fix/multiple kinases

removed 1 Proton to balance the reaction/kinase activity
wormjam-consortium · Aug 31, 2022 · d80128f · d80128f
1 parent 7ff4985
commit d80128f
Showing 1 changed file with 7 additions and 7 deletions.
diff --git a/curation/Reaction-SBtab.tsv b/curation/Reaction-SBtab.tsv
@@ -2588,8 +2588,8 @@ R_RE00548	riboflavin-5-phosphate phosphohydrolase (acid optimum)	M_h2o_e +  M_fm
 R_RE10092	carbonate hydro-lyase (carbon-dioxide-forming)	M_co2_e +  M_h2o_e <=> M_hco3_e + M_h_e	e	TRUE	WBGene00000283	PW098			RHEA:10748					Changed pathway annotation from nitrogen metabolism to miscellaneous	lenov								
 R_Riboflavin_Exchange_reactions_e	Riboflavin transport	M_ribflv_e <=>	e	TRUE		PW111								Removed space from reaction ID	jpnh								
 R_Riboflavin_transport	Riboflavin transport	M_ribflv_c <=> M_ribflv_e	ce	TRUE	WBGene00044637 or WBGene00021626	PW107																	
-R_RIBOKIN_RXN_c	Ribokinase	M_atp_c +  M_rib_D_c <=> M_r5p_c + 2.0 M_h_c + M_adp_c	c	FALSE	(WBGene00008548)	PW027	SPW004																
-R_RIBOKIN_RXN_m	Ribokinase	M_atp_m +  M_rib_D_m <=> M_r5p_m + 2.0 M_h_m + M_adp_m	m	FALSE	(WBGene00008548)	PW027	SPW004																
+R_RIBOKIN_RXN_c	Ribokinase	M_atp_c +  M_rib_D_c <=> M_r5p_c + M_h_c + M_adp_c	c	FALSE	(WBGene00008548)	PW027	SPW004																
+R_RIBOKIN_RXN_m	Ribokinase	M_atp_m +  M_rib_D_m <=> M_r5p_m + M_h_m + M_adp_m	m	FALSE	(WBGene00008548)	PW027	SPW004																
 R_RIBONUCLEOSIDE_DIP_REDUCTII_RXN_c	R_RIBONUCLEOSIDE_DIP_REDUCTII_RXN_c	M_cdp_c +  M_nrdh_ox_c <=> M_h2o_c + M_dcdp_c + M_nrdh_rd_c	c	FALSE		PW043																	
 R_RM00081	Ferrocytochrome-c:oxygen oxidoreductase	8.0 M_h_m +  M_o2_m + 4.0 M_focytC_m <=> 2.0 M_h2o_m + 4.0 M_h_c + 4.0 M_ficytC_m	m	FALSE	(WBGene00010964 and WBGene00010965 and WBGene00010962) and WBGene00000371 and WBGene00012553 and WBGene00006519 and WBGene00022170 and WBGene00017926 and WBGene00009161	PW007			"RHEA:11436;RHEA:11436;RHEA:11436"														
 R_RM00130	ATP:dephospho-CoA 3-phosphotransferase	M_atp_m +  M_dpcoa_m <=> M_h_m + M_adp_m + M_coa_m	m	FALSE	WBGene00011500 or WBGene00022031	PW037																	
@@ -2791,9 +2791,9 @@ R_RXN_12623_c	N,N'-diacetylchitobiose synthase	M_h2o_c +  M_chdex_c <=> M_chtbs_
 R_RXN_12624_c	chitotriose synthase	M_h2o_c +  M_chdex_c <=> M_chttr_c	c	FALSE	(WBGene00000503)	PW021																	
 R_RXN_12625_c	"N,N'-diacetylchitobiose&beta;-N-acetylglucosaminidase"	M_h2o_c +  M_chtbs_c <=> 2.0 M_acgam_c	c	FALSE	(WBGene00020509)	PW021																	
 R_RXN_12626_c	"chitotriose &beta;-N-acetylglucosaminidase"	M_h2o_c +  M_chttr_c <=> M_acgam_c + M_chtbs_c	c	FALSE	(WBGene00020509)	PW021																	
-R_RXN_1685_c	alpha-D-glucokinase	M_glc_aD_c +  M_atp_c <=> M_g6p_A_c + 2.0 M_h_c + M_adp_c	c	FALSE	(WBGene00008780) or (WBGene00022306) or (WBGene00010416)	PW018	SPW004																
-R_RXN_1685_m	alpha-D-glucokinase	M_glc_aD_m +  M_atp_m <=> M_g6p_A_m + 2.0 M_h_m + M_adp_m	m	FALSE	(WBGene00010416)	PW018	SPW004							why only one hexokinase associated? Are the two others not in mitochondria?									
