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He-Kai-fly authored Sep 2, 2023
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date: 2023-09-02
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# 生信爱好者周刊(第 91 期):探索的动机

这里记录每周值得分享的生信相关内容,周日发布。

本杂志开源(GitHub: [ShixiangWang/weekly](https://github.com/ShixiangWang/weekly "ShixiangWang/weekly")),欢迎提交 issue,投稿或推荐生信相关内容。
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近日,MSK研究团队开发了一种基于CRISPR新技术MACHETE,可以切割基因序列的重要靶标部分,反映癌症和其他人类疾病中出现的变化,可用于实验室模型中高效地研究大规模基因缺失,例如CNA。研究团队利用MACHETE揭示了一种导致约15%癌症的基因变化,这可能有助于识别对免疫疗法有反应的患者。

- 论文链接:https://doi.org/10.1038/s43018-022-00443-5







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