 mixing parameter

* remove extra new line

add tp53 exon processing notebook

make snaptron bash executable

adding updated snaptron results

add processing exons notebook

rerun pipeline and generate junction gz

convert from svg to pdf

also swith single quotes to double

update file name

* update sample freeze file input to tp53 notebook

update phenocopy tp53 sample freeze

* update phenocopying results

rerun pipeline to update existing results

add all TP53 classifier results

rerun pipeline

rerun pipeline and add results outside classifiers folder

rerun pipeline again
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gwaybio authored Oct 15, 2018
1 parent a868c41 commit 531f7c6
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8,035 changes: 8,035 additions & 0 deletions classifiers/TP53/classifier_coefficients.tsv

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61 changes: 61 additions & 0 deletions classifiers/TP53/classifier_summary.txt
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Parameters:
Genes: TP53
Diseases: BLCA BRCA CESC COAD ESCA GBM HNSC KICH LGG LIHC LUAD LUSC PAAD PRAD READ SARC SKCM STAD UCEC
Alternative Genes: None
Alternative Diseases: Auto
Number of Features: 8034
Drop Gene: True
Copy Number: True
Alphas: 0.1 0.13 0.15 0.18 0.2 0.3 0.4 0.6 0.7
L1_ratios: 0.1 0.125 0.15 0.2 0.25 0.3 0.35
Hypermutated Removed: True

Results:
Optimal Alpha: 0.1
Optimal L1: 0.1
Coefficients: classifiers/TP53/classifier_coefficients.tsv
Training AUROC: 0.9340136200170487
Testing AUROC: 0.9339535941334193
Cross Validation AUROC 0.915645902972101
Training AUPR: 0.9027559509594195
Testing AUPR: 0.9004359151957726
Cross Validation AUPR: 0.8737165659342406
Disease specific performance:
BLCA Training AUROC: 0.908662900188324 Testing AUROC: 0.9026315789473685 Cross Validation AUROC: 0.8647964153516461
BRCA Training AUROC: 0.9596716428092276 Testing AUROC: 0.9478458049886621 Cross Validation AUROC: 0.9430661830750514
CESC Training AUROC: 0.717351598173516 Testing AUROC: 0.6666666666666667 Cross Validation AUROC: 0.6518264840182649
COAD Training AUROC: 0.9305714649357261 Testing AUROC: 0.9848484848484849 Cross Validation AUROC: 0.9129438717067583
ESCA Training AUROC: 0.675839552238806 Testing AUROC: 0.9 Cross Validation AUROC: 0.6417910447761195
GBM Training AUROC: 0.879378837125316 Testing AUROC: 0.96875 Cross Validation AUROC: 0.8671000361141207
HNSC Training AUROC: 0.8875140607424072 Testing AUROC: 0.7352941176470589 Cross Validation AUROC: 0.8598783106657122
KICH Training AUROC: 0.8565789473684211 Testing AUROC: 1.0 Cross Validation AUROC: 0.7657894736842106
LGG Training AUROC: 0.973224297258632 Testing AUROC: 1.0 Cross Validation AUROC: 0.9670378533039478
LIHC Training AUROC: 0.9328933423258503 Testing AUROC: 1.0 Cross Validation AUROC: 0.9037479525965892
LUAD Training AUROC: 0.9104161558522613 Testing AUROC: 0.8573913043478261 Cross Validation AUROC: 0.8901321801930322
LUSC Training AUROC: 0.7090379008746356 Testing AUROC: 0.575187969924812 Cross Validation AUROC: 0.6619869925992374
PAAD Training AUROC: 0.8886446886446886 Testing AUROC: 0.86 Cross Validation AUROC: 0.8192918192918193
PRAD Training AUROC: 0.8624234200896345 Testing AUROC: 0.9825783972125435 Cross Validation AUROC: 0.8068747173224785
READ Training AUROC: 0.9264705882352942 Testing AUROC: 1.0 Cross Validation AUROC: 0.8998599439775911
SARC Training AUROC: 0.8400537634408602 Testing AUROC: 0.7416666666666667 Cross Validation AUROC: 0.8057795698924731
SKCM Training AUROC: 0.9319999999999999 Testing AUROC: 0.927536231884058 Cross Validation AUROC: 0.9167619047619049
STAD Training AUROC: 0.9240064446831364 Testing AUROC: 0.9307958477508651 Cross Validation AUROC: 0.907312925170068
UCEC Training AUROC: 0.9421921921921922 Testing AUROC: 0.9951923076923077 Cross Validation AUROC: 0.9375721875721875
BLCA Training AUPR: 0.9016969301453566 Testing AUPR: 0.8290129945285417 Cross Validation AUPR: 0.8455558343213506
BRCA Training AUPR: 0.9160947686393439 Testing AUPR: 0.9194046974481075 Cross Validation AUPR: 0.8792974978397354
CESC Training AUPR: 0.4137247471157805 Testing AUPR: 0.5555555555555556 Cross Validation AUPR: 0.34319186079556907
COAD Training AUPR: 0.9231127810137119 Testing AUPR: 0.9907216297825174 Cross Validation AUPR: 0.8973406250362697
ESCA Training AUPR: 0.9045602637629551 Testing AUPR: 0.9866269841269841 Cross Validation AUPR: 0.8997814791526315
GBM Training AUPR: 0.8319781560827086 Testing AUPR: 0.95 Cross Validation AUPR: 0.833207777068663
HNSC Training AUPR: 0.9303436707739461 Testing AUPR: 0.8472350938025608 Cross Validation AUPR: 0.9056878391985403
KICH Training AUPR: 0.8296838129417035 Testing AUPR: 1.0 Cross Validation AUPR: 0.6301928679590945
LGG Training AUPR: 0.9727474272401524 Testing AUPR: 1.0 Cross Validation AUPR: 0.9685580008970107
LIHC Training AUPR: 0.874386286443685 Testing AUPR: 1.0 Cross Validation AUPR: 0.8128001331254809
LUAD Training AUPR: 0.8866983603438293 Testing AUPR: 0.8256994547890552 Cross Validation AUPR: 0.8444501537052753
LUSC Training AUPR: 0.907204990292803 Testing AUPR: 0.8780694320440617 Cross Validation AUPR: 0.8846791118453962
PAAD Training AUPR: 0.9427279611038916 Testing AUPR: 0.9272546897546897 Cross Validation AUPR: 0.8950906607275801
PRAD Training AUPR: 0.5451147707966071 Testing AUPR: 0.8954648526077098 Cross Validation AUPR: 0.4616270021084826
READ Training AUPR: 0.9551215222701015 Testing AUPR: 1.0 Cross Validation AUPR: 0.9426077963650131
SARC Training AUPR: 0.7499328066984672 Testing AUPR: 0.735546398046398 Cross Validation AUPR: 0.715376575572616
SKCM Training AUPR: 0.7270939999724422 Testing AUPR: 0.6666666666666667 Cross Validation AUPR: 0.6622860457186759
STAD Training AUPR: 0.9065930651336558 Testing AUPR: 0.9344380869034848 Cross Validation AUPR: 0.8910930627008757
UCEC Training AUPR: 0.9129843619570152 Testing AUPR: 0.9930555555555556 Cross Validation AUPR: 0.9103680009676541
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