-R_RXN_1685_n	alpha-D-glucokinase	M_glc_aD_n +  M_atp_n <=> M_g6p_A_n + 2.0 M_h_n + M_adp_n	n	FALSE	(WBGene00008780) or (WBGene00022306) or (WBGene00010416)	PW018	SPW004																
+R_RXN_1685_c	alpha-D-glucokinase	M_glc_aD_c +  M_atp_c <=> M_g6p_A_c + M_h_c + M_adp_c	c	FALSE	(WBGene00008780) or (WBGene00022306) or (WBGene00010416)	PW018	SPW004																
+R_RXN_1685_m	alpha-D-glucokinase	M_glc_aD_m +  M_atp_m <=> M_g6p_A_m + M_h_m + M_adp_m	m	FALSE	(WBGene00010416)	PW018	SPW004							why only one hexokinase associated? Are the two others not in mitochondria?									
+R_RXN_1685_n	alpha-D-glucokinase	M_glc_aD_n +  M_atp_n <=> M_g6p_A_n +  M_h_n + M_adp_n	n	FALSE	(WBGene00008780) or (WBGene00022306) or (WBGene00010416)	PW018	SPW004																
 R_RXN_2881_c	Non enzymatic 5,10-Methylenetetrahydrofolate production	M_thf_c +  M_fald_c <=> M_h2o_c + M_mlthf_c	c	TRUE		PW091								added rxn name	jpnh								
 R_RXN_2961_c	Non enzymatic 5,10-Methylenetetrahydrofolate production	M_hmgth_c <=> M_fald_c + M_gthrd_c	c	TRUE		PW091								added rxn name	jpnh								
 R_RXN_3521_c	L-ascorbate:hydrogen-peroxide oxidoreductase	M_h2o2_c + 4.0 M_h_c + 2.0 M_ascb__L_c <=> 2.0 M_h2o_c + 2.0 M_mdascb_c	c	FALSE		PW070								"added rxn name; replaced M_ascb__L_c with M_ascb__L_c"	"jpnh; lenov"								
@@ -3053,8 +3053,8 @@ R_RXN909_261_c	ATP:dGMP phosphotransferase	  M_dgdp_c +  M_adp_c <=> M_atp_c + M
 R_RXN909_261_m	R_RXN909_261_m	  M_dgdp_m +  M_adp_m <=> M_atp_m + M_dgmp_m	m	TRUE	(WBGene00020190)	PW042								set to reversible	janna								
 R_RXN909_266_c	R_RXN909_266_c	M_gpail_c +  M_coa16_0_c <=> M_gacpail_c + M_coa_c	c	FALSE	(WBGene00022447)	PW028																	
 R_RXN909_268_c	R_RXN909_268_c	M_h2o_c +  M_deg9_c <=> M_deg10_c + M_glcur_c	c	FALSE	(WBGene00013693)	PW016								[CHECK ME] Deg9 and 10 only appear in this reaction									
-R_RXN909_27_c	R_RXN909_27_c	M_2doxrib_c +  M_atp_c <=> 2.0 M_h_c + M_adp_c + M_2dr5p_c	c	FALSE	(WBGene00008548)	PW043																	
-R_RXN909_27_m	R_RXN909_27_m	M_2doxrib_m +  M_atp_m <=> 2.0 M_h_m + M_adp_m + M_2dr5p_m	m	FALSE	(WBGene00008548)	PW043																	
+R_RXN909_27_c	R_RXN909_27_c	M_2doxrib_c +  M_atp_c <=> M_h_c + M_adp_c + M_2dr5p_c	c	FALSE	(WBGene00008548)	PW043																	
+R_RXN909_27_m	R_RXN909_27_m	M_2doxrib_m +  M_atp_m <=> M_h_m + M_adp_m + M_2dr5p_m	m	FALSE	(WBGene00008548)	PW043																	
 R_RXN909_270_c	R_RXN909_270_c	M_h2o_c +  M_cs_d_deg3_c <=> M_cs_d_deg4_c + M_glcur_c	c	FALSE	(WBGene00013693)	PW014																	
 R_RXN909_271_c	R_RXN909_271_c	M_h2o_c +  M_cs_c_deg2_c <=> M_cs_c_deg3_c + M_glcur_c	c	FALSE	(WBGene00013693)	PW014																	
 R_RXN909_272_c	R_RXN909_272_c	M_h2o_c +  M_ap4a_c <=> M_h_c + M_atp_c + M_amp_c	c	FALSE	(WBGene00003581)	PW034			RHEA:32039